Reporting on data monitoring committees in neonatal randomised controlled trials is inconsistent.

AIM: To evaluate the reported use of data monitoring committees (DMCs), the frequency of interim analysis, prespecified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high-impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria. RESULTS: Seventy neonatal trials were identified in four general medical journals: Lancet, New England Journal of Medicine (NEJM), British Medical Journal and Journal of American Medical Association. A total of 43 (61.4%) studies reported the presence of a DMC, 36 (51.4%) explicitly mentioned interim analysis, stopping rules were reported in 15 (21.4%) RCTs and seven (10%) trials were terminated early. The NEJM most frequently reported these parameters compared to the other three journals reviewed. CONCLUSION: While the majority of neonatal RCTs report on DMC involvement and interim analysis, there is still scope for improvement. Clear documentation of safety-related issues should be a central component of reporting in neonatal trials involving newborn infants.

The SSC: a decade of climate-health research and future directions.

This year marks the tenth anniversary of the development of the revised Spatial Synoptic Classification, the "SSC", by Scott Sheridan. This daily weather-type classification scheme has become one of the key analytical tools implemented in a diverse range of climatological investigations, including analysis of air quality variability, human health, vegetation growth, precipitation and snowfall trends, and broader analyses of historical and future climatic variability and trends. The continued and expanding use of the SSC motivates a review and comparison of the system's research and geographic foci to date, with the goal of identifying promising areas for future efforts, particularly within the context of human health and climate change. This review also assesses how the SSC has complemented and compares with other current environmental epidemiological studies in weather and health.

Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial.

BACKGROUND: Diarrhea is the most frequent morbidity affecting kenneled dogs in animal shelters. Diarrhea impacts animal welfare and the finances of the shelter as they must treat, clean, and house affected animals until recovered. HYPOTHESIS/OBJECTIVES: Supplementing dogs entering an animal shelter with a probiotic-prebiotic, known as a synbiotic, will decrease the incidence of diarrhea. ANIMALS: Seven hundred and seventy-three dogs entering an animal shelter in the United Kingdom. METHODS: A prospective double-blind, randomized, placebo-controlled trial. RESULTS: Statistical difference was found between the groups across 3 measures of diarrhea incidence. First, the mean percentage of scored days per dog that were scored as diarrhea throughout their stay was 2.0% in the synbiotic group and 3.2% in the placebo group (P = .0022). Second, the occurrence of diarrhea within the first 14 days' stay was 18.8% in the synbiotic product group and 27.2% in the placebo group (P = .0008). Third, the occurrence of ≥2 consecutive days of diarrhea within the first 14 days' stay was 4.6% in the synbiotic product group and 8.0% in the placebo group (P = .0300). CONCLUSIONS AND CLINICAL IMPORTANCE: Supplementing healthy dogs entering an animal shelter with a synbiotic supplement significantly decreased the incidence of diarrhea in this trial. Animal shelters can use synbiotic supplements to improve animal welfare and decrease costs involved in cleaning and housing animals as well as potentially decreasing veterinary intervention.

Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century.

Water scarcity is rapidly increasing in many regions. In a novel, multi-model assessment, we examine how human interventions (HI: land use and land cover change, man-made reservoirs and human water use) affected monthly river water availability and water scarcity over the period 1971-2010. Here we show that HI drastically change the critical dimensions of water scarcity, aggravating water scarcity for 8.8% (7.4-16.5%) of the global population but alleviating it for another 8.3% (6.4-15.8%). Positive impacts of HI mostly occur upstream, whereas HI aggravate water scarcity downstream; HI cause water scarcity to travel downstream. Attribution of water scarcity changes to HI components is complex and varies among the hydrological models. Seasonal variation in impacts and dominant HI components is also substantial. A thorough consideration of the spatially and temporally varying interactions among HI components and of uncertainties is therefore crucial for the success of water scarcity adaptation by HI.

From mice to men: what can we learn about personality from animal research?

The author explores the viability of a comparative approach to personality research. A review of the diverse animal-personality literature suggests that (a) most research uses trait constructs, focuses on variation within (vs. across) species, and uses either behavioral codings or trait ratings; (b) ratings are generally reliable and show some validity (7 parameters that could influence reliability and 4 challenges to validation are discussed); and (c) some dimensions emerge across species, but summaries are hindered by a lack of standard descriptors. Arguments for and against cross-species comparisons are discussed, and research guidelines are suggested. Finally, a research agenda guided by evolutionary and ecological principles is proposed. It is concluded that animal studies provide unique opportunities to examine biological, genetic, and environmental bases of personality and to study personality change, personality-health links, and personality perception.

Do people know how they behave? Self-reported act frequencies compared with on-line codings by observers.

Behavioral acts constitute the building blocks of interpersonal perception and the basis for inferences about personality traits. How reliably can observers code the acts individuals perform in a specific situation? How valid are retrospective self-reports of these acts? Participants interacted in a group-discussion task and then reported their act frequencies, which were later coded by observers from videotapes. For each act, observer-observer agreement, self-observer agreement, and self-enhancement bias were examined. Findings show that (a) agreement varied greatly across acts; (b) much of this variation was predictable from properties of the acts (observability, base rate, desirability, Big Five domain); (c) on average, self-reports were positively distorted; and (d) this was particularly true for narcissistic individuals. Discussion focuses on implications for research on acts, traits, social perception, and the act frequency approach.

An empirical analysis of trends in psychology.

The present research examined trends in the prominence of 4 widely recognized schools in scientific psychology: psychoanalysis, behaviorism, cognitive psychology, and neuroscience. The results, which replicated across 3 measures of prominence, showed the following trends: (a) psychoanalytic research has been virtually ignored by mainstream scientific psychology over the past several decades; (b) behavioral psychology has declined in prominence and gave way to the ascension of cognitive psychology during the 1970s; (c) cognitive psychology has sustained a steady upward trajectory and continues to be the most prominent school; and (d) neuroscience has seen only a modest increase in prominence in mainstream psychology, despite evidence for its conspicuous growth in general. The authors use these findings as a springboard for discussing different views of scientific prominence and conclude that psychologists should evaluate trends in the field empirically, not intuitively.

Personality dimensions in spotted hyenas (Crocuta crocuta).

Personality ratings of 34 spotted hyenas (Crocuta crocuta) were made by 4 observers who knew the animals well. Analyses suggest that (a) hyena personality traits were rated with generally high reliability; (b) 5 broad dimensions (Assertiveness, Excitability, Human-Directed Agreeableness, Sociability, and Curiosity) captured about 75% of the total variance; (c) this dimensional structure could not be explained in terms of dominance status, sex, age, or appearance; and (d) as expected, female hyenas were more assertive than male hyenas. Comparisons with previous research provide evidence for the cross-species generality of Excitability, Sociability, and especially Assertiveness. Discussion focuses on methodological issues in research on animal personality and on the potential contributions this research can make for understanding the biological and environmental bases of personality.

Carbon monoxide poisoning: an A&E perspective.

Carbon monoxide (CO) is a colourless, odourless, tasteless and non-irritating gas and may therefore be inhaled in large quantities by the victim without his realizing it. The toxic effect of CO is not exclusively the result of the binding of haemoglobin; the primary mechanism appears to be inhibition of cellular respiration. Carboxyhaemoglobin (COHb) is excreted fairly rapidly from the body, therefore blood levels do not necessarily reflect the severity of CO poisoning. Airway support and adequate ventilation are the primary objectives of the nursing and medical team. Oxygen is the only antidote to CO. Continuous monitoring of the patient's neurological state is necessary; conscious level is the most important guide to the patient's progress. Nurses must be aware of the clinical indications and contraindications for HBO therapy to ensure that their patients receive optimal treatment.

Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.

We have screened a human cDNA library using an expressed sequence tag related to the BM-40/secreted protein, acidic and rich in cysteine (SPARC)/osteonectin family of proteins and isolated a novel cDNA. It encodes a protein precursor of 424 amino acids that consists of a signal peptide, a follistatin-like domain, a Ca2+-binding domain, a thyroglobulin-like domain, and a C-terminal region with two putative glycosaminoglycan attachment sites. The protein is homologous to testican-1 and was termed testican-2. Testican-1 is a proteoglycan originally isolated from human seminal plasma that is also expressed in brain. Northern blot hybridization of testican-2 showed a 6.1-kb mRNA expressed mainly in CNS but also found in lung and testis. A widespread expression in multiple neuronal cell types in olfactory bulb, cerebral cortex, thalamus, hippocampus, cerebellum, and medulla was detected by in situ hybridization. A recombinant fragment consisting of the Ca2+-binding EF-hand domain and the thyroglobulin-like domain of testican-2 showed a reversible Ca2+-dependent conformational change in circular dichroism studies. Testican-1 and -2 form a novel Ca2+-binding proteoglycan family built of modular domains with the potential to participate in diverse steps of neurogenesis.