CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets.

Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatment targets is crucial to address these challenges. Circular RNA (circRNA) has emerged as a promising research biomarkers and therapeutic targets because of its tissue specificity and conservation. However, the potential role of circRNA in stroke prognosis and treatment remains largely unexplored. This review briefly elucidate the mechanism underlying circRNA's involvement in stroke pathophysiology. Additionally, this review summarizes the impact of circRNA on different forms of strokes, including ischemic stroke and hemorrhagic stroke. And, this article discusses the positive effects of circRNA on promoting cerebrovascular repair and regeneration, maintaining the integrity of the blood-brain barrier (BBB), and reducing neuronal injury and immune inflammatory response. In conclusion, the significance of circRNA as a potential prognostic biomarker and a viable therapeutic target was underscored.

Thromboelastography-guided antiplatelet therapy for patients with ischemic cerebrocardiovascular diseases: a systematic review and meta-analysis.

BACKGROUND: The effectiveness of thromboelastography (TEG)-guided antiplatelet therapy in patients with ischemic cerebrocardiovascular diseases is not well-established. This systematic review evaluates the efficacy and safety of TEG-guided antiplatelet therapy compared to standard treatment in patients with ischemic cerebrocardiovascular diseases. METHODS: Randomized controlled trials (RCTs) and observational studies comparing TEG-guided antiplatelet therapy with standard therapy in patients suffering from ischemic stroke (IS) or coronary artery disease (CAD) were identified. The primary efficacy measure was a composite of ischemic and hemorrhagic events. Secondary efficacy measures included any ischemic events, while safety was assessed by the occurrence of bleeding events. RESULTS: 10 studies involving 4 RCTs and 6 observational studies with a total of 1,678 patients were included. When considering a composite of ischemic and hemorrhagic events in RCTs, a significant reduction was observed in IS or CAD patients under TEG-guided therapy compared to standard therapy (OR 0.45, 95% CI 0.27 to 0.75, P=0.002). After pooling RCTs and observational studies together, compared to standard antiplatelet therapy, TEG-guided therapy significantly reduced the risk of a composite of ischemic and hemorrhagic events (OR 0.26, 95% CI 0.19 to 0.37; P<0.00001), ischemic events (OR 0.28, 95% CI 0.19 to 0.41; P<0.00001), and bleeding events (OR 0.31, 95% CI 0.16 to 0.62; P=0.0009) in patients with IS or CAD. CONCLUSIONS: TEG-guided antiplatelet therapy appears to be both effective and safe for patients with IS or CAD. These findings support the use of TEG testing to tailor antiplatelet therapy in individuals with ischemic cerebrocardiovascular diseases.

Effect and safety posterior scleral reinforcement on controlling myopia in children: a meta-analysis.

PURPOSE: The aim of this meta-analysis was to assess the efficacy of posterior scleral reinforcement (PSR) on the control of pediatric myopia. Electronic databases were systematically searched. METHODS: Standardized mean differences (SMDs) of outcomes were calculated. Eight studies with 357 patients with pediatric myopia were included. The SMD for the increase in mean axial length (AL) in the PSR and control group was - 1.19 (95% CI - 1.71, - 0.68). RESULTS: The SMD for decrease of best-corrected visual acuity (BCVA) LogMAR in the PSR and control group was 0.85 (95% CI 0.28, 1.43). The SMD for change in intraocular pressure (IOP) at the time of surgery and at the end of the follow-up period in the PSR group was - 0.01 (95% CI - 0.48, 0.47). CONCLUSION: This meta-analysis indicates that PSR surgery may be an effective therapeutic strategy to control the progression of myopia in childhood with acceptable adverse effects.

A Study on the Effectiveness of 650-nm Red-Light Feeding Instruments in the Control of Myopia.

INTRODUCTION: This study analyzed the effectiveness of 650-nm red-light feeding instruments in the control of myopia. METHODS: In this study, 164 school-aged participants diagnosed with myopia in the city of Shenzhen were enrolled in a red-light feeding instrument study. Of these, 41 were enrolled in the mild-to-moderate myopia group that received red-light feeding (RLMM group), 65 were enrolled in the mild-to-moderate myopia group that received single-vision spectacle treatment (SVSMM group), and 58 were included in the severe myopia group that received red-light feeding (RLS group). RESULTS: After the baseline values of the three groups were matched, the right eye data were used for statistical analysis. The average return visit time of each group was 60.42 days, and changes in the observation indexes before treatment and after follow-up treatment were compared. As the primary outcome, the axial length changes in the right eye of the SVSMM group (0.08 ± 0.40 mm), the RLMM group (-0.03 ± 0.11 mm), and the RLS group (-0.07 ± 0.11 mm) were compared and showed a statistical result of p < 0.001. CONCLUSION: The study results verified that red light had a noticeable effect on the control of myopia and that low-level red-light therapy played a vital role in the treatment of severe myopia.

The Influence of Parents' Background and Their Perception on the Progression of Myopia in Children.

Purpose: To study the influence of parents' educational backgrounds and understanding on the progress of myopia in their offspring. Methods: Spherical equivalent refraction (SE) of the children (aged 6-14) in China was assessed with cycloplegic autorefraction in a two-year longitudinal study. The parents' background information and myopia-related cognition were collected by questionnaires. Results: The offspring of parents with lower education and more myopic SE had higher myopic progression (mean = -1.42 ± 1.06) than the children of other groups (P < 0.05). The parents' understanding of the proper outdoor activity time, sleep duration, reading distance, and indoor illumination for children was not significantly correlated with the progression of myopia in their offspring. The parent's preference for eye care visit frequency had a significant correlation with the myopia development of their children (r = 0.076, P=0.001∗). The mean SE progression was -0.84 ± 1.37 and -0.58 ± 1.29 in the children whose parents considered that extracurricular classes would negatively affect myopia development progression and the children whose parents believed it would not, respectively (P=0.026∗). Conclusions: Most parents misunderstand the influence of insufficient outdoor sports time and extracurricular classes, which require extra near-vision work. Besides, for parents with low educational background and more myopic SE, their offspring had higher myopia progression and may be the key group for myopia control. Finally, parents may obtain life advice and knowledge related to preventing myopia after their children become myopic. It may be of positive significance if this process could take place before myopia onset.

A longitudinal study of the effect of ocular biometrics measures on myopia onset.

PURPOSE: To investigate the relationship between ocular biometrics (OB) and myopia onset. METHODS: OB data from students in 4 grades (aged from 6 to 14 years) in China were collected in a 1.5-year longitudinal study. Refractive error was assessed with cycloplegic autorefraction. RESULTS: At baseline, 934 (56.33%) of the subjects (right eye) had myopia. The mean spherical equivalent (SE) and axial length to corneal radius (AL/CR) were - 2.14 ± 1.49 and 3.14 ± 0.11, respectively, in the subjects with myopia and - 0.09 ± 0.21 and 2.98 ± 0.07, respectively, in the subjects without myopia. The correlation between the SE and AL/CR was r = - 0.823 (P < 0.001). The slopes of the SE changing with the AL/CR (and R-squares) were - 0.28 to - 1.80 (0.01-0.14) in the no myopia group, - 3.40 to - 6.20 (0.20-0.48) in the low myopia group, and - 3.37 to - 11.34 (0.16-0.74) in the moderate and high myopia groups. The baseline AL/CR values in grades 1, 3, and 5 were higher in those who developed myopia within 1.5 years. The odds ratio of the AL/CR to myopia onset in 1.5 years was 1.096 (95% confidence interval (CI): 1.060-1.135). CONCLUSIONS: Of the five indicators, the AL/CR showed the best correlation with the SE. The adjoint and linear relationship between the AL/CR and the SE tended to increase with SE progression. When myopia progressed beyond a certain range, the AL/CR was significantly different in those without initial myopia who developed it within 1.5 years compared with those who did not. After adjusting for age, sex, school, and grade, the interpretation capability of the current AL/CR to myopia onset in 1.5 years was limited.

A Three-Dimensional-reconstruction-based study on the ocular volume of Chinese children with high myopia.

BACKGROUND: Highly myopic eyes differ in morphology from emmetropic eyes, and the correct estimation of the vitreous volume is difficult. To explore an effective method to estimate ocular volume using refractive factors in children. METHODS: This is a retrospective study of children with high myopia who visited the Shenzhen Shekou People's Hospital (July-December 2018) before undergoing posterior scleral reinforcement surgery. Data on refractive factors and ocular 3D reconstruction imaging based on high-end CT were collected for linear correlation and linear regression analyses. RESULTS: Ten patients (20 eyes) were included. There are nine males and one female. They were 4 to 12 years of age. The spherical equivalent ranges from + 0.25 to -20.00 D. The cylindrical equivalent ranges from - 0.50 to -6.25 D. The AL(axial length, AL) ranges from 21.78 to 33.90 mm. The corneal curvature (mean) ranges from 42.44 to 46.75. The 3D reconstruction of the CT images shows that the ocular volume ranges from 4.591 to 10.988 ml. The ocular volume of the 20 eyes decreases with the increase of diopter and total curvature, both presenting a linear trend, with the Pearson correlation coefficients being - 0.776 (P < 0.001) and - 0.633 (P = 0.003), respectively. The ocular volume of the 20 eyes increases with the increasing AL, also presenting a linear trend, with the Pearson correlation coefficient being 0.939 (P < 0.001). CONCLUSIONS: In children, the ocular volume is negatively and linearly correlated with the diopter and curvature, and positively and linearly correlated with the AL.

Bioprocessing and integration of a high flux screening systematic platform based on isothermal amplification for the detection on 8 common pathogens.

During a large variety of common pathogens, E. coli, P. aeruginosa, MRSA, MRCNS, V. parahaemolyticus, L. monocytogenes and Salmonella are the leading pathogens responsible for large number of human infections and diseases. In this study, a high flux screening based on nucleic acid isothermal amplification technique has been developed. For the 8 common pathogens, species-specific targets had been selected and analyzed for their unique specificity. After optimization, separate LAMP reaction assays had been bioprocessed and integrated into one systematic detection platform, including 8 strips (PCR tubes) and 96-well plates. Eight standard strains verified for the accuracy. Application of the established high flux screening platform was used for detection for 48 samples in 4 different 96-well plates, with 2 groups of 2 operators using double-blind procedure. The accuracy of 100% was obtained, with the total time consumption as 66-75 min (for 12 samples detection on 8 different pathogens). As concluded, through the bioprocess of the systematic platform based on LAMP technique, it's been demonstrated to be capable of simultaneous detection of 8 pathogens, with high sensitivity, specificity, rapidity and convenience.

Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens.

BACKGROUND: Exploring the role of vasoactive intestinal peptide (VIP) in the lateral geniculate body (LGBd) in visual development and studying the therapeutic effect of VIP on amblyopic kittens. METHODS: Three-week-old domestic cats were divided into a control group (n = 10) and a monocular deprivation group (n = 20), with an eye mask covering the right eye of those in the deprived group. After pattern visual evoked potential (PVEP) recording confirmed the formation of monocular amblyopia, the left LGBd was isolated from 5 kittens in each group. The remaining control kittens continued to be raised, and the remaining deprivation group was divided into a VIP intervention group (n = 5), Sefsol (caprylic acid monoglyceride, VIP solution) intervention group (n = 5) and amblyopia non-intervention group (n = 5) after removal of the eye mask. Three weeks later, PVEPs, VIP immunohistochemistry and VIP mRNA expression in the left LGBd were compared across groups. RESULTS: At 6 weeks of age, there were significant differences in P100 wave latency and amplitude and VIP immunohistochemistry and in situ hybridization between the control group and the deprivation group (P < 0.05). After 3 weeks of the corresponding interventions, the latency and amplitude in the VIP intervention group were better than that in the Sefsol intervention group and amblyopia non-intervention group (P < 0.05). Furthermore, VIP treatment increased the number of immunohistochemical VIP-positive cells (P < 0.05) and the average optical density of positive cells (P > 0.05), as well as the number (P < 0.05) and average optical density of VIP mRNA-positive cells (P < 0.05). CONCLUSIONS: VIP plays an important role in visual development. Nasal administration of VIP can improve the function of neurons in the LGBd of kittens and has a certain therapeutic effect on amblyopia.

Axial Length/Corneal Radius of Curvature Ratio Assessment of Posterior Sclera Reinforcement for Pathologic Myopia.

PURPOSE: The aim of this study was to assess the axial length/corneal radius of curvature ratio changes after posterior scleral reinforcement (PSR) for pathologic myopia. PROCEDURES: This study enrolled 32 pathologically myopic eyes treated with PSR and 35 untreated pathologically myopic eyes. Axial length, refractive error, best corrected visual acuity, corneal radius of curvature, and the axial length/corneal radius of curvature ratio were evaluated during the 1-year follow-up. RESULTS: There were no statistical differences in each parameter between the 2 groups at baseline. Significant differences were found between the 2 groups in both axial elongation and best corrected visual acuity improvement. The average axial length/horizontal corneal radius of curvature ratio significantly decreased in the PSR group. CONCLUSION: The PSR surgery can effectively delay the axial elongation in pathological myopia. Axial length/horizontal corneal radius of curvature ratio significantly decreased, which may indicate less myopic progression after surgery.

GIS-based landslide susceptibility zoning using a coupled model: a case study in Badong County, China.

Landslide susceptibility zoning is necessary for landslide risk management. This study aims to conduct the landslide susceptibility evaluation based on a model coupled with information value (IV) and logistic regression (LR) for Badong County in Hubei Province, China. Through the screening of landslide predisposing factors based on correlation analysis, a spatial database including 11 landslide factors and 588 historical landslides was constructed in ArcGIS. The IV, LR and their coupled model were then developed. To validate the accuracy of the three models, the receiver operating characteristic curves (ROC) and the landslide density curves were correspondingly created. The results showed that the areas under the receiver operating characteristic curve (AUCs) of the three models were 0.758, 0.786 and 0.818, respectively. Moreover, the landslide density increased exponentially with the landslide susceptibility, but the coupled model exhibited a higher growth rate among the three models, indicating good performance of the proposed model in landslide susceptibility evaluation. The landslide susceptibility map generated by the coupled model demonstrated that the high and very high landslide susceptibility area mainly concentrated along rivers and roads. Furthermore, by counting the landslide numbers and analyzing the landslide susceptibility within each town in Badong County, it was discovered that Yanduhe, Xinling, Dongrangkou and Guandukou were the main landslide-prone areas. This research will contribute to landslide prevention and mitigation and serve as a reference for other areas.

The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Meta-analysis.

AIM: To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of myopia. METHODS: A systematic search was conducted across the Cochrane Library, PubMed, Web of Science, EMBASE, CNKI, CBM, VIP, and Wanfang database, encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17, 2024. Data extraction and quality assessment were performed, and a network Meta-analysis was executed using Stata version 14.0 Software. Results were visually represented through graphs. RESULTS: Fourteen papers comprising 2475 cases were included; five different concentrations of atropine solution were used. The network Meta-analysis, along with the surface under the cumulative ranking curve (SUCRA), showed that 1% atropine (100%)>0.05% atropine (74.9%) >0.025% atropine (51.6%)>0.02% atropine (47.9%)>0.01% atropine (25.6%)>control in refraction change and 1% atropine (98.7%)>0.05% atropine (70.4%)>0.02% atropine (61.4%)>0.025% atropine (42%)>0.01% atropine (27.4%)>control in axial length (AL) change. CONCLUSION: In Chinese children and teenagers, the five various concentrations of atropine can reduce the progression of myopia. Although the network Meta-analysis showed that 1% atropine is the best one for controlling refraction and AL change, there is a high incidence of adverse effects with the use of 1% atropine. Therefore, we suggest that 0.05% atropine is optimal for Chinese children to slow myopia progression.

Using EDDS and NTA for enhanced phytoextraction of Cd by water spinach.

A greenhouse experiment was used to test the applicability of [S,S]-Ethylenediaminedisuccinic acid (EDDS) and nitrilotriacetic acid (NTA) at rates of 2.5 mmol kg(-1) and 5.0 mmol kg(-1), respectively, to increase the uptake of Cd by water spinach (Ipomoea aquatic Forsk) in soils with 2.5-30 mg Cd kg(-1). The addition of EDDS and NTA significantly increased water soluble Cd in soils. However, the Cd concentration in the root and shoot was higher in the NTA treatment than in the EDDS treatment. No instance of Cd hyperaccumulation was observed; however, the 5.0 mmol kg(-1) NTA treatment for soil with 30 mg Cd kg(-1) caused the Cd concentration to increase to 86 mg kg(-1), which is close to the critical concentration (100 mg kg(-1)) of a hyperaccumulator. The total Cd uptake in the treatments of EDDS and NTA for soils with 2.5, 5.0, and 10 mg Cd kg(-1) was acceptable, and was higher than the control. The level of 5.0 mmol kg(-1) EDDS was excessively high for enhanced phytoextraction in soils with 20 and 30 mg Cd kg(-1). Water spinach for Cd phytoextraction is a viable alternative to using herbaceous hyperaccumulators.

Research on regional water environmental carrying capacity based on GIS and TOPSIS comprehensive evaluation model.

Water environmental carrying capacity (WECC) is an important indicator for assessing the coordination between the water environment and the social-economic-resources and environment subsystems. In this study, to determine the WECC of Changsha-Zhuzhou-Xiangtan urban agglomeration in Xiang River Basin, a three-level index system was established using an analytic hierarchy process. Because the previous evaluation system lacked continuous indicators, the results could not reflect the differences of WECC within the administrative units, thus, this study selected 4 continuous indicators, and finally an evaluation index system including 15 indicators was established. Based on the TOPSIS model and logistic regression model, the current situation and change trend of WECC in the study area were obtained in ArcGIS. The results showed that the comprehensive WECC in this region was inferior in 2020, particularly in urban concentrated areas, and it was extremely uneven in spatial distribution. The WECC decreased significantly from 2011 to 2014 and gradually improved from 2014 to 2020. According to the prediction results, the WECC will increase in the future, with an average value of 0.54 in 2025 and 0.60 in 2035. This study will have important guiding implications for the protection and improvement of the water environment in the study area and related areas.

Measurement and analysis of water ecological carrying capacity in the Yangtze River Economic Belt, China.

Water ecological carrying capacity (WECC) is a crucial index for measuring regional sustainable development. To investigate the evolution of WECC in the Yangtze River Economic Belt (YREB), this study constructed a comprehensive index system consisting of 23 indicators from six interconnected dimensions of water systems. The back propagation neural network (BPNN) model was used to quantify WECC in YREB from 2010 to 2021, and ArcGIS was utilized to visualize the distribution of WECC. To identify sensitive indicators under subsystems, sensitivity analysis was conducted based on the one-at-a-time (OAT) method. Additionally, time-series prediction of WECC was performed using the exponential smoothing (ES) method. Finally, the coupling coordinated degree (CCD) of subsystems in each province from 2010 to 2021 was calculated. The results indicated that the average WECC in YREB gradually increased from 2010 to 2021, with significant provincial differences. Sensitivity analysis revealed that R1, U2, Q4, S2, M3 and B1 had the most substantial impacts on the WECC of subsystems (Sub-CC). The fitting curve between the CCD and WECC showed that as CCD increased, the growth rate of WECC gradually slowed down. Based on these findings, relevant suggestions were proposed to improve WECC and promote the regional sustainable development in YREB.

The Effects of Binocular Visual Function Training after Concomitant Exotropia Surgery.

PURPOSE: This study investigated the effect and long-term efficacy of binocular visual function training after concomitant exotropia surgery. METHODS: A total of 92 patients who underwent concomitant exotropia surgery were randomly divided into group A (the training group) (n = 54), who received binocular four-dimensional (4D) visual function training after surgery, and group B (control group) (n = 38). The patients in group A received personalized 4D visual function training 2 weeks after surgery and were followed up for 12 months. The eye position, distant and near stereo acuity, respectively, and postoperative efficacy were compared with those of the patients in group B. RESULTS: The normal eye position rate in group A was higher than in group B at the end of the overall follow-up period (p < .05), and the near stereo acuity rate was higher than the distant stereo acuity rate in both groups A and B at 2 weeks after surgery and at the end of follow up. The distant and near stereo acuity rates of the patients in group A were higher than those in group B (p < .05) at the end of the follow-up period, and the distant stereo acuity of group A was significantly improved (p < .05). The functional complete and incomplete response rates of group A were significantly higher than those of group B at the end of the follow-up period (p < .05). CONCLUSIONS: Four-dimensional visual function training for patients after concomitant exotropia surgery could facilitate the recovery of postoperative binocular visual function, as well as prevent the recurrence of exotropia after surgery.

Hippo pathway in intestinal diseases: focusing on ferroptosis.

The incidence of intestinal diseases, such as inflammatory bowel disease, gastric cancer, and colorectal cancer, has steadily increased over the past decades. The Hippo pathway is involved in cell proliferation, tissue and organ damage, energy metabolism, tumor formation, and other physiologic processes. Ferroptosis is a form of programmed cell death characterized by the accumulation of iron and lipid peroxides. The Hippo pathway and ferroptosis are associated with various intestinal diseases; however, the crosstalk between them is unclear. This review elaborates on the current research on the Hippo pathway and ferroptosis in the context of intestinal diseases. We summarized the connection between the Hippo pathway and ferroptosis to elucidate the underlying mechanism by which these pathways influence intestinal diseases. We speculate that a mutual regulatory mechanism exists between the Hippo pathway and ferroptosis and these two pathways interact in several ways to regulate intestinal diseases.

Experimental Study of Multi-Angle Effects of Micron-Silica Fume on Micro-Pore Structure and Macroscopic Mechanical Properties of Rock-like Material Based on NMR and SEM.

The experiment of rock-like material plays an important role in the simulation of engineering fractured rock mass. To further understand the influence of raw materials on rock-like materials, this paper carried out the indoor mechanical properties test and the micro-pore structure detection combining NMR and SEM. The effects of micron-silica fume (SF) on microporous structure parameters and macroscopic mechanical properties under different conditions of water-cement ratio (WCR) and sand-cement ratio (SCR) were discussed. The intrinsic relationship between parameters of different scales was analyzed. The experimental results showed that the porosity parameters of different radii gradually decreased with the increase in SF. The reduction rate of macroporous porosity was the greatest, and the decreasing rate of microporous porosity was the smallest. With the increase in SF, the microscopic characteristics of the internal surface changed from more pores, complex morphological distribution, rough surface to fewer pores, regular morphological distribution and flat and uniform surface. The box fractal dimension also showed a decreasing trend. Micro-pore structure makes a valuable contribution to the influence of SF on mechanical properties. The compressive strength and tensile strength increased with the increase in SF. The box fractal dimension and porosity of different radii were negatively correlated with mechanical strength. Different porosity parameters conformed to a good exponential relationship with mechanical properties. The research results can provide reference value and research space for subsequent rock-like material research.

Correlation Analysis between Microscopic Pore Parameters and Macroscopic Mechanical Properties of Rock-like Materials from the Perspective of Water-Cement Ratio and Sand-Cement Ratio.

To explore the effects of water-cement ratio and sand-cement ratio on micro-pore structure characteristics and macroscopic mechanical properties and thus improve the understanding of rock-like materials, the mechanical test and detection of micro-pore structure combining NMR and SEM were carried out. The effects of WCR and SCR on different porosity parameters and mechanical properties were discussed. The correlation and internal relationship between mechanical properties and parameters of different porosities and fractal dimensions were analyzed. Experimental results showed that the different porosity parameters and fractal dimensions increased with the increase in WCR. 1.0 (SCR) was the turning point of different porosity parameters and fractal dimensions. When the SCR was less than 1.0, the porosity parameters and fractal dimension gradually decreased, while when the SCR was greater than 1.0, the porosity parameters and fractal dimension gradually increased. Microscopic porosity parameters and fractal dimension played an important role in the influence of experimental factors on mechanical properties. Different porosity parameters and fractal dimensions were negatively correlated with mechanical properties. Compressive strength and different porosity parameters conformed to a good exponential relationship, while the fitting relationship between tensile strength and mechanical properties was not obvious. This study can provide a reference for the follow-up study of rock-like materials.

Balancing Between Polarization and Conduction Loss toward Strong Electromagnetic Wave Absorption of Hard Carbon Particles with Morphology Heterogeneity.

The heterostructure and hierarchical morphology of carbonaceous absorbents play an important role in the construction of high-performance electromagnetic wave absorbing materials. Herein, novel micron-scale hard carbon particles with morphology heterogeneity were developed as lightweight superior electromagnetic wave absorbents via a facile and ecofriendly process. The as-prepared hard carbon particle composed of pseudographite and a highly disordered region shows a unique heterostructure. Concurrently, constructing a multilevel geometric shape and size can cause a decrease of the percolation threshold and an excellent balance between polarization and conduction loss, which enhances the electromagnetic wave absorption significantly. The composites (thickness d = 2.36 mm) filled with morphology-heterogeneity hard carbon particles (15 wt %) achieve an excellent electromagnetic wave absorption with a minimum reflection loss of -78.0 dB at 10.2 GHz and effective absorption bandwidth (<-10 dB) of 3.1 GHz (8.8-11.9 GHz). Compared to the traditional carbonaceous absorbents with complex microstructures and/or multiple chemical components, this work presents a feasible idea for the development of an efficient carbonaceous absorbent to realize practical applications.