Effects of size of macrocyclic polyamides on their rate of diffusion in model membranes.
Biophys J
; 73(5): 2580-7, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9370452
ABSTRACT
A series of homologous amphiphilic molecules with surface areas in the range of 0.3 nm2 to 3.0 nm2 were prepared and used to investigate the diffusion in model dimyristoylphosphatidylcholine membranes as a function of temperature. The diffusion behavior of smaller molecules can be described by the interfacial viscosity limited free area theory promoted by Vaz and his co-workers, and that of the larger molecules can best be modeled by a recent interpretation of the theoretical description proposed by Evans and Sackmann. The experimental data show that the rate of diffusion is controlled by the size of the molecules at the interface of the lipid membrane, and provide evidence for a view of the membrane as a hydrodynamic triple layer with a low-viscosity central layer encased by two more viscous, yet fluid, layers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lipossomos
/
Nylons
Idioma:
En
Revista:
Biophys J
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Canadá