Immunomodulatory effects of IL-33 and IL-25 in an ovalbumin-induced allergic rhinitis mouse model.

Both interleukin (IL)-33 and IL-25 induce Th2-type cytokine production by various cell types, suggesting that they may contribute to development of allergic disorders, however, the immunomodulatory effects of IL-33 and IL-25 in ovalbumin (OVA)-induced allergic rhinitis (AR) remain unclear. In the present study, anti-IL-33 and anti-IL-25 Abs were administrated intranasally during rechallenge in OVA-induced AR. Immunomodulatory effects were evaluated by measuring nasal rubbing, sneezing occurrence, serum OVA-specific antibodies, Th2 immune responses, neutrophil, eosinophil and mast cell recruitment into the nasal mucosa. We found that treatment with anti-IL-33 Ab markedly reduced nasal rubbing, sneezing events, Th2 immune responses, serum OVA-specific IgE and IgG1 levels, mucosal neutrophil, eosinophil and mast cell infiltration. In contrast, the effect of IL-25 antagonism was limited to attenuating the Th2 immune responses, and neutrophil and eosinophil infiltration. These observations indicate that IL-33 and IL-25 play a pathogenic role in an established AR mouse model, with a greater contribution of IL-33 than IL-25. Our findings suggest that IL-33 neutralization may be a potential approach for treatment of AR.

[A retrospective analysis of clinical characteristics, diagnosis in patients with unilateral sinus disease].

Objective:The aim of this study is to investigate the clinical features in patients with unilateral sinus disease.Method:A retrospective review of 2 480 patients who had undergone sinus surgery was performed. The clinical data were gathered and analyzed to investigate the features of the unilateral sinus disease. Descriptive and inferential statistics were computed.Result:1 350 patients (54.4%) who had bilateral sinus disease were all diagnosed as chronic rhinosinusitis pathologically confirmed after surgery. Unilateral sinus disease was identified in 1 130 patients (45.6%) and the disease entities were categorized as chronic rhinosinusitis (589 patients, 52.1%), fungal rhinosinusitis (312 patients, 27.6%), inverted papilloma (95 patients, 8.4%), sinus cyst (78 patients, 6.9%), malignant tumor (34 patients, 3%), osteoma including osteodysplasia fibrosa (11 patients, 1%) and others (11 patients, 1%) . Among the patients of malignant tumor, there were 13 cases of squamous cell carcinoma, 6 cases of malignant lymphoma, 4 cases of sarcoma, 4 cases of melanoma, 3 cases of adenocystic carcinoma, 1 case of verrucous carcinoma, 1 case of metastases from liver, 1 case of plasmacytoma,and 1 case of hemangiopericytoma. The number of fungal rhinosinusitis patient increased year by year. The common major presenting symptom for fungal rhinosinusitis was headache (46.8%) and bloody discharge (31.1%). Male accounted for a large part of both inverted papilloma and malignant tumor patients, both of which CT findings that correlated with the presence was the absorption and destruction of the sinus wall. Thirty-one cases (32.6%) of inverted papilloma patients recurred. Bloody discharge (58.8%) was major symptom of the malignant tumor.Conclusion:There were almost a half of unilateral sinus diseases that were not common chronic rhinosinusitis, in which the incidence of fungal rhinosinusitis, inverted papilloma, squamous cell carcinoma and other kinds of benign and malignant tumor was high. A careful history taking and endoscopic examination play a key role as well as imaging examination in identifying unilateral sinus disease, which is important for reaching a correct diagnosis and treatment.

Characteristics and prognostic factors for head and neck non-Hodgkin's lymphoma in Chinese patients.

BACKGROUND AND OBJECTIVES: The head and neck region is the second most frequent anatomical site of extranodal lymphomas. These tumours affect many individuals worldwide, justifying epidemiological studies in different countries. This study evaluated the characteristics, treatments and prognostic factors for non-Hodgkin's lymphoma of the head and neck in Chinese patients. METHOD: The clinical manifestations, clinicopathological characteristics, multidisciplinary treatment and prognostic factors for 102 patients with extranodal non-Hodgkin's lymphoma of the head and neck were analysed retrospectively. RESULT: The tonsil was the most commonly involved primary site, followed by the nasal cavity. The most common histological subtype was diffuse large B-cell lymphoma, followed by natural killer T-cell lymphoma. Patients receiving a combination of rituximab and chemotherapy did better than those receiving chemotherapy alone. Prognosis was significantly associated with both International Prognostic Index and histological subtype; the former was especially strongly associated with poor survival. CONCLUSION: In this group of Chinese patients, diffuse large B-cell lymphoma was the most common pathological subtype, but the incidence of T-cell lymphomas was higher than that reported in the USA. Combined rituximab and chemotherapy led to better outcomes than chemotherapy alone. Prognosis depended on both International Prognostic Index and histological subtype.

[Surgical treatment for the recurrent patients after palatopharyngoplasty].

OBJECTIVE: To study the surgical treatment for the recurrent patients after palatopharyngoplasty (PPP). METHOD: Five patients which were confirmed recurrence by sleep survey and examinations were reported. RESULT: The pharyngeal cavity was narrower obviously ten months after ppp than before ppp. The anteroposterior and transverse distances were (4.06 +/- 2.94) mm and (11.40 +/- 4.16) mm respectively. After dilatation, the distances were (11.90 +/- 3.25) mm and (21.00 +/- 4.18) mm separately, and were increased significantly than before (P < 0.01). Two patients were cured and three cases marked, and all patients were not recurrent post-operation with no complications. CONCLUSION: The recurrence was mainly concerned with the unsuitable manipulation in PPP. Selecting the cooperation and proper surgical treatment, the better effect was also obtained for the recurrent patients.

[Operations for laryngeal carcinoma with reservation of laryngeal function].

OBJECTIVE: To study the long term results and functional recovery of partial laryngectomy in the treatment of glottic and supraglottic types of laryngeal carcinoma. METHOD: A series of 70 cases operated on between July 1978 and August 1998 were analysed, of whom 60 were glottic, 10 were supraglottic type laryngeal carcinoma. Among them, 22 cases underwent vocal cord resection, 22 vertical hemilaryngectomy, 17 Majer-Piquet's operation, 7 horizontal hemilaryngectomy, 2 Arslan's operation. RESULT: 1, 3, 5-year survival rates were 98.53%, 87.04% and 78.26% respectively. Decannulation rate was 100%. All patients could finally take food by mouth without inspiration, and could speak as soon as decannulated. Complication and recurrence rates were 15.71% and 13.04% separately. CONCLUSION: Partial laryngectomy is an effective operation on laryngeal carcinoma with reservation of laryngeal function. It not only can totally excise neoplasm and prolong life, but also can better reserve laryngeal function and improve the quality of patient's life.