RESUMEN
Visceral leishmaniasis (VL) can be regarded as a rare opportunistic infection in patients with acute lymphoblastic leukemia (ALL). We report the case of a 20-year-old woman treated for ALL. During maintenance treatment, the patient presents with pallor, prolonged fever and asthenia. The examination objective splenomegaly and blood counts showed pancytopenia. The bone marrow aspiration confirmed the diagnosis of VL. The patient was treated with antimoniate of meglumine with good evolution.
Asunto(s)
Leishmaniasis Visceral/complicaciones , Leishmaniasis Visceral/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicaciones , Leucemia-Linfoma Linfoblástico de Células Precursoras/diagnóstico , Antimonio/uso terapéutico , Antiprotozoarios/uso terapéutico , Femenino , Humanos , Leishmaniasis Visceral/tratamiento farmacológico , Quimioterapia de Mantención , Meglumina/uso terapéutico , Infecciones Oportunistas/complicaciones , Infecciones Oportunistas/diagnóstico , Compuestos Organometálicos/uso terapéutico , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamiento farmacológico , Adulto JovenRESUMEN
The association between paraneoplasic nephrotic syndrome and Hodgkin's disease is rare. We report a case of Hodgkin's lymphoma in a young female patient with nephrotic syndrome. A 40-year-old woman presented with the clinical symptoms of nephrotic syndrome, kidney biopsy revealed minimal change glomerulonephritis. A treatment with prednisone was started but the response was partial. Twenty-four months after the diagnostic of nephrotic syndrome was made, she presented prolonged fever and weight loss, the physical examination showed cervical lymphadenopathy, which lymph node biopsy revealed Hodgkin lymphoma of the nodular sclerosing type. The patient was treated for Hodgkin disease stage IVB with ABVD regimen, and was in complete remission of both Hodgkin's disease and nephrotic syndrome.
Asunto(s)
Enfermedad de Hodgkin/diagnóstico , Síndrome Nefrótico/diagnóstico , Adulto , Diagnóstico Diferencial , Femenino , Enfermedad de Hodgkin/complicaciones , Humanos , Síndrome Nefrótico/complicacionesRESUMEN
The first meeting of the African Blood and Marrow Transplantation (AfBMT) was held in Casablanca from April 19, 2018 to April 21, 2018, with the aim of fostering hematopoietic stem cell transplantation (HSCT) activity in Africa. Out of the 54 African countries, HSCT is available only in six (Algeria, Egypt, Morocco, Nigeria, South Africa, and Tunisia). During this meeting, African teams and international experts from the Worldwide Network for Blood and Marrow Transplantation (WBMT) gathered to share their experience and discussed ways to help fill the gap. Nurses and patients held their meeting in parallel. International support and collaboration can help by providing expertise adapted to local resources and regional population needs. Local engagement including government and private participants are necessary to initiate and develop local HSCT capability.
Asunto(s)
Trasplante de Médula Ósea , Trasplante de Células Madre Hematopoyéticas , Congresos como Asunto , MarruecosRESUMEN
Hematopoietic Stem Cell Transplantation (HSCT) activity was evaluated in the African (AFR)/EMRO region and compared to the global activity for the years 2006-2013. Data were obtained from 1570 teams in the 6 WHO continental regions. Of these, 29 (1.85%) of all teams were active in 12 of the 68 AFR/EMRO countries. They reported 2.331 (3.3%) of the worldwide 71.036 HSCT, and a transplant rate of 32.8 (TR; HSCT/10 million inhabitants; worldwide 128.5). This reflects still the lowest regional TR despite an increase of 90% since 2006. HSCT activity in AFR/EMRO countries was characterized by a higher use of allogeneic compared to autologous HSCT, an almost exclusive use of family donors, including haploidentical family donors. These findings contrast with the prevalence of autologous over allogeneic HSCT, and a higher frequency of unrelated HSCT in other parts of the world. Of note, the increase by 200% in HSCT for hemoglobinopathies from 2006 to 2013 (72 per year) in the AFR/EMRO region. This reflects the specific role of HSCT for these disease categories with high prevalence and incidence in the AFR/EMRO region. This report provides information for the competent authorities to foster adequate infrastructure. It urges transplant organization to optimize their cooperation.
Asunto(s)
Trasplante de Células Madre Hematopoyéticas/métodos , África , Trasplante de Células Madre Hematopoyéticas/tendencias , Humanos , Estudios Retrospectivos , Acondicionamiento Pretrasplante/métodos , Acondicionamiento Pretrasplante/tendenciasAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Leucemia Mieloide Aguda/tratamiento farmacológico , Paraplejía/inducido químicamente , Femenino , Humanos , Inyecciones Espinales , Persona de Mediana Edad , MarruecosAsunto(s)
Hiperamilasemia/diagnóstico , Hiperamilasemia/etiología , Mieloma Múltiple/complicaciones , Anciano , Amilasas/sangre , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Ácidos Borónicos/administración & dosificación , Bortezomib , Dexametasona/administración & dosificación , Femenino , Humanos , Hiperamilasemia/epidemiología , Incidencia , Mieloma Múltiple/diagnóstico , Mieloma Múltiple/tratamiento farmacológico , Mieloma Múltiple/epidemiología , Pirazinas/administración & dosificación , Inducción de Remisión , Talidomida/administración & dosificaciónAsunto(s)
Leucemia Mieloide Aguda/terapia , Complicaciones Neoplásicas del Embarazo/terapia , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Femenino , Humanos , Quimioterapia de Inducción/métodos , Recién Nacido , Leucemia Mieloide Aguda/complicaciones , Leucemia Mieloide Aguda/diagnóstico , Atención Posnatal , Embarazo , Complicaciones Neoplásicas del Embarazo/diagnóstico , Pronóstico , Factores de Tiempo , Resultado del Tratamiento , Espera VigilanteAsunto(s)
Anemia Ferropénica/terapia , Hematología/tendencias , Anemia Ferropénica/sangre , Anemia Ferropénica/diagnóstico , Anemia Ferropénica/genética , Animales , Femenino , Hematología/métodos , Humanos , Lactante , Hierro/sangre , Hierro/metabolismo , Hierro/uso terapéutico , Masculino , Proteínas de la Membrana/genética , Proteínas de la Membrana/fisiología , Serina Endopeptidasas/genética , Serina Endopeptidasas/fisiologíaAsunto(s)
Anticuerpos Monoclonales de Origen Murino/uso terapéutico , Enfermedades del Sistema Inmune/tratamiento farmacológico , Complicaciones Hematológicas del Embarazo/tratamiento farmacológico , Púrpura Trombocitopénica/tratamiento farmacológico , Animales , Anticuerpos Monoclonales de Origen Murino/efectos adversos , Evaluación Preclínica de Medicamentos , Femenino , Humanos , Macaca , Embarazo , Púrpura Trombocitopénica/complicaciones , Literatura de Revisión como Asunto , Rituximab , Insuficiencia del TratamientoAsunto(s)
Linfoma de Burkitt/tratamiento farmacológico , Ciclofosfamida/administración & dosificación , Ciclofosfamida/efectos adversos , Hipo/inducido químicamente , Hiponatremia/inducido químicamente , Antineoplásicos Alquilantes/uso terapéutico , Relación Dosis-Respuesta a Droga , Hipo/complicaciones , Humanos , Hiponatremia/complicaciones , Masculino , Persona de Mediana Edad , Índice de Severidad de la EnfermedadRESUMEN
This retrospective study analyses an epidemic with germs ESBL that supervenes at the department of hematology and pediatric oncology in UHC Ibn Rochd of Casablanca. The responsible germ is the ESBL Escherichia coli. Six patients have been infected during the same period that 2 are female and 4 are male. Five patients had acute lenkemia, one patient had a non Hodgkin's disease. All the patients were in the stage of a deep postchermotherapy neutropenia. The picture of all the patients represented a severe infection with suffered fever and acute diarrhea. Five patients died with apicture of septic shock in the 48 to 72 hours after the beginning of the infection and before the identification of the germ. Their treatment consisted in the third generation of cephalosporin and aminoside. One patient who use the imipeneme more the aminoside has been apyrexized the epidemic and severe situation led to the closing of the unit during a week in order to do a disinfection. After 12 monthes of recession, few isolate episodes of infections with enterobacteries ESBL have observed and controlled. The factors that determine the increase and the diffusion of the ESBL germ are numerous and some of them are still not identified, the means of prevention consisted in: the fight against the selection of the resistant germs, the fight against the colonization of the patients by these germs and their transmission between the patients, this requires measures of hygiene and particularly the washing of the hands.
Asunto(s)
Infección Hospitalaria/epidemiología , Infecciones por Escherichia coli/epidemiología , Escherichia coli/enzimología , Choque Séptico/epidemiología , beta-Lactamasas/biosíntesis , Enfermedad Aguda , Adolescente , Adulto , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Cefalosporinas/uso terapéutico , Infección Hospitalaria/complicaciones , Infección Hospitalaria/tratamiento farmacológico , Infección Hospitalaria/microbiología , Infección Hospitalaria/mortalidad , Infección Hospitalaria/prevención & control , Urgencias Médicas , Infecciones por Escherichia coli/complicaciones , Infecciones por Escherichia coli/tratamiento farmacológico , Infecciones por Escherichia coli/microbiología , Infecciones por Escherichia coli/mortalidad , Femenino , Hospitales Universitarios , Humanos , Imipenem/administración & dosificación , Imipenem/uso terapéutico , Leucemia/complicaciones , Linfoma no Hodgkin/complicaciones , Masculino , Marruecos/epidemiología , Neutropenia/complicaciones , Estudios Retrospectivos , Choque Séptico/mortalidad , Factores de TiempoAsunto(s)
Síndrome POEMS/diagnóstico , Anciano , Edema/diagnóstico , Femenino , Humanos , Hipertricosis/diagnóstico , Masculino , Mastectomía Segmentaria , Persona de Mediana Edad , Enfermedades de la Uña/diagnóstico , Síndrome POEMS/complicaciones , Paraproteinemias/diagnóstico , Trastornos de la Pigmentación/diagnósticoRESUMEN
Inherited combined factor V and factor VIII deficiency (F5F8D) is autosomal recessive transmission disorder. Epistaxis, postsurgical bleeding, and menorrhagia are the most common symptoms. The risk of miscarriage and placental abruption is consequent. We report a case of successful pregnancy in a patient with F5F8D. 20-year-old woman, born of consanguineous parents, third gestate, first parity, two miscarriages, admitted for child birth of a spontaneous pregnancy estimated at 38 weeks and was diagnosed with F5F8D. At admission, patient was hemodynamically stable, with good obstetric conditions. The biologic results showed low levels of PT (52%), factor V (7%), and factor VIII (5%), and the activated partial thromboplastin time was prolonged (68,6%). Parturient was admitted in intensive care unit, maternal and fetal monitoring was performed. Fresh frozen plasma (FFP) and factor VIII concentrates were perfused at the induction of labor. Analgesia used fentanyl titration. The delivery gave birth to a newborn male, with Apgar 10/10 and 3000 g. The puerperium was simple without any important bleeding. Laboratory tests for the newborn were acceptable. Little literature is available on this subject and there are no guidelines available concerning pregnancy; we chose to prescribe a combination of factor VIII concentrate and FFP in pre-, per- and postpartum. The same protocol was successfully used in a patient before dental extraction and prostatectomy. Vaginal delivery is possible, as our case. Management by multidisciplinary team is recommended.
RESUMEN
Myeloid sarcoma (MS) is an extramedullary tumour consisting of myeloblasts or immature myeloid cells located in an extramedullary site. It may occur at presentation of AML, at relapse, or prior to the onset of frank leukemia. We report a rare case of MS developing in prexisting Hydroxyurea-induced leg Ulcer in a 70-year-old woman.
RESUMEN
Aplastic anemia is a rare disease caused by destruction of pluripotent stem cells in bone marrow. The occurrence of aplastic anemia during pregnancy is rare and can be fatal for both mother and child. The association is not well explained and there is no consensus on optimal management. We report the case of 30 years-old women treated for aplastic anemia during pregnancy, the evolution is favorable.
Asunto(s)
Anemia Aplásica/terapia , Complicaciones Hematológicas del Embarazo/terapia , Adulto , Transfusión Sanguínea , Femenino , Hemoglobinas/análisis , Humanos , Recuento de Plaquetas , Embarazo , Remisión Espontánea , Índice de Severidad de la EnfermedadRESUMEN
Biermer's disease is an autoimmune atrophic gastritis of the fundus predominantly responsible for a malabsorption of vitamin B12. Despite its association with several autoimmune disorders, few observations have reported an association with autoimmune hemolytic anemia (AIHA). We report a case of Biermer's disease associated with AIHA in a patient of 66 years old.