RESUMEN
Induction of sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) by two antineoplastic drugs--phopurinum (2-dimethylamino-6-diethyleneiminophosphamido-7-methylpurine) and recombinant human interferon alpha 2 (rHuIFN-alpha 2) was studied in human lymphocytes in vitro. Phopurinum was found to cause a significant increase of both SCEs and CAs in lymphocytes, while rHuIFN-alpha 2 induced only SCEs. Combined treatment with these two drugs reduced SCE and CA levels as compared with those induced by phopurinum alone. The maximal extent of reduction, however, was observed at intermediate doses of phopurinum.
Asunto(s)
Antineoplásicos/toxicidad , Aziridinas , Aberraciones Cromosómicas , Interferón Tipo I/farmacología , Compuestos Organofosforados/toxicidad , Purinas/toxicidad , Intercambio de Cromátides Hermanas/efectos de los fármacos , Adulto , Interacciones Farmacológicas , Femenino , Humanos , Interferón Tipo I/toxicidad , Proteínas RecombinantesRESUMEN
The effects of alcohol consumption, cigarette smoking and age on sister chromatid exchange (SCE) frequency in human lymphocytes were assessed by means of multiple linear regression. An increase in SCE rates was associated with alcohol consumption (p = 0.0001), smoking (p = 0.0231), and, to a small extent (p = 0.057), age. These three confounding factors explain 48% of the inter-personal variation in SCE rates among subjects studied.