RESUMEN
Repeating the BinaxNOW antigen test for severe acute respiratory syndrome coronavirus 2 using 2 groups of readers within 30 minutes resulted in high concordance (98.9%) in 2110 encounters. Same-day repeat antigen testing did not significantly improve test sensitivity (77.2% to 81.4%) while specificity remained high (99.6%).
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COVID-19 , SARS-CoV-2 , Prueba de COVID-19 , Humanos , Sensibilidad y Especificidad , Wisconsin/epidemiologíaRESUMEN
To determine prevalence of, seroprevalence of, and potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a cohort of evacuees returning to the United States from Wuhan, China, in January 2020, we conducted a cross-sectional study of quarantined evacuees from 1 repatriation flight. Overall, 193 of 195 evacuees completed exposure surveys and submitted upper respiratory or serum specimens or both at arrival in the United States. Nearly all evacuees had taken preventive measures to limit potential exposure while in Wuhan, and none had detectable SARS-CoV-2 in upper respiratory tract specimens, suggesting the absence of asymptomatic respiratory shedding among this group at the time of testing. Evidence of antibodies to SARS-CoV-2 was detected in 1 evacuee, who reported experiencing no symptoms or high-risk exposures in the previous 2 months. These findings demonstrated that this group of evacuees posed a low risk of introducing SARS-CoV-2 to the United States.
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Betacoronavirus , Técnicas de Laboratorio Clínico , Infecciones por Coronavirus/epidemiología , Neumonía Viral/epidemiología , Cuarentena/estadística & datos numéricos , Adolescente , Adulto , Anciano , COVID-19 , Prueba de COVID-19 , Niño , Preescolar , Infecciones por Coronavirus/diagnóstico , Estudios Transversales , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Pandemias , Prevalencia , SARS-CoV-2 , Estudios Seroepidemiológicos , Viaje , Estados Unidos/epidemiología , Adulto JovenRESUMEN
For clinical departments seeking to successfully navigate the challenges of modern health reform, obtaining access to operational and clinical data to establish and sustain goals for improving quality is essential. More broadly, health delivery organizations are also seeking to understand performance across multiple facilities and often across multiple electronic medical record (EMR) systems. Interpreting operational data across multiple vendor systems can be challenging, as various manufacturers may describe different departmental workflow steps in different ways and sometimes even within a single vendor's installed customer base. In 2012, The Society for Imaging Informatics in Medicine (SIIM) recognized the need for better quality and performance data standards and formed SIIM's Workflow Initiative for Medicine (SWIM), an initiative designed to consistently describe workflow steps in radiology departments as well as defining operational quality metrics. The SWIM lexicon was published as a working model to describe operational workflow steps and quality measures. We measured the prevalence of the SWIM lexicon workflow steps in both academic and community radiology environments using real-world patient observations and correlated that information with automatically captured workflow steps from our clinical information systems. Our goal was to measure frequency of occurrence of workflow steps identified by the SWIM lexicon in a real-world clinical setting, as well as to correlate how accurately departmental information systems captured patient flow through our health facility.
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Lista de Verificación , Registros Médicos/normas , Servicio de Radiología en Hospital , Vocabulario , Flujo de Trabajo , Atención a la Salud , HumanosRESUMEN
Pediatric human immunodeficiency virus (HIV) infection remains an important public health issue in resource-limited settings. In 2015, 1.4 million children aged <15 years were estimated to be living with HIV (including 170,000 infants born in 2015), with the vast majority living in sub-Saharan Africa (1). In 2014, 150,000 children died from HIV-related causes worldwide (2). Access to timely HIV diagnosis and treatment for HIV-infected infants reduces HIV-associated mortality, which is approximately 50% by age 2 years without treatment (3). Since 2011, the annual number of HIV-infected children has declined by 50%. Despite this gain, in 2014, only 42% of HIV-exposed infants received a diagnostic test for HIV (2), and in 2015, only 51% of children living with HIV received antiretroviral therapy (1). Access to services for early infant diagnosis of HIV (which includes access to testing for HIV-exposed infants and clinical diagnosis of HIV-infected infants) is critical for reducing HIV-associated mortality in children aged <15 years. Using data collected from seven countries supported by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR), progress in the provision of HIV testing services for early infant diagnosis was assessed. During 2011-2015, the total number of HIV diagnostic tests performed among HIV-exposed infants within 6 weeks after birth (tests for early infant diagnosis of HIV), as recommended by the World Health Organization (WHO) increased in all seven countries (Cote d'Ivoire, the Democratic Republic of the Congo, Haiti, Malawi, South Africa, Uganda, and Zambia); however, in 2015, the rate of testing for early infant diagnosis among HIV-exposed infants was <50% in five countries. HIV positivity among those tested declined in all seven countries, with three countries (Cote d'Ivoire, the Democratic Republic of the Congo, and Uganda) reporting >50% decline. The most common challenges for access to testing for early infant diagnosis included difficulties in specimen transport, long turnaround time between specimen collection and receipt of results, and limitations in supply chain management. Further reductions in HIV mortality in children can be achieved through continued expansion and improvement of services for early infant diagnosis in PEPFAR-supported countries, including initiatives targeted to reach HIV-exposed infants, ensure access to programs for early infant diagnosis of HIV, and facilitate prompt linkage to treatment for children diagnosed with HIV infection.
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Diagnóstico Precoz , Infecciones por VIH/diagnóstico , Tamizaje Masivo/estadística & datos numéricos , África del Sur del Sahara , Región del Caribe , Femenino , Infecciones por VIH/transmisión , Humanos , Lactante , Transmisión Vertical de Enfermedad Infecciosa , EmbarazoRESUMEN
To achieve global targets for universal treatment set forth by the Joint United Nations Programme on human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (UNAIDS), viral load monitoring for HIV-infected persons receiving antiretroviral therapy (ART) must become the standard of care in low- and middle-income countries (LMIC) (1). CDC and other U.S. government agencies, as part of the President's Emergency Plan for AIDS Relief, are supporting multiple countries in sub-Saharan Africa to change from the use of CD4 cell counts for monitoring of clinical response to ART to the use of viral load monitoring, which is the standard of care in developed countries. Viral load monitoring is the preferred method for immunologic monitoring because it enables earlier and more accurate detection of treatment failure before immunologic decline. This report highlights the initial successes and challenges of viral load monitoring in seven countries that have chosen to scale up viral load testing as a national monitoring strategy for patients on ART in response to World Health Organization (WHO) recommendations. Countries initiating viral load scale-up in 2014 observed increases in coverage after scale-up, and countries initiating in 2015 are anticipating similar trends. However, in six of the seven countries, viral load testing coverage in 2015 remained below target levels. Inefficient specimen transport, need for training, delays in procurement and distribution, and limited financial resources to support scale-up hindered progress. Country commitment and effective partnerships are essential to address the financial, operational, technical, and policy challenges of the rising demand for viral load monitoring.
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Infecciones por VIH/virología , Vigilancia de la Población , Carga Viral , África del Sur del Sahara , Fármacos Anti-VIH/uso terapéutico , Infecciones por VIH/tratamiento farmacológico , HumanosRESUMEN
On July 20, 2014, an acutely ill traveler from Liberia arrived at the international airport in Lagos, Nigeria, and was confirmed to have Ebola virus disease (Ebola) after being admitted to a private hospital. This index patient potentially exposed 72 persons at the airport and the hospital. The Federal Ministry of Health, with guidance from the Nigeria Centre for Disease Control (NCDC), declared an Ebola emergency. Lagos, (pop. 21 million) is a regional hub for economic, industrial, and travel activities and a setting where communicable diseases can be easily spread and transmission sustained. Therefore, implementing a rapid response using all available public health assets was the highest priority. On July 23, the Federal Ministry of Health, with the Lagos State government and international partners, activated an Ebola Incident Management Center as a precursor to the current Emergency Operations Center (EOC) to rapidly respond to this outbreak. The index patient died on July 25; as of September 24, there were 19 laboratory-confirmed Ebola cases and one probable case in two states, with 894 contacts identified and followed during the response. Eleven patients with laboratory-confirmed Ebola had been discharged, an additional patient was diagnosed at convalescent stage, and eight patients had died (seven with confirmed Ebola; one probable). The isolation wards were empty, and 891 (all but three) contacts had exited follow-up, with the remainder due to exit on October 2. No new cases had occurred since August 31, suggesting that the Ebola outbreak in Nigeria might be contained. The EOC, established quickly and using an Incident Management System (IMS) to coordinate the response and consolidate decision making, is largely credited with helping contain the Nigeria outbreak early. National public health emergency preparedness agencies in the region, including those involved in Ebola responses, should consider including the development of an EOC to improve the ability to rapidly respond to urgent public health threats.
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Brotes de Enfermedades/prevención & control , Fiebre Hemorrágica Ebola/epidemiología , Fiebre Hemorrágica Ebola/prevención & control , Práctica de Salud Pública , Trazado de Contacto , Ebolavirus/aislamiento & purificación , Humanos , Nigeria/epidemiología , ViajeRESUMEN
Since the World Health Organization and the Joint United Nations Programme on HIV/AIDS recommended implementation of medical male circumcision (MC) as part of HIV prevention in areas with low MC and high HIV prevalence rates in 2007, the government of Kenya has developed a strategy to circumcise 80% of uncircumcised men within five years. To facilitate the quick translation of research to practice, a national MC task force was formed in 2007, a medical MC policy was implemented in early 2008, and Nyanza Province, the region with the highest HIV burden and low rates of circumcision, was prioritized for services under the direction of a provincial voluntary medical male circumcision (VMMC) task force. The government's early and continuous engagement with community leaders/elders, politicians, youth, and women's groups has led to the rapid endorsement and acceptance of VMMC. In addition, several innovative approaches have helped to optimize VMMC scale-up. Since October 2008, the Kenyan VMMC program has circumcised approximately 290,000 men, mainly in Nyanza Province, an accomplishment made possible through a combination of governmental leadership, a documented implementation strategy, and the adoption of appropriate and innovative approaches. Kenya's success provides a model for others planning VMMC scale-up programs.
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Circuncisión Masculina/estadística & datos numéricos , Infecciones por VIH/prevención & control , Programas Nacionales de Salud/organización & administración , Adolescente , Adulto , Atención a la Salud/organización & administración , Infecciones por VIH/epidemiología , Personal de Salud/organización & administración , Política de Salud/legislación & jurisprudencia , Humanos , Kenia/epidemiología , Masculino , Persona de Mediana Edad , Programas Nacionales de Salud/legislación & jurisprudencia , Servicios Preventivos de Salud/legislación & jurisprudencia , Servicios Preventivos de Salud/organización & administración , Investigación Biomédica Traslacional , Recursos Humanos , Adulto JovenRESUMEN
PURPOSE: We aimed to assess perceptions of, and training regarding, the publishing process among US radiation oncology (RO) residents, focusing on awareness and understanding of criteria for selecting appropriate and legitimate peer-reviewed journals for academic publishing. The growing challenge of predatory publication in the broader scientific realm and its relevancy to resident training is also briefly discussed. METHODS AND MATERIALS: A survey was opened to residents of all Accreditation Council for Graduate Medical Education-accredited RO programs in the United States, focusing on 3 categories: (1) demographics; (2) submission, peer review, and publication of academic research; and (3) subjective ranking of factors for choosing an appropriate publisher/journal. Results were stratified by level of training and number of publications. RESULTS: Overall, 150 of 690 residents (19.8%) responded, with a 98% (147 of 150) completion rate. Twenty of 150 residents (13.3%) reported formal training in manuscript preparation and choosing academic journals. Only 3.4% of residents reported departmental guidelines regarding publication in "predatory" journals; 57.7% were unsure. The 3 most important factors influencing publisher and journal choice were impact factor (ranked first for 59.0%), whether a journal is found in a major index (ranked first for 18.0%), and association with a reputable organization (ranked first for 17.0%). Importance of impact factor increased with number of publications (50% with 0 publications, 48.3% with 1-5, 63.9% with 5-10, 76.2% with 10-15, and 70.6% with >15). Cost considerations influenced journal choice at least once for 79 (52.7%) residents. CONCLUSIONS: Impact factor was the most important consideration for residents when choosing an appropriate publisher, with increased emphasis with increasing number of publications. A minority had formal training in choosing appropriate academic journals and knowing how to identify so-called predatory journals or were aware if their department has proscriptions regarding publication in such journals. Additional emphasis on formal training for RO residents in manuscript preparation and choosing academic journals is warranted.
RESUMEN
OBJECTIVE: The purpose of this study was to examine the intermediate-distance visual acuity of a cross section of radiologists and to identify variation in visual acuity during a typical workday. SUBJECTS AND METHODS: Forty-eight radiologists completed a brief survey before undergoing visual acuity testing, with corrective lenses if routinely used, at three times of the day. Testing was performed with modified versions of a U.S. Federal Aviation Administration visual acuity test instrument. RESULTS: The mean acuity of radiologists across all measurements was 20/15 (logarithm of the minimum angle of resolution [logMAR], -0.109 +/- 0.105 [SD]). Visual acuity ranged from 20/30 to 20/10 (logMAR, 0.176 to -0.301). Mean visual acuity in the morning session was approximately 20/16 (logMAR, -0.0856). This value was statistically significantly lower than the mean visual acuity in both the early afternoon (logMAR, -0.124; p = 0.003) and the late afternoon (logMAR, -0.118; p = 0.015), both of which were approximately 20/15. This change was within the expected test-retest variability of Snellen acuity measurements. CONCLUSION: Although a statistically significant difference was detected between the visual acuity of radiologists in the morning and acuity in other parts of the day, this difference was relatively modest and within previously published ranges of variability for similar visual acuity tests. It is unlikely that such variation in visual acuity among radiologists influences diagnostic performance. Not every radiologist had 20/20 vision, a few needed visual correction, and more than a few had not undergone a thorough eye examination for as many as 15 years before the study.
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Médicos/estadística & datos numéricos , Garantía de la Calidad de Atención de Salud/estadística & datos numéricos , Intensificación de Imagen Radiográfica , Radiología/estadística & datos numéricos , Pruebas de Visión/estadística & datos numéricos , Agudeza Visual , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pakistán , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Estados Unidos , Recursos HumanosRESUMEN
PURPOSE: To review and assess ongoing proton beam therapy (PBT) clinical trials and to identify major gaps. METHODS AND MATERIALS: Active PBT clinical trials were identified from clinicaltrials.gov and the World Health Organization International Clinical Trials Platform Registry. Data on clinical trial disease site, age group, projected patient enrollment, expected start and end dates, study type, and funding source were extracted. RESULTS: A total of 122 active PBT clinical trials were identified, with target enrollment of >42,000 patients worldwide. Ninety-six trials (79%), with a median planned sample size of 68, were classified as interventional studies. Observational studies accounted for 21% of trials but 71% (n=29,852) of planned patient enrollment. The most common PBT clinical trials focus on gastrointestinal tract tumors (21%, n=26), tumors of the central nervous system (15%, n=18), and prostate cancer (12%, n=15). Five active studies (lung, esophagus, head and neck, prostate, breast) will randomize patients between protons and photons, and 3 will randomize patients between protons and carbon ion therapy. CONCLUSIONS: The PBT clinical trial portfolio is expanding rapidly. Although the majority of ongoing studies are interventional, the majority of patients will be accrued to observational studies. Future efforts should focus on strategies to encourage optimal patient enrollment and retention, with an emphasis on randomized, controlled trials, which will require support from third-party payers. Results of ongoing PBT studies should be evaluated in terms of comparative effectiveness, as well as incremental effectiveness and value offered by PBT in comparison with conventional radiation modalities.
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Práctica Clínica Basada en la Evidencia , Neoplasias/radioterapia , Estudios Observacionales como Asunto/estadística & datos numéricos , Selección de Paciente , Terapia de Protones , Ensayos Clínicos Controlados Aleatorios como Asunto/estadística & datos numéricos , Adulto , Neoplasias de la Mama/radioterapia , Neoplasias del Sistema Nervioso Central/epidemiología , Neoplasias del Sistema Nervioso Central/radioterapia , Niño , Bases de Datos Factuales/estadística & datos numéricos , Neoplasias Esofágicas/radioterapia , Femenino , Neoplasias Gastrointestinales/epidemiología , Neoplasias Gastrointestinales/radioterapia , Neoplasias de Cabeza y Cuello/radioterapia , Radioterapia de Iones Pesados , Humanos , Neoplasias Pulmonares/radioterapia , Masculino , Neoplasias/epidemiología , Estudios Observacionales como Asunto/normas , Fotones/uso terapéutico , Neoplasias de la Próstata/radioterapia , Terapia de Protones/normas , Terapia de Protones/estadística & datos numéricos , Ensayos Clínicos Controlados Aleatorios como Asunto/normas , Apoyo a la Investigación como Asunto/estadística & datos numéricos , Tamaño de la MuestraRESUMEN
PURPOSE: Evolving cancer screening guidelines can confuse the public. Caregivers of patients undergoing radiation oncology may represent a promising outreach target for disseminating and clarifying screening information. We aimed to: (1) determine the incidence of cancer screening in this cohort, and (2) identify barriers to and deficiencies in screening. METHODS: We distributed a 21-item survey on cancer screening history and related concerns to caregivers ≥ 18 years old at one urban and two suburban radiation oncology centers. Reported screening habits were compared with American Cancer Society/American Urological Association guidelines for breast, cervical, colon, and prostate cancer. Statistical analysis included Pearson χ(2) tests. RESULTS: A total of 209 caregivers (median age, 55.5 years; 146 women) were surveyed. Although 92% had primary care physicians (PCPs), only 58% reported being informed about recommended screening intervals. Participants ≤ 49 years old were less likely to report PCP discussion of cancer screening than older participants (41% and 66%, respectively; P = .006). Ninety-eight respondents (47%) had one or more screening concern(s). Among screening-eligible caregivers, 23 (18%) reported not undergoing regular colonoscopies. Fourteen women (13%) did not have Papanicolaou smears at recommended intervals, and 21 (18%) did not have annual mammograms. Six men (21%) did not undergo annual prostate screening. Decreased recommended screening with colonoscopy and mammography correlated with younger age. CONCLUSION: This survey of relatively unexplored caregivers identified cancer screening deficiencies and concerns that might be addressed by targeted interventions. With approximately 60% of patients with cancer receiving radiation therapy, advice in the radiation oncology setting could positively affect cancer screening behaviors in caregivers.
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Cuidadores/psicología , Detección Precoz del Cáncer , Neoplasias/diagnóstico , Neoplasias/radioterapia , Pautas de la Práctica en Medicina , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Detección Precoz del Cáncer/métodos , Femenino , Adhesión a Directriz , Encuestas de Atención de la Salud , Conocimientos, Actitudes y Práctica en Salud , Accesibilidad a los Servicios de Salud , Humanos , Masculino , Persona de Mediana Edad , Neoplasias/epidemiología , Fumar , Adulto JovenRESUMEN
Radiologists, referring physicians, and patients all have certain legal rights regarding access to medical records, including imaging data. The degree of patient access is likely to increase with the growing adoption of patient portals and personal health records. In addition, referring physicians and radiologists have a collective responsibility to ensure that important findings are transferred appropriately between their practices. In some cases when this is not possible, communicating directly with patients is the best way to protect the interests of both patients and radiologists. Even when not required, some radiologists have extensive experience communicating results directly to patients. Direct communication of radiology results to patients may present an opportunity to satisfy patients and reassert the importance of the physician-patient relationship in radiology.
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Acceso de los Pacientes a los Registros/ética , Acceso de los Pacientes a los Registros/legislación & jurisprudencia , Relaciones Médico-Paciente/ética , Radiología/ética , Radiología/legislación & jurisprudencia , Humanos , Estados UnidosRESUMEN
The process of image review and interpretation has become increasingly complex and challenging for today's nuclear medicine physician from many perspectives, especially with regard to workstation integration and reading room ergonomics. With the recent proliferation of hybrid imaging systems, this complexity has increased rapidly, along with the number of studies performed. At the same time, clinicians throughout the health care enterprise are expecting remote access to nuclear medicine images whereas nuclear medicine physicians require reliable access at the point of care to the electronic medical record and to medical images from radiology and cardiology. The authors discuss the background and challenges related to integration of nuclear medicine into the health care enterprise and provide a series of recommendations for advancing successful integration efforts. Also addressed are unique characteristics of the nuclear medicine environment as well as ergonomic, lighting, and environmental considerations in the design and redesign of the modern reading room.
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Diagnóstico por Imagen/instrumentación , Ergonomía , Sistemas de Registros Médicos Computarizados , Medicina Nuclear , Sistemas de Información Radiológica , Diseño Asistido por Computadora , Humanos , Iluminación , Ruido/prevención & control , Servicio de Radiología en HospitalRESUMEN
Implicit change detection demonstrates how the visual system can benefit from stored information that is not immediately available to conscious awareness. We investigated the role of motor action in this context. In the first two experiments, using a one-shot implicit change-detection paradigm, participants responded to unperceived changes either with an action (jabbing the screen at the guessed location of a change) or with words (verbal report), and sat either 60 cm or 300 cm (with a laser pointer) away from the display. Our observers guessed the locations of changes at a reachable distance better with an action than with a verbal judgment. At 300 cm, beyond reach, the motor advantage disappeared. In experiment 3, this advantage was also unavailable when participants sat at a reachable distance but responded with hand-held laser pointers near their bodies. We conclude that a motor system specialized for real-time visually guided behavior has access to additional visual information. Importantly, this system is not activated by merely executing an action (experiment 2) or presenting stimuli in one's near space (experiment 3). It is activated only when both conditions are fulfilled, which implies that it is the actual contact that matters to the visual system.