Búsqueda | Biblioteca Virtual en Salud Odontología. Uruguay

1.

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.

Ng, Kevin W; Boumelha, Jesse; Enfield, Katey S S; Almagro, Jorge; Cha, Hongui; Pich, Oriol; Karasaki, Takahiro; Moore, David A; Salgado, Roberto; Sivakumar, Monica; Young, George; Molina-Arcas, Miriam; de Carné Trécesson, Sophie; Anastasiou, Panayiotis; Fendler, Annika; Au, Lewis; Shepherd, Scott T C; Martínez-Ruiz, Carlos; Puttick, Clare; Black, James R M; Watkins, Thomas B K; Kim, Hyemin; Shim, Seohee; Faulkner, Nikhil; Attig, Jan; Veeriah, Selvaraju; Magno, Neil; Ward, Sophia; Frankell, Alexander M; Al Bakir, Maise; Lim, Emilia L; Hill, Mark S; Wilson, Gareth A; Cook, Daniel E; Birkbak, Nicolai J; Behrens, Axel; Yousaf, Nadia; Popat, Sanjay; Hackshaw, Allan; Hiley, Crispin T; Litchfield, Kevin; McGranahan, Nicholas; Jamal-Hanjani, Mariam; Larkin, James; Lee, Se-Hoon; Turajlic, Samra; Swanton, Charles; Downward, Julian; Kassiotis, George.

Nature ; 616(7957): 563-573, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-37046094

2.

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.

Kumar, Madhu S; Hancock, David C; Molina-Arcas, Miriam; Steckel, Michael; East, Phillip; Diefenbacher, Markus; Armenteros-Monterroso, Elena; Lassailly, François; Matthews, Nik; Nye, Emma; Stamp, Gordon; Behrens, Axel; Downward, Julian.

Cell ; 149(3): 642-55, 2012 Apr 27.

Artículo en Inglés | MEDLINE | ID: mdl-22541434

3.

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

Coelho, Matthew A; de Carné Trécesson, Sophie; Rana, Sareena; Zecchin, Davide; Moore, Christopher; Molina-Arcas, Miriam; East, Philip; Spencer-Dene, Bradley; Nye, Emma; Barnouin, Karin; Snijders, Ambrosius P; Lai, Wi S; Blackshear, Perry J; Downward, Julian.

Immunity ; 47(6): 1083-1099.e6, 2017 12 19.

Artículo en Inglés | MEDLINE | ID: mdl-29246442

4.

The Potency of a KRAS Silent Variant.

Molina-Arcas, Miriam; Downward, Julian.

N Engl J Med ; 386(26): 2523-2525, 2022 06 30.

Artículo en Inglés | MEDLINE | ID: mdl-35767444

5.

Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells.

Medina-Pulido, Lorena; Molina-Arcas, Míriam; Justicia, Carles; Soriano, Eduardo; Burgaya, Ferran; Planas, Anna M; Pastor-Anglada, Marçal.

Biochem J ; 454(3): 437-45, 2013 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-23819782

6.

Exploiting the therapeutic implications of KRAS inhibition on tumor immunity.

Molina-Arcas, Miriam; Downward, Julian.

Cancer Cell ; 42(3): 338-357, 2024 Mar 11.

Artículo en Inglés | MEDLINE | ID: mdl-38471457

7.

CRISPR-Cas9 screening identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer.

Boumelha, Jesse; de Castro, Andrea; Bah, Nourdine; Cha, Hongui; de Carné Trécesson, Sophie; Rana, Sareena; Tomaschko, Mona; Anastasiou, Panayiotis; Mugarza, Edurne; Moore, Christopher; Goldstone, Robert; East, Philip; Litchfield, Kevin; Lee, Se-Hoon; Molina-Arcas, Miriam; Downward, Julian.

Cancer Res ; 2024 Apr 18.

Artículo en Inglés | MEDLINE | ID: mdl-38635884

8.

Facts and Hopes on RAS Inhibitors and Cancer Immunotherapy.

Boumelha, Jesse; Molina-Arcas, Miriam; Downward, Julian.

Clin Cancer Res ; 29(24): 5012-5020, 2023 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-37581538

9.

Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.

Ismail, Mohamed; Martin, Stephen R; George, Roger; Houghton, Francesca; Kelly, Geoff; Chaleil, Raphaël A G; Anastasiou, Panayiotis; Wang, Xinyue; O'Reilly, Nicola; Federico, Stefania; Joshi, Dhira; Nagaraj, Hemavathi; Cooley, Rachel; Hui, Ning Sze; Molina-Arcas, Miriam; Hancock, David C; Tavassoli, Ali; Downward, Julian.

Sci Rep ; 13(1): 1889, 2023 02 02.

Artículo en Inglés | MEDLINE | ID: mdl-36732563

10.

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.

Trigueros-Motos, Laia; Pérez-Torras, Sandra; Casado, F Javier; Molina-Arcas, Míriam; Pastor-Anglada, Marçal.

BMC Cancer ; 12: 434, 2012 Sep 27.

Artículo en Inglés | MEDLINE | ID: mdl-23017148

11.

Therapeutic KRAS^G12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers.

Mugarza, Edurne; van Maldegem, Febe; Boumelha, Jesse; Moore, Christopher; Rana, Sareena; Llorian Sopena, Miriam; East, Philip; Ambler, Rachel; Anastasiou, Panayiotis; Romero-Clavijo, Pablo; Valand, Karishma; Cole, Megan; Molina-Arcas, Miriam; Downward, Julian.

Sci Adv ; 8(29): eabm8780, 2022 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-35857848

12.

An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations.

Boumelha, Jesse; de Carné Trécesson, Sophie; Law, Emily K; Romero-Clavijo, Pablo; Coelho, Matthew A; Ng, Kevin W; Mugarza, Edurne; Moore, Christopher; Rana, Sareena; Caswell, Deborah R; Murillo, Miguel; Hancock, David C; Argyris, Prokopios P; Brown, William L; Durfee, Cameron; Larson, Lindsay K; Vogel, Rachel I; Suárez-Bonnet, Alejandro; Priestnall, Simon L; East, Philip; Ross, Sarah J; Kassiotis, George; Molina-Arcas, Miriam; Swanton, Charles; Harris, Reuben; Downward, Julian.

Cancer Res ; 82(19): 3435-3448, 2022 Oct 04.

Artículo en Inglés | MEDLINE | ID: mdl-35930804

13.

Drugging the Undruggable: Advances on RAS Targeting in Cancer.

Molina-Arcas, Miriam; Samani, Amit; Downward, Julian.

Genes (Basel) ; 12(6)2021 06 10.

Artículo en Inglés | MEDLINE | ID: mdl-34200676

14.

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry.

van Maldegem, Febe; Valand, Karishma; Cole, Megan; Patel, Harshil; Angelova, Mihaela; Rana, Sareena; Colliver, Emma; Enfield, Katey; Bah, Nourdine; Kelly, Gavin; Tsang, Victoria Siu Kwan; Mugarza, Edurne; Moore, Christopher; Hobson, Philip; Levi, Dina; Molina-Arcas, Miriam; Swanton, Charles; Downward, Julian.

Nat Commun ; 12(1): 5906, 2021 10 08.

Artículo en Inglés | MEDLINE | ID: mdl-34625563

15.

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer.

Chrysostomou, Stelios; Roy, Rajat; Prischi, Filippo; Thamlikitkul, Lucksamon; Chapman, Kathryn L; Mufti, Uwais; Peach, Robert; Ding, Laifeng; Hancock, David; Moore, Christopher; Molina-Arcas, Miriam; Mauri, Francesco; Pinato, David J; Abrahams, Joel M; Ottaviani, Silvia; Castellano, Leandro; Giamas, Georgios; Pascoe, Jennifer; Moonamale, Devmini; Pirrie, Sarah; Gaunt, Claire; Billingham, Lucinda; Steven, Neil M; Cullen, Michael; Hrouda, David; Winkler, Mathias; Post, John; Cohen, Philip; Salpeter, Seth J; Bar, Vered; Zundelevich, Adi; Golan, Shay; Leibovici, Dan; Lara, Romain; Klug, David R; Yaliraki, Sophia N; Barahona, Mauricio; Wang, Yulan; Downward, Julian; Skehel, J Mark; Ali, Maruf M U; Seckl, Michael J; Pardo, Olivier E.

Sci Transl Med ; 13(602)2021 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-34261798

16.

The human concentrative nucleoside transporter-3 C602R variant shows impaired sorting to lipid rafts and altered specificity for nucleoside-derived drugs.

Errasti-Murugarren, Ekaitz; Molina-Arcas, Miriam; Casado, F Javier; Pastor-Anglada, Marçal.

Mol Pharmacol ; 78(2): 157-65, 2010 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-20421346

17.

A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum.

Errasti-Murugarren, Ekaitz; Molina-Arcas, Miriam; Casado, Fco Javier; Pastor-Anglada, Marçal.

FASEB J ; 23(1): 172-82, 2009 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-18827020

18.

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche.

Wamaitha, Sissy E; Grybel, Katarzyna J; Alanis-Lobato, Gregorio; Gerri, Claudia; Ogushi, Sugako; McCarthy, Afshan; Mahadevaiah, Shantha K; Healy, Lyn; Lea, Rebecca A; Molina-Arcas, Miriam; Devito, Liani G; Elder, Kay; Snell, Phil; Christie, Leila; Downward, Julian; Turner, James M A; Niakan, Kathy K.

Nat Commun ; 11(1): 764, 2020 02 07.

Artículo en Inglés | MEDLINE | ID: mdl-32034154

19.

Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.

Minuesa, Gerard; Volk, Christopher; Molina-Arcas, Míriam; Gorboulev, Valentin; Erkizia, Itziar; Arndt, Petra; Clotet, Bonaventura; Pastor-Anglada, Marçal; Koepsell, Hermann; Martinez-Picado, Javier.

J Pharmacol Exp Ther ; 329(1): 252-61, 2009 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-19141712

20.

Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.

Molina-Arcas, Miriam; Moore, Christopher; Rana, Sareena; van Maldegem, Febe; Mugarza, Edurne; Romero-Clavijo, Pablo; Herbert, Eleanor; Horswell, Stuart; Li, Lian-Sheng; Janes, Matthew R; Hancock, David C; Downward, Julian.

Sci Transl Med ; 11(510)2019 09 18.

Artículo en Inglés | MEDLINE | ID: mdl-31534020

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