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1.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31820981
2.
Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
J Med Chem
; 62(3): 1523-1540, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30624936
3.
Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.
J Med Chem
; 59(13): 6407-30, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27285051
4.
Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK).
J Med Chem
; 58(3): 1426-41, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25587754
5.
Structure-based design of novel class II c-Met inhibitors: 2. SAR and kinase selectivity profiles of the pyrazolone series.
J Med Chem
; 55(5): 1868-97, 2012 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22320327
6.
Structure-based design of a novel series of potent, selective inhibitors of the class I phosphatidylinositol 3-kinases.
J Med Chem
; 55(11): 5188-219, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22548365
7.
Selective class I phosphoinositide 3-kinase inhibitors: optimization of a series of pyridyltriazines leading to the identification of a clinical candidate, AMG 511.
J Med Chem
; 55(17): 7796-816, 2012 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22897589
8.
Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.
J Med Chem
; 54(13): 4735-51, 2011 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21612232
9.
Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.
J Med Chem
; 54(14): 5174-84, 2011 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-21714526
10.
Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.
J Med Chem
; 54(6): 1789-811, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21332118
11.
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J Med Chem
; 51(18): 5766-79, 2008 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-18763753
12.
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorg Med Chem Lett
; 17(11): 2992-7, 2007 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17418570
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