Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice.

Adhikary, S R; Geraghty, N J; Cuthbertson, P; Sluyter, R; Watson, D

Adhikary, S R; Geraghty, N J; Cuthbertson, P; Sluyter, R; Watson, D.

Afiliação

Adhikary SR; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia.
Geraghty NJ; Molecular Horizons, University of Wollongong, Wollongong, NSW, 2522, Australia.
Cuthbertson P; Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Sluyter R; School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia.
Watson D; Molecular Horizons, University of Wollongong, Wollongong, NSW, 2522, Australia.

Purinergic Signal ; 15(2): 177-192, 2019 06.

Article em En | MEDLINE | ID: mdl-31001750

Assuntos

Doença Enxerto-Hospedeiro/genética; Receptores Purinérgicos P2X7/genética; Receptores Purinérgicos P2X7/metabolismo; Animais; Genótipo; Humanos; Leucócitos Mononucleares/metabolismo; Camundongos; Camundongos Endogâmicos NOD; Camundongos Knockout; Camundongos SCID; Polimorfismo de Nucleotídeo Único

Palavras-chave

Bone marrow transplantation; Humanised mice; Leukocyte; P2RX7 gene single nucleotide polymorphism; P2X7 receptor; Purinergic receptor; Xenogeneic graft-versus-host disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Purinérgicos P2X7 / Doença Enxerto-Hospedeiro Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Purinergic Signal Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

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