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1.
J Magn Reson Imaging ; 2023 Sep 13.
Artículo en Inglés | MEDLINE | ID: mdl-37702553

RESUMEN

BACKGROUND: Parsonage-Turner syndrome (PTS) is characterized by severe, acute upper extremity pain and subsequent paresis and most commonly involves the long thoracic nerve (LTN). While MR neurography (MRN) can detect LTN hourglass-like constrictions (HGCs), quantitative muscle MRI (qMRI) can quantify serratus anterior muscle (SAM) neurogenic changes. PURPOSE/HYPOTHESIS: 1) To characterize qMRI findings in LTN-involved PTS. 2) To investigate associations between qMRI and clinical assessments of HGCs/electromyography (EMG). STUDY TYPE: Prospective. POPULATION: 30 PTS subjects (25 M/5 F, mean/range age = 39/15-67 years) with LTN involvement who underwent bilateral chest wall qMRI and unilateral brachial plexus MRN. FIELD STRENGTH/SEQUENCES: 3.0 Tesla/multiecho spin-echo T2-mapping, diffusion-weighted echo-planar-imaging, multiecho gradient echo. ASSESSMENT: qMRI was performed to obtain T2, muscle diameter fat fraction (FF), and cross-sectional area of the SAM. Clinical reports of MRN and EMG were obtained; from MRN, the number of HGCs; from EMG, SAM measurements of motor unit recruitment levels, fibrillations, and positive sharp waves. qMRI/MRN were performed within 90 days of EMG. EMG was performed on average 185 days from symptom onset (all ≥2 weeks from symptom onset) and 5 days preceding MRI. STATISTICAL TESTS: Paired t-tests were used to compare qMRI measures in the affected SAM versus the contralateral, unaffected side (P < 0.05 deemed statistically significant). Kendall's tau was used to determine associations between qMRI against HGCs and EMG. RESULTS: Relative to the unaffected SAM, the affected SAM had increased T2 (50.42 ± 6.62 vs. 39.09 ± 4.23 msec) and FF (8.45 ± 9.69 vs. 4.03% ± 1.97%), and decreased muscle diameter (74.26 ± 21.54 vs. 88.73 ± 17.61 µm) and cross-sectional area (9.21 ± 3.75 vs. 16.77 ± 6.40 mm2 ). There were weak to negligible associations (tau = -0.229 to <0.001, P = 0.054-1.00) between individual qMRI biomarkers and clinical assessments of HGCs and EMG. DATA CONCLUSION: qMRI changes in the SAM were observed in subjects with PTS involving the LTN. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.

2.
Muscle Nerve ; 2023 Aug 23.
Artículo en Inglés | MEDLINE | ID: mdl-37610034

RESUMEN

INTRODUCTION/AIMS: Hourglass-like constrictions (HGCs) of involved nerves in neuralgic amyotrophy (NA) (Parsonage-Turner syndrome) have been increasingly recognized with magnetic resonance neurography (MRN). This study sought to determine the sensitivity of HGCs, detected by MRN, among electromyography (EMG)-confirmed NA cases. METHODS: This study retrospectively reviewed records of patients with the clinical diagnosis of NA, and with EMG confirmation, who underwent 3-Tesla MRN within 90 days of EMG at a single tertiary referral center between 2011 and 2021. "Severe NA" positive cases were defined by a clinical diagnosis and specific EMG criteria: fibrillation potentials or positive sharp waves, along with motor unit recruitment (MUR) grades of "discrete" or "none." On MRN, one or more HGCs, defined as focally decreased nerve caliber or diffusely beaded appearance, was considered "imaging-positive." Post hoc inter-rater reliability for HGCs was measured by comparing the original MRN report against subsequent blinded interpretation by a second radiologist. RESULTS: A total of 123 NA patients with 3-Tesla MRN performed within 90 days of EMG were identified. HGCs were observed in 90.2% of all NA patients. In "severe NA" cases, based on the above EMG criteria, HGC detection resulted in a sensitivity of 91.9%. Nerve-by-nerve analysis (183 nerve-muscle pairs, nerves assessed by MRN, muscles assessed by EMG) showed a sensitivity of 91.0%. The second radiologist largely agreed with the original HGC evaluation, (94.3% by subjects, 91.8% by nerves), with no significant difference between evaluations (subjects: χ2 = 2.27, P = .132, nerves: χ2 = 0.98, P = .323). DISCUSSION: MRN detection of HGCs is common in NA.

3.
Skeletal Radiol ; 52(9): 1781-1784, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36752829

RESUMEN

Beginning in May 2022, monkeypox infection and vaccination rates dramatically increased due to a worldwide outbreak. This case highlights magnetic resonance (MR) neurography findings in an individual who developed Parsonage-Turner syndrome (PTS) 5 days after monkeypox symptom onset and 12 days after receiving the JYNNEOS vaccination. MR neurography of the patient's left suprascapular nerve demonstrated intrinsic hourglass-like constrictions, a characteristic finding of peripheral nerves involved in PTS. Other viral infections and vaccinations are well-documented triggers of PTS, an underrecognized peripheral neuropathy that is thought to be immune-mediated and results in severe upper extremity pain and weakness. The close temporal relationship between monkeypox infection and vaccination, and PTS onset, in this case, suggests a causal relationship and marks the first known report of peripheral neuropathy associated with monkeypox.


Asunto(s)
Neuritis del Plexo Braquial , Mpox , Enfermedades del Sistema Nervioso Periférico , Humanos , Neuritis del Plexo Braquial/etiología , Neuritis del Plexo Braquial/complicaciones , Mpox/complicaciones , Imagen por Resonancia Magnética/métodos , Enfermedades del Sistema Nervioso Periférico/diagnóstico por imagen , Enfermedades del Sistema Nervioso Periférico/etiología , Vacunación/efectos adversos
4.
Radiology ; 302(1): 84-87, 2022 01.
Artículo en Inglés | MEDLINE | ID: mdl-34402669

RESUMEN

Vaccination is one of the several known triggers of Parsonage-Turner syndrome (PTS). This case series describes two individuals with clinical presentations of PTS whose symptoms began 13 hours and 18 days following receipt of the Pfizer-BioNTech BNT162b2 and Moderna mRNA-1273 COVID-19 vaccine, respectively. The diagnosis of PTS was confirmed by using both electrodiagnostic testing and 3.0-T MR neurography. Although research is needed to understand the association between PTS and COVID-19 vaccination, MR neurography may be used to help confirm suspected cases of PTS as COVID-19 vaccines continue to be distributed worldwide.


Asunto(s)
Neuritis del Plexo Braquial/diagnóstico por imagen , Neuritis del Plexo Braquial/etiología , Plexo Braquial/diagnóstico por imagen , Vacunas contra la COVID-19/efectos adversos , Imagen por Resonancia Magnética/métodos , Adulto , Analgésicos , Neuritis del Plexo Braquial/tratamiento farmacológico , COVID-19/prevención & control , Gabapentina/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Prednisona/uso terapéutico
5.
J Magn Reson Imaging ; 56(4): 1104-1115, 2022 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-35195321

RESUMEN

BACKGROUND: Quantitative MRI (qMRI) metrics reflect microstructural skeletal muscle changes secondary to denervation and may correspond to conventional electromyography (EMG) assessments of motor unit recruitment (MUR) and denervation. HYPOTHESIS: Differences in quantitative T2 , diffusion-based apparent fiber diameter (AFD), and fat fraction (FF) exist between EMG grades, in patients with clinically suspected neuropathy of the brachial plexus. STUDY TYPE: Prospective. POPULATION: A total of 30 subjects (age = 37.5 ± 17.5, 21M/9F) with suspected brachial plexopathy. FIELD STRENGTH/SEQUENCE: 3-Tesla; qMRI using fast spin echo (T2 -mapping), multi-b-valued diffusion-weighted echo planar imaging (for AFD), and dual-echo Dixon gradient echo (FF-mapping) sequences. ASSESSMENT: qMRI values were compared against EMG grades (MUR and denervation). qMRI values (T2 , AFD, and FF) were obtained for five regional shoulder muscles. A 4-point scale was used for MUR/denervation severity. STATISTICAL TESTS: Linear mixed models and least-squares pairwise comparisons were used to evaluate qMRI differences between EMG grades. Predictive accuracy of EMG grades from qMRI was quantified by 10-fold cross-validated logistic models. A P value < 0.05 was considered statistically significant. RESULTS: Mean (95% confidence interval) qMRI for "full" MUR were T2  = 39.40 msec (35.72-43.08 msec), AFD = 78.35 µm (72.52-84.19 µm), and FF = 4.54% (2.11-6.97%). Significant T2 increases (+8.36 to +14.67 msec) and significant AFD decreases (-11.04 to -21.58 µm) were observed with all abnormal MUR grades as compared to "full" MUR. Significant changes in both T2 and AFD were observed with increased denervation (+9.59 to +15.04 msec, -16.25 to -18.66 µm). There were significant differences in FF between some MUR grades (-1.45 to +2.96%), but no significant changes were observed with denervation (P = 0.089-0.662). qMRI prediction of abnormal MUR or denervation was strong (mean accuracy = 0.841 and 0.810, respectively) but moderate at predicting individual grades (accuracy = 0.492 and 0.508, respectively). DATA CONCLUSION: Quantitative T2 and AFD differences were observed between EMG grades in assessing muscle denervation. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 1.


Asunto(s)
Plexo Braquial , Imagen por Resonancia Magnética , Plexo Braquial/diagnóstico por imagen , Electromiografía , Humanos , Imagen por Resonancia Magnética/métodos , Músculo Esquelético/diagnóstico por imagen , Estudios Prospectivos
7.
Curr Sports Med Rep ; 17(6): 199-207, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29889149

RESUMEN

Hip and groin injuries comprise up to 17% of athletic injuries and can pose rehabilitation challenges for many athletes. Injuries involving abnormal femoral acetabular morphology, reduced range of motion, and decreased lumbopelvic strength and endurance also may increase the risk of injury to lower extremities and delay return to play if proper rehabilitation does not take place. The rehabilitation of athletic hip injuries requires a multifaceted interdisciplinary approach that manages the interplay of multiple factors to restore preinjury function and facilitate return to play. Emphasis should be placed on activity modification, preservation of the arcs of range of motion, functional strengthening of the lumbopelvic core, and optimization of proprioceptive and neuromechanical strategies. Communication between providers and the injured athlete also is crucial to ensure that proper therapeutic approaches are being applied.


Asunto(s)
Traumatismos en Atletas/rehabilitación , Lesiones de la Cadera/rehabilitación , Atletas , Traumatismos en Atletas/diagnóstico , Ingle/lesiones , Lesiones de la Cadera/diagnóstico , Humanos , Rango del Movimiento Articular , Volver al Deporte
8.
J Pediatr Orthop ; 31(2 Suppl): S156-62, 2011 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-21857431

RESUMEN

There is a consensus among researchers that the treatment for Legg-Calvé-Perthes disease, whether conservative or surgical, is always based on the concept of "containment," that is, maintaining the femoral head inside the acetabulum socket throughout the entire evolution of the disease. Thus, the size and shape of the proximal femoral epiphysis should be monitored during the evolution of the disease. Although diagnosis is carried out by conventional radiographies in many medical institutions, this examination does not give us this information. Therefore, it becomes necessary to resort to other examination techniques, such as pneumoarthrography and magnetic resonance imaging. In our institution, we noticed the importance of hip arthrography in Legg-Calvé-Perthes disease from a study carried out by Laredo in 1985 that classified the disease into 5 groups based on the form and size of the femoral head and its position in the labrum. According to this researcher, group III, which he called "hip at premature arthrographic risk," requires action and yields the best results. The researchers have the opinion that dynamic pneumoarthrography is the best method for establishing an ideal position for the femoral head in relation to the acetabulum when surgical treatment is indicated.


Asunto(s)
Artrografía/métodos , Cabeza Femoral/patología , Enfermedad de Legg-Calve-Perthes/diagnóstico por imagen , Acetábulo , Niño , Humanos , Enfermedad de Legg-Calve-Perthes/clasificación , Enfermedad de Legg-Calve-Perthes/terapia , Imagen por Resonancia Magnética
9.
PM R ; 13(12): 1340-1349, 2021 12.
Artículo en Inglés | MEDLINE | ID: mdl-33644963

RESUMEN

BACKGROUND: Tendinosis is a chronic degenerative condition. Current research suggests both percutaneous needle tenotomy (PNT) and leukocyte-rich platelet-rich plasma (LR-PRP) may be effective treatments for chronic tendinosis, but no studies have assessed the effectiveness of PNT alone versus PNT with intratendinous LR-PRP for multiple tendon types in a single study. OBJECTIVE: To assess the efficacy of PNT versus PNT + LR-PRP to treat chronic tendinosis. STUDY DESIGN: Double-blind, randomized, controlled comparative treatment study. SETTING: Primary academic institution. PARTICIPANTS: A convenience sample of 40 participants who had chronic tendinosis (rotator cuff, wrist extensor, wrist flexor, hip abductor, proximal hamstring, patellar, or Achilles) confirmed via ultrasound, failed conservative treatment, and did not have tendon tears, known coagulopathy, or systemic illnesses. INTERVENTIONS: Participants were randomly assigned to PNT (n = 19) or PNT + LR-PRP (n = 21). Participants and outcomes assessors were blinded to treatment assignments. PNT was performed with 20-30 passes of a 22-gauge needle under ultrasound guidance, with 1% lidocaine given outside the tendon. LR-PRP was processed from whole blood (30-60 mL) and injected into the affected tendon using the same PNT technique. MAIN OUTCOME MEASURES: Primary outcome was current numerical rating scale pain at 6 weeks. Secondary outcomes were average pain, function, general well-being, and sleep quality at 6, 52, and 104 weeks. RESULTS: Baseline characteristics were similar between groups. Overall, there were no significant differences between groups over time for any of the outcomes (P > .05). Between-group analyses showed significantly lower current and average pain after PNT compared to PNT + LR-PRP at 6 weeks (estimated-mean [SE]: 3.1[0.4] vs. 4.6[0.6], P = .04; 3.4[0.4] vs. 4.9[0.5], P = .03) only. Adverse event rates were low (PNT-3.9%; PNT + LR-PRP-5.0%) and related primarily to postprocedural pain and inflammation. CONCLUSIONS: Although pain scores were lower after PNT compared to PNT + LR-PRP at 6 weeks, there were no between-group differences in outcomes at 52 or 104 weeks.


Asunto(s)
Tendón Calcáneo , Plasma Rico en Plaquetas , Tendinopatía , Humanos , Tendinopatía/terapia , Tenotomía , Resultado del Tratamiento , Ultrasonografía Intervencional
10.
Microbiology (Reading) ; 156(Pt 2): 543-554, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19762441

RESUMEN

The aquatic zoonotic pathogen Streptococcus iniae represents a threat to the worldwide aquaculture industry and poses a risk to humans who handle raw fish. Because little is known about the mechanisms of S. iniae pathogenesis or virulence factors, we established a high-throughput system combining whole-genome pyrosequencing and transposon mutagenesis that allowed us to identify virulence proteins, including Pdi, the polysaccharide deacetylase of S. iniae, that we describe here. Using bioinformatics tools, we identified a highly conserved signature motif in Pdi that is also conserved in the peptidoglycan deacetylase PgdA protein family. A Deltapdi mutant was attenuated for virulence in the hybrid striped bass model and for survival in whole fish blood. Moreover, Pdi was found to promote bacterial resistance to lysozyme killing and the ability to adhere to and invade epithelial cells. On the other hand, there was no difference in the autolytic potential, resistance to oxidative killing or resistance to cationic antimicrobial peptides between S. iniae wild-type and Deltapdi. In conclusion, we have demonstrated that pdi is involved in S. iniae adherence and invasion, lysozyme resistance and survival in fish blood, and have shown that pdi plays a role in the pathogenesis of S. iniae. Identification of Pdi and other S. iniae virulence proteins is a necessary initial step towards the development of appropriate preventive and therapeutic measures against diseases and economic losses caused by this pathogen.


Asunto(s)
Amidohidrolasas/fisiología , Streptococcus/patogenicidad , Factores de Virulencia/fisiología , Amidohidrolasas/genética , Secuencia de Aminoácidos , Animales , Adhesión Bacteriana , Proteínas Bacterianas/genética , Proteínas Bacterianas/inmunología , Proteínas Bacterianas/metabolismo , Bacteriólisis , Lubina/sangre , Lubina/microbiología , Actividad Bactericida de la Sangre , Línea Celular , Elementos Transponibles de ADN , Células Epiteliales/microbiología , Enfermedades de los Peces/microbiología , Marcación de Gen , Genes Bacterianos , Genoma Bacteriano , Datos de Secuencia Molecular , Muramidasa/metabolismo , Mutagénesis , Especies Reactivas de Oxígeno/metabolismo , Análisis de Secuencia de ADN , Homología de Secuencia de Aminoácido , Infecciones Estreptocócicas/microbiología , Infecciones Estreptocócicas/veterinaria , Streptococcus/enzimología , Virulencia/genética , Factores de Virulencia/genética
11.
PM R ; 10(8): 873-876, 2018 08.
Artículo en Inglés | MEDLINE | ID: mdl-29355747

RESUMEN

de Quervain tenosynovitis is a stenosing tenosynovitis of the first dorsal compartment of the wrist that can lead to painful functional impairment of the upper limb. This case presentation describes a rare adverse effect of corticosteroid injection (CSI) involving local skin atrophy and hypopigmentation with proximal linear extension. In this case, hypopigmentation developed from the wrist to beyond the elbow after CSI with ultrasound guidance and targeted placement of the injectate in the extensor tendon sheath of the first dorsal compartment. Dermal complications of CSI are rare but notable and potentially disfiguring events that should be discussed with every patient during the informed consent process before soft tissue CSIs. LEVEL OF EVIDENCE: V.


Asunto(s)
Enfermedad de De Quervain/tratamiento farmacológico , Glucocorticoides/administración & dosificación , Hipopigmentación/etiología , Metilprednisolona/administración & dosificación , Tenosinovitis/tratamiento farmacológico , Adulto , Negro o Afroamericano , Femenino , Humanos , Inyecciones , Ultrasonografía Intervencional
12.
Spine (Phila Pa 1976) ; 43(14): 1007-1017, 2018 07 15.
Artículo en Inglés | MEDLINE | ID: mdl-29189640

RESUMEN

STUDY DESIGN: Secondary analysis of the Back Pain Outcomes using Longitudinal Data (BOLD) cohort study. OBJECTIVE: To characterize associations of self-reported race/ethnicity with back pain (BP) patient-reported outcomes (PROs) and health care utilization among older adults with a new episode of care for BP. SUMMARY OF BACKGROUND DATA: No prior longitudinal studies have characterized associations between multiple race/ethnicity groups, and BP-related PROs and health care utilization in the United States. METHODS: This study included 5117 participants ≥65 years from three US health care systems. The primary BP-related PROs were BP intensity and back-related functional limitations over 24 months. Health care utilization measures included common diagnostic tests and treatments related to BP (spine imaging, spine-related relative value units [RVUs], and total RVUs) over 24 months. Analyses were adjusted for multiple potential confounders including sociodemographics, clinical characteristics, and study site. RESULTS: Baseline BP ratings were significantly higher for blacks vs. whites (5.8 vs. 5.0; P < 0.001). Participants in all race/ethnicity groups showed statistically significant, but modest improvements in BP over 24 months. Blacks and Hispanics did not have statistically significant improvement in BP-related functional limitations over time, unlike whites, Asians, and non-Hispanics; however, the magnitude of differences in improvement between groups was small. Blacks had less spine-related health care utilization over 24 months than whites (spine-related RVU ratio of means 0.66, 95% confidence interval [CI] 0.51-0.86). Hispanics had less spine-related health care utilization than non-Hispanics (spine-related RVU ratio of means 0.60; 95% CI 0.40-0.90). CONCLUSION: Blacks and Hispanics had slightly less improvement in BP-related functional limitations over time, and less spine-related health care utilization, as compared to whites and non-Hispanics, respectively. Residual confounding may explain some of the association between race/ethnicity and health outcomes. Further studies are needed to understand the factors underlying these differences and which differences reflect disparities. LEVEL OF EVIDENCE: 3.


Asunto(s)
Dolor de Espalda/etnología , Episodio de Atención , Etnicidad , Aceptación de la Atención de Salud , Medición de Resultados Informados por el Paciente , Grupos Raciales/etnología , Anciano , Anciano de 80 o más Años , Dolor de Espalda/terapia , Estudios de Cohortes , Femenino , Humanos , Estudios Longitudinales , Masculino
13.
J Pediatr Orthop B ; 16(4): 262-5, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17527103

RESUMEN

Eighty knees of 40 musculoskeletally normal infants whose age ranged from 0 to 24 months (average 9.65 months) were ultrasonographically analyzed. The lengths of the patella, patellar ligament - and the Insall-Salvati index, knee being flexed at 30 degrees , were assessed. The angles of the femoral cartilaginous sulcus knee flexed at 0, 30, 60, and 90 degrees were also defined. Patellar length varied from 1.84 to 2.02 cm (mean, 93.3 cm; standard deviation, 0.35); patellar ligament length varied from 1.67 to 1.86 (mean, 1.76 cm; standard deviation, 0.25); the Insall-Salvati index varied from 1.04 to 1.13, (mean, 1.09; standard deviation, 0.14); and femoral cartilaginous sulcus angle ranged from 148.7 to 149.3 degrees (average, 148.9 degrees and standard deviation, 6.20). Statistical tests showed no significant difference in the proposed measures according to sex and side (right/left). Moreover, we did not observe significant difference in the femoral cartilaginous sulcus angle with respect to the various degrees of knee flexion. Thus, we conclude that ultrasonography is useful for determining the normal values of the Insall-Salvati index and femoral cartilaginous sulcus angle in infants from 0 to 24 months. Then, we suggest standardization of this imaging procedure for the early diagnosis of deformities, which might impair the knee in infants within this range of age.


Asunto(s)
Fémur/diagnóstico por imagen , Articulación de la Rodilla/diagnóstico por imagen , Articulación de la Rodilla/fisiología , Rótula/diagnóstico por imagen , Cartílago Articular/diagnóstico por imagen , Cartílago Articular/fisiología , Preescolar , Femenino , Fémur/fisiología , Humanos , Lactante , Recién Nacido , Masculino , Rótula/fisiología , Rango del Movimiento Articular/fisiología , Ultrasonografía
14.
J Pediatr Orthop B ; 16(4): 266-8, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17527104

RESUMEN

An ultrasonographic study was carried out in 25 infants (50 knees) with Down syndrome, whose age ranged from zero to 24 months, average being 13.2 months; 13 were males and 12 were females. The ultrasonographic investigation was performed with the knee being in full extension for the transversal view and in 30 degrees flexion for the sagittal view. The Insall-Salvati index and femoral cartilaginous sulcus angle were measured. Insall-Salvati index values ranged from 1.06 to 1.15 (average 1.10), with standard deviation of 0.16. No significant differences were observed with regard to Insall-Salvati index values in normal children. The femoral cartilaginous sulcus angle in infants with Down syndrome ranged from 152.7 to 155.8 degrees (average 154.3) with standard deviation of 7.959. In Down syndrome we noticed significant difference as compared to the normal values. The authors suggest that ultrasonography is useful in Down syndrome for an early diagnosis of instability of the patella.


Asunto(s)
Síndrome de Down/fisiopatología , Fémur/diagnóstico por imagen , Articulación de la Rodilla/diagnóstico por imagen , Rótula/diagnóstico por imagen , Cartílago Articular/diagnóstico por imagen , Cartílago Articular/fisiopatología , Estudios de Casos y Controles , Preescolar , Femenino , Fémur/fisiopatología , Humanos , Lactante , Recién Nacido , Articulación de la Rodilla/fisiopatología , Masculino , Rótula/fisiopatología , Rango del Movimiento Articular/fisiología , Ultrasonografía
15.
J Orthop Res ; 24(6): 1240-8, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16705708

RESUMEN

We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. The histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl2) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. The serum level of IgA was elevated at the 4th and 6th month postoperatively. The persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment.


Asunto(s)
Antraquinonas/uso terapéutico , Antiinflamatorios no Esteroideos/uso terapéutico , Enfermedades de los Cartílagos/tratamiento farmacológico , Cartílago Articular/efectos de los fármacos , Articulación de la Cadera , Prótesis de Cadera/efectos adversos , Acetábulo/efectos de los fármacos , Acetábulo/cirugía , Acetábulo/ultraestructura , Animales , Hilos Ortopédicos , Enfermedades de los Cartílagos/etiología , Enfermedades de los Cartílagos/metabolismo , Cartílago Articular/metabolismo , Cartílago Articular/ultraestructura , Complemento C3/análisis , Complemento C4/análisis , Modelos Animales de Enfermedad , Perros , Epífisis Desprendida , Cabeza Femoral/efectos de los fármacos , Cabeza Femoral/cirugía , Cabeza Femoral/ultraestructura , Articulación de la Cadera/patología , Articulación de la Cadera/cirugía , Inmunoglobulinas/sangre , Complicaciones Posoperatorias , Falla de Prótesis , Proteoglicanos/metabolismo , Membrana Sinovial/efectos de los fármacos , Membrana Sinovial/metabolismo , Membrana Sinovial/patología
16.
J Shoulder Elbow Surg ; 15(6): 675-8, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-17055748

RESUMEN

For hemiarthroplasty reconstruction of a proximal humeral fracture, accurate restoration of humeral head position is challenging, and incorrect prosthetic placement is associated with a poor outcome of surgical treatment. The purpose of this study was to validate the pectoralis major tendon as a reproducible landmark for accurate restoration of humeral length with hemiarthroplasty reconstruction. We dissected 20 cadavers (40 shoulders), and the distance between the upper border of the pectoralis major tendon insertion on the humerus and the top of the humeral head was measured (PMT). The PMT averaged 5.6 +/- 0.5 cm (with a confidence level of 95%). In only 4 of 40 shoulders did this distance exceed 6.0 cm, and there was no correlation between the size of the patient and this measurement. The PMT is a useful landmark that will aid in accurate restoration of humeral length when reconstructing complex proximal humeral fractures where landmarks are otherwise lost because of fracture comminution.


Asunto(s)
Artroplastia de Reemplazo/métodos , Húmero , Músculos Pectorales/anatomía & histología , Fracturas del Hombro/cirugía , Tendones/anatomía & histología , Adulto , Anciano , Anciano de 80 o más Años , Cadáver , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia
17.
Phys Med Rehabil Clin N Am ; 27(1): 179-202, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26616183

RESUMEN

The popularity of running among young athletes has significantly increased over the past few decades. As the number of children who participate in running increases, so do the potential number of injuries to this group. Proper care of these athletes includes a thorough understanding of the unique physiology of the skeletally immature athlete and common injuries in this age group. Treatment should focus on athlete education, modification of training schedule, and correction of biomechanical deficits contributing to injury. Early identification and correction of these factors will allow a safe return to running sports.


Asunto(s)
Traumatismos en Atletas/prevención & control , Carrera/lesiones , Adolescente , Fenómenos Biomecánicos , Niño , Humanos , Educación y Entrenamiento Físico
18.
J Pediatr Orthop B ; 11(1): 15-28, 2002 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-11866077

RESUMEN

This is a roentgenographic and retrospective study comparing the results of two different operative procedures used in the treatment of Legg-Calvé-Perthes disease: Salter innominate osteotomy, and Augmented Acetabuloplasty. Group I comprised 43 patients (50 hips) who underwent Salter osteotomy. Another 40 patients (40 hips) were treated by Augmented Acetabuloplasty and formed Group 2. In Group 1, 11 (25.58%) patients were girls and 32 (74.42%) were boys. In Group 2, there were 4 (10%) girl and 36 (90%) boy patients. The average age was 6.62 years in Group 1 and 6.35 years in Group 2. Follow-up varied from 2 years to 10 years in both Groups 1 and 2. In Group 1, 18 (36%) hips were in the stage of necrosis, 28 (56%) in fragmentation, and 4 (8%) in reossification; in Group 2, 16 (40%) hips were in necrosis, 23 (57.5%) in fragmentation, and only 1 (2.5%) in reossification. All hips in necrosis were included in Salter and Thompson group B; all hips in fragmentation were classed as Catterall group 3 or 4. Preoperative arthrographs of the 50 hips in Group I were graded according to Laredo: 29 (58%) in group III, 18 (36%) in group IV, and 3 (6%) in group V. Only 23 of the 43 hips of Group 2 had preoperative arthrographs; there were 14 (60.87%) in group III, 8 (34.78%) in group IV, and 1 (4.35%) in group V. The preoperative Wiberg's Center-Edge (CE) angle of Group 2 (19.4 degrees) was significantly greater than that of Group 1 (16.7 degrees). The percentage difference (A%) between immediate postoperative and preoperative CE angle was significantly greater in Group 2. The delta% between final and immediate postoperative CE angle was significantly greater in Group 1, and within Group 1 it was significantly greater at age 4 years to 6 years. The A% between final and preoperative CE angle was statistically the same in both Group I and Group 2. The distribution of good, fair and poor Mose ratings did not differ in Group 1 and Group 2, but there was a tendency of better results after Augmented Acetabuloplasty in children older than 6 years. Younger patients of Group 1 (4-6 years) ended up with good results at a significantly higher frequency than the older ones. Group 1 children with preoperative Laredo III arthrography had good results in a significantly greater number of cases, as compared with Laredo grade IV. The delta% between final and immediate postoperative CE angle was greater in those hips with good Mose rating.


Asunto(s)
Acetábulo/cirugía , Cadera/diagnóstico por imagen , Enfermedad de Legg-Calve-Perthes/cirugía , Osteotomía/métodos , Acetábulo/diagnóstico por imagen , Acetábulo/patología , Factores de Edad , Niño , Preescolar , Femenino , Cadera/patología , Humanos , Enfermedad de Legg-Calve-Perthes/clasificación , Enfermedad de Legg-Calve-Perthes/diagnóstico por imagen , Masculino , Radiografía , Estudios Retrospectivos , Resultado del Tratamiento
19.
J Pediatr Orthop B ; 12(5): 303-6, 2003 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-12973036

RESUMEN

Eosinophilic granuloma is a benign, self-limited condition most commonly seen in children around 10 years of age. There is no known cause concerning its etiology. The lesion is usually solitary and can involve the whole vertebral body with massive destruction and vertebral collapse ('coin lesion') but this appearance is not pathognomonic. Vertebral collapse may lead to neurological symptoms that might be severe. We describe two cases of eosinophilic granuloma, in which the patients have thoracic pain, numbness and weakness in their legs. Radiography, computed axial tomography and magnetic resonance imaging showed vertebral collapse and compression of the spinal cord. A biopsy was performed and the diagnosis of eosinophilic granuloma was confirmed by histological analysis. Both patients were treated surgically and they had gradual recovery of neurological deficit after the surgery.


Asunto(s)
Descompresión Quirúrgica , Granuloma Eosinófilo/cirugía , Niño , Granuloma Eosinófilo/diagnóstico , Femenino , Humanos , Laminectomía , Masculino , Toracotomía
20.
Acta Ortop Bras ; 22(2): 78-81, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24868184

RESUMEN

OBJECTIVE: To compare different radiographic methods of spine evaluation to estimate the reducibility and flexibility of the scoliosis curves. METHODS: Twenty one patients with Lenke types I and III adolescent idiopathic scoliosis (AIS) were included. Radiographic evaluations were made preoperatively on the orthostatic, supine decubitus with lateral inclination to the right and left and supine positions with manual reduction, with support in the apex of each curve on the X-ray table. On the day of surgery, when the patient was anesthetized, radiography was taken with longitudinal traction through divergent forces, holding under the arms and ankles, and with translational force at the apex of the deformity for curve correction. After one week, a post-operative radiography was performed in orthostatic position. RESULTS: The correction and flexibility of the main thoracic and thoracic/lumbar curves were statistically different between the supine radiographs, manual reduction, modified traction under general anesthesia, lateral inclination and postoperatively. The modified maneuver for traction under general anesthesia is the one which showed greater flexibility, besides presenting higher radiographic similarity to postoperative aspects. CONCLUSION: Among the radiographic modalities evaluated the study under anesthesia with traction and reduction showed better correlation with postoperative radiographic appearance. Level of Evidence IV, Case Series.

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