Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study.

PURPOSE: Vitamin D deficiency has been associated with multiple chronic diseases, including metabolic disorders such as insulin resistance and type 2 diabetes (T2D). The aim of the study was to analyze the association between validated predicted serum vitamin D status and the risk of developing T2D in a large prospective cohort based on a Mediterranean population. METHODS: The SUN project is a prospective and dynamic Spanish cohort that gathers university graduates who have answered lifestyle questionnaires, including a validated Food Frequency Questionnaire. The association between predicted serum vitamin D and the risk of T2D was assessed through Cox regression models according to quartiles (Q) of predicted vitamin D at baseline. The models were adjusted for potential confounders and sensitivity analyses were performed to ensure the robustness of our findings. RESULTS: Our study included a total of 18,594 participants and after a total follow-up of 238,078 person-years (median follow-up of 13.5 years), 209 individuals were diagnosed with incident T2D. We found a significant inverse association between predicted levels of serum vitamin D and the risk of developing T2D, after adjusting for potential confounders and performing different sensitivity analyses (hazard ratio Q4 vs. Q1: 0.48, 95% CI 0.26-0.88; p for trend = 0.032). CONCLUSION: The outcomes suggest that higher levels of vitamin D at baseline may be associated with a reduced risk of developing T2D.

Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population.

OBJECTIVES: To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up. METHODS: n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 ± 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control. RESULTS: The presence of T2D increased the likelihood of higher levels of depressive symptoms (χ2 = 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (χ2 = 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c ≥ 7% at 1-year level (Wald-χ2 = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up. CONCLUSIONS: This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

Substitution of water or fresh juice for bottled juice and type 2 diabetes incidence: The SUN cohort study.

BACKGROUND AND AIMS: The relationship between juice consumption and type 2 diabetes (T2D) has not been widely evidenced. Our aims were to prospectively evaluate the associations with T2D incidence of: 1) isovolumetric substitution of a water serving/day for one of fruit juice (different types), and of fresh fruit juice for its bottled version; 2) consumption of total, fresh or bottled juice; 3) energy intake from juices. METHODS AND RESULTS: We followed 17,518 adults without T2D at baseline. Beverage consumption was assessed at baseline through a validated food-frequency questionnaire. The outcome was T2D incidence, according to American Diabetes Association's criteria. During a median follow-up of 10.2 years, 142 incident cases of T2D were identified. In substitution models, the substitution of water for bottled juice was associated with a lower T2D incidence, and also if the replacement was done by fresh juice, or especially fresh orange juice [HR 0.75 (95% CI 0.57-0.99), 0.65 (95% CI 0.43-0.98) and 0.56 (95% CI 0.34-0.92); respectively]. Each additional serving/day of bottled juice was directly associated with T2D incidence [HR 1.33 (95% CI 1.01-1.75)]. No significant association was observed for energy coming for bottled juice [HR 1.74 (95% CI 0.94-3.20)]. CONCLUSION: Our results suggest that isovolumetric substitution of water or fresh juice for bottled juice was inversely associated with T2D incidence in a long-term prospective study. Thus, these substitutions could be useful to tackle the diabetes epidemic.

Consumption of fried foods and weight gain in a Mediterranean cohort: the SUN project.

BACKGROUND AND AIMS: The consumption of fried foods is believed to be linked with obesity and higher weight gain, however, the evidence from long-term randomized trials or prospective epidemiological studies is scarce. Therefore, the aim of our study was to prospectively evaluate the association between the consumption of fried foods and weight change and the incidence of overweight/obesity in a Mediterranean cohort. METHODS AND RESULTS: Prospective cohort study of 9850 men and women with a mean age of 38.1 years (SD 11.4) were followed-up for a median of 6.1 years to assess average yearly change in body weight, and incidence of overweight/obesity. The consumption of fried foods was associated with higher weight gain, but the differences were of small magnitude and statistically non-significant. The incidence of overweight/obesity during follow-up was also assessed in the subset of 6821 participants with initial body mass index <25 kg/m(2) (initially free of overweight/obesity), after adjusting for potential confounders, the odds ratio for developing overweight/obesity among participants who consumed fried foods >4 times/week was 1.37 (95% confidence interval: 1.08 to 1.73) in comparison with those who consumed fried foods <2 times/week (p for trend = 0.02). CONCLUSION: In this Mediterranean prospective cohort, a more frequent consumption of fried foods at baseline was associated with a higher risk of subsequently developing overweight/obesity during follow-up.

[Validity of self-reported body mass index in the National Health Survey]. / Validación del índice de masa corporal auto-referido en la Encuesta Nacional de Salud.

OBJECTIVE: To assess the validity of self-reported body mass index in the National Health Survey. METHODS: 120 participants were selected and questioned about their weight and height with exactly the same questions that the National Health Survey uses. Afterwards, and once informed consent was obtained, participants were weighed and measured, and this data was used as the gold standard. RESULTS: On average, participants underestimated their weight by 1.39 kg, overestimated their height by 0.55 cm and underestimated their body mass index by 0.71 kg/m2. The sensitivity of self-reported self reported body mass index (BMI) to detect overweight was 77%, the specificity was 97%, the positive predictive value was 0.95 and the negative predictive value was 0.86. The Kappa index was 0.76 and the quadratically weighted Kappa index was 0.85. The correlation coefficient between self-reported and measured BMI was 0.96 and the intra-class correlation coefficient was 0.97. CONCLUSIONS: Self-reported data is an efficient way of obtaining information about BMI, although with limitations, because self-reported data tends to underestimate weight and overestimate height, thus underestimating BMI and the proportion of participants with elevated BMI.

Egg consumption and cardiovascular disease according to diabetic status: The PREDIMED study.

BACKGROUND: Eggs are a major source of dietary cholesterol and their consumption has been sometimes discouraged. A relationship between egg consumption and the incidence of cardiovascular disease (CVD) has been suggested to be present exclusively among patients with type2 diabetes. AIMS: To assess the association between egg consumption and CVD in a large Mediterranean cohort where approximately 50% of participants had type 2 diabetes. METHODS: We prospectively followed 7216 participants (55-80 years old) at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) study for a mean of 5.8 years. All participants were initially free of CVD. Yearly repeated measurements of dietary information with a validated 137-item food-frequency questionnaire were used to assess egg consumption and other dietary exposures. The endpoint was the rate of major cardiovascular events (myocardial infarction, stroke or death from cardiovascular causes). RESULTS: A major cardiovascular event occurred in 342 participants. Baseline egg consumption was not significantly associated with cardiovascular events in the total population. Non-diabetic participants who ate on average >4 eggs/week had a hazard ratio (HR) of 0.96 (95% confidence interval, 0.33-2.76) in the fully adjusted multivariable model when compared with non-diabetic participants who reported the lowest egg consumption (<2 eggs/week). Among diabetic participants, the HR was 1.33 (0.72-2.46). There was no evidence of interaction by diabetic status. HRs per 500 eggs of cumulative consumption during follow-up were 0.94 (0.66-1.33) in non-diabetics and 1.18 (0.90-1.55) in diabetics. CONCLUSIONS: Low to moderated egg consumption was not associated with an increased CVD risk in diabetic or non-diabetic individuals at high cardiovascular risk. This trial was registered at controlled-trials.com as ISRCTN35739639.

Meat Consumption and Risk of Developing Type 2 Diabetes in the SUN Project: A Highly Educated Middle-Class Population.

BACKGROUND: Meat consumption has been consistently associated with the risk of diabetes in different populations. The aim of our study was to investigate the incidence of type 2 diabetes according to baseline total meat consumption in a longitudinal assessment of a middle-aged Mediterranean population. METHODS: We followed 18,527 participants (mean age: 38 years, 61% women) in the SUN Project, an open-enrolment cohort of a highly educated population of middle-class Spanish graduate students. All participants were initially free of diabetes. Diet was assessed at baseline using a semi-quantitative food frequency questionnaire of 136-items previously validated. Incident diabetes was defined according to the American Diabetes Association's criteria. RESULTS: We identified 146 incident cases of diabetes after a maximum of 14 years of follow-up period (mean: 8.7 years). In the fully adjusted model, the consumption of ≥3 servings/day of all types of meat was significantly associated with a higher risk of diabetes (HR: 1.85; 95% CI: 1.03-3.31; p for trend = 0.031) in comparison with the reference category (<2 servings/day). When we separated processed from non-processed meat, we observed a non-significant higher risk associated with greater consumption of processed meat and a non-significant lower risk associated with non-processed meat consumption (p for trend = 0.123 and 0.487, respectively). No significant difference was found between the two types of meat (p = 0.594). CONCLUSIONS: Our results suggest that meat consumption, especially processed meat, was associated with a higher risk of developing diabetes in our young Mediterranean cohort.

Consumption of fried foods and risk of metabolic syndrome: the SUN cohort study.

BACKGROUND & AIMS: There is scarce evidence from long-term prospective studies relating the consumption of fried foods with the incidence of Metabolic Syndrome (MS). The aim of this study was to assess the association between fried food consumption and the incidence of MS. METHODS: We followed 8289 participants (2813 men and 5476 women, mean age = 35.9 y, SD = 10.4) during a median period of 8.3-y. They were initially free of any MS criteria. MS was defined according to the American Heart Association and the International Diabetes Federation criteria as outlined in the harmonized definition for MS. Each component of the MS was assessed at the 6th and 8th-y of follow-up. The outcome was defined as the presence of ≥3 of the components of MS after ≥6 years of follow-up. RESULTS: During 65335 person-years, 420 incident cases of MS were identified. Frequent consumption of fried foods was not associated with the incidence of MS [HR = 0.98 (95% CI: 0.77-1.26) p for trend = 0.862]. However, two components of the MS, central adiposity and high blood pressure were positively associated with fried food consumption [HR for consumption >4 times/week compared with ≤2 times/week = 1.10 (95% CI: 1.01-1.19) (p for trend 0.022) and HR = 1.16 (95% CI: 1.02-1.32) (p for trend 0.011), respectively] after multivariable adjustment. CONCLUSIONS: In this Mediterranean cohort of relatively young adults, frequent consumption of fried foods was not associated with MS. Two out of five components of MS (central adiposity and high blood pressure) were positively associated with frequent fried food consumption.

Adherence to the Mediterranean dietary pattern and heart rate in the SUN project.

BACKGROUND: A higher heart rate has been related to an increase of total and cardiovascular mortality. The aim of this study was to assess the relation between adherence to the Mediterranean diet and heart rate. DESIGN: The SUN project is an ongoing multipurpose cohort study based on university graduates from Spain. METHODS: This cross-sectional study included 15,863 participants of the SUN project. Adherence to the Mediterranean dietary pattern was assessed through a validated 136-item food frequency questionnaire and calculated according to the 9-point score proposed by Trichopoulou. Multiple linear regression models were fitted to assess the relationship between adherence to the Mediterranean dietary pattern and heart rate and 95% confidence intervals were calculated. RESULTS: The multivariable-adjusted models revealed that participants with a high adherence (7--9 points) to the Mediterranean dietary pattern had a heart rate 2.2 bpm (95% CI 1.4-3.1) lower than participants with a low adherence (0--2 points). CONCLUSIONS: Adherence to the Mediterranean dietary pattern seems to be related to a lower heart rate.

Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study.

OBJECTIVE: To assess the relation between adherence to a Mediterranean diet and the incidence of diabetes among initially healthy participants. DESIGN: Prospective cohort study with estimates of relative risk adjusted for sex, age, years of university education, total energy intake, body mass index, physical activity, sedentary habits, smoking, family history of diabetes, and personal history of hypertension. SETTING: Spanish university department. PARTICIPANTS: 13 380 Spanish university graduates without diabetes at baseline followed up for a median of 4.4 years. MAIN OUTCOME MEASURES: Dietary habits assessed at baseline with a validated 136 item food frequency questionnaire and scored on a nine point index. New cases of diabetes confirmed through medical reports and an additional detailed questionnaire posted to those who self reported a new diagnosis of diabetes by a doctor during follow-up. Confirmed cases of type 2 diabetes. RESULTS: Participants who adhered closely to a Mediterranean diet had a lower risk of diabetes. The incidence rate ratios adjusted for sex and age were 0.41 (95% confidence interval 0.19 to 0.87) for those with moderate adherence (score 3-6) and 0.17 (0.04 to 0.75) for those with the highest adherence (score 7-9) compared with those with low adherence (score <3). In the fully adjusted analyses the results were similar. A two point increase in the score was associated with a 35% relative reduction in the risk of diabetes (incidence rate ratio 0.65, 0.44 to 0.95), with a significant inverse linear trend (P=0.04) in the multivariate analysis. CONCLUSION: Adherence to a Mediterranean diet is associated with a reduced risk of diabetes.

Use of national health interview data to measure the burden of disease and injuries.

BACKGROUND: Although it is acknowledged that injuries place a substantial burden on populations throughout the world, few studies have measured the burden of non-fatal injuries and compared it with that of other health conditions. METHODS: Data for the adult population were obtained from the 2001 Spanish National Health Interview, a household telephone survey of the Spanish population. Differences in six measures of burden were compared for up to 11 conditions by age and gender. Proportions and their 95% CIs are reported. RESULTS: Injuries contribute 11-23% of the total health burden of the adult Spanish population, depending on which of the six indicators is used. They rank first and second out of the 11 conditions with regard to emergency visits and hospital admission, respectively. They rank third to sixth when other measures are chosen (ie, reduction in leisure activities, reduction in main activities, consulting a doctor, bedridden for half a day). Rheumatological, cardiovascular, and respiratory conditions are the only other conditions with a burden of comparable magnitude. CONCLUSION: In the adult Spanish population, injuries are an important cause of burden, regardless of the specific indicator used to define burden. These findings are likely to be equally applicable in similar countries. This type of comparison may raise the profile of injuries among health professionals and policy makers.

Validación del índice de masa corporal auto-referido en la Encuesta Nacional de Salud / Validity of self-reported body mass index in the National Health Survey

Objetivo. Valorar la validez del índice de masa corporal auto-referido en la Encuesta Nacional de Salud. Material y métodos. Se seleccionaron 120 participantes. Se recogió su peso y su talla usando exactamente las mismas preguntas utilizadas en la Encuesta Nacional de Salud. A continuación, y tras obtener el consentimiento informado, se procedió a la medición del peso y de la talla, que se usaron como gold standard. Resultados. Por término medio los participantes infraestimaron el peso en 1,39 kg, sobreestimaron la talla en 0,55 cm e infraestimaron el índice de masa corporal (IMC) en 0,71 kg/m2. La sensibilidad del IMC auto-referido para detectar sobrepeso u obesidad fue del 77%, la especificidad del 97%, el valor predictivo positivo 0,95 y el valor predictivo negativo 0,86. El índice Kappa fue 0,76 y el índice Kappa ponderado cuadraticamente 0,85. El coeficiente de correlación entre el IMC medido y reportado fue 0,96 y el coeficiente de correlación intraclase fue 0,97. Conclusiones. Los datos auto-referidos son una forma eficiente de tener datos sobre el IMC, aunque con limitaciones dado que al subestimar el peso y sobreestimar la altura, se infraestima el IMC y la proporción de individuos con IMC elevado

Objective. To assess the validity of self-reported body mass index in the National Health Survey. Methods. 120 participants were selected and questioned about their weight and height with exactly the same questions that the National Health Survey uses. Afterwards, and once informed consent was obtained, participants were weighed and measured, and this data was used as the gold standard. Results. On average, participants underestimated their weight by 1.39 kg, overestimated their height by 0.55 cm and underestimated their body mass index by 0.71 kg/m2. The sensitivity of self-reported self reported body mass index (BMI) to detect overweight was 77%, the specificity was 97%, the positive predictive value was 0.95 and the negative predictive value was 0.86. The Kappa index was 0.76 and the quadratically weighted Kappa index was 0.85. The correlation coefficient between self-reported and measured BMI was 0.96 and the intraclass correlation coefficient was 0.97. Conclusions. Self-reported data is an efficient way of obtaining information about BMI, although with limitations, because self-reported data tends to underestimate weight and overestimate height, thus underestimating BMI and the proportion of participants with elevated BMI

Análisis de los resultados de la terapia subcutánea continua de insulina como alternativa al tratamiento intensivo en pacientes con diabetes mellitus tipo 1 / Analysis of the results of continuous subcutaneous insulin therapy as an alternative to intensive treatment in type 1 diabetic patients

Objetivo: Verifi car la efectividad del tratamiento y determinar las característicasclínicas de los pacientes que han podido infl uir en elcontrol metabólico posterior. Materiales y métodos: Se estudió a37 pacientes (21 varones y 16 mujeres), con una media de edad de36,2 ± 9,4 años. El tiempo de evolución de la diabetes previa a lainfusión subcutánea continua de insulina (ISCI) fue de 16,2 ± 7,4 años.Las complicaciones angiopáticas fueron la retinopatía (50%), la nefropatía(19%) y la neuropatía (11,4%). Los motivos de indicaciónde ISCI fueron los siguientes: mal control (33,3%), petición propia(27,8%), hipoglucemias (22,2%), variabilidad glucémica (13,9%)y otros (2,7%). Resultados: Se observó un descenso de la hemoglobinaglucosilada (HbA1c) a los 12 meses de –0,71 ± 0,58%(p <0,001), que se mantuvo a los 36 meses en valores de –0,9 ±0,54% (p <0,001). Los requerimientos de insulina basal disminuyerony posteriormente se mantuvieron estables (inicio: 0,29 ± 0,08U/kg/día; 36 meses: 0,32 ± 0,14 U/kg/día). Se apreció una gananciade peso en los pacientes de 2,7 ± 4,8 kg a los 3 años con ISCI.Los participantes con una mayor HbA1c basal y un tiempo más largode evolución de la diabetes presentaron un descenso superior de laHbA1c con ISCI. Conclusiones: Se constató una mejora mantenidadel control glucémico y un descenso de las necesidades de insulinabasal. El mayor descenso de la HbA1c se obtuvo en los pacientes conuna mayor evolución de la diabetes y un peor control, que eran factorespronóstico de una mejor respuesta a esta terapia(AU)

Aim: To verify the efficacy of CSII treatment and determine patient’sclinical features that could have influenced the posterior metaboliccontrol. Methods: 37 patients; 21 males and 16 females, meanage of 36.2 ± 9.4 years. Mean duration of diabetes prior to CSII of16.2 ± 7.4 years and previous year mean A1c of 8.1 ± 0.9%. Diabeticcomplications: 50% retinopathy, 19% nephropathy, and 11.4%neuropathy. Indications for CSII: poor metabolic control (33.3%), patientrequest (27.8%), frequent hypoglycaemia (22.2%), glycaemicvariability (13.9%) and other (2.8%). Results: Starting A1c was loweredsignificantly in the first year of CSII –0.71 ± 0.58% (p <0.001)and stable –0.9 ± 0.54% (p <0.001) after 36 months. Basal insulinrequirements decreased and subsequently remained stable(start: 0.29 ± 0.08 U/kg/d; after 36 months: 0.32 ± 0.14 U/kg/d;p <0.001). The greatest reduction in A1c was found in patients withhigher baseline A1c and longer duration of diabetes. Conclusions:CSII resulted in a steady improvement in glycaemic control and reductionin insulin requirements. it could be considered a predictorfactor of treatment effect(AU)