RESUMEN
On May 9-10, 2011, the Walter Reed Army Institute of Research, as the Army Center of Excellence for Infectious Disease, assembled over a dozen leaders in areas related to research into the communities of microorganisms which colonize and infect traumatic wounds. The objectives of the workshop were to obtain guidance for government researchers, to spur research community involvement in the field of traumatic wound research informed by a microbiome perspective, and to spark collaborative efforts serving the Wounded Warriors and similarly wounded civilians. During the discussions, it was made clear that the complexity of these infections will only be met by developing a new art of clinical practice that engages the numerous microbes and their ecology. It requires the support of dedicated laboratories and technologists who advance research methods such as community sequencing, as well as the kinds of data analysis expertise and facilities. These strategies already appear to be bearing fruit in the clinical management of chronic wounds. There are now funding announcements and programs supporting this area of research open to extramural collaborators.
Asunto(s)
Metagenoma , Infección de Heridas/diagnóstico , Infección de Heridas/microbiología , Heridas y Lesiones , Bacterias/clasificación , Bacterias/genética , Investigación Biomédica , HumanosRESUMEN
Biofilm formation in 92 unrelated strains of Acinetobacter baumannii isolated in a multicentre cohort study was investigated using a microtitre plate assay. Fifty-six (63%) isolates formed biofilm. These isolates were less frequently resistant to imipenem or ciprofloxacin than were non-biofilm-forming isolates (25% vs. 47%, p 0.04; and 66% vs. 94%, p 0.004, respectively). All catheter-related urinary or bloodstream infections and the sole case of shunt-related meningitis were caused by biofilm-forming strains. Multivariate analysis revealed that treatment in an intensive care unit, ciprofloxacin resistance and isolation from a respiratory sample were associated with non-biofilm-forming isolates, while previous aminoglycoside use was associated with biofilm-forming isolates.
Asunto(s)
Infecciones por Acinetobacter/microbiología , Acinetobacter baumannii/fisiología , Biopelículas/crecimiento & desarrollo , Adulto , Anciano , Antibacterianos/farmacología , Bacteriemia/microbiología , Catéteres de Permanencia/efectos adversos , Ciprofloxacina/farmacología , Estudios de Cohortes , Farmacorresistencia Bacteriana , Femenino , Humanos , Imipenem/farmacología , Masculino , Meningitis/microbiología , Persona de Mediana Edad , Infecciones Urinarias/microbiologíaRESUMEN
Of 22 foals from 4 localities in southwestern Montana, 59% were found to be infected with Eimeria leuckarti. Oocysts collected from feces of 4 positive horses were sporulated and subsequently administered to a 5- to 6-month-old foal. The prepatent period was 31 days and the patent period was between 5 and 10 days.