1.
Med Mycol
; 48(1): 197-200, 2010 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20055745
RESUMEN
We describe the development of resistance in an Aspergillus fumigatus strain, originally sensitive to itraconazole and voriconazole, recovered from a case of pulmonary aspergilloma treated with voriconazole. A G448S mutation on the cyp51A gene was detected by sequencing. Frequent culture and in vitro antifungal susceptibility testing is suggested for early detection of the development of multi-azole resistance in patients on long-term therapy for A. fumigatus infections.