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Am J Transplant ; 14 Suppl 1: 45-68, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-24373167

RESUMEN

The number of pancreas transplants has decreased over the past decade, most notably numbers of pancreas after kidney (pak) and pancreas transplant alone (pta) procedures. This decrease may be mitigated in the future when changes to national pancreas allocation policy approved by the Organ Procurement and Transplantation Network Board of Directors in 2010 are implemented. The new policy will combine waiting lists for pak, pta, and simultaneous pancreas-kidney (spk) transplants), and give equal priority to candidates for all three procedures. This policy change may also eliminate geographic variation in waiting times caused by geographic differences in allocation policy. Deceased donor pancreas donation rates have been declining since 2005, and the donation rate remains low. The outcomes of pancreas grafts are difficult to describe due to lack of a uniform definition of graft failure in the transplant community. However long-term survival is better for spk versus pak and pta transplants. This may represent the difficulty of detecting rejection in the absence of a simultaneously transplanted kidney. The challenges of pancreas transplant are reflected in high rates of rehospitalization, most occurring within the first 6 months posttransplant. Pancreas transplant is associated with higher incidence of rejection compared with kidney transplant.


Asunto(s)
Trasplante de Páncreas , Adulto , Niño , Infecciones por Citomegalovirus/inmunología , Infecciones por Virus de Epstein-Barr/inmunología , Prueba de Histocompatibilidad , Humanos , Terapia de Inmunosupresión/métodos , Trasplante de Riñón , Trasplante de Páncreas/economía , Trasplante de Páncreas/mortalidad , Estados Unidos/epidemiología , Listas de Espera/mortalidad
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