RESUMEN
Whether the variations in the hemochromatosis (HFE) gene increase Alzheimer's disease (AD) risk is still undetermined. We performed a meta-analysis in order to systematically summarize the possible association. Studies were identified by searching PUBMED, Web of Science and EMBASE databases complemented with screening the references of the retrieved studies. The association was measured using random-effect or fixed-effect odds ratio (OR) combined with 95% confidence intervals (CIs) according to the studies' heterogeneity. For C282Y polymorphism, we did not find any association using data from 22 studies including 4,365 cases and 8,652 controls. For H63D polymorphism, on the basis of 2,795 cases and 7,424 controls from 17 studies, we observed a significant association (allele contrast: OR = 0.902, 95% CI = 0.819-0.994, P = 0.037; minor-allele-dominant model: OR = 0.887, 95% CI = 0.790-0.996, P = 0.043). No publication bias was detected in this meta-analysis. The synthesis of available evidence supports mutant of HFE H63D polymorphism plays a protective role for AD risk.
Asunto(s)
Enfermedad de Alzheimer/epidemiología , Enfermedad de Alzheimer/genética , Predisposición Genética a la Enfermedad/genética , Antígenos de Histocompatibilidad Clase I/genética , Proteínas de la Membrana/genética , Polimorfismo Genético/genética , Estudios de Casos y Controles , Frecuencia de los Genes , Estudios de Asociación Genética , Proteína de la Hemocromatosis , Humanos , Patrón de Herencia/genética , Oportunidad Relativa , Sesgo de Publicación , Factores de RiesgoRESUMEN
BACKGROUND: The impact of an overall healthy lifestyle on early-onset stroke is still unclear. Our study thus aimed to investigate the association of overall healthy lifestyle on early-onset stroke in Chinese hospitalized stroke patients. METHODS: This retrospective study included 821 hospitalized stroke patients from the First People's Hospital of Changzhou. An overall healthy lifestyle was defined as the presence of more than 2 of the following items: healthy diet, no smoking, normal body mass index (BMI <24 kg/m2 ), engaging in moderate to high physical activity (≥3 times/week, and ≥30 minutes each time). Early-onset stroke was defined as a stroke first occurring at 50 years old or younger. RESULTS: Among all participants, there were 98 early-onset stroke patients and 723 late-onset stroke patients. Early-onset patients had a lower prevalence of overall healthy lifestyles than that of late-onset patients (P<0.001). Multivariate logistic regression revealed that an overall healthy lifestyle significantly reduced the risk of early-onset stroke. In reference to those without an overall healthy lifestyle, the multivariate-adjusted odds ratios (ORs) for early-onset stroke among participants with an overall healthy lifestyle was 0.27 [95% confidence interval (CI): 0.07-0.98]. CONCLUSIONS: In Chinese stroke patients, a healthy lifestyle was significantly associated with early-onset stroke. Individuals who were adhering to an overall healthy lifestyle had a lower risk of early-onset stroke compared to those who were not.