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1.
Z Geburtshilfe Neonatol ; 219(2): 93-8, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25525815

RESUMEN

BACKGROUND: The demographic change in -Germany describes an ongoing process of population development of which the eastern German states tend to be more affected. These ongoing changes have an influence on the reproductive behavior of the population. After twenty-three years of German reunification, the present study has investigated the question to what extent the somatic classification of newborns in Mecklenburg-Pomerania (M-P), Germany, is affected. MATERIAL AND METHODS: Newborn singleton births (n=174,084) were classified from the existing data of the German Perinatal Survey between 1994 and 2011. The rate of premature birth, SGA, and LGA rate as well as the rate of low birth weight ≤2,499 g were determined both gender-dependently and independently. In addition, a combined analysis of the rates has been taken into account. The obtained data material from M-P made it possible for the first time to compare by values. National and international reference studies were considered in this comparison. RESULTS: In M-P, the premature birth rate is 5.2%; the rate of newborns with low birth weight ≤ 2,499 g is 4.4%. Among newborns of ≤2,499 g and SGA newborns, girls compose a higher percentage (4.7%, 12.5%) compared to boys (4.0%, 7.4%). The premature birth rate and LGA newborns appear conversely. For these, the percentage of boys (5.6%, 12.6%) is higher than that of girls (4.8%, 7.0%). 60.6% of the gender non-specific newborns ≤2,499 g are simultaneously premature newborn infants. Only a very small percentage of 0.5% of SGA newborns is at the same time premature infants and newborns with low birth weight. CONCLUSIONS: By getting nationwide country-specific figures, a detailed analysis of the newborns in M-P can be performed. The analysis supports the existing national values and is a helpful addition for practice-oriented advice.


Asunto(s)
Peso Corporal/fisiología , Edad Gestacional , Resultado del Embarazo/epidemiología , Embarazo/fisiología , Embarazo/estadística & datos numéricos , Nacimiento Prematuro/epidemiología , Tasa de Natalidad , Femenino , Alemania/epidemiología , Encuestas de Atención de la Salud , Humanos , Recién Nacido de Bajo Peso/fisiología , Prevalencia , Distribución por Sexo
2.
Z Geburtshilfe Neonatol ; 218(2): 74-9, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24788836

RESUMEN

BACKGROUND: This communication presents precise percentile values for birth weight, birth length and cranial circumference of infants in Mecklenburg-Pomerania, Germany. MATERIAL AND METHODS: Based on data from the German Perinatal Survey of the years 1994-2011 in Mecklenburg-Pomerania, the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentile values for birth weight, birth length and head circumference are specified. The measurements of a total of 174,084 infants from non-multiple births are shown. RESULTS: The statistically calculated percentile values are presented in tabular and graph forms. The mean birth weight of the infants was 3,437.8 g. The average age of the mothers was 27.9 years. The average duration of pregnancy was 39.4 complete weeks. CONCLUSIONS: The insights gained from many years of data collection are presented as standardised, regional percentile values and curves for Mecklenburg-Pomerania for the first time. The differentiated presentation for the federal state opens the possibility for individually tailored consultations in clinical practice and may provide support for recognised national curves for these values.


Asunto(s)
Antropometría/métodos , Peso al Nacer/fisiología , Tamaño Corporal/fisiología , Recolección de Datos , Resultado del Embarazo/epidemiología , Interpretación Estadística de Datos , Femenino , Alemania/epidemiología , Edad Gestacional , Humanos , Recién Nacido , Masculino , Embarazo , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Distribución por Sexo
3.
Z Geburtshilfe Neonatol ; 217(1): 24-7, 2013 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-23440658

RESUMEN

BACKGROUND: We have previously described the prevalence in pregnancy of hypertension, proteinuria, oedema and preeclampsia/eclampsia according to maternal body mass index (BMI) and smoking status. We found that these disorders were less frequent among smoking women. To investigate whether this relationship is causal or a chance finding, we here present an analysis according to BMI and smoking specified according to the number of cigarettes consumed per day. MATERIALS AND METHODS: Data were from the German Perinatal Survey of 1998-2000. We classified women by BMI as underweight (BMI<18.5 kg/m2), normal weight (BMI 18.5-24.99 kg/m2), overweight (25.0-29.99 kg/m2), or obese (BMI≥30 kg/m2). Smoking was categorised as being a non-smoker or smoking 1-7, 8-14 or ≥ 15 cigarettes per day. Datasets from 433 669 singleton pregnancies with information on maternal BMI and smoking were included in the analysis. RESULTS: In all BMI categories hypertension, moderate to severe oedema, and preeclampsia/eclampsia became less prevalent with increasing maternal cigarette consumption. CONCLUSIONS: Dose-dependence was not convincing for proteinuria.Dose-dependence in the relationship between smoking and hypertensive disorders of pregnancy argues against a chance finding and for a causal relationship.


Asunto(s)
Índice de Masa Corporal , Hipertensión/epidemiología , Sobrepeso/epidemiología , Preeclampsia/epidemiología , Complicaciones Cardiovasculares del Embarazo/epidemiología , Proteinuria/epidemiología , Fumar/epidemiología , Adolescente , Adulto , Comorbilidad , Femenino , Alemania/epidemiología , Humanos , Incidencia , Persona de Mediana Edad , Embarazo , Medición de Riesgo , Adulto Joven
4.
Z Geburtshilfe Neonatol ; 215(1): 23-8, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21348006

RESUMEN

BACKGROUND: Maternal body mass index (BMI) outside the normal range and smoking are both associated with adverse perinatal outcomes, but their interaction needs further investigation. AIM: The aim of this study was to analyse the combined effects of smoking and BMI on birth weight, preterm birth rate, the somatic development of neonates, and complications of pregnancy. MATERIAL AND METHODS: Data from 508 926 singleton pregnancies from the German Perinatal Survey of 1998-2000 were analysed according to maternal BMI and smoking. RESULTS: Preterm birth rates were higher for non-smoking underweight (8.3%) and obese women (6.7%) than for normal weight (6.0%) or overweight women (5.6%); rates were higher in smokers than in non-smokers for every BMI category. The mean birth weight increased with increasing BMI and was decreased by smoking; it was 2,964 g in underweight smokers and 3,556 g in obese non-smokers. Small for gestational age (SGA) rates were least in obese women and highest in underweight women; large for gestational age (LGA) rates varied in the opposite direction. In smokers SGA rates were higher than in non-smokers for every BMI category and LGA rates were always lower. Hypertension, proteinuria, oedema, and pre-eclampsia/eclampsia were more common as BMI increased but were always lower in smokers. Pre-eclampsia/eclampsia occurred in 0.7% of underweight smokers but in 9.6% of obese non-smokers. CONCLUSIONS: Smoking and low maternal BMI in combination can cause high rates of preterm birth and SGA neonates as well as low mean birth weight. Although smoking offers some apparent benefit regarding LGA rates and pre-eclampsia this should not distract from its overall adverse influence.


Asunto(s)
Recién Nacido de Bajo Peso , Obesidad/epidemiología , Nacimiento Prematuro/epidemiología , Fumar/epidemiología , Adulto , Índice de Masa Corporal , Comorbilidad , Femenino , Alemania/epidemiología , Encuestas Epidemiológicas , Humanos , Recién Nacido , Persona de Mediana Edad , Embarazo , Prevalencia , Medición de Riesgo , Factores de Riesgo , Adulto Joven
5.
Z Geburtshilfe Neonatol ; 214(6): 229-33, 2010 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-21207322

RESUMEN

AIM: The aim of this study was to compare neonatal outcomes in primiparous women with and without previous extrauterine pregnancies. MATERIAL AND METHODS: We analysed data from 207 171 singleton pregnancies in primiparous women from the German Perinatal Survey of 1998-2000. To minimise confounding factors, we only included women without previous miscarriages or terminations of pregnancy and performed comparisons separately for 3 maternal age groups as well as for all cases together. RESULTS: Women with and without previous extrauterine pregnancies were of comparable height and weight but women with previous extrauterine pregnancies were on average older (29.2 vs. 26.6 years). The preterm birth rate was higher in women with previous extrauterine pregnancies (9.4% vs. 6.8%, odds ratio 1.42 [95% confidence interval 1.18-1.69], p<0.001; analysing all cases together) as was the rate of neonates with a low birth weight ≤ 2 499 g (7.9% vs. 5.7%, odds ratio 1.43 [95% confidence interval 1.17-1.72], p>0.001; analysing all cases together). The proportions of neonates classified as small, appropriate, or large for gestational age were rather similar in women with and without previous extrauterine pregnancies; likewise Apgar scores differed only slightly, although for some comparisons statistical significance was reached in spite of the small magnitude of differences. CONCLUSIONS: Previous extrauterine pregnancies are associated with higher rates of preterm birth and infants of low birth weight in subsequent pregnancies.


Asunto(s)
Recién Nacido de Bajo Peso , Resultado del Embarazo/epidemiología , Embarazo Ectópico/mortalidad , Embarazo , Nacimiento Prematuro/epidemiología , Adulto , Recolección de Datos , Femenino , Alemania/epidemiología , Humanos , Recién Nacido , Masculino , Prevalencia , Medición de Riesgo , Factores de Riesgo , Análisis de Supervivencia , Tasa de Supervivencia
6.
Z Geburtshilfe Neonatol ; 214(6): 243-8, 2010 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-21207325

RESUMEN

AIM: We aimed to set-up a passive malformations registry for 2002-2004 for the German Federal State of Mecklenburg-Western Pomerania in order to estimate the prevalence of congenital malformations among live births, stillbirths, miscarriages, and induced abortions. POPULATION AND STUDY DESIGN: Under the guidance of the working group "Neonatology Mecklenburg-Vorpommern" a standardised malformations record form modelled after the Mainz registry was developed and used to record malformations among live births, stillbirths, miscarriages, and induced abortions in all 21 obstetric departments in Mecklenburg-Western Pomerania between 2002 and 2004. We compared the population of neonates with malformations with a general population sample from the German Perinatal Survey of 1995-1997. RESULTS: There were 768 neonates with at least one major malformation among a total of 37 634 neonates in Mecklenburg-Western Pomerania; this means that the prevalence of major malformations was 203.53 per 10 000 neonates. The prevalence of major malformations in liveborn infants was 178.61 per 10 000. The most common malformations in the total study population were ventricular septal defect (prevalence: 37.2 per 10 000), hydronephrosis (16.7 per 10 000), hypospadias (14.8 per 10 000), Down syndrome (10.1 per 10 000), and cleft lip and palate (9.0 per 10 000). Among the induced abortions the most common diagnoses were Down syndrome, anencephalus, Edwards syndrome, and congenital hydrocephalus. The preterm birth rate among the 637 liveborn and stillborn infants with malformations was 19.6%; 5.6% were born before 32 completed weeks of gestation. The small for gestational age rate for infants with malformations was 14.2% for girls and 14.5% for boys, thus increased compared with the general population sample (9.7%). CONCLUSIONS: Congenital malformations are important determinants of childhood morbidity and mortality. Malformation prevalence and types of malformations, along with morbidity and mortality, are important parameters in perinatal medicine. The establishment of active malformation registries is therefore an important task.


Asunto(s)
Aborto Inducido/estadística & datos numéricos , Aborto Espontáneo/epidemiología , Anomalías Congénitas/mortalidad , Nacimiento Vivo/epidemiología , Sistema de Registros/estadística & datos numéricos , Mortinato/epidemiología , Estudios de Cohortes , Femenino , Alemania/epidemiología , Humanos , Recién Nacido , Masculino , Medición de Riesgo , Factores de Riesgo
7.
Z Geburtshilfe Neonatol ; 214(4): 161-6, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-20806151

RESUMEN

AIM: A description of preterm birth rates - specified according to maternal age - after the exclusion of anamnestic risk factors. MATERIAL AND METHODS: Data for this study were taken from the German Perinatal Survey of 1998-2000. We analysed data from 492,576 singleton pregnancies and determined preterm birth rates according to maternal age after a stepwise exclusion of anamnestic risk factors. RESULTS: There was a U-shaped dependence of preterm birth rates on maternal age. The lowest preterm birth rate (without excluding women with anamnestic risk factors) was 5.6% at a maternal age of 29 years. The prevalence of some anamnestic risk factors for preterm birth, such as previous stillbirths, spontaneous and induced abortions, and ectopic pregnancies, increased with maternal age. Excluding women with anamnestic risk factors lowered the preterm birth rates substantially. The lowest preterm birth rates were found in women with one previous live birth, without any anamnestic risk factors, and with a body mass index (BMI) of 25.00-29.99. With these restrictions, we found preterm birth rates of under 2% for women aged 24-31 years. CONCLUSIONS: The magnitude and age-dependence of the preterm birth rate can to some extent be explained with the age-dependent prevalence of anamnestic risk factors for preterm birth. Excluding women with anamnestic risk factors from our study population lowered the preterm birth rates substantially.


Asunto(s)
Encuestas Epidemiológicas , Atención Perinatal/estadística & datos numéricos , Nacimiento Prematuro/epidemiología , Adolescente , Adulto , Distribución por Edad , Femenino , Alemania/epidemiología , Humanos , Masculino , Edad Materna , Persona de Mediana Edad , Embarazo , Factores de Riesgo , Adulto Joven
8.
Z Geburtshilfe Neonatol ; 213(5): 194-200, 2009 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-19856242

RESUMEN

BACKGROUND: Smoking is the most important risk factor for adverse pregnancy outcomes in industrialized nations and is associated with, amongst other adverse effects, a higher rate of small-for-gestational-age (SGA) neonates. The rate of SGA neonates born before 32 weeks and its association with smoking have so far not been the focus of attention. MATERIAL AND METHODS: Using data of 643,288 primiparous women from the German perinatal statistics of 1995-2000, we aimed to investigate this relationship. We also analyzed our data according to daily cigarette consumption. RESULTS: We found that smoking during pregnancy was strongly associated with lower birth weight and higher SGA rates. This effect was especially pronounced in women >or=31 years. There was clear dose dependence with regard to daily cigarette consumption. An increase in SGA rates in smokers versus non-smokers can already be seen for very early preterm deliveries (31 weeks of gestation or less). CONCLUSIONS: Our results allow the definition of groups of women who are at higher risk of SGA births. We show that especially older primiparous women (aged >or=31 years) who smoke >10 cigarettes a day are at increased risk of experiencing fetal growth restriction.


Asunto(s)
Retardo del Crecimiento Fetal/epidemiología , Edad Gestacional , Recién Nacido Pequeño para la Edad Gestacional , Exposición Materna/estadística & datos numéricos , Exposición Materna/normas , Efectos Tardíos de la Exposición Prenatal/epidemiología , Fumar/epidemiología , Comorbilidad , Femenino , Alemania/epidemiología , Humanos , Incidencia , Recién Nacido , Embarazo , Medición de Riesgo , Factores de Riesgo
9.
Z Geburtshilfe Neonatol ; 213(4): 138-46, 2009 Aug.
Artículo en Alemán | MEDLINE | ID: mdl-19685406

RESUMEN

OBJECTIVE: We aimed to examine the individual and combined effects of nine maternal parameters (biological, medical, and social) on rates of prematurity. Our objective was to provide obstetricians with a way of screening women for likely premature deliveries. METHODS: We conducted a retrospective analysis on the data of about 2.3 million pregnancies taken from the German perinatal statistics of 1995-2000. Rates of prematurity were calculated with single and multi-dimensional analyses on the basis of nine maternal parameters (age, weight, height, number of previous live births, stillbirths, miscarriages and terminations of pregnancy, smoking status, previous premature delivery). The following combinations of parameters were investigated in particular: rates of prematurity according to the number of previous stillbirths, miscarriages, and terminations; rates of prematurity according to the number of previous live births and maternal age, height and weight. We also included daily cigarette consumption and previous premature deliveries in our analyses. RESULTS: The rate of prematurity (< or =36 weeks of gestation) in our population was 7.0%; the rate of moderately early premature deliveries (32-36 weeks) was 5.9%, and the rate of very early premature deliveries (< or =31 weeks) was 1.1%. Our multi-dimensional analyses revealed rates of prematurity (< or =36 weeks) between 5.1% and 27.5% depending on the combination of parameters. We found the highest rate of prematurity of 27.5% in women with the following combination of parameters: > or =1 stillbirth, > or =2 terminations of pregnancy and > or =2 miscarriages. A rather high risk of premature delivery (>11%) was also found for elderly (> or =40 years) grand multiparous women as well as small (< or =155 cm) and slim women (< or =45 kg). CONCLUSIONS: We have shown that certain combinations of maternal parameters are associated with a high risk of premature deliveries (>10%). The risk table that we present here may assist in predicting premature delivery.


Asunto(s)
Aborto Inducido/estadística & datos numéricos , Aborto Espontáneo/epidemiología , Peso Corporal , Nacimiento Prematuro/epidemiología , Fumar/epidemiología , Distribución por Edad , Comorbilidad , Femenino , Alemania/epidemiología , Humanos , Incidencia , Embarazo , Medición de Riesgo/métodos , Factores de Riesgo
10.
Z Geburtshilfe Neonatol ; 212(6): 206-10, 2008 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19085736

RESUMEN

OBJECTIVES: The aim of this study was to analyse the age distribution of primiparous women and its influence on pregnancy and birth risks, presentation at birth and mode of delivery. STUDY DESIGN: We analysed the perinatal statistics of eight German federal states for the years 1998-2000. For our analysis we defined maternal age groups as follows: < 22, 22-32, > 32 years. RESULTS: We identified a total of 508,926 singleton pregnancies. 247,593 of these were delivered by primiparous women without preceding live or stillbirths. The mean age of the primiparas was 26.9 years. For older primiparas > 32 years the proportion with previous miscarriages and terminations of pregnancy was > 20 %. The risk of premature rupture of membranes, abnormal CTG and prolonged labour increased clearly with age. 91.0 % of women < 22 years and 84.5 % of women > 32 years had a normal cephalic presentation. Regarding the mode of delivery, 77.1 % (< 22 years) and 53.1 % (> 32 years) experienced spontaneous delivery, 14.5 % (< 22 years) and 32.3 % (> 32 years) had a Caesarean section. CONCLUSIONS: Older primiparas have a higher proportion of previous miscarriages and terminations of pregnancy. They more commonly experience pathological presentations and also more frequently require Caesarean section. This means that a delayed first pregnancy - an increasingly common phenomenon in Germany - goes along with an increased likelihood of birth risks, Caesarean sections and peripartal interventions. Older primiparous women constitute a special risk group which may require a more intense level of care.


Asunto(s)
Aborto Inducido/estadística & datos numéricos , Aborto Espontáneo/epidemiología , Parto Obstétrico/estadística & datos numéricos , Presentación en Trabajo de Parto , Resultado del Embarazo/epidemiología , Adolescente , Adulto , Distribución por Edad , Femenino , Alemania/epidemiología , Humanos , Embarazo , Prevalencia , Medición de Riesgo/métodos , Factores de Riesgo , Adulto Joven
11.
Z Geburtshilfe Neonatol ; 212(6): 201-5, 2008 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19085735

RESUMEN

AIM: We aimed to illustrate the relationship between maternal obesity during pregnancy and maternal and fetal outcomes. We examined the influence of maternal BMI at the beginning of pregnancy on risks of pregnancy and birth, and on the somatic classification of the neonates. MATERIAL AND METHODS: In our retrospective cohort study we included 499,267 singleton pregnancies taken from the German perinatal statistics of 1998-2000. 51,506 obese pregnant women (BMI >or= 30) were compared to 320,148 pregnant women of normal weight (BMI 18.50-24.99). We divided obesity into 3 BMI-categories: BMI = 30.00-34.99, BMI = 35.00-39.99, and BMI >or= 40.00. We defined small-for-gestational-age (SGA), appropriate-for-gestational-age (AGA), and large-for-gestational-age (LGA) status by birth weight percentiles. RESULTS: 10.3 % of all pregnant women had a BMI >or= 30.00 and 0.8 % had a BMI >or= 40.00. The frequency of hypertension increased with the extent of obesity: 7.1 % (BMI = 30.00-34.99), 12.5 % (BMI = 35.00-39.99) and 18.3 % (BMI >or= 40.00) compared to 1.2 % (BMI 18.50-24.99). Cephalopelvic disproportion was found in 6.8 % (BMI >or= 40.00) compared to 2.8 % (BMI 18.50-24.99). Fetal macrosomia occurred in 24.8 % (BMI >or= 40.00) compared to 7.9 % in the control group. Rates of pre-eclampsia, gestational diabetes, and fetal structural anomalies also increased with maternal BMI. Women with different BMIs differed in parity but not in age. CONCLUSIONS: Obesity during pregnancy is associated with a range of maternal and fetal adverse outcomes. Pregnancy in obese women therefore calls for close monitoring and careful planning of delivery. Pre-conceptional weight reduction should be considered.


Asunto(s)
Enfermedades Fetales/epidemiología , Obesidad/epidemiología , Complicaciones del Embarazo/epidemiología , Resultado del Embarazo/epidemiología , Adolescente , Adulto , Comorbilidad , Femenino , Enfermedades Fetales/diagnóstico , Alemania/epidemiología , Humanos , Incidencia , Obesidad/diagnóstico , Embarazo , Complicaciones del Embarazo/diagnóstico , Medición de Riesgo/métodos , Factores de Riesgo , Adulto Joven
12.
Anticancer Res ; 27(4A): 2001-3, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17649812

RESUMEN

BACKGROUND: The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope, Galbeta1-3GalNAc) has long been known as a pancarcinoma antigen. Specific carrier proteins of the TF-antigen are the mucins, in particular Mucin 1. Here, we present our results of immunohistochemical identification of this carbohydrate antigen in human placenta. MATERIALS AND METHODS: Paraffin-embedded placental and decidual tissues from patients with the diagnosis hydatidiform mole were incubated with different monoclonal antibodies directed against TF-epitope (CD 176, IgM) and against Mucin 1 (CD 227, IgG). RESULTS: No expression of the TF-antigen or of Mucin 1 (Muc 1) was found in the decidual tissues, but the samples of chorionic tissues were TF- and Muc 1-antigen positive. As positive control, placental samples of the first trimester were investigated. CONCLUSION: A disorder of the extravillous trophoblast cells is present in hydatidiform mole.


Asunto(s)
Antígenos de Carbohidratos Asociados a Tumores/biosíntesis , Mola Hidatiforme/diagnóstico , Placenta/metabolismo , Neoplasias Uterinas/diagnóstico , Femenino , Humanos , Mola Hidatiforme/metabolismo , Inmunohistoquímica , Mucina-1/biosíntesis , Embarazo , Neoplasias Uterinas/metabolismo
13.
Anticancer Res ; 27(4A): 2023-5, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17649816

RESUMEN

BACKGROUND: Glycodelin A (GdA), also known as placental protein 14 (PP14), has been detected in endometrial, cervical and ovarian carcinoma cells. It is suspected to be a marker of human ovarian cancer tissues. MATERIALS AND METHODS: We investigated serum, tissue and cyst fluid samples of patients with an ovarian carcinoma in contrast to patients with benign and malignant diseases such as uterine myoma, endometriosis, cervical, uterine and breast cancer, and metastases of bladder and colon carcinoma. Used methods were enzyme-immunoassay, immunohistochemistry (IHC) and polymerase chain reaction (PCR). RESULTS: In 81% of the control group the GdA-expression was negative, which was confirmed by IHC and PCR. Of the ovarian carcinoma group only 52% showed correspondence between IHC and PCR. CONCLUSION: These results indicate that determination of GdA is not sensitive or specific enough for use as a tumour marker.


Asunto(s)
Biomarcadores de Tumor/análisis , Expresión Génica , Glicoproteínas/biosíntesis , Neoplasias Ováricas/diagnóstico , Proteínas Gestacionales/biosíntesis , Ensayo de Inmunoadsorción Enzimática , Femenino , Glicodelina , Glicoproteínas/genética , Humanos , Inmunohistoquímica , Neoplasias Ováricas/metabolismo , Reacción en Cadena de la Polimerasa , Proteínas Gestacionales/genética , ARN Mensajero/análisis , Sensibilidad y Especificidad
14.
Anticancer Res ; 27(4A): 2053-8, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17649821

RESUMEN

BACKGROUND: Phytoestrogens are a diverse group of nonsteroidal plant compounds which have similar effects to endogenous estrogens in humans and have been ascribed potential anticarcinogenic activities. We tested the effects of phytoestrogen extracts from different plant organs of flax, Linum usitatissimum, on cell proliferation in trophoblast tumour cells of the cell line Jeg3. MATERIALS AND METHODS: Phytoestrogen extracts were prepared from leaves, stems and roots of L. usitatissimum using different extraction methods. The isolated phytoestrogens were identified using HPLC-MS analysis. The influence on cell proliferation (MTT test) was determined in the trophoblast tumour cells, Jeg3. RESULTS: Cell proliferation of trophoblast tumour Jeg3 cells was significantly affected by the phytoestrogens isolated from leaves, stems and roots of L. usitatissimum. Root extracts inhibited Jeg3 cell growth significantly. CONCLUSION: A cell culture model system of the human trophoblast tumour cell line, Jeg3, was established to test the effect of potential phytoestrogens on cell proliferation. It was shown that the roots of L. usitatissimum contain measurable concentrations of lignans and isoflavones.


Asunto(s)
Lino/química , Fitoestrógenos/farmacología , Extractos Vegetales/farmacología , Neoplasias Trofoblásticas/metabolismo , Neoplasias Uterinas/metabolismo , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Cromatografía Líquida de Alta Presión , Femenino , Humanos , Espectrometría de Masas , Fitoestrógenos/aislamiento & purificación , Fitoterapia/métodos , Extractos Vegetales/aislamiento & purificación , Embarazo
15.
Int J Gynaecol Obstet ; 97(2): 115-9, 2007 May.
Artículo en Inglés | MEDLINE | ID: mdl-17368647

RESUMEN

OBJECTIVE: To investigate whether corticotropin-releasing hormone (CRH) and corticotropin (ACTH) plasma concentrations in women diagnosed with preterm labor are of potential clinical value in the assessment of the risk of preterm birth. METHOD: Plasma samples of 79 women diagnosed with preterm labor were used in this study. Samples were divided into three groups based on the week of gestation (24th-28th, 29th-32nd, 33rd-37th). CRH and ACTH values were determined by ELISA. RESULT: Mean maternal peripheral plasma values of CRH and ACTH were significantly higher (p<0.001) in women who were initially diagnosed with preterm labor and finally delivered a preterm birth, compared to women with the same diagnosis but with term birth. CONCLUSION: CRH and ACTH serum levels in women diagnosed with preterm labor could be used as predictors for the timing of parturition.


Asunto(s)
Hormona Adrenocorticotrópica/sangre , Hormona Liberadora de Corticotropina/sangre , Trabajo de Parto Prematuro/sangre , Nacimiento Prematuro/diagnóstico , Adulto , Biomarcadores , Femenino , Edad Gestacional , Humanos , Trabajo de Parto Prematuro/fisiopatología , Valor Predictivo de las Pruebas , Embarazo
16.
Anticancer Res ; 25(3A): 1567-74, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16033062

RESUMEN

BACKGROUND: Primary melanoma of the female genital system are extremely rare (2-3%). PATIENTS AND METHODS: A retrospective review was undertaken of patients with primary melanoma of the female genital system treated from 1990-2003 at Rostock University Hospital, Germany. Different treatments (sentinel node biopsy, inguinofemoral lymphadenectomy, en bloc resection, adjuvant Interferon-alpha-therapy, adjuvant chemotherapy) are discussed. The complicated classification is reduced to a clinical path for daily use (UICC stage and invasion depth of Breslow, Clark's level and Chung's level). RESULTS: We report on 10 patients, aged 26 to 76 years, with primary melanoma of the female genital tract. Seven women developed a vulvar melanoma and one woman a malignant melanoma of the cutaneous inguinal region, while another 2 women had an unusual primary location of the malignant melanoma, the cervico-vaginal region (n=1) and the left ovary (n = 1). CONCLUSION: Initial surgical modality did not influence long-term survival, but affected disease-free survival significantly.


Asunto(s)
Neoplasias de los Genitales Femeninos/diagnóstico , Melanoma/diagnóstico , Adulto , Anciano , Quimioterapia Adyuvante , Terapia Combinada , Femenino , Neoplasias de los Genitales Femeninos/tratamiento farmacológico , Neoplasias de los Genitales Femeninos/radioterapia , Neoplasias de los Genitales Femeninos/cirugía , Neoplasias de los Genitales Femeninos/terapia , Humanos , Interferón-alfa/uso terapéutico , Escisión del Ganglio Linfático , Melanoma/tratamiento farmacológico , Melanoma/radioterapia , Melanoma/terapia , Persona de Mediana Edad , Estudios Retrospectivos
17.
Anticancer Res ; 25(3A): 1603-6, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16033067

RESUMEN

There are only a few cases of primary ovarian melanoma described in the literature. Here, we report a rare case of ovarian mixed neoplasm with parts of malignant melanoma and fibrothecoma in a 76-year-old female who was hospitalized for a cataract operation. To our knowledge, cases of a combination of malignant melanoma and fibrothecoma in the ovary have not been described. In this study, new markers for malignant melanoma (S-100, tyrosinase mRNA) were also tested.


Asunto(s)
Fibroma/diagnóstico , Melanoma/diagnóstico , Neoplasias Ováricas/diagnóstico , Anciano , Femenino , Fibroma/patología , Humanos , Melanoma/patología , Neoplasias Ováricas/patología
18.
Anticancer Res ; 25(3A): 1645-8, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16033075

RESUMEN

BACKGROUND: Lung cancer is the second most common malignant tumor, with increasing incidence in the female population. The most frequent metastatic sites are the regional lymph nodes and surrounding areas as well as liver, adrenal gland, bones and brain. Metastases in the vagina of primary lung cancer have not been previously reported. CASE REPORT: Lung cancer was diagnosed in a 67-year-old, postmenopausal woman. Two years following partial lung resection (right apical lobe, R0-resection, CR), the patient complained of increasing problems with urination. A suspect tumor was identified with palpation and confirmed sonographically. Histological and immunohistochemical examinations of a vaginal excisional biopsy revealed metastatic adenocarcinoma, with the staining reactivity as primary lung neoplasm. Anterior exenteration was performed. CONCLUSION: Some cases of vaginal metastases from extragenital tumors have been previously reported. This is the first report of vaginal metastases from primary lung cancer. We suggest that adenocarcinoma especially tend to form metastases in the female genital tract. The present case emphasizes that, in women with unclear symptoms and findings in the small pelvis (e.g. urination problems, suspect vaginal tumor), the formation of such metastases should be taken into account.


Asunto(s)
Neoplasias Pulmonares/patología , Neoplasias Vaginales/secundario , Anciano , Femenino , Humanos , Inmunohistoquímica , Neoplasias Vaginales/diagnóstico
19.
Anticancer Res ; 25(3A): 1675-8, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16033081

RESUMEN

The Thomsen-Friedenreich antigen (TF), or more precisely epitope, has been known as a pancarcinoma antigen. It consists of galactose-beta1-3-N-acetylgalactose. We have already described the expression of TF in the normal placenta. TF is expressed by the syncytium and by extravillous trophoblast cells. In this study, we investigated the expression of TF in the abort placenta. Frozen samples of human abort placentas (12 placentas), obtained from the first and second trimesters of pregnancy and, for comparison, samples of normal placentas (17 placentas) from the first, second and third trimesters of pregnancy, were used. Expression of TF was investigated by immunohistochemical methods. For identification of TF-positive cells in abort placentas, immunofluorescence methods were used. Evaluation of simple and double immunofluorescence was performed on a laser scanning microscope. Furthermore, we isolated trophoblast cells from first and third trimester placentas and evaluated cytokeratin 7 and Muc1 expression by immunofluorescence methods. We observed expression of TF antigen in the syncytiotrophoblasts layer of the placenta in all three trimesters of pregnancy in normal and abort placentas evaluated by immunohistochemical methods. There was no expression of TF antigen in the decidua of abort placentas. Immunofluorescence double staining of TF antigen and cytokeratin 7 showed reduced expression of both antigens in the abort decidua and co-expression of both antigens in the syncytiotrophoblast layer of normal and abort placentas. TF expression in the syncytiotrophoblast was reduced in abort placentas. In the isolated trophoblast cells, no TF expression was found, however, Muc1 expression was visualized. Expression of TF antigen was reduced in the first and second trimester abort decidua compared to the normal decidua during the same time of pregnancy. TF antigen was restricted to the syncytiotrophoblast and extravillous trophoblast cells in the decidua. Abort placentas expressed TF antigen on the syncytiotrophoblast layer, but with lower intensity compared to normal placentas. We found a significantly reduced co-expression of TF antigen and cytokeratin 7 in the decidua of abort placentas. These data suggested a reduction of extravillous trophoblast cells in the decidua of abort placentas. In addition, we found higher numbers of CD45-positive cells in the abort decidua compared to normal placentas.


Asunto(s)
Aborto Inducido , Antígenos de Carbohidratos Asociados a Tumores/inmunología , Placenta/inmunología , Técnica del Anticuerpo Fluorescente , Humanos , Inmunohistoquímica
20.
Anticancer Res ; 25(3A): 1667-70, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-16033079

RESUMEN

The concentrations of pregnancy protein 1 (SP1), placental-specific tissue protein 10 (PP10), placental-specific tissue protein 12 (PP12) and alpha1-Fetoprotein (AFP) were analyzed in serum samples of 83 patients with bronchial carcinoma at stages II-IV Protein levels were determined by means of single radial immunodiffusion, rocket immuno-electrophoresis, radioimmunoassay and enzyme- immunoassay. PP12 and AFP serum concentrations were significantly increased in the cancer group compared with the control group. PP12 (control group: x=54.08 microg/l; s=61. 70; tumor group: x = 122.52 microg/l; s = 131.16); AFP (control group: x=3.05 microg/l; s=3. 76; tumor group: x = 8.29 microg/l; s = 17.75). SPI was found in only 22 cases of the tumor group. PP10 (control group: x = 2.25 microg/l; s = 0.866; tumor group: x = 2.503 microg/l; s=1.508). Given that at least two of the tested parameters were determined to be in the pathological range, the sensitivity amounted to 0.64 and the specificity to 0.92.


Asunto(s)
Biomarcadores de Tumor/sangre , Neoplasias de los Bronquios/sangre , Femenino , Glicoproteínas/sangre , Humanos , Inmunodifusión , Técnicas para Inmunoenzimas , Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina , Proteínas de Unión a Factor de Crecimiento Similar a la Insulina/sangre , Masculino , Proteínas Gestacionales/sangre , Radioinmunoensayo , alfa-Fetoproteínas/metabolismo
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