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1.
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies.
Biol Chem
; 403(5-6): 495-508, 2022 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35073465
2.
Novel ß-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization.
Angew Chem Int Ed Engl
; 60(10): 5436-5442, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33238058
3.
Mapping the conformational space accessible to catechol-O-methyltransferase.
Acta Crystallogr D Biol Crystallogr
; 70(Pt 8): 2163-74, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25084335
4.
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 3): 253-60, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22349227
5.
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
J Med Chem
; 65(19): 13052-13073, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36178776
6.
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.
Chemistry
; 17(23): 6369-81, 2011 May 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21538606
7.
P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation.
Protein Eng Des Sel
; 32(5): 207-218, 2019 12 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-31504896
8.
Variable heavy-variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly.
Protein Eng Des Sel
; 31(7-8): 289-299, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30169707
9.
Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.
J Med Chem
; 59(22): 10163-10175, 2016 11 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27685665
10.
Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.
Angew Chem Int Ed Engl
; 48(48): 9092-6, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19882607
11.
Correction to Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.
J Med Chem
; 60(9): 4099, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28448141
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