RESUMEN
Volume-phase holographic (VPH) gratings have been designed for use in many areas of science and technology, such as optical communication, optical imaging, and astronomy. In this paper, the design of a volume-phase holographic grating, simultaneously optimized to operate in the red, green, and blue wavelengths, is presented along with a study of its fabrication tolerances. The grating is optimized to produce 98% efficiency at λ=532 nm and at least 75% efficiency in the region between 400 and 700 nm, when the incident light is unpolarized. The optimization is done for recording in dichromated gelatin with a thickness of 12 µm, an average refractive index of 1.5, and a refractive index modulation of 0.022.
RESUMEN
Bayfol® HX200 photopolymer is a holographic recording material used in a variety of applications such as a holographic combiner for a heads-up display and augmented reality, dispersive grating for spectrometers, and notch filters for Raman spectroscopy. For these systems, the thermal properties of the holographic material are extremely important to consider since temperature can affect the diffraction efficiency of the hologram as well as its spectral bandwidth and diffraction angle. These thermal variations are a consequence of the distance and geometry change of the diffraction Bragg planes recorded inside the material. Because temperatures can vary by a large margin in industrial applications (e.g., automotive industry standards require withstanding temperature up to 125°C), it is also essential to know at which temperature the material starts to be affected by permanent damage if the temperature is raised too high. Using thermogravimetric analysis, as well as spectral measurement on samples with and without hologram, we measured that the Bayfol® HX200 material does not suffer from any permanent thermal degradation below 160°C. From that point, a further increase in temperature induces a decrease in transmission throughout the entire visible region of the spectrum, leading to a reduced transmission for an original 82% down to 27% (including Fresnel reflection). We measured the refractive index change over the temperature range from 24°C to 100°C. Linear interpolation give a slope 4.5×10-4K-1 for unexposed film, with the extrapolated refractive index at 0°C equal to n0=1.51. This refractive index change decreases to 3×10-4K-1 when the material is fully cured with UV light, with a 0°C refractive index equal to n0=1.495. Spectral properties of a reflection hologram recorded at 532 nm was measured from 23°C to 171°C. A consistent 10 nm spectral shift increase was observed for the diffraction peak wavelength when the temperature reaches 171°C. From these spectral measurements, we calculated a coefficient of thermal expansion (CTE) of 384×10-6K-1 by using the coupled wave theory in order to determine the increase of the Bragg plane spacing with temperature.
RESUMEN
BACKGROUND: A longitudinal Anopheles gambiae s.l. insecticide resistance monitoring programme was established in four sentinel sites in Chad 2008-2010. When this programme ended, only sporadic bioassays were performed in a small number of sites. METHODS: WHO diagnostic dose assays were used to measure the prevalence of insecticide resistance to 0.1% bendiocarb, 4% DDT, 0.05% deltamethrin, 1% fenitrothion, and 0.75% permethrin in the main malaria vectors at the beginning and end of the malaria transmission season for three years 2008-2010, with subsequent collections in 2011 and 2014. Species and molecular identification of An. gambiae M and S forms and kdr genotyping was performed using PCR-RLFP; circumsporozoite status was assessed using ELISA. RESULTS: Between 2008 and 2010, significant changes in insecticide resistance profiles to deltamethrin and permethrin were seen in 2 of the sites. No significant changes were seen in resistance to DDT in any site during the study period. Testing performed after the period of routine monitoring had ended showed dramatic increases to DDT and pyrethroid resistance in 3 sites. No resistance to organophosphate or carbamate insecticides was detected. An. arabiensis was the predominate member of the An. gambiae complex in all 4 sites; adult collections showed temporal variation in species composition in only 1 site. Kdr analysis identified both 1014F and 1014S alleles in An. gambiae S only. Circumsporozoite analysis showed the highest vector infection rates were present in Donia, a site with extensive use of agricultural insecticides. CONCLUSIONS: During the monitoring gap of four years, significant changes occurred in resistance prevalence in 3 of the 4 sites (p = <0.001), endangering the efficacy of currently implemented malaria control interventions. Significant changes in insecticide resistance profiles and a lack of kdr resistance alleles in adult populations highlight the urgent need for comprehensive entomological monitoring to be implemented and sustained in country.
Asunto(s)
Anopheles/efectos de los fármacos , Vectores de Enfermedades , Resistencia a los Insecticidas , Insecticidas/farmacología , Malaria/diagnóstico , Malaria/tratamiento farmacológico , Animales , Anopheles/genética , Proteínas de Insectos/genética , Estudios Longitudinales , Malaria/mortalidadRESUMEN
The search for the earliest fossil evidence of the human lineage has been concentrated in East Africa. Here we report the discovery of six hominid specimens from Chad, central Africa, 2,500 km from the East African Rift Valley. The fossils include a nearly complete cranium and fragmentary lower jaws. The associated fauna suggest the fossils are between 6 and 7 million years old. The fossils display a unique mosaic of primitive and derived characters, and constitute a new genus and species of hominid. The distance from the Rift Valley, and the great antiquity of the fossils, suggest that the earliest members of the hominid clade were more widely distributed than has been thought, and that the divergence between the human and chimpanzee lineages was earlier than indicated by most molecular studies.