Brush Polymer Coatings with Hydrophilic Main-Chains for Improving Surface Antibacterial Properties.
ACS Macro Lett
; 12(4): 428-432, 2023 04 18.
Article
em En
| MEDLINE
| ID: mdl-36926830
ABSTRACT
Polymer coatings with improved surface antibacterial properties are of great importance for the application and development of implantable medical devices. Herein, we report the design, preparation, and antibacterial properties of a series of brush polymers (Dex-KEs) with hydrophilic dextran main-chains and mixed-charge polypeptide (KE) side-chains. Dex-KEs showed higher bactericidal activity and antifouling and antibiofilm properties than maleic acid modified dextran (Dex-Ma), KE, Dex-Ma/KE blend coatings, and brush polymer coatings with hydrophobic main-chains (AcDex-KEs). They also showed negligible in vitro cytotoxicity toward different mammalian cells and good in vivo biocompatibility. Dex-KE-coated implants exhibited potent in vivo resistance to bacterial infection before or after implantation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Dextranos
Limite:
Animals
Idioma:
En
Revista:
ACS Macro Lett
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China