Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi-center study.

Frontal fibrosing alopecia (FFA) mainly affects the anterior hairline and eyebrows and its etiology and associated factors remain obscure. The aim of this study was to evaluate the allergic contact dermatitis with patch test in patients with FFA. In this prospective study, 20 patients with FFA and 24 age and sex-matched healthy individuals were evaluated with patch testing. Diagnosis was made histologically, clinically and based on dermoscopic findings. Demographic data, age of onset, disease duration and FFA severity index are evaluated in all patients. Positive patch test reaction to one or more allergen was observed in 65% of patients while it was 37.5% in control group (P = .003). There was a significant difference between age (P = .006) and positive patch test results. No statistical significant difference was observed in the results of patch testing and disease duration (P = .519), menopausal status (P = .085), and FFA severity index (P = .573). Our findings suggest an association between FFA and allergic contact dermatitis. The utility of patch testing in FFA patients can explore the role of allergic etiology and may have an enormous impact on the diagnostic potential and quality of life of these patients.

Postherpetic neuralgia and recalcitrant cystic lesions following herpes zoster: A case report and review of treatment options.

Acute herpes zoster lesions in most cases are self-limited except in older and immunocompromised patients, wherein the pain can cause significant suffering. Postherpetic neuralgia is a painful situation for patients that can compromise the quality of life. Here, we report a 30-year-old healthy young man who developed treatment-resistant postherpetic neuralgia after herpes zoster (fourth/fifth thoracic segment) without any underlying immunocompromised state. He also developed some cystic lesions, which were removed by aspiration and surgery. The skin lesions improved 2 weeks after the surgery and postherpetic neuralgia was completely cured after 5 months, however cystic lesions recurred multiple times and were excised completely during each visit. Postherpetic neuralgia has a significant impact on the health-care cost borne by the society and affected individual, hence, it is essential to select appropriate treatment to manage the pain of postherpetic neuralgia.

Anterior, frontal congenital triangular alopecia, redundancy in therapy without improvement.

Congenital triangular alopecia (CTA) is a benign noncicatricial localized pattern of hair loss with unknown etiology. Although referred to as "congenital," CTA may develop in adulthood. It is believed that many cases of CTA are never diagnosed or are misdiagnosed; causing the incidence to be underestimated. The present study evaluates a case of 20-year-old woman presenting with a single circular to oval area of hair-loss in the mid-frontal region of her scalp. To date, about 170 cases of CTA have been reported and we present the first case in which the alopecic patch is located in the mid-frontal region of the scalp. We present this case not only to challenge the preconceived notion that all CTAs are frontotemporal, but also to inform other practitioners about this rare condition and prevent redundant medical treatment.

Removal of Penicillin G from aqueous medium by PPI@SBA-15/ZIF-8 super adsorbent: Adsorption isotherm, thermodynamic, and kinetic studies.

In the present paper, synthesis of SBA-15 nanoparticles was carried out from tetraethyl orthosilicate (TEOS) precursor using the sol-gel process. After being combined with Poly propylene imine, and ZIF-8 they were employed for the removal of Penicillin G. The synthesized combination morphology was assessed using nitrogen adsorption and desorption (BET), Fourier transform infrared (FTIR) spectroscopy, and X-ray powder diffraction (XRD). The parameters affecting Penicillin G removal, including pH, amount of adsorbent, time of contact, temperature, and concentration, were optimized, and the optimum levels of the mentioned variables were reported to be pH = 3, 0.03 g, 90 min, 25 °C, and 100 ppm, respectively. In addition, application of Freundlich, Langmuir, Dubinin-Radushkevhch, and Tempkin models and pseudo-first-order and pseudo-second-order adsorption synthetic equations aimed at determining the type of adsorbent isotherm. The results showed that the best fitting of Langmuir (R2 = 0.9944, qm = 400 mg/g) for adsorption isotherm and pseudo-second-order model (R2 = 0.9905) for kinetics studies. Furthermore, data of Gibbs free energy and enthalpy demonstrated an exothermic and spontaneous process in the research.