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1.
Prehosp Emerg Care ; 18(2): 163-73, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24641269

RESUMEN

This report describes the development of an evidence-based guideline for external hemorrhage control in the prehospital setting. This project included a systematic review of the literature regarding the use of tourniquets and hemostatic agents for management of life-threatening extremity and junctional hemorrhage. Using the GRADE methodology to define the key clinical questions, an expert panel then reviewed the results of the literature review, established the quality of the evidence and made recommendations for EMS care. A clinical care guideline is proposed for adoption by EMS systems. Key words: tourniquet; hemostatic agents; external hemorrhage.


Asunto(s)
Servicios Médicos de Urgencia/normas , Medicina Basada en la Evidencia/normas , Hemorragia/terapia , Hemostáticos/administración & dosificación , Guías de Práctica Clínica como Asunto , Torniquetes/normas , Administración Tópica , Servicios Médicos de Urgencia/métodos , Extremidades/lesiones , Hemorragia/mortalidad , Hemostáticos/normas , Humanos , Recuperación del Miembro/métodos , Medicina Militar/métodos , Medicina Militar/normas , Choque/prevención & control , Choque/terapia , Estados Unidos , Heridas y Lesiones/complicaciones , Heridas y Lesiones/mortalidad , Heridas y Lesiones/terapia
2.
J Surg Res ; 185(1): 294-9, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23816247

RESUMEN

BACKGROUND: High ratios of fresh frozen plasma:packed red blood cells in damage control resuscitation (DCR) are associated with increased survival. The impact of volume and type of resuscitative fluid used during high ratio transfusion has not been analyzed. We hypothesize a difference in outcomes based on the type and quantity of resuscitative fluid used in patients that received high ratio DCR. METHODS: A matched case control study of patients who received transfusions of ≥ four units of PRBC during damage control surgery over 4 1/2 y, was conducted at a Level I Trauma Center. All patients received a high ratio DCR, >1:2 of fresh frozen plasma:packed red blood cells. Demographics and outcomes of the type and quantity of resuscitative fluids used in combination with high ratio DCR were compared and analyzed. A Kaplan-Meier survival analysis was computed among four groups: colloid (median quantity = 1.0 L), <3 L crystalloid, 3-6 L crystalloid, and >6 L crystalloid. RESULTS: There were 56 patients included in the analysis (28 in the crystalloid group and 28 in the colloid group). Demographics were statistically similar. Intraoperative median units of PRBC: crystalloid versus colloid groups was 13 (IQR 8-21) versus 16 (IQR 12-19), P = 0.135; median units of FFP: 12 (IQR 7-18) versus 12 (IQR 10-18), P = 0.440. OR for 10-d mortality in the crystalloid group was 8.41 [95% CI 1.65-42.76 (P = 0.01)]. Kaplan-Meier survival analysis demonstrated lowest mortality in the colloid group and higher mortality with increasing amounts of crystalloid (P = 0.029). CONCLUSIONS: During high ratio DCR, resuscitation with higher volumes of crystalloids was associated with an overall decreased survival, whereas low volumes of colloid use were associated with increased survival. In order to improve outcomes without diluting the survival benefit of hemostatic resuscitation, guidelines should focus on effective low volume resuscitation when high ratio DCR is used. A multi-institutional analysis is needed in order to validate these results.


Asunto(s)
Coloides/uso terapéutico , Soluciones Isotónicas/uso terapéutico , Resucitación/mortalidad , Resucitación/métodos , Heridas y Lesiones/mortalidad , Heridas y Lesiones/terapia , Adulto , Estudios de Casos y Controles , Soluciones Cristaloides , Femenino , Humanos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Centros Traumatológicos , Heridas y Lesiones/cirugía , Adulto Joven
3.
J La State Med Soc ; 164(3): 131-4, 136-9, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22866353

RESUMEN

Trauma is the leading cause of death in persons under 45 years of age. A looming physician shortage, comparatively high rates of injury in the state, and the high cost of caring for the injured has raised the question of how to best deal with this problem in Louisiana. A 37-question survey was sent to all 324 Louisiana members of the American College of Surgeons. The survey assessed characteristics of surgeons, the hospitals and their resources, and perceived impediments to trauma care. Seventy-three percent of responders provide trauma coverage to their hospitals. Ninety percent of hospitals have a blood bank; only 27.4% had 24-hour operating room availability. Most hospitals had adequate subspecialty availability. Major deterrents to trauma coverage that were identified were no control of schedule, no repayment for care, and interruption of a surgeon's elective schedule. Eighty-six percent of responders agreed the state should implement a statewide network. More than 90% said tertiary trauma centers should be in New Orleans, Shreveport, and Baton Rouge to provide trauma care. Louisiana has a surgical workforce trained and capable of trauma care. Impediments to surgeon involvement revolve upon reimbursement and interruption of elective practice. An organized trauma system will help triage critically ill patients to appropriate trauma centers for improved care by appropriate surgeons.


Asunto(s)
Heridas y Lesiones/terapia , Adulto , Femenino , Cirugía General , Encuestas de Atención de la Salud , Humanos , Louisiana , Masculino , Persona de Mediana Edad , Centros Traumatológicos/estadística & datos numéricos , Traumatología/organización & administración , Traumatología/estadística & datos numéricos
4.
Am Surg ; 77(2): 201-6, 2011 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21337881

RESUMEN

Damage control surgery emphasizes limited operations with control of bleeding and contamination. Traditional management centered upon correction of acidosis and hypotension with crystalloids. Damage control resuscitation (DCR) is permissive hypotension and early hemostatic resuscitation combined identified and corrects coagulopathy with fresh-frozen plasma (FFP), restricting use of crystalloids. We hypothesize a survival advantage in patients managed with DCR when compared with a historical cohort of patients. During the 2-year retrospective review, a 1-year period after institution of DCR was compared with a historical control. Resuscitation strategies were analyzed and stratified into emergency department (ED) resuscitation and intraoperative resuscitation. Univariate analysis of continuous data was done with Student's t test followed by multiple logistic regression. Fifty-seven and 61 patients were managed during the NonDCR and DCR periods respectively. Baseline demographic patient characteristics and physiologic variables were similar between groups. ED DCR patients received less crystalloids: 1.1 versus 4.7 liters (P = 0.0001), more FFP: 1.8 versus 0.5 (P = 0.001). NonDCR had a lower initial systolic pressure in the operating room when compared with DCR: 81 mm Hg versus 95 mm Hg (P = 0.03). DCR patients received less intraoperative crystalloids: 5.7 versus 15.8 liters (P = 0.0001) and more FFP: 15.1 versus 6.2 (P = 0.0001). DCR conveyed a survival benefit (Odds Ratio; 95% confidence interval: 0.40 (0.18-0.90), P = 0.024). NonDCR group had 13.2 days longer hospital length of stay. Damage control resuscitation, beginning in the ED, used more packed red blood cells and FFP minimizing crystalloids. DCR was associated with a survival advantage and shorter length of stay in patients with severe hemorrhage.


Asunto(s)
Hemostasis Quirúrgica/métodos , Resucitación/métodos , Choque Hemorrágico/terapia , Heridas y Lesiones/cirugía , Soluciones Cristaloides , Servicio de Urgencia en Hospital , Humanos , Periodo Intraoperatorio , Soluciones Isotónicas/uso terapéutico , Tiempo de Internación , Modelos Lineales , Modelos Logísticos , Quirófanos , Estudios Retrospectivos
5.
J Am Acad Orthop Surg ; 19 Suppl 1: S44-8, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21304048

RESUMEN

Military, governmental, and civilian agencies routinely respond to disasters around the world, including large-scale mass casualty events such as the earthquake in Pakistan in 2005, Hurricane Katrina in the United States in 2005, and the earthquake in Haiti in 2010. Potential exists for improved coordination of medical response between civilian and military sectors and for the creation of a planned and practiced interface. Disaster preparedness could be enhanced with more robust disaster education for civilian responders; creation of a database of precredentialed, precertified medical specialists; implementation of a communication bridge; and the establishment of agreements between military and civilian medical/surgical groups in advance of major catastrophic events.


Asunto(s)
Planificación en Desastres/organización & administración , Servicios Médicos de Urgencia/organización & administración , Cooperación Internacional , Incidentes con Víctimas en Masa , Tormentas Ciclónicas , Terremotos , Haití , Humanos , Pakistán , Estados Unidos
6.
Am Surg ; 76(3): 312-6, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20349663

RESUMEN

Polytrauma patients needing aggressive resuscitation can develop intra-abdominal hypertension (IAH) with subsequent secondary abdominal compartment syndrome (SACS). After patients fail medical therapy, decompressive laparotomy is the surgical last resort. In patients with severe pancreatitis SACS, the use of linea alba fasciotomy (LAF) is an effective intervention to lower IAH without the morbidity of laparotomy. A pilot study of LAF was designed to evaluate its benefit in patients with SACS polytrauma. We conducted an observational study of blunt injury polytrauma patients undergoing LAF. Variables measured before and after LAF included intra-abdominal pressure (IAP, mmHg), abdominal perfusion pressure (APP, mmHg), right ventricular end diastolic volume index (RVEDVI, mL/m2), and ejection fraction. Of the five trauma patients with SACS, the mean age was 36 +/- 17, four (80%) male with an Injury Severity Score of 27 +/- 9. Pre- and post-LAF, IAP was 20.6 +/- 4.7 and 10.6 +/- 2.7 (P < 0.0001), APP 55.2 +/- 5.5 and 77.6 +/- 7.1 (P < 0.0001), RVEDVI 86.4 +/- 9.3 and 123.6 +/- 11.9 (P < 0.0001), and EF 27.6 +/- 4.2 and 40.8 +/- 5 (P < 0.0001), respectively. One patient needed full decompression for bile ascites from unrecognized liver injury. Linea alba fasciotomy, as a first-line intervention before committing to full abdominal decompression in patients with SACS trauma, improved physiological variables without mortality. Consideration for LAF as a bridge before full abdominal decompression needs further evaluation in patients with polytrauma SACS.


Asunto(s)
Síndromes Compartimentales/cirugía , Fasciotomía , Traumatismo Múltiple/complicaciones , Heridas no Penetrantes/complicaciones , Adulto , Síndromes Compartimentales/etiología , Síndromes Compartimentales/fisiopatología , Descompresión Quirúrgica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Traumatismo Múltiple/fisiopatología , Pancreatitis/complicaciones , Proyectos Piloto , Volumen Sistólico , Resultado del Tratamiento , Función Ventricular Derecha , Adulto Joven
7.
J Trauma ; 68(3): 515-8, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20220412

RESUMEN

BACKGROUND: : Installation of red light cameras (RLC) at intersections associated with a high number of traffic accidents are currently in use to reduce the number of traffic collisions. The primary objective of this study was to evaluate the sustained effect of RLC on driver behavior. The secondary objective was to evaluate the number of collisions before and after RLC implementation. METHODS: : For the primary objective, an 8-month prospective observational study after installation of RLC in September 2007 was undertaken at the intersection with the highest incidence of traffic accidents in the State of Louisiana. For the secondary objective, collision occurrences were collected 10 months before and after RLC installation. The mean number of citations was calculated by month, and the statistical significance of trend was obtained from a linear regression model across the study period and by t test to compare before and after citations were issued. The number of traffic collisions was compared using chi. RESULTS: : During the initial 30 days, 2,428 violations per week were recorded, whereas in the subsequent 30 days, there were 534 citations per week issued (p < 0.001). After eight months, the number of citations was reduced to an average of 356 citations per week (p < 0.01). Mean number of citations decreased significantly during implementation of RLC. Three drivers received more than one citation. Although there was a trend in reduction of collisions from 122 to 97 before and after RLC, this did not reach statistical significance; p = 0.18. CONCLUSION: : A significant and sustained reduction in the number of citations occurred as driving behavior was modified. Despite reducing the number of cars entering this intersection during a red light, RLC do not seem to prevent traffic collisions at this monitored intersection. Alternative means of injury prevention must be investigated.


Asunto(s)
Prevención de Accidentes/instrumentación , Accidentes de Tránsito/prevención & control , Accidentes de Tránsito/estadística & datos numéricos , Conducción de Automóvil/psicología , Aplicación de la Ley , Fotograbar , Humanos , Estudios Longitudinales , Estudios Retrospectivos
8.
J Trauma ; 69(1): 46-52, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20622577

RESUMEN

BACKGROUND: Damage control laparotomy (DCL) improves outcomes when used in patients with severe hemorrhage. Correction of coagulopathy with close ratio resuscitation while limiting crystalloid forms a new methodology known as damage control resuscitation (DCR). We hypothesize a survival advantage in DCL patients managed with DCR when compared with DCL patients managed with conventional resuscitation efforts (CRE). METHODS: This study is a 4-year retrospective study of all DCL patients who required >or=10 units of packed red blood cells (PRBC) during surgery. A 2-year period after institution of DCR (DCL and DCR) was compared with the preceding 2 years (DCL and CRE). Univariate analysis of continuous data was done with Student's t test followed by multiple logistic regression. RESULTS: One Hundred twenty-four and 72 patients were managed during the DCL and CRE and DCL and DCR time periods, respectively. Baseline patient characteristics of age, Injury Severity Score, % penetrating, blood pressure, hemoglobin, base deficit, and INR were similar between groups. There was no difference in quantity of intraoperative PRBC utilization between DCL and CRE and DCL and DCR study periods: 21.7 units versus 25.5 units (p = 0.53); however, when compared with DCL and CRE group, patients in the DCL and DCR group received less intraoperative crystalloids, 4.7 L versus 14.2 L (p = 0.009); more fresh frozen plasma (FFP), 18.2 versus 6.4 (p = 0.002); a closer FFP to PRBC ratio, 1 to 1.2 versus 1 to 4.2 (p = 0.002); platelets to PRBC ratio, 1:2.3 versus 1:5.9 (0.002); shorter mean trauma intensive care unit length of stay, 11 days versus 20 days (p = 0.01); and greater 30-day survival, 73.6% versus 54.8% (p < 0.009). The addition of DCR to DCL conveyed a survival benefit (odds ratio; 95% confidence interval: 0.19 (0.05-0.33), p = 0.005). CONCLUSION: This is the first civilian study that analyses the impact of DCR in patients managed with DCL. During the DCL and DCR study period more PRBC, FFP, and platelets with less crystalloid solution was used intraoperatively. DCL and DCR were associated with a survival advantage and shorter trauma intensive care unit length of stay in patients with severe hemorrhage when compared with DCL and CRE.


Asunto(s)
Hemorragia/cirugía , Laparotomía/mortalidad , Resucitación/mortalidad , Heridas y Lesiones/cirugía , Heridas no Penetrantes/cirugía , Adulto , Transfusión Sanguínea , Femenino , Hemorragia/mortalidad , Humanos , Puntaje de Gravedad del Traumatismo , Laparotomía/métodos , Masculino , Análisis Multivariante , Análisis de Regresión , Soluciones para Rehidratación/uso terapéutico , Resucitación/métodos , Estudios Retrospectivos , Análisis de Supervivencia , Heridas y Lesiones/mortalidad , Heridas no Penetrantes/mortalidad , Heridas Penetrantes/mortalidad , Heridas Penetrantes/cirugía
9.
Surg Today ; 40(7): 587-91, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20582507

RESUMEN

The aftermath and response to a disaster can be divided into four phases. The importance of each depends on the length of time without resupply and the resources that are required. This in turn depends on the time span of the disaster; the area involved; the number of the population affected; the resupply available; the extent of the devastation; and the size of the evacuation. The above phases are discussed using hurricane Katrina as an example. The phases are as follows: immediate response, evacuation, backfill and resupply, and restoration. The restoration phase is usually the longest and requires the most resources. This article addresses the situation of Katrina, the mistakes that were made, the lessons that were learned, and the solutions that are needed. Appropriate training and practice are required for all participants using realistic scenarios.


Asunto(s)
Tormentas Ciclónicas , Planificación en Desastres/organización & administración , Desastres , Humanos , Nueva Orleans
10.
Am Surg ; 75(12): 1193-8, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19999911

RESUMEN

Intra-abdominal hypertension (IAH) after damage control laparotomy (DCL) is not unusual and because of this, patients are treated with open-abdomen techniques to prevent abdominal compartment syndrome (ACS). The occurrence of recurrent ACS (R-ACS) after abdominal wall closure under tension in patients managed with DCL can be a trigger factor for second hit syndrome. Outcomes in this subset have not been previously described. In this 1-year retrospective study of severely injured patients in a Level I trauma center managed with DCL and sequential abdominal wall closure, 26 patients were identified. After attempted abdominal wall closure, 13 (50%) patients had R-ACS and 13 (50%) non-R-ACS. R-ACS patients had a statistically significant higher incidence of multisystem organ failure, acute respiratory distress syndrome, and sepsis as well as requiring longer ventilator support and longer hospital length of stay. We concluded that failure to recognize and treat IAH with development of R-ACS after tension abdominal wall closure in patients with DCL will trigger the second hit syndrome with increased risk of morbidity. Institution of a management algorithm with intra-abdominal pressure/abdominal perfusion pressure surveillance at the time of abdominal wall closure can potentially ameliorate complications.


Asunto(s)
Abdomen , Traumatismos Abdominales/cirugía , Pared Abdominal/cirugía , Síndromes Compartimentales/epidemiología , Laparotomía/métodos , Adulto , Femenino , Humanos , Persona de Mediana Edad , Insuficiencia Multiorgánica/epidemiología , Presión , Recurrencia , Estudios Retrospectivos , Factores de Tiempo , Adulto Joven
11.
Am Surg ; 75(12): 1227-33, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19999917

RESUMEN

Open-book pelvic fractures (OBPF) with concomitant intra-abdominal injuries carry a high morbidity and mortality; the significance of associated perineal open wound (OBPF-POW) has not been defined. We hypothesize that the presence of perineal open wounds increases morbidity, mortality, and concomitant use of hospital resources. Patients diagnosed with OBPF over a 5-year period at a Level I trauma center were identified by trauma registry review, and were retrospectively reviewed under an Institutional Review Board-approved protocol. Patients with OBPF without a perineal open wound were compared with those with OBPF-POW. Data collected included patient demographics, injury details, management, and outcomes. A total of 1,635 patients with blunt pelvic fractures were identified, of which 177 (10.8%) had OBPF. OBPF-POW (36/177) significantly increased the use of angioembolization, occurrence of sepsis, pelvic sepsis, ARDS, and multi-organ system failure. Patients with OBPF-POW had an increase of 13 days in length of hospitalization compared with the OBPF group (P < 0.001), with cost of $120,647.30 and $62,952.72 respectively (P < 0.001). Perineal open wounds complicate open-book pelvic fractures with significant increase in hospital resource utilization. Aggressive multidisciplinary evaluation and management is appropriate to detect and prevent complications.


Asunto(s)
Fracturas Óseas/epidemiología , Traumatismo Múltiple/terapia , Huesos Pélvicos/lesiones , Perineo/lesiones , Traumatismos Abdominales/epidemiología , Adulto , Femenino , Fracturas Óseas/economía , Costos de Hospital , Humanos , Tiempo de Internación , Louisiana , Masculino , Persona de Mediana Edad , Pronóstico , Respiración Artificial/estadística & datos numéricos , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Adulto Joven
12.
Am Surg ; 75(4): 284-6, 2009 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-19385285

RESUMEN

Charity Hospital (CH) was devastated by Hurricane Katrina and remains closed. Design and staffing of a new, temporary dedicated trauma hospital relied on data from prior experience at CH, updated census information, and a changed trauma demographic. The study objective was to analyze the new trauma program and evaluate changes in demographics, injury patterns, and outcomes between pre- (PK) and post-Katrina (POK) trauma populations. A retrospective review of trauma patients' demographics, anatomical variables, and physiological variables 6 months PK and POK was performed under an approved Institutional Review Board protocol. Trauma activation triage criteria between study periods were also analyzed. Continuous data comparisons between the two time periods were made with Student's t test. Dichotomous data were analyzed using chi2 test. The demographic of trauma patients is different in the POK interval, reflecting changes in the New Orleans population. Modification of triage criteria by the exclusion of mechanism as an activation criterion resulted in an increase of patients with higher acuity and Injury Severity Score, lower initial Glasgow Coma Score, and a higher proportion of penetrating mechanism. Outcome measures reflect longer length of stay (4.4 vs. 6.8 days, P < 0.0001) without a significant difference in mortality (6.0 vs 7.5, P = 0.227). Hospital data demonstrates that the POK trauma system was stressed by the increased acuity, penetrating injury, and number of procedures per patient (1.7 vs. 3.4). Resources should be directed toward patients requiring multidisciplinary care by increasing intensive care unit beds and operating room capacity. Future resource planning in the recovery phases of large-scale natural disasters should take into account these observations.


Asunto(s)
Tormentas Ciclónicas , Atención a la Salud/tendencias , Desastres , Etnicidad , Traumatismos Faciales/etnología , Admisión del Paciente/tendencias , Adulto , Atención a la Salud/métodos , Traumatismos Faciales/diagnóstico , Traumatismos Faciales/terapia , Humanos , Louisiana/epidemiología , Estudios Retrospectivos , Índices de Gravedad del Trauma
13.
J Trauma ; 67(1): 108-12; discussion 112-4, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19590318

RESUMEN

BACKGROUND: Obesity is an independent predictor of increased morbidity and mortality in critically injured trauma patients. We hypothesized that obese patients in need of damage control laparotomy (DCL) will encounter an increase incidence of postsurgical complications with a concomitant increase mortality when compared with a cohort of nonobese patients. METHODS: All adult trauma patients who underwent DCL during a 4-year period at a Level I Trauma Center were retrospectively reviewed. Patients were categorized into nonobese (body mass index [BMI] < or = 29 kg/m), obese (BMI 30-39 kg/m), and severely obese (BMI > or = 40 kg/m) groups. Outcome measures included the occurrence of postoperative infectious complications, failure of primary abdominal wall fascial closure, acute respiratory distress syndrome, acute renal insufficiency, multiple system organ failure, days of ventilator support, hospital length of stay, and death. RESULTS: During a 4-year period, 12,759 adult trauma patients were admitted to our Level I Trauma Center of which 1,812 (14.2%) underwent emergent laparotomy. Of these, 104 (5.7%) were treated with DCL: nonobese, n = 51 (49%); obese, n = 38 (37%); and severely obese, n = 15 (14%). In a multivariate adjusted model, multiple system organ failure was 1.82 times more likely in severely obese (95% CI: 1.14-2.90) and 1.74 times more likely in the obese patients (95% CI: 1.14-2.66) when compared with patients with normal BMI after DCL (p < 0.01). In the severely obese patients undergoing DCL, significantly elevated prevalence ratios (PR) for development of postoperative infectious complications, acute renal insufficiency, and failure of primary abdominal wall fascial closure were 1.75, 3.07, and 2.62, respectively. Days of ventilator support, length of stay, and mortality rates were significantly higher in severely obese patients (24 days, 27 days, and 60%) compared with obese (14 days, 14 days, and 21%) and nonobese (9.8 days, 14 days, and 28%) patients. CONCLUSION: Severe obesity was significantly associated with adverse outcomes and increased resource utilization in trauma patients treated with DCL. Measures to improve outcomes in this vulnerable patient population must be directed at multiple levels of health care.


Asunto(s)
Traumatismos Abdominales/cirugía , Laparotomía , Obesidad/complicaciones , Traumatismos Abdominales/complicaciones , Traumatismos Abdominales/mortalidad , Adulto , Índice de Masa Corporal , Femenino , Estudios de Seguimiento , Humanos , Tiempo de Internación , Masculino , Morbilidad , Obesidad/epidemiología , Complicaciones Posoperatorias/epidemiología , Pronóstico , Estudios Retrospectivos , Factores de Riesgo , Población Rural , Tasa de Supervivencia , Centros Traumatológicos , Estados Unidos/epidemiología
14.
J Trauma ; 67(1): 33-7; discussion 37-9, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19590305

RESUMEN

BACKGROUND: Although hemostatic resuscitation with a 1:1 ratio of fresh-frozen plasma (FFP) to packed red blood cells (PRBC) after severe hemorrhage has been shown to improve survival, its benefit in patients with traumatic-induced coagulopathy (TIC) after >10 units of PRBC during operation has not been elucidated. We hypothesized that a survival benefit would occur when early hemostatic resuscitation was used intraoperatively after injury in patients with TIC. METHODS: A 7-year retrospective study of patients with emergency department diagnosis of TIC after transfusion of >10 units of PRBC in the operating room. TIC was defined as initial emergency department international normalized ratio > 1.2, prothrombin time > 16 seconds, and partial thromboplastin time > 50 seconds. Patients were divided into FFP:PRBC ratios of 1:1, 1:2, 1:3, and 1:4. Patients with diagnosis of TIC who received transfusion of both FFP and PRBC during surgery were included. Other variables evaluated included age, gender, mechanism of injury, initial base deficit, mean operative time, trauma intensive care unit length of stay (TICU LOS) and Injury Severity Score. The primary outcome measure evaluated was the impact of the early FFP:PRBC ratio on mortality. RESULTS: Four hundred thirty-five patients underwent emergency operations postinjury and received FFP with >10 units of PRBC in the operating room; 135 (31.0%) of these patients had TIC and 53 died (39.5% mortality). Mean operative time was 137 minutes (SD +/- 49). There were no differences with regard to age, gender, mechanism of injury, initial base deficit, or Injury Severity Score among all groups. A significant difference in mortality was found in patients who received >10 units of PRBC when FFP:PRBC ratio was 1:1 versus 1:4 (28.2% vs. 51.1%, p = 0.03). Intermediate mortality rates were noted in patients with 1:2 and 1:3 ratios (38% and 40%, respectively). From a linear regression model, 13 days of increased TICU LOS was observed among 1:4 group compared with 1:1 group (p < 0.01). CONCLUSION: TIC is common after severe injury and is associated with a high mortality in patients transfused with >10 units of PRBC during surgery. Early hemostatic resuscitation during first hours after injury improves survival with shorter TICU LOS in patients with TIC.


Asunto(s)
Transfusión de Componentes Sanguíneos/métodos , Coagulación Intravascular Diseminada/terapia , Hemostasis/fisiología , Técnicas Hemostáticas , Cuidados Intraoperatorios/métodos , Resucitación/métodos , Heridas y Lesiones/complicaciones , Adulto , Coagulación Intravascular Diseminada/etiología , Coagulación Intravascular Diseminada/mortalidad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Estudios Retrospectivos , Tasa de Supervivencia/tendencias , Factores de Tiempo , Estados Unidos/epidemiología , Heridas y Lesiones/mortalidad , Heridas y Lesiones/cirugía
16.
Am Surg ; 74(12): 1159-65, 2008 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19097529

RESUMEN

Recombinant factor VII (rFVIIa) has arisen as an option for the control of life-threatening traumatic bleeding unresponsive to other means. The timing of administration, dosage, mortality, units of blood transfusion saved, risk of thrombotic events, and risk/benefits ratio are presently poorly defined. A Medline search from 1995 through March 2008 was conducted. All English language articles containing the terms "trauma" and "factor VII" or its variants were retrieved. Letters to the editor, animal studies, and general reviews were excluded. A total of 19 articles met inclusion criteria. These articles were then reviewed and stratified into three classes of evidence according to the quality assessment instrument developed by the Brain and Trauma Foundation. Levels of recommendation were developed. A total of 118 articles were identified. Only one Class I study was identified. This study demonstrated that three doses of rFVIIa given in blunt traumatic hemorrhage yielded a significant reduction of 2.6 of red blood cells used. These findings were not statistically significant for penetrating trauma patients. There was no reduction in mortality and no increase in thromboembolic events. Four Class II studies were identified; three showed a significant decrease of blood product usage and one demonstrated significant reductions in 24-hour and 30 day death from hemorrhage in patients receiving rFVIIa. The remaining 14 studies were Class III reviews of databases, registries, case series, and case reports. No identified study specifically addressed the cost/benefit analysis of rFVIIa usage in trauma hemorrhage. Utility of rFVIIa in trauma-associated hemorrhage remains controversial. There is Level I supporting the use of rFVIIa for blunt trauma patients only. There is no Class I evidence supporting decreased mortality or differences in thromboembolic events. Minimal effective dosing regimens and cost/benefit analyses have not yet been examined.


Asunto(s)
Coagulantes/uso terapéutico , Factor VIIa/uso terapéutico , Hemorragia/tratamiento farmacológico , Guías de Práctica Clínica como Asunto , Heridas y Lesiones/complicaciones , Medicina Basada en la Evidencia , Hemorragia/etiología , Humanos , Proteínas Recombinantes/uso terapéutico , Índices de Gravedad del Trauma
17.
J Trauma ; 65(1): 49-53, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18580509

RESUMEN

BACKGROUND: Nonoperative management (NOM) of low-grade blunt pancreatic injuries (LGBPI) diagnosed by computed tomographic (CT) abnormalities of the pancreas in the adult hemodynamically stable (HDS) patient has not been previously defined. We report our experience of patients with LGBPI at a single Level I Trauma Center. METHODS: Adult HDS patients during a 5-year period with blunt pancreatic injuries with an abbreviated injury score of

Asunto(s)
Páncreas/lesiones , Heridas no Penetrantes/terapia , Adulto , Algoritmos , Presión Sanguínea , Estudios de Cohortes , Árboles de Decisión , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tomografía Computarizada por Rayos X , Índices de Gravedad del Trauma , Resultado del Tratamiento , Heridas no Penetrantes/diagnóstico por imagen , Heridas no Penetrantes/fisiopatología
18.
J Trauma ; 65(6): 1346-51; discussion 1351-3, 2008 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19077625

RESUMEN

BACKGROUND: Although splenic angioembolization (SAE) has been introduced and adopted in many trauma centers, the appropriate selection for and utility of SAE in trauma patients remains under debate. This study examined the outcomes of proximal SAE as part of a management algorithm for adult traumatic splenic injury compared with splenectomy. METHODS: A retrospective cohort analysis was performed on all hemodynamically stable (HDS) blunt trauma patients with isolated splenic injury and computed tomographic (CT) evidence of active contrast extravasation that presented to a level 1 Trauma Center over a period of 5 years. The cohorts were defined by two separate 30 month periods and included 78 patients seen before (group I) and 76 patients seen after (group II) the introduction of an institutional SAE protocol. Demographics, splenic injury grade, and outcomes of the two groups were compared using Student's t test, or chi2 test. Analysis was by intention-to-treat. RESULTS: Six hundred eighty-two patients with blunt splenic injury were identified; 154 patients (29%) were HDS with CT evidence of active contrast extravasation. Group I (n = 78) was treated with splenectomy and group II (n = 76) was treated with proximal SAE. There was no difference in age (33 +/- 14 vs. 37 +/- 17 years), Injury Severity Score (31 +/- 13 vs. 29 +/- 11), or mortality (18% vs. 15%) between the two groups. However, the incidence of Adult Respiratory Distress Syndrome (ARDS) was 4-fold higher in those patients that underwent proximal SAE compared with those that underwent splenectomy (22% vs. 5%, p = 0.002). Twenty two patients failed nonoperative management (NOM) after SAE. This failure appeared to be directly related to the grade of splenic organ injury (grade I and II: 0%; grade III: 24%; grade IV: 53%; and grade V: 100%). CONCLUSION: Introduction of proximal SAE in NOM of HDS splenic trauma patients with active extravasation did not alter mortality rates at a Level 1 Trauma Center. Increased incidence of ARDS and association of failure of NOM with higher splenic organ injury score identify areas for cautionary application of proximal SAE in the more severely injured trauma patient population. Better patient selection guidelines for proximal SAE are needed. Without these guidelines, outcomes from SAE will still lack transparency.


Asunto(s)
Traumatismos Abdominales/terapia , Angiografía , Embolización Terapéutica , Bazo/lesiones , Heridas no Penetrantes/terapia , Traumatismos Abdominales/diagnóstico por imagen , Traumatismos Abdominales/mortalidad , Adolescente , Adulto , Algoritmos , Estudios de Cohortes , Estudios Transversales , Extravasación de Materiales Terapéuticos y Diagnósticos/diagnóstico por imagen , Extravasación de Materiales Terapéuticos y Diagnósticos/mortalidad , Extravasación de Materiales Terapéuticos y Diagnósticos/terapia , Femenino , Humanos , Incidencia , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Síndrome de Dificultad Respiratoria/epidemiología , Síndrome de Dificultad Respiratoria/etiología , Estudios Retrospectivos , Bazo/irrigación sanguínea , Esplenectomía , Tasa de Supervivencia , Tomografía Computarizada por Rayos X , Insuficiencia del Tratamiento , Heridas no Penetrantes/diagnóstico por imagen , Heridas no Penetrantes/mortalidad , Adulto Joven
19.
J Trauma ; 64(1): 92-7; discussion 97-8, 2008 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-18188104

RESUMEN

OBJECTIVES: Only preliminary reports have evaluated the impact of telemedicine in trauma care. This study will analyze outcomes before (pre-TM) and after (post-TM) implementation of telemedicine in the management of rural trauma patients initially treated at local community hospitals (LCH) before trauma center (TC) transfer. METHODS: Seven rural hospital emergency departments in Mississippi were equipped with dual video cameras with remote control capability. All trauma patients initially treated at these LCH with TC consultation were reviewed. Data included patient demographics, Injury Severity Score, institutional volume of patients, mode of transportation, length of stay in LCH, transfer time (TT), mortality, and hospital cost. Patients were grouped in the pre-TM and post-TM periods. Statistical testing was with two-sample Student's t test or chi analysis as appropriate. RESULTS: During 5 years, 814 traumatically injured patients (pre-TM, n = 351; post-TM, n = 463) presented to the LCH. In the pre-TM period, 351 patients were transferred directly from the LCH for definitive management to the TC. In the post-TM period, 463 virtual consults were received, of which 51 patients were triaged to the TC. There were no differences in patient age, sex, or mode of transportation. When comparing post-TM with pre-TM era, patients had a higher Injury Severity Score (18 vs. 10, p < 0.001); less incidence of blunt trauma 35 (68%) versus 290 (82%), p < 0.05; a decrease in length of stay at LCH 1.5 hours versus 47 hours, p < 0.001; as well as TT LCH to TC 1.7 hours versus 13 hours, p < 0.001. After arrival to TC during the post-TM era patients received more units of packed red bed cell 13 units versus 5 units, p < 0.001 but without difference in mortality 4 (7.8%) versus 17 (4.8%), when compared with pre-TM era. Of statistical significance there was a dramatic decrease in hospital cost when comparing post-TM and pre-TM eras ($1,126,683 vs. $7,632,624, p < 0.001). CONCLUSION: Telemedicine significantly improved rural LCH evaluation and management of trauma patients. More severely injured trauma patients were identified and more rapidly transferred to the TC. Total TC hospital costs were significantly decreased without significant changes in TC mortality. Introduction of telemedicine consultation to rural LCH emergency departments expanded LCH trauma capabilities and conserved TC resources, which were directed to more severely injured patients.


Asunto(s)
Servicio de Urgencia en Hospital , Servicios de Salud Rural , Telemedicina , Heridas y Lesiones/terapia , Femenino , Hospitales Comunitarios , Hospitales Rurales , Humanos , Puntaje de Gravedad del Traumatismo , Masculino , Mississippi , Evaluación de Resultado en la Atención de Salud , Transferencia de Pacientes , Traumatología/métodos , Comunicación por Videoconferencia
20.
J Trauma ; 65(5): 1126-32, 2008 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-19001986

RESUMEN

BACKGROUND: The purpose of this study was to compare disaster preparedness of a Level I Trauma Center with performance in an actual disaster. Previous disaster response evaluations have shown that the key to succeeding in responding to a catastrophic event is to anticipate the event, plan the response, and practice the plan. The Emergency Management Team had identified natural disaster as the hospital's highest threat. The hospital also served as the regional hospital for the Louisiana Health Resources and Service Administration Bioterrorism Hospital Preparedness Program. METHODS: The hospital master disaster plan, including the Code Gray annex, was retrospectively reviewed and compared with the actual events that occurred after Hurricane Katrina. Vital support areas were evaluated for adequacy using a systematic approach. In addition, a survey of 10 key personnel from trauma and emergency medicine present during Hurricane Katrina was conducted. The survey of vital support areas were scored as adequate (3 pts), partially adequate (2 pts), or inadequate (1 pt). RESULTS: Ninety-three percent of the line items on the Code Gray Checklist were accomplished before landfall of the storm. The results of the survey of vital support areas were water-3.0, food-2.4, sanitation-1.5, communication-1.4, and power-1.5. CONCLUSION: Despite identifying the threat of a major hurricane, preparing a response plan, and exercising the plan, a major medical center can be overwhelmed by a catastrophic disaster like Hurricane Katrina. We offer our lessons-learned as an aid for other medical centers that are developing and exercising their plans.


Asunto(s)
Tormentas Ciclónicas , Planificación en Desastres/organización & administración , Desastres , Centros Traumatológicos , Humanos , Louisiana , Estudios Retrospectivos
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