RESUMEN
The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating cell volume homeostasis. All of these genes have paralogs and are functionally buffered for osmo-sensing and cell volume control. Within seconds of hyperosmotic stress, TSC22D, WNK, and NRBP family members physically associate into biomolecular condensates, a process that is dependent on intrinsically disordered regions (IDRs). A close examination of these protein families across metazoans revealed that TSC22D genes evolved alongside a domain in NRBPs that specifically binds to TSC22D proteins, which we have termed NbrT (NRBP binding region with TSC22D), and this co-evolution is accompanied by rapid IDR length expansion in WNK-family kinases. Our study reveals that TSC22D, WNK, and NRBP genes evolved in metazoans to co-regulate rapid cell volume changes in response to osmolarity.
Asunto(s)
Tamaño de la Célula , Proteína Quinasa Deficiente en Lisina WNK 1 , Humanos , Animales , Proteína Quinasa Deficiente en Lisina WNK 1/metabolismo , Proteína Quinasa Deficiente en Lisina WNK 1/genética , Evolución Molecular , Células HEK293 , Unión Proteica , Familia de Multigenes , Presión OsmóticaRESUMEN
La familia presenta importantes tareas en la sociedad, relacionadas directamente con la preservación de la vida humana, su desarrollo y bienestar. Así, existen características en la dinámica familiar que impulsan a los alumnos a mantener su nivel de rendimiento académico o no, por ejemplo, la disfuncionalidad. En este trabajo se aborda brevemente cómo las familias disfuncionales pueden ser unas de las causas del bajo rendimiento académico en estudiantes de años básicos(AU)
The family has important tasks in society, directly related to the preservation of the human life, its development and well-being. Thus, there are characteristics in the family dynamics which impel the students to maintain or not the level of academic results, for instance, the dysfunction. This work shortly deals on how dysfunctional families can be one of the causes of low academic results in basic years students(AU)
Asunto(s)
Humanos , Masculino , Femenino , Adulto Joven , Rendimiento Escolar Bajo , Relaciones Familiares , Familia , Estudiantes , ComunicaciónRESUMEN
La familia presenta importantes tareas en la sociedad, relacionadas directamente con la preservación de la vida humana, su desarrollo y bienestar. Así, existen características en la dinámica familiar que impulsan a los alumnos a mantener su nivel de rendimiento académico o no, por ejemplo, la disfuncionalidad. En este trabajo se aborda brevemente cómo las familias disfuncionales pueden ser unas de las causas del bajo rendimiento académico en estudiantes de años básicos.
The family has important tasks in society, directly related to the preservation of the human life, its development and well-being. Thus, there are characteristics in the family dynamics which impel the students to maintain or not the level of academic results, for instance, the dysfunction. This work shortly deals on how dysfunctional families can be one of the causes of low academic results in basic years students.