Detalles de la búsqueda
1.
Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell
; 186(5): 1013-1025.e24, 2023 03 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36827973
2.
The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model.
Antimicrob Agents Chemother
; 68(2): e0104323, 2024 Feb 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38132181
3.
Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 68(4): e0156223, 2024 Apr 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38376228
4.
Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis.
Antimicrob Agents Chemother
; 67(12): e0078923, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37966090
5.
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model.
Antimicrob Agents Chemother
; 67(4): e0003523, 2023 04 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36920217
6.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother
; 66(6): e0013222, 2022 06 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35607978
7.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(12): e0141221, 2021 11 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34570644
8.
Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis.
Antimicrob Agents Chemother
; 65(4)2021 03 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33526488
9.
Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis.
Antimicrob Agents Chemother
; 65(7): e0025321, 2021 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-33903099
10.
Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30833432
11.
Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Proc Natl Acad Sci U S A
; 110(36): E3445-54, 2013 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-23946421
12.
Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.
Bioorg Med Chem Lett
; 24(12): 2707-11, 2014 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24815509
13.
Combating antimicrobial resistance in malaria, HIV and tuberculosis.
Nat Rev Drug Discov
; 2024 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38750260
14.
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv
; 10(11): eadj6406, 2024 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38489355
15.
The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model.
bioRxiv
; 2023 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37609351
16.
A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum.
mBio
; 14(2): e0059823, 2023 04 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-37017524
17.
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis.
ACS Infect Dis
; 9(2): 221-238, 2023 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36606559
18.
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.
Microbiol Spectr
; 10(5): e0245121, 2022 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36106881
19.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36220877
20.
Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates.
Prostaglandins Other Lipid Mediat
; 92(1-4): 33-43, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20214997