Glutathione-depletion mesoporous organosilica nanoparticles as a self-adjuvant and Co-delivery platform for enhanced cancer immunotherapy.

Lu, Yao; Yang, Yannan; Gu, Zhengying; Zhang, Jun; Song, Hao; Xiang, Guangya; Yu, Chengzhong

Lu, Yao; Yang, Yannan; Gu, Zhengying; Zhang, Jun; Song, Hao; Xiang, Guangya; Yu, Chengzhong.

Afiliação

Lu Y; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Yang Y; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Gu Z; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Zhang J; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Song H; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Xiang G; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: gyxiang1968@hotmail.com.
Yu C; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: c.yu@uq.edu.au.

Biomaterials ; 175: 82-92, 2018 08.

Article em En | MEDLINE | ID: mdl-29803106

Assuntos

Adjuvantes Imunológicos/administração & dosagem; Vacinas Anticâncer/administração & dosagem; Glutationa/metabolismo; Melanoma Experimental/terapia; Nanopartículas/química; Dióxido de Silício/química; Animais; Células Apresentadoras de Antígenos/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Endossomos/fisiologia; Humanos; Imunoterapia; Melanoma Experimental/imunologia; Melanoma Experimental/patologia; Camundongos; Oligodesoxirribonucleotídeos/administração & dosagem; Ovalbumina/administração & dosagem; Oxirredução; Polietilenoimina/química; Porosidade; Linfócitos T Citotóxicos/patologia; Receptor Toll-Like 9/agonistas

Palavras-chave

Cancer immunotherapy; Co-delivery; Glutathione depletion; ROS generation; Tetrasulfide-bridged organosilica

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Melanoma Experimental / Adjuvantes Imunológicos / Dióxido de Silício / Vacinas Anticâncer / Nanopartículas / Glutationa Limite: Animals / Humans Idioma: En Revista: Biomaterials Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália

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