Targeted co-delivery of Trp-2 polypeptide and monophosphoryl lipid A by pH-sensitive poly (ß-amino ester) nano-vaccines for melanoma.

Zou, Chenming; Jiang, Guiying; Gao, Xueqin; Zhang, Wei; Deng, Huan; Zhang, Chong; Ding, Jiahui; Wei, Rui; Wang, Xueqian; Xi, Ling; Tan, Songwei

Zou, Chenming; Jiang, Guiying; Gao, Xueqin; Zhang, Wei; Deng, Huan; Zhang, Chong; Ding, Jiahui; Wei, Rui; Wang, Xueqian; Xi, Ling; Tan, Songwei.

Afiliação

Zou C; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jiang G; Department of Gynecologic Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Gao X; Department of Pharmacy, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang W; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Deng H; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhang C; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ding J; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wei R; Department of Gynecologic Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wang X; Department of Gynecologic Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xi L; Department of Gynecologic Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: lxi@tjh.tjmu.edu.cn.
Tan S; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: tansongwei@gmail.com.

Nanomedicine ; 22: 102092, 2019 11.

Article em En | MEDLINE | ID: mdl-31593795

Assuntos

Vacinas Anticâncer/imunologia; Sistemas de Liberação de Medicamentos; Lipídeo A/análogos & derivados; Melanoma Experimental/imunologia; Melanoma Experimental/terapia; Nanopartículas/química; Peptídeos/administração & dosagem; Polímeros/química; Animais; Vacinas Anticâncer/efeitos adversos; Citocinas/metabolismo; Células Dendríticas/imunologia; Feminino; Concentração de Íons de Hidrogênio; Imunização; Lipídeo A/administração & dosagem; Linfonodos/metabolismo; Melanoma Experimental/patologia; Camundongos Endogâmicos C57BL; Nanopartículas/ultraestrutura; Resultado do Tratamento

Palavras-chave

Cancer immunotherapy; Immune checkpoint therapy; Nano-vaccine; Poly (ß-amino ester); Polypeptide antigen

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Polímeros / Melanoma Experimental / Sistemas de Liberação de Medicamentos / Vacinas Anticâncer / Nanopartículas / Lipídeo A Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Nanomedicine Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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