Búsqueda | Biblioteca Virtual en Salud Odontología. Uruguay

1.

Functional modulation of chemical mediators in microbial communities.

Stallforth, Pierre; Mittag, Maria; Brakhage, Axel A; Hertweck, Christian; Hellmich, Ute A.

Trends Biochem Sci ; 48(1): 71-81, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-35981931

2.

Biallelic variants in SLC4A10 encoding a sodium-dependent bicarbonate transporter lead to a neurodevelopmental disorder.

Maroofian, Reza; Zamani, Mina; Kaiyrzhanov, Rauan; Liebmann, Lutz; Karimiani, Ehsan Ghayoor; Vona, Barbara; Huebner, Antje K; Calame, Daniel G; Misra, Vinod K; Sadeghian, Saeid; Azizimalamiri, Reza; Mohammadi, Mohammad Hasan; Zeighami, Jawaher; Heydaran, Sogand; Toosi, Mehran Beiraghi; Akhondian, Javad; Babaei, Meisam; Hashemi, Narges; Schnur, Rhonda E; Suri, Mohnish; Setzke, Jonas; Wagner, Matias; Brunet, Theresa; Grochowski, Christopher M; Emrick, Lisa; Chung, Wendy K; Hellmich, Ute A; Schmidts, Miriam; Lupski, James R; Galehdari, Hamid; Severino, Mariasavina; Houlden, Henry; Hübner, Christian A.

Genet Med ; 26(3): 101034, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38054405

3.

Dynamic ion channel defies dogma.

Hellmich, Ute A.

Nature ; 621(7977): 46-47, 2023 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-37648820

4.

Trapping of a Polyketide Synthase Module after C-C Bond Formation Reveals Transient Acyl Carrier Domain Interactions.

Dell, Maria; Tran, Mai Anh; Capper, Michael J; Sundaram, Srividhya; Fiedler, Jonas; Koehnke, Jesko; Hellmich, Ute A; Hertweck, Christian.

Angew Chem Int Ed Engl ; 63(9): e202315850, 2024 Feb 26.

Artículo en Inglés | MEDLINE | ID: mdl-38134222

5.

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization.

Aisenberg, William H; McCray, Brett A; Sullivan, Jeremy M; Diehl, Erika; DeVine, Lauren R; Alevy, Jonathan; Bagnell, Anna M; Carr, Patrice; Donohue, Jack K; Goretzki, Benedikt; Cole, Robert N; Hellmich, Ute A; Sumner, Charlotte J.

J Biol Chem ; 298(4): 101826, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35300980

6.

[4.3.1]Bicyclic FKBP Ligands Inhibit Legionella Pneumophila Infection by LpMip-Dependent and LpMip-Independent Mechanisms.

Deutscher, Robin C E; Safa Karagöz, M; Purder, Patrick L; Kolos, Jürgen M; Meyners, Christian; Oki Sugiarto, Wisely; Krajczy, Patryk; Tebbe, Frederike; Geiger, Thomas M; Ünal, Can; Hellmich, Ute A; Steinert, Michael; Hausch, Felix.

Chembiochem ; 24(21): e202300442, 2023 11 02.

Artículo en Inglés | MEDLINE | ID: mdl-37489700

7.

Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.

El Hamdaoui, Yamina; Zheng, Fang; Fritz, Nikolas; Ye, Lian; Tran, Mai Anh; Schwickert, Kevin; Schirmeister, Tanja; Braeuning, Albert; Lichtenstein, Dajana; Hellmich, Ute A; Weikert, Dorothee; Heinrich, Markus; Treccani, Giulia; Schäfer, Michael K E; Nowak, Gabriel; Nürnberg, Bernd; Alzheimer, Christian; Müller, Christian P; Friedland, Kristina.

Mol Psychiatry ; 27(12): 5070-5085, 2022 12.

Artículo en Inglés | MEDLINE | ID: mdl-36224261

8.

Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.

Johé, Patrick; Jaenicke, Elmar; Neuweiler, Hannes; Schirmeister, Tanja; Kersten, Christian; Hellmich, Ute A.

J Biol Chem ; 296: 100565, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33745969

9.

Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A.

Bando, Yuko; Hou, Yu; Seyfarth, Lydia; Probst, Jannik; Götze, Sebastian; Bogacz, Marta; Hellmich, Ute A; Stallforth, Pierre; Mittag, Maria; Arndt, Hans-Dieter.

Chemistry ; 28(20): e202104417, 2022 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-35199896

10.

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis.

Previti, Santo; Ettari, Roberta; Di Chio, Carla; Ravichandran, Rahul; Bogacz, Marta; Hellmich, Ute A; Schirmeister, Tanja; Cosconati, Sandro; Zappalà, Maria.

Molecules ; 27(12)2022 Jun 11.

Artículo en Inglés | MEDLINE | ID: mdl-35744891

11.

Metal-Free Twofold Electrochemical C-H Amination of Activated Arenes: Application to Medicinally Relevant Precursor Synthesis.

Wesenberg, Lars J; Diehl, Erika; Zähringer, Till J B; Dörr, Carolin; Schollmeyer, Dieter; Shimizu, Akihiro; Yoshida, Jun-Ichi; Hellmich, Ute A; Waldvogel, Siegfried R.

Chemistry ; 26(72): 17574-17580, 2020 Dec 23.

Artículo en Inglés | MEDLINE | ID: mdl-32866328

12.

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.

Klein, Philipp; Barthels, Fabian; Johe, Patrick; Wagner, Annika; Tenzer, Stefan; Distler, Ute; Le, Thien Anh; Schmid, Paul; Engel, Volker; Engels, Bernd; Hellmich, Ute A; Opatz, Till; Schirmeister, Tanja.

Molecules ; 25(9)2020 Apr 28.

Artículo en Inglés | MEDLINE | ID: mdl-32354191

13.

New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain.

Klein, Philipp; Johe, Patrick; Wagner, Annika; Jung, Sascha; Kühlborn, Jonas; Barthels, Fabian; Tenzer, Stefan; Distler, Ute; Waigel, Waldemar; Engels, Bernd; Hellmich, Ute A; Opatz, Till; Schirmeister, Tanja.

Molecules ; 25(6)2020 Mar 23.

Artículo en Inglés | MEDLINE | ID: mdl-32210166

14.

Predicting ¹⁹ FâNMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase-Inhibitor Complex.

Dietschreit, Johannes C B; Wagner, Annika; Le, T Anh; Klein, Philipp; Schindelin, Hermann; Opatz, Till; Engels, Bernd; Hellmich, Ute A; Ochsenfeld, Christian.

Angew Chem Int Ed Engl ; 59(31): 12669-12673, 2020 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-32239740

15.

19F NMR as a versatile tool to study membrane protein structure and dynamics.

Rose-Sperling, Dania; Tran, Mai Anh; Lauth, Luca M; Goretzki, Benedikt; Hellmich, Ute A.

Biol Chem ; 400(10): 1277-1288, 2019 09 25.

Artículo en Inglés | MEDLINE | ID: mdl-31004560

16.

Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Wagner, Annika; Le, Thien Anh; Brennich, Martha; Klein, Philipp; Bader, Nicole; Diehl, Erika; Paszek, Daniel; Weickhmann, A Katharina; Dirdjaja, Natalie; Krauth-Siegel, R Luise; Engels, Bernd; Opatz, Till; Schindelin, Hermann; Hellmich, Ute A.

Angew Chem Int Ed Engl ; 58(11): 3640-3644, 2019 03 11.

Artículo en Inglés | MEDLINE | ID: mdl-30605929

17.

Comparison of mechanistic transport cycle models of ABC exporters.

Szöllosi, Dániel; Rose-Sperling, Dania; Hellmich, Ute A; Stockner, Thomas.

Biochim Biophys Acta Biomembr ; 1860(4): 818-832, 2018 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-29097275

18.

Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

Howard, Rebecca J; Carnevale, Vincenzo; Delemotte, Lucie; Hellmich, Ute A; Rothberg, Brad S.

Biochim Biophys Acta Biomembr ; 1860(4): 927-942, 2018 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-29258839

19.

Diverse relations between ABC transporters and lipids: An overview.

Neumann, Jennifer; Rose-Sperling, Dania; Hellmich, Ute A.

Biochim Biophys Acta Biomembr ; 1859(4): 605-618, 2017 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-27693344

20.

The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.

Hacker, Carolin; Christ, Nina A; Duchardt-Ferner, Elke; Korn, Sophie; Göbl, Christoph; Berninger, Lucija; Düsterhus, Stefanie; Hellmich, Ute A; Madl, Tobias; Kötter, Peter; Entian, Karl-Dieter; Wöhnert, Jens.

J Biol Chem ; 290(48): 28869-86, 2015 Nov 27.

Artículo en Inglés | MEDLINE | ID: mdl-26459561

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