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1.
Metabol Open ; 14: 100176, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-35392380

RESUMEN

Overweight/obesity is a growing pandemic that affects many organs and tissues. We have investigated whether a high-lipid diet provokes an imbalance between type 1 and type 2 angiotensin II (Ang II) receptors signaling, leading to liver alterations associated with cardiovascular and kidney disturbances. Chronic administration of a high-lipid diet can provoke hepatocardiorenal syndrome resulting from activation of the Ang II→type 1 receptor axis, which is entirely counteracted by Ang-(3-4), the allosteric enhancer of the Ang II→type 2 receptor pathway.

2.
Biochim Biophys Acta Mol Basis Dis ; 1867(3): 166012, 2021 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-33212189

RESUMEN

Hypertension, one of the most common and severe comorbidities of obesity and overweight, is a worldwide epidemic affecting over 30% of the population. We induced overweight in young male rats (aged 58 days) by exposure to a hypercaloric high lipid (HL) diet in which 70% of the calories originated from fat. The HL diet also contained 33 or 57% higher Na+ than the control (CTR) diet. Over the following weeks the HL rats gradually became overweight (490 ± 12 g vs 427 ± 7 g in the CTR group after 15 weeks) with high visceral fat. They developed elevated systolic blood pressure (SBP) (141 ± 1.9 mmHg), which was fully restored to CTR values (128 ± 1.1 mmHg) by oral administration of Ang-(3-4) (Val-Tyr), the shortest renin-angiotensin-derived peptide. The overweight rats had lower plasma Na+ concentration that augmented to CTR values by Ang-(3-4) treatment. Na+ ingestion was depressed by 40% as result of the Ang-(3-4) treatment, whereas the urinary excretion of Na+ (UNaV) remained unmodified. The preservation of UNaV after Ang-(3-4) treatment - despite the sharp decrease in the dietary Na+ intake - can be ascribed to the normalization of renal type 1 angiotensin II receptors and Na+-transporting ATPases, both up-regulated in overweight rats. These renal effects complete a counterregulatory action on elevated renin-angiotensin activity that allows the high SBP to be normalized and body Na+ homeostasis to be restored concomitantly in overweight rats.


Asunto(s)
Angiotensinas/uso terapéutico , Presión Sanguínea/efectos de los fármacos , Ingestión de Energía/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Sobrepeso/tratamiento farmacológico , Fragmentos de Péptidos/uso terapéutico , Animales , Hipertensión/complicaciones , Hipertensión/fisiopatología , Hipertensión/orina , Masculino , Sobrepeso/complicaciones , Sobrepeso/fisiopatología , Sobrepeso/orina , Ratas , Ratas Wistar , Sodio/metabolismo , Sodio/orina
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