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Nature ; 452(7190): 949-55, 2008 Apr 24.
Artículo en Inglés | MEDLINE | ID: mdl-18362917

RESUMEN

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.


Asunto(s)
Genes de Insecto/genética , Genoma de los Insectos/genética , Tribolium/genética , Animales , Composición de Base , Tipificación del Cuerpo/genética , Sistema Enzimático del Citocromo P-450/genética , Elementos Transponibles de ADN/genética , Crecimiento y Desarrollo/genética , Humanos , Insecticidas/farmacología , Neurotransmisores/genética , Oogénesis/genética , Filogenia , Proteoma/genética , Interferencia de ARN , Receptores Acoplados a Proteínas G/genética , Receptores Odorantes/genética , Secuencias Repetitivas de Ácidos Nucleicos/genética , Gusto/genética , Telómero/genética , Tribolium/clasificación , Tribolium/embriología , Tribolium/fisiología , Visión Ocular/genética
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