Association of Thr241Met polymorphism of XRCC3 gene with risk of colorectal cancer in the Polish population.

DNA double strand breaks (DSBs) are the most dangerous lesions which can lead to carcinogenesis. Homologous recombination (HR) is an important pathway responsible for maintaining genome integrity through repair of DSBs. Single nucleotide polymorphism (SNP) is an essential source of genetic variation whose presence in genes involved in HR may have a crucial role in modulation of DNA repair capacity. This case-control study was designed to evaluate the influence of XRCC3 gene Thr241Met polymorphism on CRC risk and progression among Polish population. Genotyping was performed by RFLP-PCR (restriction length fragment polymorphism). The subject of our study was consist of 194 patients with CRC and 204 cancer-free individuals who were age and sex-matched as a control group. Obtained genotype distributions in controls as well as patients fit to the Hardy-Weinberg expectations. Odd ratio analysis indicates diminished risk for heterozygous model and Met allele. Comparison of patients with noninvasive and advanced stage of CRC did not imply any statistical significance. Our results suggest that Thr241Met XRCC3 gene polymorphism might be regarded as CRC potential molecular marker. Nevertheless, that hypothesis needs to be confirmed by subsequent studies.

[Inflammatory fibroid polyp of the stomach--a case report]. / Wlóknisty polip zapalny zokldka--opis przypadku.

Inflammatory fibroid polyp of the stomach is a rare benign mass of unknown etiology, mostly located within the pyloric area. Histopathological findings mainly reveal the presence of mononuclear fusiforme cells forming loose extensive bundles or rotary structures of rotated spirals with abundant amount of eosinophilic cytoplasm. These cells are negatively stained for S-100 protein and desmine and positively stained for CD-34. Symptoms of the disease depend on the localization and the size of the polyp. We report a case of 50-year-old woman with a large inflammatory fibroid polyp with a diameter of 60 x 50 x 40 mm imitating benign gastric tumour. She mainly suffered from abdominal pain and lab tests revealed symptoms of severe anaemia. We performed partial gastrectomy with Hofmeister-Finsterer modification. Postoperative pathological findings certified sings of inflammatory fibroid polyp. During the two year followup period we did not report any signs of recurrence or dissemination. Clinical manifestation of large inflammatory fibroid polyp of the stomach can imitate symptoms of gastric cancer. Partial gastrectomy with an unaltered, healthy wall margin of 2 to 3 cm is sufficient, curative treatment modality in such cases.

[Squamous cell carcinoma of caecum--case report]. / Rak plaskonablonkowy katnicy--opis przypadku.

Squamous cell cancer is a very rare malignancy in colon and rectum. It accounts for 0.05-0.1% of all types of cancers in this localization. It predominantly occurs in caecum. In the article we present a case of 77 year old women who was operated due to tumor of caecum which infiltrated the proximal transverse colon. During the operation a right hemicolectomy was performed. There were no macroscopic signs of metastases in liver and lymph nodes. Histopathological examination of removed tumor revealed squamous cell carcinoma of caecum in pT4 stage. In the Clinic retrospective material squamous cell cancer of colon accounts for 0.07% of the total colon cancer cases. The patient was disqualified from post-operative chemotherapy because of the age and general condition. Four months after the operation liver metastases and ascites occurred. The patient died five months after the surgery. Despite the radical surgical treatment the course of the disease was rapid.

[Gastric complaints or postcholecystectomy syndrome?]. / Dolegliwosci gastryczne czy zespól po cholecystektomii?

UNLABELLED: Postcholecystectomy syndrome (PCS) is a complex of symptoms from gastrointestinal tract that could develop and maintain after cholecystectomy. PCS usually consists of: abdominal pain or colic, dyspepsia, constipation or diarrhoea, nausea, bloating, fatty food intolerance. Regarding PSC as disease entity is still a point of many controversies. THE AIM OF THE STUDY: To estimate the prevalence of PCS in patients after cholecystectomy performed in Department of General and Colorectal Surgery of Medical University in Lodz. Material and methods. From the cohort of 243 patients (pts) operated on due to symptomatic cholecystitis the group of 150 pts was surveyed. We included 86 pts who answered the questionnaire. The prevalence of PCS and intensity of symptoms were measured with the use of modified Gastrointestinal Symptoms Rating Scale (GSRS)--only 6 complaints commonly connected with pathology of biliary system were chosen (abdominal pain, rebounding, constipation, urgent diarrhea, nausea, bloating). RESULTS: After cholecystectomy gastric complains were revealed in 32 pts (37.2%). In a group of 12 pts (13.9%) symptoms were noted at the same level of intense. However in 20 pts (23.25%) either more intense or appeared as brand new manifestation. Excessive amount of intestinal gases (93.75%) and bloating (87.5%) were the most common symptoms unlike abdominal pain, heartburn and diarrhea. CONCLUSIONS: Gastric symptoms of PCS occur in one third of pts after elective cholecystectomies. Complete PCS develops after 3 months postoperatively what is likely connected with the change of diet. Excessive amount of intestinal gases, bloating, abdominal pain and diarrhea were the most common symptoms. The most intense complaint is persistent abdominal pain likely indicating comorbidities.