Genipin crosslinked quaternary ammonium chitosan hydrogels for wound dressings.
Biomed Mater
; 19(4)2024 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-38815598
ABSTRACT
Bacterial infection can lead to various complications, such as inflammations on surrounding tissues, which can prolong wound healing and thus represent a significant clinical and public healthcare problem. Herein, a report on the fabrication of a novel genipin/quaternized chitosan (CS) hydrogel for wound dressing is presented. The hydrogel was prepared by mixing quaternized CS and genipin under 35 °C bath. The hydrogels showed porous structure (250-500 µm) and mechanical properties (3000-6000 Pa). In addition, the hydrogels displayed self-healing ability and adhesion performance on different substrates. Genipin crosslinked quaternized CS hydrogels showed antibacterial activities againstE. coliandS. aureus. The CCK-8 and fluorescent images confirmed the cytocompatibility of hydrogels by seeding with NIH-3T3 cells. The present study showed that the prepared hydrogel has the potential to be used as wound dressing.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Bandagens
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Cicatrização
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Hidrogéis
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Reagentes de Ligações Cruzadas
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Iridoides
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Quitosana
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Escherichia coli
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Compostos de Amônio Quaternário
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Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Biomed Mater
Assunto da revista:
ENGENHARIA BIOMEDICA
Ano de publicação:
2024
Tipo de documento:
Article