[Suicidal attempt with colchicine]. / Intento autolítico con colchicina.

Colchicine is an alkaloid that has been successfully used for a long time in the treatment of acute gout episodes. It's efficacy lies in its inhibition of inflammation cell migration and in the action of specific cytokines, as well as of the production of lactic acid and deposition of uric acid in affected tissues. Colchicine toxicity is rare but may entail highly negative consequences for health unless a rapid gastric decontamination with stomach lavage and active carbon is carried out, and adequate support measures are taken as wellas appropriate hydration and electrolyte replacement. We present the case of a patient who was admitted to hospital after ingesting colchicine with suicidal intention. Colchicine inhibits cell division, which explains its distinct toxicity stages. The lack of proportion existing between ingested dose and clinical impact may result from concomitant treatment with other drugs or from peculiarities in its metabolism.

Rabdomiolisis inducida por el ejercicio / Exercise-induced rhabdomyolysis

La rabdomiolisis constituye un síndrome clínico y bioquímico resultado del daño muscular, necrosis del músculo esquelético y liberación del contenido celular al torrente circulatorio. Existe una gran heterogeneidad en la forma de presentación clínica, los pacientes suelen referir dolores musculares, debilidad y malestar general, pero las complicaciones pueden ser severas: arritmias cardiacas y fracaso renal agudo. Se han descrito numerosas causas (enfermedades hereditarias del metabolismo, traumatismos, ejercicio, fármacos, inmovilización, trastornos metabólicos, enfermedades infecciosas, etc.). Presentamos el caso de un varón de 38 años, bombero de profesión y gran deportista , que refería una historia de dolor muscular, calambres y debilidad de dos días de evolución, tras la práctica de ejercicio (AU)

Mujer de 49 años con fiebre y esplenomegalia / A 49-year-old woman with fever and splenomegaly

No disponible