The BDNF rs7934165 polymorphism is a biomarker of central obesity and cardiometabolic risk in Mexican women.

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a cornerstone in the hypothalamic regulation of food intake and energy homeostasis. Polymorphisms in the BDNF gene may thus contribute to obesity traits. The aim of this investigation was to analyze the association of rs6265 and rs7934165 BDNF polymorphisms in women from Northeast Mexico classified as obese or overweight using their BMI and waist-to-height ratio (WHtR). PATIENTS AND METHODS: A total of 296 women were enrolled and further divided into normal weight and obese overweight groups according to their BMI status and WHtR classifications, which were low and high at < 0.50 and ≥ 0.50, respectively. Genotyping of BDNF rs6265 and rs7934165 polymorphisms was performed using a TaqMan assay. Distinct anthropometric, biochemical, clinical, and dietary parameters were obtained and used as covariates in the statistical analyses. RESULTS: The rs6265-G allele and its homozygote state (GG) were the most prominent without statistically significant differences between groups (p = 0.412). The study of rs7934165 with BMI showed marginal associations. Moreover, the rs7934165-AA genotype was more frequent among individuals with a high WHtR than those with a low WHtR (43.4 vs. 25.2%, p = 0.01). This association was maintained after adjustments for age and caloric intake through logistic regression analysis (OR = 2.20, 95% CI = 1.15-4.18, p = 0.016). CONCLUSIONS: The present study indicates that the BDNF-rs7934165-AA genotype is associated with a higher WHtR which is related to central obesity and its comorbidities. This suggests that this SNP could act as a potential biomarker for central obesity and cardiometabolic risk.

[Association of polymorphism TaqI of vitamin de receptor with bone mineral density in young Mexican women]. / Asociación del polimorfismo TaqI del gen del receptor de la vitamina D con la densidad mineral ósea en mujeres Mexicanas jóvenes.

INTRODUCTION: Osteoporosis is a multifactorial disease characterized by a low bone mineral density (BMD). Osteoporosis and the occurrence of fractures in postmenopausal women have been associated to the TaqI polymorphism in the vitamin D receptor (VDR) gene. OBJECTIVE: To analyze the association of the different genotypes of TaqI polymorphism of the VDR gene with BMD in young Mexican women. METHODS: Dual X-ray absorptiometry was carried out in 150 women aged 19 to 29 years in order to determine their total bone mineral density (tBMD) and dual BMD of the femur (dfBMD). DNA was extracted from peripheral blood to determine the genotype of the TaqI polymorphism in the VDR gene. The data obtained were analyzed by simple linear regression and ANOVA. RESULTS: Mean tBMD was 1.096 ± 0.064 mean dfBMD was 0.960 ± 0.107 g/cm². The frequency of the TaqI polymorphisms was 57% (TT), 37% (Tt) and 6% (tt), the frequency of the alleles was 75% (T) and 25% (t). Ths statistical analysis showed a lack of association between BMD and the genotypes of TaqI polymorphism in the VDR gene. DISCUSSION AND CONCLUSIONS: These results suggest that may exist factors other than the TaqI polymorphism in the VDR gene contributing to BMD in young women from Northern Mexico.