[Recent advances in nephronectin].
Sheng Li Xue Bao
; 71(5): 799-805, 2019 Oct 25.
Article
em Zh
| MEDLINE
| ID: mdl-31646334
ABSTRACT
Nephronectin (NPNT) is a novel extracellular matrix protein and a new ligand of integrin α8ß1. Recent studies showed that NPNT is highly expressed in kidney, lung, thyroid, etc, and it may play an important role in many pathological conditions. NPNT is involved in the process of kidney development and acute kidney injury, regulates proliferation and differentiation of osteoblast, and induces the vasculogenesis in vitro. NPNT may play a key role in pathological osteoporosis and therefore be a new therapeutic target of bone diseases. NPNT gene variants are not only associated with lung function, but also potentially implicated in chronic airway diseases development. Moreover, NPNT is also an important factor that mediates pathology of cardiac, epidermis, breast, liver and teeth diseases. In this paper, we reviewed some research progresses on the structure, distribution, physiological and pathophysiological functions of NPNT.
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Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Proteínas da Matriz Extracelular
/
Rim
Limite:
Humans
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China