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Introduction Organ Donation Transplant Ireland (ODTI) was established in 2014 to provide leadership and governance of the transplant programme in Ireland. We aim to establish if the implementation of ODTI translates into a decrease in waiting list mortality. Methods A retrospective analysis of all patients listed for lung transplantation on the Irish Heart and Lung Transplant Programme, between January 2011 and December 2016, was performed. We compared mortality on the waiting list before and after the establishment of ODTI. Results During the study period, a total of 259 patients were on the lung transplant list. Sixty percent of patients underwent lung transplantation. Following establishment of ODTI, there was a statistically significant reduction of waiting list mortality from 46% in the era prior to ODTI to 33% after ODTI formation (p=0.02). Conclusion This study demonstrates the establishment of the governing body ODTI reduced mortality on the lung transplant waiting list.
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Trasplante de Pulmón , Obtención de Tejidos y Órganos/organización & administración , Listas de Espera/mortalidad , Adolescente , Adulto , Anciano , Estudios de Cohortes , Femenino , Humanos , Irlanda , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tasa de Supervivencia , Factores de Tiempo , Adulto JovenRESUMEN
BACKGROUND: Adult onset idiopathic isolated focal dystonia presents with a number of phenotypes. Reported prevalence rates vary considerably; well-characterized cohorts are important to our understanding of this disorder. AIM: To perform a nationwide epidemiological study of adult onset idiopathic isolated focal dystonia in the Republic of Ireland. METHODS: Patients with adult onset idiopathic isolated focal dystonia were recruited from multiple sources. Diagnosis was based on assessment by a neurologist with an expertise in movement disorders. When consent was obtained, a number of clinical features including family history were assessed. RESULTS: On the prevalence date there were 592 individuals in Ireland with adult onset idiopathic isolated focal dystonia, a point prevalence of 17.8 per 100 000 (95% confidence interval 16.4-19.2). Phenotype numbers were cervical dystonia 410 (69.2%), blepharospasm 102 (17.2%), focal hand dystonia 39 (6.6%), spasmodic dysphonia 18 (3.0%), musician's dystonia 17 (2.9%) and oromandibular dystonia six (1.0%). Sixty-two (16.5%) of 375 consenting index cases had a relative with clinically confirmed adult onset idiopathic isolated focal dystonia (18 multiplex and 24 duplex families). Marked variations in the proportions of patients with tremor, segmental spread, sensory tricks, pain and psychiatric symptoms by phenotype were documented. CONCLUSIONS: The prevalence of adult onset idiopathic isolated focal dystonia in Ireland is higher than that recorded in many similar service-based epidemiological studies but is still likely to be an underestimate. The low proportion of individuals with blepharospasm may reflect reduced environmental exposure to sunlight in Ireland. This study will serve as a resource for international comparative studies of environmental and genetic factors in the pathogenesis of the disorder.
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Trastornos Distónicos/epidemiología , Trastornos Distónicos/genética , Adulto , Factores de Edad , Edad de Inicio , Anciano , Anciano de 80 o más Años , Blefaroespasmo/epidemiología , Blefaroespasmo/etiología , Progresión de la Enfermedad , Trastornos Distónicos/complicaciones , Ambiente , Femenino , Humanos , Irlanda/epidemiología , Masculino , Trastornos Mentales/etiología , Trastornos Mentales/psicología , Persona de Mediana Edad , Prevalencia , Factores Sexuales , Luz Solar , Temblor/etiología , Temblor/fisiopatología , Adulto JovenRESUMEN
The case of a giant thoracic desmoid tumour in a 44-year-old woman, who presented two years following a breast reconstruction with a latissimus dorsi (LD) flap and implant, is reported. Clinical findings included a rapidly growing, painless mass. Computed tomography (CT) suggested skin and intercostal soft tissue invasion. The tumour was resected en bloc with the LD muscle, implant capsule and underlying rib segments. The resultant thoracic and abdominal wall defects were reconstructed with Dualmesh® and polypropylene meshes respectively. There was no evidence of recurrence at thirty-six months follow-up.
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Fibromatosis Agresiva/diagnóstico por imagen , Mamoplastia/efectos adversos , Complicaciones Posoperatorias/diagnóstico por imagen , Músculos Superficiales de la Espalda/trasplante , Pared Abdominal/patología , Pared Abdominal/cirugía , Adulto , Femenino , Fibromatosis Agresiva/patología , Fibromatosis Agresiva/cirugía , Humanos , Mamoplastia/métodos , Invasividad Neoplásica , Complicaciones Posoperatorias/patología , Complicaciones Posoperatorias/cirugía , Piel/patología , Colgajos Quirúrgicos , Tomografía Computarizada por Rayos XRESUMEN
Lobar lung transplantation is an option that provides the possibility of transplantation of small size recipients with size-mismatch donor lungs by surgically reducing the size of donor lungs. We report our first experience of bilateral lobar lung transplantation of big donor lungs, in a small size urgently listed recipient, after size reduction. A 24 years old girl with end stage cystic fibrosis received the bilateral lobar lung transplant. She made very good recovery postoperatively and was discharged home two weeks following surgery.
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Fibrosis Quística , Trasplante de Pulmón/métodos , Pulmón/patología , Fibrosis Quística/patología , Fibrosis Quística/cirugía , Femenino , Humanos , Tamaño de los Órganos , Resultado del Tratamiento , Adulto JovenRESUMEN
We report ATP1A3-associated rapid-onset dystonia-parkinsonism with an atypical presentation including myoclonus and exaggerated startle in four patients. Their prominence over parkinsonism prompted consideration of a syndromic diagnosis of myoclonus dystonia. ATP1α3 dysfunction in GABAergic neurons could explain these examination findings. The spectrum of ATP1A3-associated movement disorders includes myoclonus-dystonia.
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Distonía , Trastornos Distónicos , Mioclonía , Trastornos Parkinsonianos , Humanos , Distonía/complicaciones , Mioclonía/complicaciones , Mioclonía/diagnóstico , Mutación , Trastornos Distónicos/complicaciones , Trastornos Distónicos/diagnóstico , Trastornos Distónicos/genética , Trastornos Parkinsonianos/complicaciones , Trastornos Parkinsonianos/genética , ATPasa Intercambiadora de Sodio-PotasioRESUMEN
BACKGROUND: Through Edward Reynolds' collaboration with Samuel Alexander Kinnier Wilson's (SAKW) son, James, on Babylonian neurology and psychiatry, and his contact with James' nephew, Jim, grandson of SAKW, a remarkable film of patients with movement disorders, made by SAKW in the mid-1920s, has come to light. METHODS/RESULTS: The 20-min silent film with captions by SAKW includes patients with senile tremor, Parkinson's disease and postencephalitic parkinsonism, hemiballismus, Huntington's chorea, Sydenham's chorea, hysterical palsy and tremor, multiple sclerosis, and progressive lenticular degeneration. Most of the patients are filmed in the square outside the National Hospital. The British Film Institute dates the film to 1924 and the captions to 1925. The case records of 6 of the 14 patients, who were admitted to the National Hospital, Queen Square, under the care of Dr. SAKW have been identified and summarized. DISCUSSION: SAKW may have been stimulated and facilitated to make this film through his personal contact with Charlie Chaplin with whom he stayed at his Californian estate, probably in the summer of 1924. The first films of neurological patients were made in Europe and USA at the beginning of the 20th century, although most have perished. This may be one of the oldest examples from UK. It is also notable for the inclusion of Wilson's disease and a brief shot of SAKW himself.
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Películas Cinematográficas/historia , Trastornos del Movimiento/historia , Neurología/historia , Historia del Siglo XX , Humanos , LondresRESUMEN
We profile the practises and attitudes of university students in Ireland towards consent for organ donation. 1103 students were surveyed. Only 34.6% (382/1103) carried organ donor consent cards, although the majority were favourably disposed towards donation. Only 9% (96/1103) were against donation. In regard to presumed consent only 38% (177/470) were in favour of changing the current "opt-in" consent methodology to presumed consent. These findings show a favourable opinion towards donation among Irish university students. However this may result in few actual donations in the event of brain death, as the majority do not carry donor cards and do not want to change to a presumed consent regime. The most common answer for not carrying a card was that the individual had not formalised a decision. Mandated choice at a fixed point could significantly reduce this ambivalence.
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Consentimiento Informado , Trasplante de Órganos , Estudiantes , Universidades , Densidad Ósea , Muerte Encefálica , Recolección de Datos , Conocimientos, Actitudes y Práctica en Salud , Humanos , Irlanda , Encuestas y CuestionariosRESUMEN
BACKGROUND: Oculopharyngeal muscular dystrophy (OPMD) is caused by expansions of the poly (A) binding protein 2 (PABP2) gene. Previous histological analyses have revealed mitochondrial abnormalities in the muscles of OPMD patients but their significance remains uncertain. OBJECTIVE: We had the rare opportunity to study monozygotic twins with identical expansions of the PABP2 gene but with markedly different severities of OPMD. Both had histological features of mitochondrial myopathy. We determined whether mitochondrial DNA abnormalities underlay these changes. METHODS: Clinical information was obtained by history and examination. Muscle biopsies were obtained from each subject and genetic analysis was performed using long-range PCR and Southern blotting. RESULTS: We demonstrate, for the first time, the presence of mitochondrial DNA (mtDNA) deletions by Southern blotting in individuals with OPMD. This correlates with the presence of mitochondrial myopathy in both twins. Moreover, both twins had different mtDNA deletions, which might explain their phenotypic differences. CONCLUSION: We hypothesise that mitochondrial dysfunction may occur as a consequence of PABP2 gene mutations, and that this dysfunction may affect the phenotypic manifestations of OPMD.
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ADN Mitocondrial/genética , Eliminación de Gen , Distrofia Muscular Oculofaríngea/genética , Mutación Puntual/genética , Proteína II de Unión a Poli(A)/genética , Gemelos Monocigóticos/genética , Anciano , Biopsia , Southern Blotting , Análisis Mutacional de ADN , Humanos , Masculino , Músculo Esquelético/patología , Distrofia Muscular Oculofaríngea/patología , Fenotipo , Reacción en Cadena de la PolimerasaRESUMEN
LRRK2-associated Parkinson's disease is common enough to raise clinical questions such as which patients should be tested and what advice should be given. We discuss practical issues in the light of our experiences with real life Parkinson's disease patients. Neurologists should consider testing LRRK2 in Parkinson's disease patients with affected first degree relatives where the onset is over the age of 40 years. A common G2019S mutation makes genetic testing straightforward and cost-effective. Age-related or reduced genetic penetrance means that LRRK2 mutations are also found in sporadic Parkinson's disease patients; however, at present, there is little to support the widespread testing of these patients except in high-risk ethnic groups such as North African Arabs and Ashkenazi Jews. Incomplete penetrance also complicates presymptomatic testing, which is best undertaken in the context of appropriate genetic counselling.
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Predisposición Genética a la Enfermedad/genética , Mutación/genética , Enfermedad de Parkinson/diagnóstico , Proteínas Serina-Treonina Quinasas/genética , Edad de Inicio , Análisis Mutacional de ADN/normas , Etnicidad/genética , Familia , Femenino , Asesoramiento Genético/normas , Pruebas Genéticas/normas , Humanos , Patrón de Herencia/genética , Proteína 2 Quinasa Serina-Treonina Rica en Repeticiones de Leucina , Persona de Mediana Edad , Enfermedad de Parkinson/etnología , Enfermedad de Parkinson/genéticaRESUMEN
Parkinson's disease is a common incurable neurodegenerative disease whose molecular aetiology remains unclear. The identification of Mendelian genes causing rare familial forms of Parkinson's disease has revealed novel proteins and pathways that are likely to be relevant in the pathogenesis of sporadic Parkinson's disease. Recently, mutations in a novel gene, PINK1, encoding a 581 amino acid protein with both mitochondrial targeting and serine/threonine kinase domains, were identified as a cause of autosomal recessive parkinsonism. This provided important evidence for the role of the mitochondrial dysfunction and kinase pathways in neurodegeneration. In this study, we report the first characterization of the PINK1 protein in normal human and sporadic Parkinson's brains, in addition to Parkinson's cases with heterozygous PINK1 mutations. The possible role of the PINK1 protein was also assessed in a number of neurodegenerative diseases characterized by proteinaceous inclusions. For these studies, rabbit polyclonal antibodies were raised against two peptide sequences within the N-terminal hydrophilic loops of PINK1 protein. Using immunohistochemistry and western blotting we were able to demonstrate that PINK1 is a ubiquitous protein expressed throughout the human brain and it is found in all cell types showing a punctate cytoplasmic staining pattern consistent with mitochondrial localization. Fractionation studies of human and rat brain confirm that PINK1 is localized to the mitochondrial membranes. In addition, we show that PINK1 is detected in a proportion of Lewy bodies in cases of sporadic Parkinson's disease and Parkinson's disease associated with heterozygous mutations in the PINK1 gene, which are clinically and pathologically indistinguishable from the sporadic cases. PINK1 was absent in cortical Lewy bodies, in neurofibrillary tangles in Alzheimer's disease, progressive supranuclear palsy and corticobasal degeneration, and in the glial and neuronal alpha-synuclein positive inclusions in multiple system atrophy. These studies provide for the first time in vivo morphological and biochemical evidence to support a mitochondrial localization of PINK1 and underpin the significance of mitochondrial dysfunction in the pathogenesis of nigral cell degeneration in Parkinson's disease.
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Encéfalo/metabolismo , Enfermedad de Parkinson/metabolismo , Proteínas Quinasas/metabolismo , Enfermedad de Alzheimer/metabolismo , Animales , Carbonatos/farmacología , Femenino , Heterocigoto , Humanos , Técnicas para Inmunoenzimas , Enfermedad por Cuerpos de Lewy/metabolismo , Masculino , Persona de Mediana Edad , Mitocondrias/metabolismo , Membranas Mitocondriales/metabolismo , Atrofia de Múltiples Sistemas/metabolismo , Mutación , Enfermedad de Parkinson/genética , Proteínas Quinasas/genética , Ratas , Ratas Wistar , Partículas Submitocóndricas/efectos de los fármacos , Partículas Submitocóndricas/metabolismoRESUMEN
The focus of research in allograft rejection has targeted the lymphocyte, with little attention given to the neutrophil. Recent data indicate that a perioperative neutrophil influx into the cardiac allograft influences early rejection. Factors that influence neutrophil transendothelial migration might offer predictive markers of rejection. We explored the relationship between the number of circulating neutrophils in heart transplant recipients and the development of rejection. Differential white cell counts were obtained prior to transplantation and concurrently with subsequent endomyocardial rejection surveillance biopsies for 53 heart transplant recipients undergoing 410 biopsies. Preoperative differential white cell counts had no relationship with rejection. In the first 3 months after transplantation, no relationship was found between contemporary differential white cell counts and rejection. However, more than 3 months following surgery, rejection grade positively correlated on univariate analysis with neutrophil counts and the usage of cyclosporine, prednisolone, and mycophenolate. There was no relationship with eosinophils or lymphocytes. Multivariate analysis demonstrated a persistent relationship among rejection severity, neutrophil count, and prednisolone usage. A significant positive association of higher steroid usage with higher rejection grades must reflect efforts to treat patients with rejection. The significant association of higher neutrophil counts with higher rejection severity might suggest a pathological contribution to rejection. However, given the neutrophilia response to acute steroid administration, we must conclude that the neutrophil association was related to steroid administration. The absence of a relationship between white cell counts and rejection suggests that functional rather than antiproliferative strategies may offer the greatest therapeutic potential.
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Rechazo de Injerto/sangre , Trasplante de Corazón/patología , Trasplante de Corazón/fisiología , Recuento de Leucocitos , Biopsia , Estudios de Seguimiento , Humanos , Trasplante HomólogoRESUMEN
The introduction of the European Working Time Directive has led to intensive debate regarding the working conditions, training and service delivery of Non Consultant Hospital Doctors. Surgical specialties are especially affected by the directive as they have always been associated with long working hours. These have been defended on the basis that these were required to achieve surgical competence. This study aims to survey the working hours and examine the activity of cardiothoracic surgery trainees, who traditionally worked long hours, in a single institution. Arising from the survey results, a novel working model is proposed.
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Admisión y Programación de Personal , Cirugía Torácica , Tolerancia al Trabajo Programado , Competencia Clínica , Educación de Postgrado en Medicina , Europa (Continente) , Encuestas de Atención de la Salud , Humanos , Internado y Residencia , Irlanda , Sistema de Registros , Encuestas y CuestionariosRESUMEN
BACKGROUND: Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation recipients. METHODS: All heart, lung and heart-lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study. RESULTS: A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart-lung (n = 5) transplantation received a renal transplant. The mean duration to development of end-stage kidney disease (ESKD) was 115 ± 45.9 months. The most common contributor to ESKD was calcineurin inhibitor nephrotoxicity. The 5-year patient survival and graft survival rates were 91.7 and 85.6%, respectively. The median creatinine level at the most recent follow-up was 123 µmol/L, IQR 90.8-147.5. CONCLUSIONS: The overall outcome of renal transplantation following previous non-renal solid organ transplantation is excellent considering the medical complexity and co-morbidities of this patient population. Renal transplantation represents an important treatment option for ESKD in non-renal solid organ transplant recipients.
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Trasplante de Corazón/métodos , Trasplante de Corazón-Pulmón/métodos , Trasplante de Riñón/métodos , Insuficiencia Renal Crónica/etiología , Femenino , Trasplante de Corazón/mortalidad , Trasplante de Corazón-Pulmón/mortalidad , Humanos , Trasplante de Riñón/mortalidad , Masculino , Estudios Retrospectivos , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
The recent identification of fragile X-associated tremor ataxia syndrome (FXTAS) associated with premutations in the FMR1 gene and the possibility of clinical overlap with multiple system atrophy (MSA) has raised important questions, such as whether genetic testing for FXTAS should be performed routinely in MSA and whether positive cases might affect the specificity of current MSA diagnostic criteria. We genotyped 507 patients with clinically diagnosed or pathologically proven MSA for FMR1 repeat length. Among the 426 clinically diagnosed cases, we identified four patients carrying FMR1 premutations (0.94%). Within the subgroup of patients with probable MSA-C, three of 76 patients (3.95%) carried premutations. We identified no premutation carriers among 81 patients with pathologically proven MSA and only one carrier among 622 controls (0.16%). Our results suggest that, with proper application of current diagnostic criteria, FXTAS is very unlikely to be confused with MSA. However, slowly progressive disease or predominant tremor are useful red flags and should prompt the consideration of FXTAS. On the basis of our data, the EMSA Study Group does not recommend routine FMR1 genotyping in typical MSA patients.
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Ataxia/genética , Síndrome del Cromosoma X Frágil/genética , Atrofia de Múltiples Sistemas/genética , Temblor/genética , Anciano , Ataxia/complicaciones , Ataxia/diagnóstico , Ataxia Cerebelosa/complicaciones , Ataxia Cerebelosa/diagnóstico , Ataxia Cerebelosa/genética , Estudios de Cohortes , Diagnóstico Diferencial , Femenino , Proteína de la Discapacidad Intelectual del Síndrome del Cromosoma X Frágil , Síndrome del Cromosoma X Frágil/complicaciones , Síndrome del Cromosoma X Frágil/diagnóstico , Frecuencia de los Genes , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Atrofia de Múltiples Sistemas/diagnóstico , Mutación , Proteínas del Tejido Nervioso/genética , Enfermedades del Sistema Nervioso Periférico/complicaciones , Enfermedades del Sistema Nervioso Periférico/genética , Proteínas de Unión al ARN/genética , Secuencias Repetitivas de Ácidos Nucleicos/genética , Temblor/complicaciones , Temblor/diagnósticoRESUMEN
Pulmonary hypertension associated with mitral valve disease can significantly complicate mitral valve replacement. Nitric oxide (NO) has an established role in congenital heart surgery and in cardiac transplantation. However the evidence to date suggests that iNO does not provide a clinical advantage in pulmonary hypertension associated with valvular heart disease. We discuss a 56-year-old male with acute mitral incompetence who underwent emergency surgery. Following mitral valve replacement he was weaned off cardiopulmonary bypass with an intra-aortic balloon pump and high doses of inotropic support but continued to be hypotensive. Inspection of the heart showed right-sided dysfunction and evidence of pulmonary hypertension. Following the introduction of iNO he rapidly improved. He was successfully separated from the cardiopulmonary bypass support and subsequently made a full recovery and was discharged. We believe that this case demonstrates the utility of iNO in the management of pulmonary hypertension secondary to valvular disease in the acute setting. This is in contrast to the evidence against its utility in established pulmonary hypertension in chronic valvular heart disease. Further confirmation of this observation may lead to the therapeutic use of NO in this subpopulation of cardiac surgery patients.
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Factores Relajantes Endotelio-Dependientes/administración & dosificación , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Hipertensión Pulmonar/terapia , Insuficiencia de la Válvula Mitral/cirugía , Óxido Nítrico/administración & dosificación , Disfunción Ventricular Derecha/terapia , Administración por Inhalación , Puente Cardiopulmonar , Humanos , Hipertensión Pulmonar/etiología , Contrapulsador Intraaórtico , Masculino , Persona de Mediana Edad , Insuficiencia de la Válvula Mitral/complicaciones , Disfunción Ventricular Derecha/etiologíaRESUMEN
BACKGROUND: The first Irish heart transplant was performed on the 10th of September 1985. Over the next 20 years, 229 transplants were performed in 228 recipients. AIMS: To evaluate the success of the first generation of cardiac transplantation in Ireland. METHODS: Analysis of clinical outcomes and survival statistics for patients undergoing heart transplantation in Ireland and comparison with international standards. RESULTS: There has been a steady improvement in transplant outcome over this time and survival figures for recipients between 2000 and 2004 show a hospital, 1-year and 5-year survival rate of 85.7%, 84.1% and 76.8% respectively. Thirty-eight of the 99 heart transplants performed between 1985 and 1994 are still alive more than 10 years later and the longest survivor is now 19 years post transplantation. CONCLUSIONS: The results compare favourably with international figures. Heart transplantation offers excellent longterm survival and quality of life but remains challenged by a shortage of suitable donor organs.
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Trasplante de Corazón , Adolescente , Adulto , Anciano , Niño , Femenino , Supervivencia de Injerto , Trasplante de Corazón/mortalidad , Trasplante de Corazón/estadística & datos numéricos , Humanos , Terapia de Inmunosupresión/estadística & datos numéricos , Irlanda , Masculino , Persona de Mediana Edad , Análisis de Supervivencia , Factores de TiempoRESUMEN
BACKGROUND: On October 31st 2002 a system of cumulative penalty points for road traffic offences was introduced. Early evidence suggested a reduction in road traffic accident (RTA) related morbidity. AIMS: To evaluate the persistence of the initial reduction in RTA related spinal injuries following penalty points introduction. METHODS: Retrospective review of all acute spinal trauma admissions to the NSIU between November 1st 1998 and October 31st 2004 (n = 966). Patient demographics and injury aetiology were assessed. Follow-up questionnaires evaluated RTA circumstances. RESULTS: RTA related spinal injuries accounted for 39.3% of NSIU admissions. These injuries were significantly more common in males aged 16-24, drivers (70.8%), on routine journeys (77.5%) and rural roads (48.8%). The highest proportion of accidents occurred during weekends (64.3% from Fri-Sun) and from midnight to 6am (29.3%). CONCLUSIONS: The initial reduction in RTA related spinal injuries has not been sustained. Young male drivers are the greatest at risk group.
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Accidentes de Tránsito/estadística & datos numéricos , Conducción de Automóvil/legislación & jurisprudencia , Derecho Penal , Traumatismos Vertebrales/epidemiología , Accidentes de Tránsito/prevención & control , Adolescente , Adulto , Análisis de Varianza , Femenino , Humanos , Irlanda/epidemiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Traumatismos Vertebrales/etiología , Traumatismos Vertebrales/prevención & control , Factores de TiempoRESUMEN
We describe an 11-year-old child who presented with a traumatic aortic transection. This is an extremely rare occurrence in this age group. In managing the injury the future growth of the child must be considered. Primary repair is ideal when possible, but in choosing a graft, the choice of size and material should take cognisance of the risk of a coarctation-like syndrome in the future.
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Rotura de la Aorta/etiología , Rotura de la Aorta/cirugía , Traumatismos Torácicos/complicaciones , Anastomosis Quirúrgica , Puente Cardiopulmonar , Humanos , Técnicas de SuturaRESUMEN
Cardiac transplantation is a successful treatment for end-stage heart disease. However the number of potential candidates is significantly greater then number of suitable organ donors. We reviewed the characteristics of new transplant candidates presenting for assessment for cardiac transplantation to the Irish Heart & Lung Transplant programme over a one year period. Of 44 patients referred for assessment, 24 (54.5%) were listed for cardiac transplantation. Six have died while awaiting transplantation, seven have been transplanted and eleven remain on the active transplant list. The six month survival rate on the transplant waiting list is 74%. Although the Irish system of organ donation has traditionally provided high organ donation rates in comparison with other countries, the demand for suitable heart donors exceeds supply. Newer methods of promoting and facilitating organ donation may prove beneficial in improving the number of donations and addressing the long waiting time for cardiac transplantation.