RESUMEN
BACKGROUND: Thus far, studies on Klebsiella pneumoniae carbapenemase (KPC)-producing organisms have only been reported in those with a history of foreign travel, and a specific Japanese KPC-producing isolate has not yet been reported. CASE PRESENTATION: We describe a Japanese patient, with no history of travel to foreign countries, admitted due to aspiration pneumonia, and a KPC-producing isolate detected in his sputum. Fortunately, his pneumonia resolved. His close contacts did not have a history of foreign travel, and the isolate was not detected in other patients. CONCLUSIONS: The potential for KPC-producing organisms to become endemic in Japan is currently of great concern.
Asunto(s)
Proteínas Bacterianas/metabolismo , Infecciones por Klebsiella/microbiología , Klebsiella pneumoniae/metabolismo , Neumonía Bacteriana/microbiología , beta-Lactamasas/metabolismo , Anciano de 80 o más Años , Proteínas Bacterianas/genética , Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos , Humanos , Japón , Infecciones por Klebsiella/tratamiento farmacológico , Infecciones por Klebsiella/etiología , Klebsiella pneumoniae/efectos de los fármacos , Klebsiella pneumoniae/genética , Klebsiella pneumoniae/aislamiento & purificación , Masculino , Neumonía Bacteriana/tratamiento farmacológico , Neumonía Bacteriana/etiología , Salud Pública , Esputo/microbiología , Viaje , beta-Lactamasas/genéticaRESUMEN
Highly ordered, macropore arrays, that is, inverse opal structures, of Na2W4O13 were successfully synthesized by spray pyrolysis using polystyrene (PS) colloidal crystals as templates. A densely packed monolayer of monodisperse PS microspheres was deposited on a silica glass substrate by use of the Langmuir-Blodgett thin film technique. Subsequently, Na2W4O13 layers were deposited on the PS templates as a thin layer by spray pyrolysis of a 5(NH4)2O.12WO(3).5H2O-NaCl solution. The PS templates were, finally, removed by thermal treatment, generating a surface with features (inverse opal structures) located where the interstitial space of the densely hexagonal-packed PS microspheres had been. The macroporous structures obviously depended on the annealing conditions such as time and temperature. The macropores were basically hemispherical in shape and highly honeycombed arrangement, which corresponded well to the PS templates. The inverse opal textures of Na2W4O13 layer surfaces enhanced their hydrophobicity. The surfaces modified by fluoroalkylsilane (FAS) were converted from hydrophobic (water contact angle=127 degrees) to hydrophilic (30 degrees) by photocatalytic oxidation using the Na2W4O13 crystal layer. The Na2W4O13 crystals exhibited high activity for FAS photodegradation.