Búsqueda | Biblioteca Virtual en Salud Odontología. Uruguay

1.

In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer.

Dubrot, Juan; Du, Peter P; Lane-Reticker, Sarah Kate; Kessler, Emily A; Muscato, Audrey J; Mehta, Arnav; Freeman, Samuel S; Allen, Peter M; Olander, Kira E; Ockerman, Kyle M; Wolfe, Clara H; Wiesmann, Fabius; Knudsen, Nelson H; Tsao, Hsiao-Wei; Iracheta-Vellve, Arvin; Schneider, Emily M; Rivera-Rosario, Andrea N; Kohnle, Ian C; Pope, Hans W; Ayer, Austin; Mishra, Gargi; Zimmer, Margaret D; Kim, Sarah Y; Mahapatra, Animesh; Ebrahimi-Nik, Hakimeh; Frederick, Dennie T; Boland, Genevieve M; Haining, W Nicholas; Root, David E; Doench, John G; Hacohen, Nir; Yates, Kathleen B; Manguso, Robert T.

Nat Immunol ; 23(10): 1495-1506, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-36151395

2.

Author Correction: Subsets of exhausted CD8⁺ T cells differentially mediate tumor control and respond to checkpoint blockade.

Miller, Brian C; Sen, Debattama R; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V; LaFleur, Martin W; Yates, Kathleen B; Lako, Ana; Felt, Kristen; Naik, Girish S; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R; Ishizuka, Jeffrey J; Collier, Jenna L; Griffin, Gabriel K; Maleri, Seth; Comstock, Dawn E; Weiss, Sarah A; Brown, Flavian D; Panda, Arpit; Zimmer, Margaret D; Manguso, Robert T; Hodi, F Stephen; Rodig, Scott J; Sharpe, Arlene H; Haining, W Nicholas.

Nat Immunol ; 20(11): 1556, 2019 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-31582823

3.

Subsets of exhausted CD8⁺ T cells differentially mediate tumor control and respond to checkpoint blockade.

Miller, Brian C; Sen, Debattama R; Al Abosy, Rose; Bi, Kevin; Virkud, Yamini V; LaFleur, Martin W; Yates, Kathleen B; Lako, Ana; Felt, Kristen; Naik, Girish S; Manos, Michael; Gjini, Evisa; Kuchroo, Juhi R; Ishizuka, Jeffrey J; Collier, Jenna L; Griffin, Gabriel K; Maleri, Seth; Comstock, Dawn E; Weiss, Sarah A; Brown, Flavian D; Panda, Arpit; Zimmer, Margaret D; Manguso, Robert T; Hodi, F Stephen; Rodig, Scott J; Sharpe, Arlene H; Haining, W Nicholas.

Nat Immunol ; 20(3): 326-336, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30778252

4.

ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy.

Wang, Mingchao; Ran, Xiaojuan; Leung, Wendy; Kawale, Ajinkya; Saxena, Sneha; Ouyang, Jian; Patel, Parasvi S; Dong, Yuting; Yin, Tao; Shu, Jian; Manguso, Robert T; Lan, Li; Wang, Xiao-Fan; Lawrence, Michael S; Zou, Lee.

Genes Dev ; 37(19-20): 929-943, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-37932012

5.

In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma.

Dubrot, Juan; Lane-Reticker, Sarah Kate; Kessler, Emily A; Ayer, Austin; Mishra, Gargi; Wolfe, Clara H; Zimmer, Margaret D; Du, Peter P; Mahapatra, Animesh; Ockerman, Kyle M; Davis, Thomas G R; Kohnle, Ian C; Pope, Hans W; Allen, Peter M; Olander, Kira E; Iracheta-Vellve, Arvin; Doench, John G; Haining, W Nicholas; Yates, Kathleen B; Manguso, Robert T.

Immunity ; 54(3): 571-585.e6, 2021 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-33497609

6.

Tumor-Derived PGE2 Gives NK Cells a Headache.

Knudsen, Nelson H; Manguso, Robert T.

Immunity ; 53(6): 1131-1132, 2020 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-33326763

7.

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.

Griffin, Gabriel K; Wu, Jingyi; Iracheta-Vellve, Arvin; Patti, James C; Hsu, Jeffrey; Davis, Thomas; Dele-Oni, Deborah; Du, Peter P; Halawi, Aya G; Ishizuka, Jeffrey J; Kim, Sarah Y; Klaeger, Susan; Knudsen, Nelson H; Miller, Brian C; Nguyen, Tung H; Olander, Kira E; Papanastasiou, Malvina; Rachimi, Suzanna; Robitschek, Emily J; Schneider, Emily M; Yeary, Mitchell D; Zimmer, Margaret D; Jaffe, Jacob D; Carr, Steven A; Doench, John G; Haining, W Nicholas; Yates, Kathleen B; Manguso, Robert T; Bernstein, Bradley E.

Nature ; 595(7866): 309-314, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33953401

8.

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade.

Ishizuka, Jeffrey J; Manguso, Robert T; Cheruiyot, Collins K; Bi, Kevin; Panda, Arpit; Iracheta-Vellve, Arvin; Miller, Brian C; Du, Peter P; Yates, Kathleen B; Dubrot, Juan; Buchumenski, Ilana; Comstock, Dawn E; Brown, Flavian D; Ayer, Austin; Kohnle, Ian C; Pope, Hans W; Zimmer, Margaret D; Sen, Debattama R; Lane-Reticker, Sarah K; Robitschek, Emily J; Griffin, Gabriel K; Collins, Natalie B; Long, Adrienne H; Doench, John G; Kozono, David; Levanon, Erez Y; Haining, W Nicholas.

Nature ; 565(7737): 43-48, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30559380

9.

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

Manguso, Robert T; Pope, Hans W; Zimmer, Margaret D; Brown, Flavian D; Yates, Kathleen B; Miller, Brian C; Collins, Natalie B; Bi, Kevin; LaFleur, Martin W; Juneja, Vikram R; Weiss, Sarah A; Lo, Jennifer; Fisher, David E; Miao, Diana; Van Allen, Eliezer; Root, David E; Sharpe, Arlene H; Doench, John G; Haining, W Nicholas.

Nature ; 547(7664): 413-418, 2017 07 27.

Artículo en Inglés | MEDLINE | ID: mdl-28723893

10.

Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy.

Revach, Or-Yam; Cicerchia, Angelina M; Shorer, Ofir; Petrova, Boryana; Anderson, Seth; Park, Joshua; Chen, Lee; Mehta, Arnav; Wright, Samuel J; McNamee, Niamh; Tal-Mason, Aya; Cattaneo, Giulia; Tiwari, Payal; Xie, Hongyan; Sweere, Johanna M; Cheng, Li-Chun; Sigal, Natalia; Enrico, Elizabeth; Miljkovic, Marisa; Evans, Shane A; Nguyen, Ngan; Whidden, Mark E; Srinivasan, Ramji; Spitzer, Matthew H; Sun, Yi; Sharova, Tatyana; Lawless, Aleigha R; Michaud, William A; Rasmussen, Martin Q; Fang, Jacy; Palin, Claire A; Chen, Feng; Wang, Xinhui; Ferrone, Cristina R; Lawrence, Donald P; Sullivan, Ryan J; Liu, David; Sachdeva, Uma M; Sen, Debattama R; Flaherty, Keith T; Manguso, Robert T; Bod, Lloyd; Kellis, Manolis; Boland, Genevieve M; Yizhak, Keren; Yang, Jiekun; Kanarek, Naama; Sade-Feldman, Moshe; Hacohen, Nir; Jenkins, Russell W.

bioRxiv ; 2024 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-38405985

11.

Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors.

Lane-Reticker, Sarah Kate; Kessler, Emily A; Muscato, Audrey J; Kim, Sarah Y; Doench, John G; Yates, Kathleen B; Manguso, Robert T; Dubrot, Juan.

STAR Protoc ; 4(1): 102082, 2023 03 17.

Artículo en Inglés | MEDLINE | ID: mdl-36861834

12.

Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening.

Ramos, Azucena; Koch, Catherine E; Liu-Lupo, Yunpeng; Hellinger, Riley D; Kyung, Taeyoon; Abbott, Keene L; Fröse, Julia; Goulet, Daniel; Gordon, Khloe S; Eidell, Keith P; Leclerc, Paul; Whittaker, Charles A; Larson, Rebecca C; Muscato, Audrey J; Yates, Kathleen B; Dubrot, Juan; Doench, John G; Regev, Aviv; Vander Heiden, Matthew G; Maus, Marcela V; Manguso, Robert T; Birnbaum, Michael E; Hemann, Michael T.

Nat Commun ; 14(1): 8048, 2023 Dec 05.

Artículo en Inglés | MEDLINE | ID: mdl-38052854

13.

Extracellular matrix proteins regulate NK cell function in peripheral tissues.

Bunting, Mark D; Vyas, Maulik; Requesens, Marta; Langenbucher, Adam; Schiferle, Erik B; Manguso, Robert T; Lawrence, Michael S; Demehri, Shadmehr.

Sci Adv ; 8(11): eabk3327, 2022 03 18.

Artículo en Inglés | MEDLINE | ID: mdl-35294229

14.

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment.

Collins, Natalie B; Al Abosy, Rose; Miller, Brian C; Bi, Kevin; Zhao, Qihong; Quigley, Michael; Ishizuka, Jeffrey J; Yates, Kathleen B; Pope, Hans W; Manguso, Robert T; Shrestha, Yashaswi; Wadsworth, Marc; Hughes, Travis; Shalek, Alex K; Boehm, Jesse S; Hahn, William C; Doench, John G; Haining, W Nicholas.

J Immunother Cancer ; 10(3)2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-35264433

15.

Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders.

Zhou, Liye; Zeng, Zexian; Egloff, Ann Marie; Zhang, Fan; Guo, Fei; Campbell, Katie M; Du, Peter; Fu, Jingxin; Zolkind, Paul; Ma, Xiaojing; Zhang, Zhe; Zhang, Yi; Wang, Xiaoqing; Gu, Shengqing; Riley, Rachel; Nakahori, Yasutaka; Keegan, Joshua; Haddad, Robert; Schoenfeld, Jonathan D; Griffith, Obi; Manguso, Robert T; Lederer, James A; Liu, X Shirley; Uppaluri, Ravindra.

J Immunother Cancer ; 10(1)2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-35058328

16.

Mutant IDH Inhibits IFNÎ³-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.

Wu, Meng-Ju; Shi, Lei; Dubrot, Juan; Merritt, Joshua; Vijay, Vindhya; Wei, Ting-Yu; Kessler, Emily; Olander, Kira E; Adil, Ramzi; Pankaj, Amaya; Tummala, Krishna Seshu; Weeresekara, Vajira; Zhen, Yuanli; Wu, Qibiao; Luo, Meiqi; Shen, William; García-Beccaria, María; Fernández-Vaquero, Mirian; Hudson, Christine; Ronseaux, Sebastien; Sun, Yi; Saad-Berreta, Rodrigo; Jenkins, Russell W; Wang, Tong; Heikenwälder, Mathias; Ferrone, Cristina R; Goyal, Lipika; Nicolay, Brandon; Deshpande, Vikram; Kohli, Rahul M; Zheng, Hongwu; Manguso, Robert T; Bardeesy, Nabeel.

Cancer Discov ; 12(3): 812-835, 2022 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-34848557

17.

Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer.

Biancur, Douglas E; Kapner, Kevin S; Yamamoto, Keisuke; Banh, Robert S; Neggers, Jasper E; Sohn, Albert S W; Wu, Warren; Manguso, Robert T; Brown, Adam; Root, David E; Aguirre, Andrew J; Kimmelman, Alec C.

Cell Metab ; 33(1): 199-210.e8, 2021 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-33152323

18.

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.

Juneja, Vikram R; McGuire, Kathleen A; Manguso, Robert T; LaFleur, Martin W; Collins, Natalie; Haining, W Nicholas; Freeman, Gordon J; Sharpe, Arlene H.

J Exp Med ; 214(4): 895-904, 2017 04 03.

Artículo en Inglés | MEDLINE | ID: mdl-28302645

19.

Pooled in vivo screens for cancer immunotherapy target discovery.

Lane-Reticker, Sarah K; Manguso, Robert T; Haining, W Nicholas.

Immunotherapy ; 10(3): 167-170, 2018 03.

Artículo en Inglés | MEDLINE | ID: mdl-29370725

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