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In this research, magnetic MgFe2O4-CaFe2O4 photocatalyst powder was prepared from recycling of electric arc furnace (EAF) dust as a secondary source through a two-step leaching process followed by co-precipitation method. To maximize the total Fe to Ca recovery ratio (F/C) and evaluate the effective parameters of sulfuric acid concentration and temperature, response surface methodology (RSM) as a design of experiment was used. The best temperature and acid concentration were obtained as 85 °C and 1 M, respectively for the second step of the leaching process. X-ray diffraction (XRD) results indicated that the synthesized nanocomposite sample contains MgFe2O4 and CaFe2O4 phases together with a small amount of Ca2Fe2O5. The saturation magnetization and optical band gap of the synthesized composite powder were 24 emu/g and 2.17 eV, respectively. X-Ray photoelectron spectroscopy (XPS) result revealed the oxidation states as Fe3+, Ca2+, Mg2+ and O2-. Energy dispersive X-ray spectroscopy (EDS) showed that the elements were uniformly distributed within the nanostructured particles. Field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM) results indicated the presence of CaFe2O4 and MgFe2O4 nanoparticles with good contact between them. The nanocomposite sample showed the capability of 45% for degrading methylene blue (MB) dye under 240 min visible light irradiation. The reusability tests showed that the photocatalytic activity of the nanocomposite was not considerably changed after three cycles.
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Polvo , Nanocompuestos , Catálisis , Luz , ReciclajeRESUMEN
BACKGROUND: Carbamazepine (CBZ) is used for the treatment of epileptic seizures. This study was designed to evaluate the effect of Interferon-gamma on the fetal heart and kidney histopathological changes of CBZ-treated pregnant mice. METHODS: Twenty pregnant mice were divided into four groups. The control group received distilled water. The second group received 240 mg/kg of CBZ by gastric gavage. The third group received intraperitoneal injection (IP) of IFN-γ. The fourth group received IP injection of IFN-γ with 240 mg/kg CBZ by gavage. The fetuses were delivered by hysterectomy on the 18th day of gestation. RESULTS: The mean weight, crown-rump length, the total volume of the heart and kidney of the fetuses in the CBZ-treated group were significantly reduced when compared with the control, INF-γ and CBZ + INF-γ groups (p < 0.05). INF-γ prevented histopathological changes when used with CBZ (p < 0.05). CONCLUSION: CBZ induced structural changes in the fetal tissues of the pregnant mice. However, IFN-γ could reduce these changes (Tab. 1, Fig. 4, Ref. 26).
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Anticonvulsivantes , Carbamazepina , Epilepsia , Interferón gamma , Animales , Anticonvulsivantes/toxicidad , Benzodiazepinas , Carbamazepina/toxicidad , Epilepsia/tratamiento farmacológico , Femenino , Corazón/efectos de los fármacos , Interferón gamma/farmacología , Riñón/efectos de los fármacos , Ratones , Embarazo , ConvulsionesRESUMEN
OBJECTIVE: Examine the effects of obesity and metabolic syndrome on outcome in bipolar disorder. METHOD: The Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer and a Classic Mood Stabilizer for Bipolar Disorder (Bipolar CHOICE) study randomized 482 participants with bipolar disorder in a 6-month trial comparing lithium- and quetiapine-based treatment. Baseline variables were compared between groups with and without obesity, with and without abdominal obesity, and with and without metabolic syndrome respectively. The effects of baseline obesity, abdominal obesity, and metabolic syndrome on outcomes were examined using mixed effects linear regression models. RESULTS: At baseline, 44.4% of participants had obesity, 48.0% had abdominal obesity, and 27.3% had metabolic syndrome; neither obesity, nor abdominal obesity, nor metabolic syndrome were associated with increased global severity, mood symptoms, or suicidality, or with poorer functioning or life satisfaction. Treatment groups did not differ on prevalence of obesity, abdominal obesity, or metabolic syndrome. By contrast, among the entire cohort, obesity was associated with less global improvement and less improvement in total mood and depressive symptoms, suicidality, functioning, and life satisfaction after 6 months of treatment. Abdominal obesity was associated with similar findings. Metabolic syndrome had no effect on outcome. CONCLUSION: Obesity and abdominal obesity, but not metabolic syndrome, were associated with less improvement after 6 months of lithium- or quetiapine-based treatment.
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The neurobiology of mood states is complicated by exposure to everyday stressors (e.g., psychosocial, ubiquitous environmental infections like CMV), each fluctuating between latency and reactivation. CMV reactivation induces proinflammatory cytokines (e.g., TNF-α) associated with induction of neurotoxic metabolites and the presence of mood states in bipolar disorder (BD). Whether CMV reactivation is associated with bipolar diagnoses (trait) or specific mood states is unclear. We investigated 139 BD type I and 99 healthy controls to determine if concentrations of IgG antibodies to Herpesviridae (e.g., CMV, HSV-1, and HSV-2) were associated with BD-I diagnosis and specific mood states. We found higher CMV antibody concentration in BD-I than in healthy controls (T234 = 3.1, P uncorr = 0.002; P corr = 0.006) but no difference in HSV-1 (P > 0.10) or HSV-2 (P > 0.10). Compared to euthymic BD-I volunteers, CMV IgG was higher in BD-I volunteers with elevated moods (P < 0.03) but not different in depressed moods (P > 0.10). While relationships presented between BD-I diagnosis, mood states, and CMV antibodies are encouraging, they are limited by the study's cross sectional nature. Nevertheless, further testing is warranted to replicate findings and determine whether reactivation of CMV infection exacerbates elevated mood states in BD-I.
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Afecto/fisiología , Trastorno Bipolar/virología , Infecciones por Citomegalovirus/diagnóstico , Adulto , Anticuerpos Antivirales/sangre , Trastorno Bipolar/complicaciones , Infecciones por Citomegalovirus/complicaciones , Infecciones por Citomegalovirus/inmunología , Femenino , Humanos , Inmunoglobulina G/sangre , MasculinoRESUMEN
We conducted an assessment of maternal, newborn and child health and progress towards achieving Millennium Development Goals (MDG) 4 and 5 in the Eastern Mediterranean Region (EMR). We provide recommendations for scaling up and sustaining gains post-2015. Data were obtained from global data repositories. We constructed time trends from 1990 to 2013 and evaluated inequities across the Region. Under-5, neonatal and maternal mortality rates decreased 46%, 35%, and 50% respectively from 1990 to 2013. Pneumonia and diarrhoea accounted for 50% of all post-neonatal deaths; pregnancy- and delivery-related complications were the leading causes of neonatal and maternal deaths. Coverage of maternal, newborn and child health interventions is suboptimal, and poverty, food insecurity and conflict are pervasive across the Region. The EMR has made progress but is unlikely to attain MDG 4 and 5 targets. To sustain and further accelerate gains, the Region must reduce inequities and scale up implementation of recommendations made by the independent Expert Review Group.
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Mortalidad del Niño/tendencias , Mortalidad Infantil/tendencias , Mortalidad Materna/tendencias , Servicios de Salud Materno-Infantil/organización & administración , Niño , Preescolar , Humanos , Lactante , Recién Nacido , Región Mediterránea , Determinantes Sociales de la SaludRESUMEN
Heat and drought adaptive quantitative trait loci (QTL) in a spring bread wheat population resulting from the Seri/Babax cross designed to minimize confounding agronomic traits have been identified previously in trials conducted in Mexico. The same population was grown across a wide range of environments where heat and drought stress are naturally experienced including environments in Mexico, West Asia, North Africa (WANA), and South Asia regions. A molecular genetic linkage map including 475 marker loci associated to 29 linkage groups was used for QTL analysis of yield, days to heading (DH) and to maturity (DM), grain number (GM2), thousand kernel weight (TKW), plant height (PH), canopy temperature at the vegetative and grain filling stages (CTvg and CTgf), and early ground cover. A QTL for yield on chromosome 4A was confirmed across several environments, in subsets of lines with uniform allelic expression of a major phenology QTL, but not independently from PH. With terminal stress, TKW QTL was linked or pleiotropic to DH and DM. The link between phenology and TKW suggested that early maturity would favor the post-anthesis grain growth periods resulting in increased grain size and yields under terminal stress. GM2 and TKW were partially associated with markers at different positions suggesting different genetic regulation and room for improvement of both traits. Prediction accuracy of yield was improved by 5 % when using marker scores of component traits (GM2 and DH) together with yield in multiple regression. This procedure may provide accumulation of more favorable alleles during selection.
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Adaptación Biológica/genética , Clima , Hibridación Genética , Fenotipo , Sitios de Carácter Cuantitativo/genética , Triticum/crecimiento & desarrollo , Triticum/genética , África del Norte , Asia , Mapeo Cromosómico , Marcadores Genéticos/genética , México , Análisis de RegresiónRESUMEN
BACKGROUNDS: The last 30 years have witnessed major improvements in understanding of all aspects of infective endocarditis (IE). The Iranian Registry of Infective Endocarditis (IRIE) was formed to address epidemiological aspects of IE vis-à-vis its main pathogens and underlying heart diseases over a 12-year period. Indeed, a multidisciplinary team (MDT) for IE was developed alongside. METHODS: In a longitudinal observational study, data of adult patients with definite or possible IE based on modified Duke criteria were collected from 2007 to 2016 in our tertiary centre, Iran. From 2016 until 2019, we run a prospective observational study using formation of an IE MDT to provide better patient management and compared data before and after this. RESULTS: Totally, 645 patients with mean age of 48 ± 17 years were enrolled. Data of 445 and 200 patients were compared before and after IRIE and MDT formation, respectively. We found significantly reduced type and number of applied antibiotics (p = 0.04) and higher rate of positive blood culture (p = 0.001). Hospital length of stay increased significantly after formation of the IRIE and IE MDT (p = 0.02). The rate of heart failure, new abscess formation and cerebral emboli were significantly decreased after IRIE and IE MDT (p < 0.001) and consequently in-hospital mortality reduced significantly (p = 0.05). CONCLUSION: Developing national registries and MDTs has potential to enhance patient management and reduce IE burden. Our results demonstrated that establishment of the Iranian IRIE and IE MDT conferred better diagnoses, standardised treatments and significantly reduced cardiac and extra cardiac morbidity.
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Endocarditis Bacteriana , Endocarditis , Adulto , Anciano , Endocarditis/diagnóstico , Endocarditis/epidemiología , Endocarditis/terapia , Endocarditis Bacteriana/diagnóstico , Endocarditis Bacteriana/epidemiología , Endocarditis Bacteriana/terapia , Humanos , Irán/epidemiología , Persona de Mediana Edad , Grupo de Atención al Paciente , Sistema de RegistrosRESUMEN
COVID-19 has presented society with one of the greatest challenges in living memory. Community Mental Health Teams (CMHTs)have needed to adapt quickly to a rapidly developing situation which has had a dramatic impact on society. In this piece, we describe some of the early challenges for CMHTs within two mental health services based in Dublin and Wicklow. We also discuss ongoing developments and anticipate the need for further vigilance as the COVID-19 pandemic continues to evolve.
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Betacoronavirus , Servicios Comunitarios de Salud Mental/métodos , Infecciones por Coronavirus/psicología , Trastornos Mentales/terapia , Neumonía Viral/psicología , Servicios de Salud Rural , Servicios Urbanos de Salud , COVID-19 , Humanos , Irlanda , Trastornos Mentales/psicología , Pandemias , SARS-CoV-2RESUMEN
Many kinds of neuroscience data are being acquired regarding the dynamic behaviour and phenotypic diversity of nerve cells. But as the size, complexity and numbers of 3D neuroanatomical datasets grow ever larger, the need for automated detection and analysis of individual neurons takes on greater importance. We describe here a method that detects and identifies neurons within confocal image stacks acquired from the zebrafish brainstem. The first step is to create a template that incorporates the location of all known neurons within a population - in this case the population of reticulospinal cells. Once created, the template is used in conjunction with a sequence of algorithms to determine the 3D location and identity of all fluorescent neurons in each confocal dataset. After an image registration step, neurons are segmented within the confocal image stack and subsequently localized to specific locations within the brainstem template - in many instances identifying neurons as specific, individual reticulospinal cells. This image-processing sequence is fully automated except for the initial selection of three registration points on a maximum projection image. In analysing confocal image stacks that ranged considerably in image quality, we found that this method correctly identified on average approximately 80% of the neurons (if we assume that manual detection by experts constitutes 'ground truth'). Because this identification can be generated approximately 100 times faster than manual identification, it offers a considerable time savings for the investigation of zebrafish reticulospinal neurons. In addition to its cell identification function, this protocol might also be integrated with stereological techniques to enhance quantification of neurons in larger databases. Our focus has been on zebrafish brainstem systems, but the methods described should be applicable to diverse neural architectures including retina, hippocampus and cerebral cortex.
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Automatización , Tronco Encefálico/citología , Imagenología Tridimensional/métodos , Microscopía Confocal/métodos , Neuronas/citología , Pez Cebra , AnimalesRESUMEN
To determine the most appropriate composting process in an active municipal solid waste system, an experiment was carried out using a nested design method with three aeration rates. During each aeration rate, parameters such as temperature, pH, EC, carbon-to-nitrogen ratio, NO(3)-N, nitrogen, potassium and phosphorous were measured and the efficiency of different composting processes was evaluated. The result of this study showed that the lower and medium aeration rates had a significant impact on nitrogen, carbon-to-nitrogen ratio and temperature profile, while higher aeration rates led to higher EC values. Furthermore, the thermophilic phase lasted 13, 9 and 4 weeks for the aeration rates of 0.4, 0.6 and 0.9 L min(-1)kg(-1), respectively. Accordingly, it was concluded that starting at a rate of 0.6 L min(-1)kg(-1) during first 2 months (about 9 weeks) of the process and continuing at a rate of 0.4 L min(-1)kg(-1)until the end of composting process would result in lower energy consumption.
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Oxígeno , Eliminación de Residuos/métodos , Suelo/normas , Temperatura , Factores de TiempoRESUMEN
Nowadays, electrospray is becoming a favourable approach for preparing monodispersed nanoparticles. However, this approach is quite recent and requires further works to optimize control over physicochemical properties of its products. This study aimed to determine the possible effects of sonication as a pretreatment to reduce the size of azelaic acid-chitosan particle before using electrospray. The results showed that sonication treatment can produce submicron particles of azelaic acid-chitosan. By diluting the solution and increasing sonication time and amplitude, smaller particles were obtained with the smallest one at 516 nm, sized by dynamic light scattering. The pretreated solution was then electrosprayed to reduce the size of nanoparticles to 80 nm, indicating that sonication may play an important role in reducing the size of electrosprayed nanoparticles. The electrosprayed nanoparticles were nearly monodispersed and almost spherical in shape.
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Quitosano/química , Ácidos Dicarboxílicos/química , Portadores de Fármacos/química , Sistemas de Liberación de Medicamentos/veterinaria , Nanopartículas/química , Sonicación/veterinaria , Sistemas de Liberación de Medicamentos/métodos , Tamaño de la Partícula , Sonicación/métodosRESUMEN
Electrospinning method was employed for fabrication of SiO2-CaO-P2O5 bioactive glass (BG) nanofibers, poly-l-lactic acid (PLLA) nanofibers and nanocomposite scaffolds fabricated from as-prepared nanofibers. Characterization of the prepared nanofibers and scaffolds by XRD, FTIR, and SEM techniques revealed the formation of nanofibers with mean diameter of about 500nm and fully fibrous scaffolds with porous structure and interconnected pores. The growth, viability and proliferation of cultured human bone marrow mesenchymal stem cells in the fabricated nanofibers and bioactive glass-poly-l-lactic acid (BG-PLLA) nanocomposite scaffolds were studied using various biological assays including MTT, ALP activity, calcium deposit content, Alizarin red staining, and RT-PCR test. Based on the obtained results, incorporation of BG nanofibers in the nanocomposite scaffolds causes the better biological behavior of the scaffolds. In addition, three-dimensional and fibrous-porous structure of the scaffolds further contributes to their improved cell behavior compared to the components.
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Células de la Médula Ósea , Diferenciación Celular , Proliferación Celular , Humanos , Nanocompuestos , Nanofibras , Osteoblastos , Poliésteres , Dióxido de Silicio , Células Madre , Ingeniería de Tejidos , Andamios del TejidoRESUMEN
Effects of interface alloying and the thickness dependence of magnetic properties of Fe/Co(001) multilayers have been investigated. The thicknesses of the Fe layers have been varied between two and 14 monolayers while the Co layers have been held constant at 7 ML. From conversion electron Mössbauer spectroscopy (CEMS) measurements and electronic structure calculations it is found that the magnitude of the Fe magnetic hyperfine field is larger close to the interface and smaller in the middle of thick (≥9 ML) Fe layers. For a thinner Fe layer (≤5 ML) the largest field is found in the centre of the Fe layer. By modelling the effects of interface alloying from earlier data for bulk Fe-Co alloys, and comparing with the experimental results, the degree of interface alloying is estimated to be 2-3 ML at each interface.
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The aim of this study was to identify the features of first episode schizophrenia that predict adherence antipsychotic medication at six-month follow-up. We used validated instruments to assess clinical and socio-demographic variables in all patients with first episode schizophrenia from a defined geographical area admitted to a Dublin psychiatric hospital over a four-year period (N=100). At six-month follow-up (N=60) we assessed adherence to medication using the Compliance Interview. One third of patients with schizophrenia were non-adherent with medication within six months of their first episode of illness. High levels of positive symptoms at baseline, lack of insight at baseline, alcohol misuse at baseline and previous drug misuse predict non-adherence. These results indicate that an identifiable subgroup of patients with first episode schizophrenia is at high risk of early non-adherence to medication. While high positive symptom scores pre-date and predict non-adherence in most patients, reduced insight is the best predictor of non-adherence in patients who do not misuse alcohol or other drugs.
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Antipsicóticos/uso terapéutico , Cooperación del Paciente/estadística & datos numéricos , Esquizofrenia/tratamiento farmacológico , Esquizofrenia/epidemiología , Adulto , Demografía , Femenino , Estudios de Seguimiento , Humanos , Masculino , Estudios ProspectivosRESUMEN
Having a diagnosis of schizophrenia is a risk factor for involuntary admission to psychiatric inpatient care, but we have a limited understanding of why some patients and not others require involuntary admission. We aimed to identify the predictors of involuntary admission in first episode schizophrenia. We used validated instruments to assess clinical and socio-demographic variables in all patients (n = 78) with first episode schizophrenia from a defined geographical area admitted to a Dublin psychiatric hospital over a 4-year period. Involuntary patients (n = 17) could not be distinguished from voluntary patients (n = 61) on the basis of age, gender, living status, marital status, drug abuse or duration of untreated psychosis. Neither positive nor negative symptoms were useful predictors of admission status. Lack of insight was a strong predictor of involuntary status.
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Internamiento Obligatorio del Enfermo Mental/estadística & datos numéricos , Esquizofrenia/clasificación , Esquizofrenia/diagnóstico , Psicología del Esquizofrénico , Adulto , Factores de Edad , Femenino , Predicción , Hospitales Psiquiátricos , Humanos , Entrevista Psicológica , Irlanda/epidemiología , Modelos Logísticos , Masculino , Estado Civil , Valor Predictivo de las Pruebas , Escalas de Valoración Psiquiátrica , Características de la Residencia , Factores de Riesgo , Esquizofrenia/epidemiología , Factores Sexuales , Trastornos Relacionados con Sustancias/complicaciones , Trastornos Relacionados con Sustancias/psicología , Factores de TiempoRESUMEN
A kinetic model of the cytochrome bf complex was developed on the assumption that the Q-cycle operates. The bf complex was considered as a membrane enzyme catalyzing the electron transfer from plastoquinol to plastocyanine, which is coupled with proton translocation from the chloroplast stroma to the thylakoid lumen. The dependence of the electron transfer rates on the value of the transmembrane electric potential was taken into account. The model was applied to describe the experimental data on the flash-induced turnover of cytochromes b, plastocyanine, and the kinetics of proton deposition in the thylakoid lumen. The estimation of model parameters was performed.
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Complejo de Citocromo b6f/química , Modelos Biológicos , Plastoquinona/análogos & derivados , Transporte de Electrón , Cinética , Potenciales de la Membrana , Oxidación-Reducción , Plastocianina/química , Plastoquinona/química , Bombas de Protones/química , Tilacoides/químicaRESUMEN
Factors affecting the sex ratio are examined using data for 1,169,489 births occurring in rural and urban districts of Tehran, Iran, between 1971 and 1979. Attention is given to geographic, socioeconomic, psychological, and nutritional factors. It is found that "male births occurred more in Winter and Spring in the urban and rural areas, respectively. Female births occurred more in Fall in both urban and rural areas. Mean sex ratio was 108.20 in rural and 105.44 in urban areas." Reasons for the differentials between urban and rural areas are suggested.
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Geografía , Fenómenos Fisiológicos de la Nutrición , Psicología , Población Rural , Estaciones del Año , Distribución por Sexo , Razón de Masculinidad , Factores Socioeconómicos , Población Urbana , Asia , Conducta , Demografía , Países en Desarrollo , Economía , Salud , Irán , Población , Características de la Población , Dinámica Poblacional , Factores SexualesRESUMEN
Background. Hemipelvectomy amputation is a surgical procedure in which lower limb and a portion of pelvic are removed. There are a few studies in the literature regarding the performance of subjects with hip disarticulation during walking. However, there is no study on gait analysis of hemipelvectomy subject. Therefore, the aim of this paper was to evaluate the gait and stability of subject with hemipelvectomy amputation. Case Description and Methods. A subject with hemipelvectomy amputation at right side was involved in this study. He used a Canadian prosthesis with single axis ankle joint, 3R21 knee joint, and 7E7 hip joint for more than 10 years. The kinetic and kinematic parameters were collected by a motion analysis system and a Kistler force platform. Findings and Outcomes. There was a significant difference between knee, hip, and ankle range of motions and their moments in the sound and prosthesis sides. In the other side, the stability of the subject in the anteroposterior direction seems to be better than that in the mediolateral direction. Conclusions. There was a significant asymmetry between the kinetic and kinematic performance of the sound and prosthesis sides, which may be due to lack of muscular power and alignment of prosthesis components.
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A lattice Boltzmann (LB) method is presented for solving the energy conservation equation in two phases when the phase change effects are included in the model. This approach employs multiple distribution functions, one for a pseudotemperature scalar variable and the rest for the various species. A nonideal equation of state (EOS) is introduced by using a pseudopotential LB model. The evolution equation for the pseudotemperature variable is constructed in such a manner that in the continuum limit one recovers the well known macroscopic energy conservation equation for the mixtures. Heats of reaction, the enthalpy change associated with the phase change, and the diffusive transport of enthalpy are all taken into account; but the dependence of enthalpy on pressure, which is usually a small effect in most nonisothermal flows encountered in chemical reaction systems, is ignored. The energy equation is coupled to the LB equations for species transport and pseudopotential interaction forces through the EOS by using the filtered local pseudotemperature field. The proposed scheme is validated against simple test problems for which analytical solutions can readily be obtained.
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Research utilizing visual event-related brain potentials (ERPs) has demonstrated that reduced P300 amplitude and prolonged latency may qualify as a biological marker (biomarker) for schizophrenia (SZ). We examined P300 characteristics in response inhibition among three putatively distinct psychopathology groups including schizophrenia (SZ), bipolar I disorder (BD) and schizoaffective disorder (SA) in comparison with healthy controls (CT) to determine their electrophysiological distinctiveness. In two separate studies, deficits in response inhibition indexed by the P300 component were investigated using a lateralized Go/NoGo task. We hypothesized that deficits in response inhibition would be present and distinctive among the groups. In both studies, SZ showed response inhibition deficits as measured by P300 when stimuli were presented to the right visual field. In Study 2, delayed cognitive stimulus evaluation was observed in BD as indexed by prolonged P300 latency for NoGo trials. Six selected NoGo P300 variables out of thirty six NoGo P300 variables (18 amplitude, 18 latency) correctly classified SZ (79%), SA (64%) in Study 1 and seven variables selected in Study 2 classified CT (80%), and SZ (61%), BD (67%) and CT (68%) with the accuracy higher than chance level (33%). The findings suggest that distinct P300 features in response inhibition may be biomarkers with the capacity to distinguish BD and SZ, although SA was not clearly distinguishable from SZ and CT.