2D linear and iterative reconstruction algorithms for a PET-insert scanner.

We are developing novel insert devices for existing whole body PET scanners to achieve better resolution in selected regions of interest such as the head, neck, breast or abdomen. The insert considered here is a full ring of high resolution detectors, which can be placed around the object of interest. Adding the insert inside the scanner leads to three different types of coincidences: insert-insert, insert-scanner and scanner-scanner. The insert-insert and scanner-scanner coincidences are similar to the coincidences obtained in a traditional PET system. The insert-scanner coincidences have an inherent fan-beam geometry for which a spatially variant system matrix is proposed. The system matrix is computed using the intersection of a fan beam with a pixel. A filtered back-projection (FBP) algorithm for the insert-scanner geometry is presented. This FBP algorithm yields images with significantly reduced artifacts compared to FBP reconstructions on insert-scanner data rebinned into parallel beams. This is demonstrated using simulated point source data acquired using SimSET. It is proposed to use a penalized ML-EM (PML-EM) algorithm using a log-cosh roughness penalty function to reconstruct a single activity distribution from all three data sets. This is demonstrated qualitatively using simulated point source data. A quantitative comparison of PML-EM and FBP was performed on data acquired from insert-scanner coincidences using a phantom with hot and cold tumors imaged in an experimental setup. The quantitative studies demonstrate that the resolution/noise tradeoff of PML-EM is improved relative to FBP.

Intravascular probe for detection of vulnerable plaque.

PURPOSE: Coronary angiography defines geometry of lumen of artery. However, perhaps 70% of heart attacks occur when minimally obstructive thin capped fibroatheroma rupture, causing thrombus and arterial occlusion. We have developed an intravascular imaging detector to identify vulnerable coronary artery plaque. PROCEDURE: Detector measures beta or conversion electron emissions from plaque-binding radiotracers. Detector assembly fits into a 2-mm diameter catheter and overcomes technical constraints of size, sensitivity, and conformance to intravascular environment. RESULTS: Device was tested by stepping test point sources past detector to verify function. System resolution is 6.7 mm and sensitivity is 400 cps/microCi one mm from detector. CONCLUSION: This prototype is a first step in imaging of labeled vulnerable plaque in coronary arteries. This type of system may assist in development of targeted and cost effective therapies to lower incidence of acute coronary artery diseases (CAD) such as unstable angina, acute myocardial infarction, and sudden cardiac death.