RESUMEN
Mastomys natalensis rodents are natural hosts for Lassa virus (LASV). Detection of LASV in 2 mitochondrial phylogroups of the rodent near the Niger and Benue Rivers in Nigeria underlines the potential for LASV emergence in fresh phylogroups of this rodent. A Mobala-like sequence was also detected in eastern Nigeria.
Asunto(s)
ADN Mitocondrial/genética , Fiebre de Lassa/veterinaria , Virus Lassa/clasificación , Murinae/virología , Filogenia , ARN Viral/genética , Animales , Citocromos b/genética , Reservorios de Enfermedades , Variación Genética , Interacciones Huésped-Patógeno , Humanos , Fiebre de Lassa/epidemiología , Fiebre de Lassa/transmisión , Fiebre de Lassa/virología , Virus Lassa/genética , Virus Lassa/aislamiento & purificación , Mitocondrias/química , Mitocondrias/genética , Murinae/clasificación , Murinae/genética , Nigeria/epidemiología , Filogeografía , Enfermedades de los Roedores/epidemiología , Enfermedades de los Roedores/virología , ZoonosisRESUMEN
Lassa virus (LASV) causes a deadly haemorrhagic fever in humans, killing several thousand people in West Africa annually. For 40 years, the Natal multimammate rat, Mastomys natalensis, has been assumed to be the sole host of LASV. We found evidence that LASV is also hosted by other rodent species: the African wood mouse Hylomyscus pamfi in Nigeria, and the Guinea multimammate mouse Mastomys erythroleucus in both Nigeria and Guinea. Virus strains from these animals were isolated in the BSL-4 laboratory and fully sequenced. Phylogenetic analyses of viral genes coding for glycoprotein, nucleoprotein, polymerase and matrix protein show that Lassa strains detected in M. erythroleucus belong to lineages III and IV. The strain from H. pamfi clusters close to lineage I (for S gene) and between II &III (for L gene). Discovery of new rodent hosts has implications for LASV evolution and its spread into new areas within West Africa.