Distorted views of biodiversity: spatial and temporal bias in species occurrence data.

Boakes et al. compile and analyze a historical dataset of 170,000 bird sightings over two centuries and show how changing trends in data gathering may confound a true picture of biodiversity change.

Inhibitory effects of Notch receptor blocker MWI67 on the proliferation of U87 glioma cells in vitro / 中华神经医学杂志

Objective To observe the effect of Notch receptor blocker MW167 on the proliferation and apoptosis of U87 glioma cell line in vitro. Methods The inhibitory effect of MW167 on the proliferation of U87 cells was investigated by MTT assay, and flow cytometry with Annexin-FITC and PI staining was performed to detect the apoptotic rate of U87 cells after MW167 treatment. Results MTT assay demonstrated an obvious concentration-dependent inhibitory effect of MW167 on the proliferation of U87 cells. Flow cytometry showed that MW167 also concentration-dependently induced U87 cell apoptosis. Conclusion MW167 significantly inhibits the proliferation and induces apoptosis of U87 glioma cells, suggesting the potential therapeutic value of MW167 in the treatment of human glioma. [Key wnrds] Notch signaling;MWI67;Proliferation;Apoptosis;Glioma