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1.
Clin Pract Epidemiol Ment Health ; 20: e17450179311620, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39130190

RESUMEN

Background: Nomophobia is a public health issue that involves the fear of being without a mobile phone. The study aimed to estimate the prevalence of nomophobia and its relation to psychological factors, including depression and insomnia, among the general population in Makkah Province and Al-Madinah Province, Saudi Arabia. Methods: This analytical cross-sectional study was conducted and data were obtained through a self-administered online questionnaire using the Patient Health Questionnaire-2 (PHQ-2) for depression, the Nomophobia Questionnaire (NMP-Q), and Insomnia Severity Index (ISI). Results: A total of 1022 participants completed the questionnaire. The prevalence of nomophobia was 96.7%. Moderate nomophobia was prevalent (47.8%). Based on the PHQ-2, possible depression was identified in 47.3% of the respondents. 37.1% had sub-threshold insomnia. In terms of personal psychiatric history, the most common mental disorders in the participants included generalized anxiety disorder (9.9%) and major depressive disorder (9.7%). 61.6% of them used mobile devices for more than four hours per day. Conclusion: Nomophobia is prevalent in the Makkah and Al-Madinah provinces in Saudi Arabia. The risk of nomophobia was significantly higher for participants who spent more hours using mobile devices, those with possible depression, and those having irritable bowel syndrome.

2.
BMC Vet Res ; 17(1): 280, 2021 Aug 21.
Artículo en Inglés | MEDLINE | ID: mdl-34419043

RESUMEN

BACKGROUND: Fourteen-years after the last Rift Valley fever (RVF) virus (RVFV) outbreak, Somalia still suffers from preventable transboundary diseases. The tradition of unheated milk consumption and handling of aborted materials poses a public health risk for zoonotic diseases. Limited data are available on RVF and Brucella spp. in Somali people and their animals. Hence, this study has evaluated the occurrence of RVFV and Brucella spp. antibodies in cattle, goats and sheep sera from Afgoye and Jowhar districts of Somalia. METHODS: Serum samples from 609 ruminants (201 cattle, 203 goats and 205 sheep), were serologically screened for RVF by a commercial cELISA, and Brucella species by modified Rose Bengal Plate Test (mRBPT) and a commercial iELISA. RESULTS: Two out of 609 (0.3 %; 95 %CI: 0.04-1.2 %) ruminants were RVF seropositive, both were female cattle from both districts. Anti-Brucella spp. antibodies were detected in 64/609 (10.5 %; 95 %CI: 8.2-13.2 %) ruminants by mRBPT, which were 39/201 (19.4 %) cattle, 16/203 (7.9 %) goats and 9/205 (4.4 %) sheep. Cattle were 5.2 and 2.8 times more likely to be Brucella-seropositive than sheep (p = 0.000003) and goats (p = 0.001), respectively. When mRBPT-positive samples were tested by iELISA, 29/64 (45.3 %; 95 %CI: 32.8-58.3 %) ruminant sera were positive for Brucella spp. Only 23/39 (58.9 %) cattle sera and 6/16 (37.5 %) goat sera were positive to Brucella spp. by iELISA. CONCLUSIONS: The present study showed the serological evidence of RVF and brucellosis in ruminants from Afgoye and Jowhar districts of Somalia. Considering the negligence of the zoonotic diseases at the human-animal interface in Somali communities, a One Health approach is needed to protect public health.


Asunto(s)
Brucella/aislamiento & purificación , Brucelosis/veterinaria , Fiebre del Valle del Rift/epidemiología , Virus de la Fiebre del Valle del Rift/aislamiento & purificación , Animales , Brucelosis/epidemiología , Bovinos , Enfermedades de los Bovinos/epidemiología , Enfermedades de los Bovinos/microbiología , Femenino , Enfermedades de las Cabras/epidemiología , Enfermedades de las Cabras/microbiología , Cabras , Estudios Seroepidemiológicos , Ovinos , Enfermedades de las Ovejas/epidemiología , Enfermedades de las Ovejas/microbiología , Somalia/epidemiología , Zoonosis/epidemiología
3.
BMC Oral Health ; 21(1): 28, 2021 01 13.
Artículo en Inglés | MEDLINE | ID: mdl-33435897

RESUMEN

BACKGROUND: Orthodontic treatment may result in undesirable side effects, such as root resorption and a decrease in the size of the pulp tissue which could be associated with the duration of the orthodontic treatment. Piezocision-assisted tooth movement was introduced as a minimally invasive surgical procedure to shorten orthodontic treatment time. This prospective randomized clinical trial was aimed to compare the pulp volume changes of maxillary anterior teeth after en-masse retraction with or without piezocision-assisted orthodontics. METHODS: Patients who required orthodontic treatment with bilateral maxillary first premolar extractions and en-masse retraction were recruited. Patients were randomly divided into extraction with piezocision, or only extraction, serving as controls. Pulp volume and root length changes of the maxillary six anterior teeth were measured and compared between the two groups using a 3-Dimensional analytical software. Paired and independent sample t-tests were used to compare within and between groups. Bivariate correlation was done between the mean change in pulp volume and its corresponding root length. The significance level was set at α = 0.05. RESULTS: A total of 23 patients were included, 12 in the piezocision, and 11 in the control group. At the end of the en-masse retraction phase, (mean = 122.74 ± 3.06 days) pulp volume was significantly decreased in all six anterior teeth in both groups (P < 0.01). The decrease in pulp volume was not statistically different between both groups, (P > 0.05). There was a statistically significant but moderate correlation only between the pulp volume change of the right canine and its root length, r = 0.44, P = 0.034. CONCLUSIONS: The effect of piezocision-assisted orthodontic tooth movement on the pulp volume was comparable to the conventional orthodontic treatment. The degree of change in pulp volume does not appear to be related to the amount of root resorption. Trial registration NCT03180151. Registered December 25, 2016, retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT03180151 .


Asunto(s)
Ortodoncia , Resorción Radicular , Diente Premolar , Humanos , Estudios Prospectivos , Técnicas de Movimiento Dental
4.
Parasitology ; 147(14): 1786-1791, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32951618

RESUMEN

African animal trypanosomiasis (AAT) affects the livestock of 12.3 million Somalis and constrains their development and wellbeing. There is missing data on AAT in the country after the civil war of the 1990s. Therefore, this study has aimed to assess the prevalence of Trypanosoma spp. in 614 blood samples from cattle (n = 202), goats (n = 206) and sheep (n = 206) in Afgoye and Jowhar districts, Somalia using parasitological and molecular methods. Twenty-one out of 614 (3.4%; 95% CI: 2.1-5.2%) and 101/614 (16.4%; 95% CI: 13.6-19.6%) ruminants were positive for Trypanosoma spp. by buffy coat technique (BCT) and internal transcribed spacer 1 (ITS1)-polymerase chain reaction (PCR), respectively. Using ITS1-PCR, the highest prevalence was observed in cattle (23.8%; 95% CI: 18.4-30.1%) followed by goats (17.5%; 95% CI: 12.9-23.3%) and sheep (8.3%; 95% CI: 5.1-12.9%). A total of 74/101 (73.3%; 95% CI: 63.5-81.6%) ruminants were shown coinfection with at least two Trypanosome species. The four T. brucei-positive samples have tested negative for T. b. rhodesiense, by the human-serum-resistance-associated-PCR. Trypanosoma evansi, T. godfreyi, T. vivax, T. brucei, T. simiae and T. congolense were the Trypanosoma species found in this study. This is the first study on the molecular detection of Trypanosoma sp. in ruminants in Somalia. Further investigations and control measures are needed to manage Trypanosomiasis spreading in the country. Studies should also focus on the detection of T. b. rhodesiense in the country.


Asunto(s)
Enfermedades de los Bovinos/epidemiología , Enfermedades de las Cabras/epidemiología , Enfermedades de las Ovejas/epidemiología , Trypanosoma/aislamiento & purificación , Tripanosomiasis Africana/epidemiología , Animales , Bovinos , Enfermedades de los Bovinos/parasitología , Enfermedades de las Cabras/parasitología , Cabras , Prevalencia , Estudios Seroepidemiológicos , Ovinos , Enfermedades de las Ovejas/parasitología , Oveja Doméstica , Somalia/epidemiología , Tripanosomiasis Africana/parasitología
5.
Eur J Orthop Surg Traumatol ; 30(5): 869-875, 2020 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32124073

RESUMEN

The treatment of post-traumatic femoral deformity with circular frames can be difficult both for the patient and for the surgeon. Patients frequently suffer from residual knee stiffness, and the cumbersome location of the frame can even result in psychiatric problems such as depression and anxiety during their treatment. Here we describe a novel technique of constructing the Taylor spatial frame (TSF) eccentrically from the femur to allow the same level of comfort as a monolateral external fixator, while applying trigonometric principles to successfully retain the utility of the TSF prescription software. Deformity correction and fracture compression can therefore still be achieved in a controlled and predictable manner on an outpatient basis.


Asunto(s)
Fijadores Externos , Fracturas del Fémur/complicaciones , Fracturas del Fémur/cirugía , Fijación de Fractura/métodos , Adulto , Femenino , Fijación de Fractura/instrumentación , Humanos , Recurrencia
6.
Immunol Invest ; 47(3): 293-302, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29336618

RESUMEN

OBJECTIVE: Demonstration of rheumatoid arthritis (RA) characteristics in a large cohort of Egyptian patients. METHODS: Retrospective analysis of data of 3219 RA patients attending the Rheumatology outpatient clinic, Kasr Alainy Hospital, Cairo University; from January 1995 till December 2015. RESULTS: Mean age at disease onset was 36.1 ±13.4 years; 2774 (84%) were females and mean disease duration was 12.9 ±7.9 years. Regarding number of joint affected at disease onset; polyarticular pattern was found in 77.1%, pattern of joint involvement; combined small and large joints involvement was in 83.2%, subcutaneous nodules in 14.2%, interstitial lung disease in 0.3%, secondary Sjogren's syndrome in 10.5%, hand bony erosions at diagnosis in 20.6%. Rheumatoid factor was positive in 52%. There was annual increase in the newly diagnosed cases (P = 0.017) reflecting increase in patients' awareness and improvement of medical service, also annual increase in: mean age of onset (P < 0.001) reflecting changes in health measures, also in cases with monoarticular or oligoarticular patterns at disease onset (P = 0.02, 0.01 respectively) reflecting earlier diagnosis of patients and in patients with small joint involvement (P = 0.001) with a significant decline in: polyarticular pattern (P = 0.001), combined small and large joint affection (P < 0.001), and number of cases with hand bony erosions (P = 0.01) denoting earlier diagnosis, tight disease control. CONCLUSION: We found a female predominance, younger age at disease onset, lower frequency of extra articular manifestations, more frequent polyarticular pattern at disease onset and less erosive disease, denoting changing referral patterns, earlier diagnosis, improved disease control in Egyptian RA patients over 2 decades. ABBREVIATIONS: SNs: Subcutaneous nodules; 2ry SS: 2ry Sjogren's syndrome; ILD: Interstitial lung disease; ACPA: Anti-cyclic citrullinated peptide antibodies; DMARDs: Disease modifying anti-rheumatic drugs.


Asunto(s)
Artritis Reumatoide/epidemiología , Adolescente , Adulto , Edad de Inicio , Antirreumáticos/farmacología , Antirreumáticos/uso terapéutico , Artritis Reumatoide/diagnóstico , Artritis Reumatoide/tratamiento farmacológico , Artritis Reumatoide/etiología , Comorbilidad , Egipto/epidemiología , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Vigilancia de la Población , Estudios Retrospectivos , Factores de Riesgo , Factores Sexuales , Adulto Joven
8.
West Afr J Med ; 33(1): 37-43, 2014.
Artículo en Inglés, Francés | MEDLINE | ID: mdl-24872265

RESUMEN

BACKGROUND: Hypoxaemia constitutes a possible complication of severe respiratory illness which is often under-reported in developing countries. Therefore, the current study was carried out to determine the prevalence and clinical predictors of hypoxaemia in hospitalized under-five children with pneumonia in Ilorin, Nigeria. METHODS: This is a descriptive cross-sectional study of 200 children aged between two months and five years with pneumonia recruited consecutively. Socio-demographic, clinical and laboratory data were obtained. The pulse oximetry measurement was recorded after a stable reading for at least one minute while the child was breathing room air. Hypoxaemia was defined as an arterial oxygen saturation of less than 90%. Data was analyzed using the SPSS 20.0 software. RESULTS: The male/female ratio was 1.5:1.The prevalence of hypoxaemia in the children with pneumonia was 41.5%.Using a linear regression analysis, the clinical features that were significantly associated with hypoxaemia were restlessness, lower chest wall indrawing, bronchial breath sounds and tender hepatomegaly (p<0.05 each). Restlessness had a sensitivity of 22.9%, specificity of 91.5%, while chest wall indrawing had a sensitivity of 86.7% and specificity of 53.3%. Bronchial breath sound had a sensitivity of 16.9%, a specificity of 95.7% whereas tender hepatomegaly had a sensitivity of 48.2% and specificity of 82.9%. CONCLUSION: There is a high local burden of pneumonia-associated hypoxaemia. Restlessness, chest wall indrawing, bronchial breath sounds and tender hepatomegaly could be useful in detecting pneumonia-related hypoxemia in poorly equipped health facilities.


Asunto(s)
Hospitalización , Hipoxia/epidemiología , Neumonía/complicaciones , Factores de Edad , Preescolar , Estudios de Cohortes , Estudios Transversales , Femenino , Humanos , Hipoxia/diagnóstico , Lactante , Masculino , Nigeria , Valor Predictivo de las Pruebas , Prevalencia
9.
Heliyon ; 10(11): e32353, 2024 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-38912472

RESUMEN

The discrepancy between the operating and design capacities of solar plants in eastern Uganda is alarming; about 35 % underperformance in solar power generation is observed. The goal of the current study is to minimize this disparity by improving the design models. Considering only cell temperature in the power generation model is responsible for the observed difference in design and operational solar power generated, the present study used a thermocouple to directly measure cell temperature, an anemometer to measure wind speed, and a solar power meter to measure irradiance. These extrinsic factors were used to modify the power generation model based only on cell temperature through the direct correlation of cell temperature, wind speed, and irradiance with solar power generation. Thus, the absence of extrinsic factors (wind speed and irradiance) in the design models is responsible for the colossal drop in solar power generated. Empirically, the missing extrinsic factors were used to transform the implicit solar power model into an explicit model. The development of a solar power generation model, multiple differential models, simulation and experimentation with a pilot solar rig served as alternate model for the prediction of solar power generation. The second-order differential model validated well with empirical solar power generated in Busitema, Mayuge, Soroti, and Tororo study areas based on RMSEs (0.6437, 0.6692, 0.2008, 0.1804, respectively), thus, narrowing the gap between the designed and operational solar power generated. Mayuge and Soroti recorded the highest solar power generation of 9.028 MW compared to Busitema (8.622 MW) and Tororo (8.345 MW), suggesting that it has a conducive site for installing future solar plants. The above results support the use of empirical explicit (triple) and second-order differential models for the design and operation of power plants.

10.
Resusc Plus ; 18: 100653, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38716381

RESUMEN

Background: Airway management is a core component of the treatment of cardiac arrest. Where a rescuer cannot establish a patent airway to provide oxygenation and ventilation using standard basic and advanced airway techniques, there may be a need to consider emergency front-of-neck airway access (eFONA, e.g., cricothyroidotomy), but there is limited evidence to inform this approach. Objectives: This scoping review aims to identify the evidence for the use of eFONA techniques in patients with cardiac arrest. Methods: In November 2023, we searched Medline, Embase, and Cochrane Central to identify studies on eFONA in adults. We included randomised controlled trials, non-randomised studies, and case series with at least five cases that described any use of eFONA. We extracted data, including study setting, population characteristics, intervention characteristics, and outcomes. Our analysis focused on four key areas: incidence of eFONA, eFONA success rates, clinical outcomes, and complications. Results: The search identified 21,565 papers, of which 18,934 remained after de-duplication. After screening, we included 69 studies (53 reported incidence, 40 reported success rate, 38 reported clinical outcomes; 36 studies reported complications). We identified only one randomised controlled trial. Across studies, there was a total of 4,457 eFONA attempts, with a median of 31 attempts (interquartile range 16-56.5) per study. There was marked heterogeneity across studies that precluded any pooling of data. There were no studies that included only patients in cardiac arrest. Conclusion: The available evidence for eFONA is extremely heterogeneous, with no studies specifically focusing on its use in adults with cardiac arrest.

11.
Cureus ; 16(10): e70640, 2024 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-39359332

RESUMEN

This editorial explores the recent advancements in generative artificial intelligence with the newly-released OpenAI o1-Preview, comparing its capabilities to the traditional ChatGPT (GPT-4) model, particularly in the context of healthcare. While ChatGPT has shown many applications for general medical advice and patient interactions, OpenAI o1-Preview introduces new features with advanced reasoning skills using a chain of thought processes that could enable users to tackle more complex medical queries such as genetic disease discovery, multi-system or complex disease care, and medical research support. The article explores some of the new model's potential and other aspects that may affect its usage, like slower response times due to its extensive reasoning approach yet highlights its potential for reducing hallucinations and offering more accurate outputs for complex medical problems. Ethical challenges, data diversity, access equity, and transparency are also discussed, identifying key areas for future research, including optimizing the use of both models in tandem for healthcare applications. The editorial concludes by advocating for collaborative exploration of all large language models (LLMs), including the novel OpenAI o1-Preview, to fully utilize their transformative potential in medicine and healthcare delivery. This model, with its advanced reasoning capabilities, presents an opportunity to empower healthcare professionals, policymakers, and computer scientists to work together in transforming patient care, accelerating medical research, and enhancing healthcare outcomes. By optimizing the use of several LLM models in tandem, healthcare systems may enhance efficiency and precision, as well as mitigate previous LLM challenges, such as ethical concerns, access disparities, and technical limitations, steering to a new era of artificial intelligence (AI)-driven healthcare.

12.
Biomimetics (Basel) ; 9(4)2024 Apr 20.
Artículo en Inglés | MEDLINE | ID: mdl-38667262

RESUMEN

ß-tricalcium phosphate (ß-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped ß-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca9.5-xSrxCu(PO4)7 was obtained by the method of solid-phase reactions. The Rietveld method of structural refinement revealed the presence of Sr2+ ions in four crystal sites: M1, M2, M3, and M4. The M5 site is completely occupied by Cu2+. Isomorphic substitution of Ca2+ → (Sr2+and Cu2+) expands the concentration limits of the existence of the solid solution with the ß-TCP structure. No additional phases were formed up to x = 4.5 in Ca9.5-xSrxCu(PO4)7. Biocompatibility tests were performed on cell lines of human bone marrow mesenchymal stromal cells (hMSC), human fibroblasts (MRC-5) and osteoblasts (U-2OS). It was demonstrated that cytotoxicity exhibited a concentration dependence, along with an increase in osteogenesis and cell proliferation. Ca9.5-xSrxCu(PO4)7 powders showed significant inhibitory activity against pathogenic strains Escherichia coli and Staphylococcus aureus. Piezoelectric properties of Ca9.5-xSrxCu(PO4)7 were investigated. Possible ways to achieve high piezoelectric response are discussed. The combination of bioactive properties of Ca9.5-xSrxCu(PO4)7 renders them multifunctional materials suitable for bone substitutes.

13.
Adv Med Educ Pract ; 15: 433-446, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38799239

RESUMEN

Purpose: This study aims to assess the knowledge, attitudes, and practices of emergency physicians (EPs) related to psychiatric emergencies (PEs) in Makkah's general hospitals. Sample and Methods: This study was an observational cross-sectional study using an online survey distributed to 138 EPs in the emergency departments (EDs) of six public hospitals in Makkah City, Saudi Arabia, between March 15 and May 1, 2023. A convenience sample was used for data collection. The questionnaire was developed after related surveys in the literature were reviewed. Results: 59.9% of the physicians were aged 20-30 years. Most (68.8%) worked in hospitals that had psychiatric facilities. Regarding knowledge, only 30% of the emergency doctors were considered knowledgeable: the majority could identify PEs (79.7%), perform mental status examinations (71.0%), distinguish physical and mental symptoms (66.7%), and communicate with psychiatric patients (58.0%). However, only 52.9% could initiate management plans by prescribing psychiatric medication to patients. In relation to attitude, most physicians disagreed with the idea that healthcare practitioners do not need to advocate for psychiatric patients (67.4%), but many (62.3%) assumed that they do not have the responsibility to manage psychiatric patients, and they felt that conducting psychiatric evaluations in public hospitals is challenging because of the busy environment there. As regards practice, mentally ill patients (60.9%) were managed or referred by practices, and 56.5% of the EPs advised these patients upon discharge. Conclusion: The study showed that EPs have positive attitudes toward psychiatric patients, but their knowledge varied based on age, occupation levels, and years of experience. There were significant knowledge gaps, particularly regarding effective communication with psychiatric patients. Additionally, many EPs manage psychiatric patients without being aware of the psychiatric resources in their hospital. Improving medical school curricula and postgraduate training can enhance care. However, more research in this field is needed.

14.
Cureus ; 16(9): e70548, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-39351040

RESUMEN

Aim and background Medical emergencies (MEs) pose urgent threats to life and occur frequently, with primary care providers seeing at least one emergency per year. Common MEs include asthma, anaphylaxis, seizures, and cardiac arrest. However, many medical offices are ill-equipped to handle these emergencies. Practices should obtain appropriate emergency equipment and medications based on their patient population, provider expertise, and proximity to the ER. A lack of emergency preparedness and training can have fatal consequences, so all healthcare providers must be well-prepared to respond. Providing basic life support (BLS) is the crucial first step until definitive treatment is available. The study aimed to assess emergency-related knowledge, its relationship to expertise, and the need for emergency management training among medical/dental students at University of Ha'il (UOH) in Saudi Arabia. Methods The study included 214 participants. It consisted of male and female dental and medical students in their clinical years at the UOH in Saudi Arabia. This targeted sampling approach ensured the study focused on the relevant demographic factors of dental and medical students to provide insights into their level of MR-related knowledge and its relationship to their expertise, as well as their awareness and need for training in ME management. The researchers aimed to assess these factors among the medical and dental students at the UOH. Result Dental and medical students show a strong grasp of emergency care fundamentals, with 78.6% familiar with BLS protocols. Most students correctly identify crucial actions, such as assessing airway, breathing, and circulation (ABCs), and immobilizing the head and neck for spinal injuries. Responses to emergencies include starting chest compressions, calling 911, and administering appropriate treatments for cardiovascular, respiratory, and neurological issues. Despite high competency levels, continuous education is vital to maintain and enhance their preparedness for emergencies. Conclusions Dental and medical students demonstrate a solid understanding of BLS, with 78.6% familiar with protocols and many identifying critical emergency actions. However, inconsistencies in responses highlight the need for ongoing education to improve decision-making and preparedness. Continuous training will ensure these future healthcare professionals are equipped to handle real-world emergencies effectively.

15.
Zoonoses Public Health ; 71(5): 568-577, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38816921

RESUMEN

BACKGROUND: Bartonellosis, caused by bacteria of the genus Bartonella, is a zoonotic disease with several mammalian reservoir hosts. In Somalia, a country heavily reliant on livestock, zoonotic diseases pose significant public health and economic challenges. To the best of our knowledge, no study has been performed aiming to verify the occurrence of Bartonella spp. in Somalia. This study investigated the occurrence and molecular characterization of Bartonella in dromedary (Camelus dromedarius, Linnaeus, 1758), cattle, sheep, and goats from Somalia. MATERIALS AND METHODS: 530 blood samples were collected from various animals (155 dromedary, 199 goat, 131 cattle, and 45 sheep) in Benadir and Lower Shabelle regions. DNA was extracted for molecular analysis, and a qPCR assay targeting the NADH dehydrogenase gamma subunit (nuoG) gene was used for Bartonella screening. Positive samples were also subjected to PCR assays targeting seven molecular markers including: nuoG, citrate synthase gene (gltA), RNA polymerase beta-subunit gene (rpoB), riboflavin synthase gene (ribC), 60 kDa heat-shock protein gene (groEL), cell division protein gene (ftsZ), and pap31 and qPCR targeting the 16-23S rRNA internal transcribed spacer (ITS) followed by Sanger sequencing, BLASTn and phylogenetic analysis. RESULTS: Out of 530 tested animals, 5.1% were positive for Bartonella spp. by the nuoG qPCR assay. Goats showed the highest Bartonella occurrence (17/199, 8.5%), followed by sheep (6/44, 6.8%), cattle (4/131, 3.1%), and dromedary (1/155, 1.9%). Goats, sheep, and cattle had higher odds of infection compared to dromedary. Among nuoG qPCR-positive samples, 11.1%, 14.8%, 11.1%, and 25.9% were positive in PCR assays based on nuoG, gltA, and pap31 genes, and in the qPCR based on the ITS region, respectively. On the other hand, nuoG qPCR-positive samples were negative in the PCR assays targeting the ribC, rpoB, ftsZ, and groEL genes. While Bartonella bovis sequences were detected in cattle (nuoG and ITS) and goats (gltA), Bartonella henselae ITS sequences were detected in dromedary, goat, and sheep. Phylogenetic analysis placed gltA Bartonella sequence from a goat in the same clade of B. bovis. CONCLUSION: The present study showed, for the first time, molecular evidence of Bartonella spp. in dromedary and ruminants from Somalia and B. henselae in sheep and goats globally. These findings contribute valuable insights into Bartonella spp. occurrence in Somali livestock, highlighting the need for comprehensive surveillance and control measures under the One Health approach.


Asunto(s)
Infecciones por Bartonella , Bartonella , Camelus , Animales , Bartonella/genética , Bartonella/aislamiento & purificación , Infecciones por Bartonella/veterinaria , Infecciones por Bartonella/epidemiología , Infecciones por Bartonella/microbiología , Camelus/microbiología , Rumiantes/microbiología , Cabras , Ovinos , Enfermedades de las Cabras/microbiología , Enfermedades de las Cabras/epidemiología , Filogenia , Bovinos , ADN Bacteriano/genética
16.
J Med Entomol ; 2024 Nov 04.
Artículo en Inglés | MEDLINE | ID: mdl-39495094

RESUMEN

Hemotropic mycoplasmas (hemoplasmas) are small pleomorphic bacteria that parasitize the surface of red blood cells of mammals. Hemoplasmas have been described in different species from the Camelidae Family, such as llamas and alpacas (South American camelids), but data on dromedary camels (Camelus dromedarius) are limited to a few reports. Somalia has one of the world's largest dromedary camel populations, and studies on hemoplasmas and tick-borne pathogens are lacking. Accordingly, this study aimed to screen dromedaries from Somalia for hemoplasmas by PCR-based assays. A total of 155 dromedary camel blood samples from 2 different areas of Mogadishu (n = 104) and the Lower Shabelle Region (n = 51) of the country were collected. All blood DNA samples were screened for hemoplasmas using a SYBR Green Universal Real-Time PCR (qPCR), nested PCR (nPCR), and conventional PCR (cPCR) assays targeting the 16S rRNA gene of hemoplasmas. Five out of 155 animals (3.23%; 95% confidence interval [CI]: 1.39-7.33%) were positive for hemoplasmas. A total of 346 (228 M, 117 F, and 1 nymph) ticks were collected from 79/155 (50.9%; 95% CI: 42.8-59.1%) dromedary camels with a mean of 4.4 ticks per animal. Ticks were identified as Rhipicephalus pulchellus (174/346; 50.3%), Hyalomma dromedarii (103/346; 29.8%), Hyalomma rufipes (35/346; 10.1%), Hyalomma marginatum (16/346; 4.6%), Rhipicephalus humeralis (14/346; 4.0%), Amblyomma lepidum (2/346; 0.6%), Amblyomma gemma (1/346; 0.3%), and Ornithodoros sp. (1/185; 0.5). This is the first study on the molecular screening for hemoplasmas in dromedary camels from Somalia and the first report of A. lepidum and R. humeralis in Somali dromedary camels.

17.
Heliyon ; 9(7): e17654, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37501966

RESUMEN

The digital economy, driven by Information and Communication Technology (ICT), has emerged as a significant contributor to economies worldwide. However, accurately defining and measuring its impact on national economies remains a complex endeavor. This paper explores the definition, measurement, role, and impacts of the digital economy across various economies. It also examines the involvement of governments and telecommunication regulators in assessing the digital economy and identifies future directions for developing countries. A systematic literature review utilizing the PRISMA Model is employed to investigate the factors and indices used to measure the digital economy. The findings highlight ongoing efforts to harmonize the definition and metrics; nonetheless, challenges persist due to the scarcity of appropriate datasets and variations in country-specific definitions. Additionally, the effectiveness of existing digital economy indices and toolkits in assessing the level of digitalization in developing countries is evaluated. The paper concludes that despite ongoing efforts to bridge the gaps, the concept of the digital economy remains defined and measured differently, necessitating a new definition that accounts for various contextual peculiarities. Furthermore, a roadmap is proposed to develop a toolkit that ensures comprehensive measurement, thus preventing an underestimation of the digital economy's contribution to the Gross Domestic Product (GDP) in developing countries. The paper underscores the need for international and multi-stakeholder dialogue to establish a common understanding of the digital economy's definition and measurement. Developing countries, such as Nigeria, are urged to develop or adopt new metrics tailored to their unique circumstances, facilitating an accurate and efficient quantification of the digital economy's impact on crucial indicators like GDP. Improved statistical data collection and recording methodologies are recommended for both governments and the private sector. Moreover, the paper advocates for the establishment of a Digital Economy Advisory Board (DEAB) in developing countries to maximize the benefits of the ongoing global transition to the digital economy.

18.
Int J Oral Maxillofac Surg ; 52(5): 569-576, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-35989230

RESUMEN

The aim of this study was to assess the accuracy and clinical implications of pterygomaxillary junction (PMJ) disjunction with a transmucosal PMJ osteotomy using a piezoelectric hand-piece device, in the context of Le Fort I osteotomy, by evaluating the level of PMJ disarticulation and the need for bone trimming around the pedicle. An ambidirectional 1-month follow-up cohort study was designed involving consecutive patients undergoing minimally invasive maxillary Le Fort I osteotomy through the twist technique. Two cohorts were defined according to whether or not the transmucosal PMJ osteotomy was performed. The site of PMJ disjunction was analysed radiographically. A total of 114 patients were included in the study, 57 in each group. The overall accuracy of the PMJ disjunction path was higher in the test group (43.9%) than in the control group (15.8%). Multiple logistic regression analysis identified the need for bone trimming (odds ratio 0.02; P < 0.001) and removal of the upper third molar (odds ratio 0.17; P < 0.001) as relevant factors. In conclusion, compared with the originally described twist technique, combination of the latter with the PMJ osteotomy increased its accuracy at the level of the PMJ. As a result, there is a decrease in resistance during down-fracture and decrease in the need for bone trimming around the pedicle, with preservation of the minimally invasive concept.


Asunto(s)
Craneotomía , Osteotomía , Humanos , Estudios de Seguimiento , Diente Molar , Maxilar/diagnóstico por imagen , Maxilar/cirugía , Osteotomía Le Fort
19.
Vet World ; 16(9): 1829-1832, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37859955

RESUMEN

Background and Aim: The primary domestic animal in Somali communities is the goat. Their main economic importance is as a food source and a main form of agriculture in the country. There has been a recent decline in the goat population in Somalia, which may be due to the shortage of feed and an increasingly contaminated environment that is affecting the population's food supply and nutritional status. This study aimed to estimate the prevalence and the factors associated with indigestible foreign bodies (IFBs) ingestion in goats in Mogadishu, Somalia. Materials and Methods: A cross-sectional study was conducted at the Somalia Meat Company in Mogadishu, Somalia, in February 2022. A total of 250 goats were included in this study, and records were kept on age, sex, body condition, and location. Following the slaughter, goats were inspected for IFBs, and their stomach compartments were incised and examined. Indigestible foreign body classifications was noted and subjected to analysis using the Statistical Package for the Social Sciences version 26.0. Results: A total of 90/250 (36%; 95% confidence interval [CI]: 30.1-42.3) goats presented IFBs, being 71/90 (79%; 95% CI: 69-87) in the rumen, 12/90 (13%; 95% CI: 7-22) in the reticulum, and seven/90 (8%; 95% CI: 3-15) on both. The most observed IFBs were plastic in 71/90 (79%; 95% CI: 69-87), followed by ropes in eight/90 (10%; 95% CI: 5-18). A high IFB prevalence was observed in goats aged >2-≤3 years (44%), followed by >3 years (36%). The lowest frequency was observed in goats aged <2 years (30%). Overall, there was an association between IFBs in goats and poor body conditions (χ2 = 47%, p < 0.04). Conclusion: The absence of a plastic waste disposal system in the area, and communal free-grazing of livestock in highly contaminated sites, appeared to be significant contributors to the high occurrence of IFBs in goats. Therefore, appropriate policies for solid waste management should be implemented.

20.
Cureus ; 15(4): e37717, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-37206527

RESUMEN

INTRODUCTION: The study assessed coronary artery bypass grafting (CABG) postoperative outcomes and associated factors in Saudi male and female patients. This was a retrospective cohort of patients who underwent CABG at the King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia, from January 2015 to December 2022.  Results: We included 392 patients, of whom 63 (16.1%) were female. Female undergoing CABG were significantly older (p=0.0001), had a significantly higher incidence of diabetes (p=0.0001), obesity (p=0.001), hypertension (p=0.001), and congestive heart failure (p=0.005), with a smaller body surface area (BSA) (p=0.0001) than male. Though renal dysfunction, previous cerebrovascular accident/transient ischemic attack (CVA/TIA), and myocardial infarction (MI), incidences were similar in both genders. Females were at significantly higher risk of mortality (p=0.0001), longer hospital stay (p=0.0001), and prolonged ventilation (p=0.0001). Preoperative renal dysfunction was the only statistically significant predictor of postoperative complications (p=0.0001). Female gender and preoperative renal dysfunction, were significant independent predictors of postoperative mortality and prolonged ventilation (p=0.005). CONCLUSION: This study's findings indicated that females have worse CABG outcomes and a higher risk of morbidities and complications. Uniquely our study showed a higher incidence of prolonged ventilation in females postoperatively.

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