[Angioimmunoblastic lymphadenopathy. Case report with ultrastructural study (author's transl)]. / Linfadenopatía angioinmunoblástica. Aportación de un caso con microscopia electrónica.

Angioimmunoblastic lymphadenopathy is a rare clinical entity, first described in 1974, characterized by asthenia, anorexia, fever, sweating, generalized lymph node enlargement, hepatosplenomegaly, rash, hypergammaglobulinemia, and often Coomb's positive hemolytic anemia. Main histopathologic findings are lymphoplasmocytic and immunoblastic proliferations, increased vascular neshwork and interstitial granular PAS positive material deposits. A lymph node excised from a woman with angioimmunoblastic lymphadenopathy was examined under electron microscopy. Results of ultrastructural study are compared to the typical histologic pattern observed under light microscopy. Analysis of the cellularity and the significance of fibrous collagen found in the interstitial PAS positive material are commented on.

[Genetic epidemiology in oncology]. / Epidemiología genética en oncología.

Genetic Epidemiology is a discipline which studies the incidence of diseases among the population, trying to quantify at the same time the individual risk of developing them. In Oncology, it is based on the analysis of the patients genealogies and on the study of the polymorphisms in their DNA with specific markers. Its operation requires a laboratory duly equipped with the techniques of Molecular Biology, a section responsible of data collection regarding patients and relatives and another area for the computer processing of data and results. Its funding shall be through public agencies, but the private companies related with this field must be aware of the need to participate in these projects.