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1.
Ann Hum Biol ; 43(1): 73-7, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26065693

RESUMEN

BACKGROUND: The most abundant of the collagen protein family, type I collagen is encoded by the COL1A2 gene. The COL1A2 restriction fragment length polymorphisms (RFLPs) EcoRI, RsaI and MspI in samples from several different central-eastern Mediterranean populations were analysed and found to be potentially informative anthropogenetic markers. AIM: The objective was to define the genetic variability of COL1A2 in the central-eastern Mediterranean and to shed light on its genetic distribution in human groups over a wide geographic area. SUBJECTS AND METHODS: PCR-RFLP analysis of EcoRI, RsaI and MspI polymorphisms of the COL1A2 gene was performed on oral swab and blood samples from 308 individuals from the central-eastern Mediterranean Basin. The genetic similarities among these groups and other populations described in the literature were investigated through correspondence analysis. RESULTS: Single-marker data and haplotype frequencies seemed to suggest a genetic homogeneity within the European populations, whereas a certain degree of differentiation was noted for the Egyptians and the Turks. CONCLUSIONS: The genetic variability in the central-eastern Mediterranean area is probably a result of the geographical barrier of the Mediterranean Sea, which separated European and African populations over time.


Asunto(s)
Colágeno Tipo I/genética , Genética de Población , Polimorfismo de Longitud del Fragmento de Restricción , Croacia , Egipto , Femenino , Frecuencia de los Genes , Geografía , Haplotipos , Humanos , Italia , Funciones de Verosimilitud , Masculino , Región Mediterránea , Fenotipo , Serbia , Turquía
2.
Am J Phys Anthropol ; 149(3): 380-90, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22976802

RESUMEN

Stable isotope analysis of human remains has been used to address long-standing debates regarding the speed and degree to which the introduction of farming transformed diet. In Europe, this debate has centered on northern and Atlantic regions with much less attention devoted to the arrival of farming across the Mediterranean. This study presents carbon and nitrogen stable isotope analyses of collagen from 19 human and 37 faunal remains from eight sites in the Apulia and Marche regions of south-eastern and central Italy, dating to the early phases of agricultural adoption during the first half of the 6th Millennium BC. Where collagen preservation permitted, sulfur stable isotope analysis was also performed. Overall, there was significant isotopic variation between the different geographic regions, although there was also considerable uncertainty in interpreting these data, especially given heterogeneous isotope values for fauna from site to site. By considering isotope data from each region separately, it was noticeable that the degree of carbon isotope enrichment in humans compared to fauna was higher for individuals buried near the coast, consistent with increased marine consumption. Coastal individuals also had higher sulfur isotope values. Nitrogen isotope values were very variable between individuals and regions and, in some cases, were consistent with very high plant food consumption. Overall, early "farmers" in south-east and central Italy consumed a wide range of foods, including marine, and had much more variable stable isotope values than those observed in central and northern Europe during this period, perhaps indicating a different mode for agricultural adoption.


Asunto(s)
Agricultura/historia , Arqueología , Isótopos de Carbono/análisis , Dieta/historia , Isótopos de Nitrógeno/análisis , Adulto , Animales , Huesos/química , Colágeno Tipo I/análisis , Colágeno Tipo I/química , Historia Antigua , Humanos , Italia
3.
Am J Phys Anthropol ; 139(4): 572-83, 2009 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19280672

RESUMEN

Here we report on a stable isotope palaeodietary study of a Imperial Roman population interred near the port of Velia in Southern Italy during the 1st and 2nd centuries AD. Carbon and nitrogen stable isotope analyses were performed on collagen extracted from 117 adult humans as well as a range of fauna to reconstruct individual dietary histories. For the majority of individuals, we found that stable isotope data were consistent with a diet high in cereals, with relatively modest contributions of meat and only minor contributions of marine fish. However, substantial isotopic variation was found within the population, indicating that diets were not uniform. We suggest that a number of individuals, mainly but not exclusively males, had greater access to marine resources, especially high trophic level fish. However, the observed dietary variation did not correlate with burial type, number of grave goods, nor age at death. Also, individuals buried at the necropolis at Velia ate much less fish overall compared with the contemporaneous population from the necropolis of Portus at Isola Sacra, located on the coast close to Rome. Marine and riverine transport and commerce dominated the economy of Portus, and its people were in a position to supplement their own stocks of fish with imported goods in transit to Rome, whereas at Velia marine exploitation existed side-by-side with land-based economic activities.


Asunto(s)
Dieta/historia , Fósiles , Factores de Edad , Isótopos de Carbono/análisis , Colágeno/química , Historia Antigua , Humanos , Italia , Isótopos de Nitrógeno/análisis , Factores Sexuales
4.
Ann Hum Biol ; 34(4): 425-36, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17620151

RESUMEN

BACKGROUND: Restriction fragment length polymorphisms (RFLPs) of the COL1A2 and CYP1A1 and short tandem repeats of HS1,2 Ig enhancer genes are proving to be useful markers for describing human populations and thus are of interest for anthropogenetic research. Moreover, they can provide useful information in identifying alleles and haplotypes associated with particular forms of common diseases or for pharmacogenomics studies. AIM: The objective of this study was to define the genetic structure of Libyan Tuaregs and to establish the degree of genetic homogeneity amongst the El Awaynat and Tahala groups. SUBJECTS AND METHODS: Tuareg individuals from El Awaynat (n = 99) and Tahala (n = 18), in Libyan Sahara, were analysed for the RFLPs of COL1A2 and CYP1A1 and short tandem repeats of HS1,2 Ig enhancer genes. In order to provide a clearer picture of COL1A2, CYP1A1 and HS1,2 Ig enhancer allele and haplotype frequency distributions in various human groups distributed over a wide geographic area, comparisons with other African, European and Asian populations were carried out by analysis of molecular variance (AMOVA) and genetic distance analysis. RESULTS: No significant level of differentiation was evident between the two Libyan Tuareg groups according to AMOVA. For the CYP1A1 gene, a possible new haplotype was observed, even though at a very low frequency. Linkage disequilibrium was assessed only for COL1A2, since CYP1A1 turned out to be poorly polymorphic for m2 and m3. CONCLUSIONS: Statistical analyses showed that Tuaregs from Libya are located in a intermediate position between south Saharan populations on one side and the Europeans and the Asians on the other.


Asunto(s)
Población Negra , Colágeno/genética , Citocromo P-450 CYP1A1/genética , Elementos de Facilitación Genéticos/genética , Polimorfismo de Nucleótido Simple/genética , Grupos de Población/genética , Adolescente , Adulto , Población Negra/etnología , Población Negra/genética , Colágeno Tipo I , Femenino , Genes de las Cadenas Pesadas de las Inmunoglobulinas/genética , Genética de Población , Humanos , Inmunoglobulinas/genética , Libia , Masculino , Repeticiones de Microsatélite , Persona de Mediana Edad , Polimorfismo de Longitud del Fragmento de Restricción , Migrantes
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