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Pediatr Blood Cancer ; 69(11): e29923, 2022 11.
Artículo en Inglés | MEDLINE | ID: mdl-35969146

RESUMEN

Neutropenia related to ELANE gene mutations predisposes patients to infection and leukemia/myelodysplasia, but little is known about the predisposition to cancer. Among a cohort of 147 patients, we identified four with malignant solid tumors (papillary thyroid cancer, anal squamous cell cancer, papillary renal cell carcinoma, and adrenocortical carcinoma), all aged 25-50 years. Three occurred with cyclic neutropenia, and one occurred with severe chronic neutropenia. Previous radiotherapy was identified as a risk factor in one patient. No genetic predisposition was identified in the three other patients.


Asunto(s)
Neoplasias , Neutropenia , Humanos , Elastasa de Leucocito/genética , Mutación , Neoplasias/complicaciones , Neutropenia/genética , Neutropenia/patología , Sistema de Registros
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