RESUMEN
The changing global climate have given rise to abiotic stresses that adversely affect the metabolic activities of plants, limit their growth, and agricultural output posing a serious threat to food production. The abiotic stresses commonly lead to production of reactive oxygen species (ROS) that results in cellular oxidation. Over the course of evolution, plants have devised efficient enzymatic and non-enzymatic anti-oxidative strategies to counteract harmful effects of ROS. Among the emerging non-enzymatic anti-oxidative technologies, the chloroplast lipophilic antioxidant vitamin A (Tocopherol) shows great promise. Working in coordination with the other cellular antioxidant machinery, it scavenges ROS, prevents lipid peroxidation, regulates stable cellular redox conditions, simulates signal cascades, improves membrane stability, confers photoprotection and enhances resistance against abiotic stresses. The amount of tocopherol production varies based on the severity of stress and its proposed mechanism of action involves arresting lipid peroxidation while quenching singlet oxygen species and lipid peroxyl radicals. Additionally, studies have demonstrated its coordination with other cellular antioxidants and phytohormones. Despite its significance, the precise mechanism of tocopherol action and signaling coordination are not yet fully understood. To bridge this knowledge gap, the present review aims to explore and understand the biosynthesis and antioxidant functions of Vitamin E, along with its signal transduction and stress regulation capacities and responses. Furthermore, the review delves into the light harvesting and photoprotection capabilities of tocopherol. By providing insights into these domains, this review offers new opportunities and avenues for using tocopherol in the management of abiotic stresses in agriculture.
RESUMEN
Emerging variants of COVID-19 have threatened the effectiveness of intramuscular (IM) vaccines since that are made to target only the spike protein. Development of Intranasal (IN) vaccination has been proven to provide both the mucosal and systemic immune responses for broader and long lasting protection. Many IN vaccine candidates (virus-vectored vaccines, recombinant subunit vaccines and live attenuated vaccines) are in different phases of clinical trials and in near future many companies would be releasing their vaccines into the drug market. Potential advantages of IN vaccination over IM vaccination makes them ideal to be administered in children and developing populations of the world. This paper focuses on the very recent developments in intranasal vaccination with a spotlight on their safety and efficacy concerns. IN vaccination can prove to be game-changer in handling COVID-19 and potential viral contagious diseases in future.
Asunto(s)
COVID-19 , Vacunas contra la Influenza , Niño , Humanos , Vacunas contra la COVID-19 , Anticuerpos Antivirales , COVID-19/prevención & control , Administración IntranasalRESUMEN
In this case report, two uncommon fractures of the root located at the apex of the mandibular anterior teeth region were successfully treated and preserved using non-surgical endodontic procedures. These teeth possess a unique size, characterized by the presence of exceptionally elongated lateral incisors measuring approximately 29 mm, central incisors measuring approximately 25 mm, and canines measuring approximately 30 mm. For the lower left central incisor, the root canal was carefully navigated to the coronal fragment, whereas the apical fragment was left undisturbed and preserved. In the case of the remarkably elongated lower right lateral incisor, the process of 'unification' between the apical and coronal fragments was accomplished through the utilization of Gutta-percha and Ah plus sealer. Subsequently, the mandibular anterior teeth were stabilized and immobilized using dental splints for a duration of one and a half months, with regular follow-ups conducted over a span of six months and one year, during which positive healing outcomes were observed.
RESUMEN
We introduce thiazolo[5,4-d]thiazole (TT)-based derivatives featuring carbazole, phenothiazine, or triphenylamine donor units as hole-selective materials to enhance the performance of wide-bandgap perovskite solar cells (PSCs). The optoelectronic properties of the materials underwent thorough evaluation and were substantially fine-tuned through deliberate molecular design. Time-of-flight hole mobility TTs ranged from 4.33 × 10-5 to 1.63 × 10-3 cm2 V-1 s-1 (at an electric field of 1.6 × 105 V cm-1). Their ionization potentials ranged from -4.93 to -5.59 eV. Using density functional theory (DFT) calculations, it has been demonstrated that S0 â S1 transitions in TTs with carbazolyl or ditert-butyl-phenothiazinyl substituents are characterized by local excitation (LE). Mixed intramolecular charge transfer (ICT) and LE occurred for compounds containing ditert-butyl carbazolyl-, dimethoxy carbazolyl-, or alkoxy-substituted triphenylamino donor moieties. The selected derivatives of TT were used for the preparation of hole-selective layers (HSL) in PSC with the structure of glass/ITO/HSLs/Cs0.18FA0.82Pb(I0.8Br0.2)3/PEAI/PC61BM/BCP/Ag. The alkoxy-substituted triphenylamino containing TT (TTP-DPA) has been demonstrated to be an effective material for HSL. Its layer also functioned well as an interlayer, improving the surface of control HSL_2PACz (i.e., reducing the surface energy of 2PACz from 66.9 to 52.4 mN m-1), thus enabling precise control over perovskite growth energy level alignment and carrier extraction/transportation at the hole-selecting contact of PSCs. 2PACz/TTP-DPA-based devices showed an optimized performance of 19.1 and 37.0% under 1-sun and 3000 K LED (1000 lx) illuminations, respectively. These values represent improvements over those achieved by bare 2PACz-based devices, which attained efficiencies of 17.4 and 32.2%, respectively. These findings highlight the promising potential of TTs for the enhancement of the efficiencies of PSCs.
RESUMEN
Renal cell carcinoma (RCC) has a predilection for metastatic spread, aggressive behavior. RCC is known for recurrence even after years of presentation. RCC has been linked to uncommon metastatic locations and unusual presenting symptoms from the disseminated illness. Common sites of metastasis include the lungs, liver, bones, brain, and adrenal glands, and many case reports are explaining the ability of RCCs to occur almost anywhere in the body. This case report states the unusual site of recurrence of RCC metastatic spread around the tip of the nose as exophytic growth years following nephrectomy. No such case is reported in the literature. We submit this case to report its occurrence, emphasize the rarity, presentation, diagnostic and therapeutic challenges, as well as a review of the literature. Renal cell carcinoma is the third most common cause of distant head and neck metastases and should be considered in the differential diagnosis of rapidly growing head and neck lesions.