Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.
J Nat Prod
; 59(9): 839-42, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8864237
ABSTRACT
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.
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Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
HIV-1
/
Inibidores da Transcriptase Reversa
/
Cumarínicos
/
Transcriptase Reversa do HIV
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Tailândia