Differential disease diagnoses of epistaxis based on dynamic uncertain causality graph.

PURPOSE: Epistaxis is a common symptom and can be caused by various diseases, including nasal diseases, systemic diseases, etc. Many misdiagnosis and missed diagnosis of epistaxis are caused by lack of clinical knowledge and experience, especially some interns and the clinicans in primary hospitals. To help inexperienced clinicans improve their diagnostic accuracies of epistaxis, a computer-aided diagnostic system based on Dynamic Uncertain Causality Graph (DUCG) was designed in this study. METHODS: We build a visual epistaxis knowledge base based on medical experts' knowledge and experience. The knowledge base intuitively expresses the causal relationship among diseases, risk factors, symptoms, signs, laboratory checks, and image examinations. The DUCG inference algorithm well addresses the patients' clinical information with the knowledge base to deduce the currently suspected diseases and calculate the probability of each suspected disease. RESULT: The model can differentially diagnose 24 diseases with epistaxis as the chief complaint. A third-party verification was performed, and the total diagnostic precision was 97.81%. In addition, the DUCG-based diagnostic model was applied in Jiaozhou city and Zhongxian county, China, covering hundreds of primary hospitals and clinics. So far, the clinicians using the model have all agreed with the diagnostic results. The 432 real-world application cases show that this model is good for the differential diagnoses of epistaxis. CONCLUSION: The results show that the DUCG-based epistaxis diagnosis model has high diagnostic accuracy. It can assist primary clinicians in completing the differential diagnosis of epistaxis and can be accepted by clinicians.

An Industrial Fault Diagnostic System Based on a Cubic Dynamic Uncertain Causality Graph.

This study presents an industrial fault diagnosis system based on the cubic dynamic uncertain causality graph (cubic DUCG) used to model and diagnose industrial systems without sufficient data for model training. The system is developed based on cloud native technology. It contains two main parts, the diagnostic knowledge base and the inference method. The knowledge base was built by domain experts modularly based on professional knowledge. It represented the causality between events in the target industrial system in a visual and graphical form. During the inference, the cubic DUCG algorithm could dynamically generate the cubic causal graph according to the real-time data and perform the logic and probability calculations based on the generated cubic DUCG models, visually displaying the dynamic causal evolution of faults. To verify the system's feasibility, we rebuild a fault-diagnosis model of the secondary circuit system of No. 1 at the Ningde nuclear power plant based on the new system. Twenty-four fault cases were used to test the diagnostic accuracy of the system, and all faults were correctly diagnosed. The results showed that it was feasible to use the cubic DUCG platform for fault diagnosis.

Computer-Aided Diagnoses for Sore Throat Based on Dynamic Uncertain Causality Graph.

The causes of sore throat are complex. It can be caused by diseases of the pharynx, adjacent organs of the pharynx, or even systemic diseases. Therefore, a lack of medical knowledge and experience may cause misdiagnoses or missed diagnoses in sore throat diagnoses, especially for general practitioners in primary hospitals. This study aims to develop a computer-aided diagnostic system to assist clinicians in the differential diagnoses of sore throat. The computer-aided system is developed based on the Dynamic Uncertain Causality Graph (DUCG) theory. We cooperated with medical specialists to establish a sore throat DUCG model as the diagnostic knowledge base. The construction of the model integrates epidemiological data, knowledge, and clinical experience of medical specialists. The chain reasoning algorithm of the DUCG is used for the differential diagnoses of sore throat. The system can diagnose 27 sore throat-related diseases. The model builder initially tests it with 81 cases, and all cases are correctly diagnosed. Then the system is verified by the third-party hospital, and the diagnostic accuracy is 98%. Now, the system has been applied in hundreds of primary hospitals in Jiaozhou City, China, and the degree of recognition for doctors to the diagnostic results of the system is more than 99.9%. It is feasible to use DUCG for the differential diagnoses of sore throat, which can assist primary doctors in clinical diagnoses and the diagnostic results are acceptable to clinicians.