Effect of nimodipine, diltiazem and BAY K 8644 on the behavioural and neurochemical changes associated with naloxone-precipitated withdrawal in the rat. A comparison with clonidine.
Gen Pharmacol
; 24(1): 35-41, 1993 Jan.
Article
em En
| MEDLINE
| ID: mdl-7683298
ABSTRACT
1. Nimodipine, diltiazem and BAY K 8644 decreased the incidence of wet dog shakes, teeth chattering, grooming and diarrhoea to a similar degree of clonidine. 2. Nimodipine, diltiazem and BAY K 8644 had no effect on changes in the serotonin metabolism induced by naloxone precipitated abstinence syndrome. 3. Clonidine decreased the ratio of serotonin turnover in the brain of morphine-dependent rats. 4. From these experiments it is concluded that nimodipine, diltiazem and BAY K 8644 exert their effects in preventing morphine withdrawal symptoms through a mechanism independent of the serotonergic system.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Diltiazem
/
Éster Metílico do Ácido 3-Piridinacarboxílico, 1,4-Di-Hidro-2,6-Dimetil-5-Nitro-4-(2-(Trifluormetil)fenil)
/
Nimodipina
/
Clonidina
/
Naloxona
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Gen Pharmacol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Espanha