Bioavailability and uptake of smelter emissions in freshwater zooplankton in northeastern Washington, USA lakes using Pb isotope analysis and trace metal concentrations.

The upper Columbia River and associated valley systems are highly contaminated with metal wastes from nearby smelting operations in Trail, British Columbia, Canada (Teck smelter), and to a lesser extent, Northport, Washington, USA (Le Roi smelter). Previous studies have investigated depositional patterns of airborne emissions from these smelters, and documented the Teck smelter as the primary metal contamination source. However, there is limited research directed at whether these contaminants are bioavailable to aquatic organisms. This study investigates whether smelter derived contaminants are bioavailable to freshwater zooplankton. Trace metal (Zn, Cd, As, Sb, Pb and Hg) concentrations and Pb isotope compositions of zooplankton and sediment were measured in lakes ranging from 17 to 144 km downwind of the Teck smelter. Pb isotopic compositions of historic ores used by both smelters are uniquely less radiogenic than local geologic formations, so when zooplankton assimilate substantial amounts of smelter derived metals their compositions deviate from local baseline compositions toward ore compositions. Sediment metal concentrations and Pb isotope compositions in sediment follow significant (p < 0.001) negative exponential and sigmoidal patterns, respectively, as distance from the Teck smelting operation increases. Zooplankton As, Cd, and Sb contents were related to distance from the Teck smelter (p < 0.05), and zooplankton Pb isotope compositions suggest As, Cd, Sb and Pb from historic and current smelter emissions are biologically available to zooplankton. Zooplankton from lakes within 86 km of the Teck facility display isotopic evidence that legacy ore pollution is biologically available for assimilation. However, without water column data our study is unable to determine if legacy contaminants are remobilized from lake sediments, or erosional pathways from the watershed.

Dynamic aspects of the continuity illusion: perception of level and of the depth, rate, and phase of modulation.

The perception of modulation of a tone interrupted by a noise burst was investigated. The tone and its modulation were perceived as continuing through the noise. In experiment 1, subjects rated the similarity of an uninterrupted tone and a tone interrupted by noise, in terms of the perceived level and modulation depth of the sinusoidal carrier. The values of these parameters in the central portion of the uninterrupted tone were systematically varied. Both amplitude and frequency modulation (AM and FM) were used. The results indicated that the perceived level and modulation depth of the carrier did not change greatly during the noise burst. When the modulation rate differed before and after the noise burst, the modulation-rate transition was perceived to occur near the end of the noise burst for the FM stimuli. Hence, for these stimuli, the continuity illusion appears to be dominated by the portion of the tone before, rather than after, the interruption. Results for the AM stimuli showed a non-significant trend in the same direction. Experiment 2 used forced-choice tasks to evaluate the ability to detect a change in the ongoing phase of AM and FM following interruption by a noise burst. The results confirmed earlier findings for FM tones, and extended them to AM tones, showing that listeners lost track of the phase of the modulation, even though the modulation was perceived as continuous.

Free intracellular Ca2+ concentration ([Ca2+]i) and growth hormone release from purified rat somatotrophs. I. GH-releasing factor-induced Ca2+ influx raises [Ca2+]i.

This study was carried out to investigate the role of free intracellular Ca2+ ([Ca2+]i) in the action of GH-releasing factor (GRF) by determining whether GRF causes and increase in [Ca2+]i and whether this increase results from changes in Ca2+ influx/efflux and/or mobilization of intracellular Ca2+ stores. We used a purified preparation of normal rat somatotrophs and examined the changes in 45Ca uptake, [Ca2+]i measured with indo-1, intracellular cAMP, and GH release induced by GRF. GRF stimulated a concentration-related biphasic increase in [Ca2+]i. Both the GRF-dependent increase in [Ca2+]i and GH release were blocked by incubation in low Ca2+ medium and by the organic Ca2+ antagonists nifedipine and diltiazem. The measurement of 45Ca uptake, in both steady state and nonsteady state conditions, demonstrated directly that GRF stimulates Ca2+ influx into somatotrophs. These data demonstrate that the GRF-stimulated increase in [Ca2+]i is dependent on Ca2+ influx. Redistribution of intracellularly stored Ca2+ could not be detected, even though intracellular Ca2+ stores were present. Therefore, the increase is due to Ca2+ influx, and the biphasic nature of the increase in [Ca2+]i induced by GRF is due to a difference in the rate of activation of Ca2+ influx and Ca2+ removal from the cytosol.

COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) have as their common mechanism the inhibition of cyclooxygenase (COX) enzymes, of which two isoforms (COX-1 and COX-2) exist. The effect of NSAIDs on chemoprevention and tumor regression has been shown in animal models, epidemiologic studies, and in treatment of patients. The exact biochemical and cellular mechanisms underlying each of these phenomena is only partially understood. Processes that have been recently implicated as being important include the inhibition of tumor cell growth, prevention of angiogenesis, and induction of apoptosis in neoplastic cells.

Psychoacoustic consequences of compression in the peripheral auditory system.

Input-output functions on the basilar membrane of the cochlea show a strong compressive nonlinearity at midrange levels for frequencies close to the characteristic frequency of a given place. This article shows how many different phenomena can be explained as consequences of this nonlinearity, including the "excess" masking produced when 2 nonsimultaneous maskers are combined, the nonlinear growth of forward masking with masker level, the influence of component phase on the effectiveness of complex forward maskers, changes in the ability to detect increments and decrements with level, temporal integration, and the influence of component phase and level on the perception of vowellike sounds. Cochlear hearing loss causes basilar-membrane responses to become more linear. This can account for loudness recruitment, linear additivity of nonsimultaneous masking, linear growth of forward masking, reduced temporal resolution for sounds with fluctuating envelopes, and reduced temporal integration.

Psychophysical evaluation of cochlear hair cell damage due to the A3243G mitochondrial DNA mutation.

Mitochondrial dysfunction is an important cause of human deafness, implicated in genetic deafness, toxin and noise damage. We assessed the mechanism of cochlear dysfunction in a population of 11 subjects with a specific mitochondrial disorder caused by the A3243G mitochondrial DNA mutation. Psychophysical tests were carried out to assess the inner and outer hair cell functions in vivo. Inner hair cell function was assessed using a measure of hearing threshold in the presence of "threshold-equalizing noise" which can indicate "dead regions" where the transduction mechanism fails. Outer hair cell function was assessed by using the notched-noise method to measure auditory filter width, dependent on active mechanisms in the outer hair cell. The results support the conclusion that this mitochondrial disorder causes both inner and outer hair cell dysfunctions. Evidence of inner hair cell dysfunction was found mainly in basal (high frequency) regions of the cochlea and occurred even in some subjects with only mild hearing loss. Evidence of outer hair cell dysfunction was found in some instances where pure tone threshold was at or close to normal. The common occurrence of dead regions in the basal cochlea has treatment implication for this form of deafness; such people may not be helped by amplification of high frequencies.

Temporal analysis in normal and impaired hearing.

The ear contains an array of filters that separate the components of a complex signal into "channels" tuned to different center frequencies. Temporal analysis can be considered as two processes: analysis of the time pattern occurring within each channel, and comparison of the time patterns across channels. Within-channel acuity can be characterized by tasks such as gap detection, or by the ability to detect amplitude modulation as a function of modulation rate. The smallest detectable gap duration for a white noise stimulus is 2-3 ms. The results can be modeled by an array of filters, with each filter followed by a nonlinearity and a (central) sliding temporal integrator. Hearing impairment of cochlear origin can have adverse effects on temporal resolution because it often reduces the audible bandwidth of the stimuli, and because it results in a reduced sensation level of the stimuli. The sliding temporal integrator appears to be unaffected by hearing loss, although the nonlinearity preceding the integrator may be abnormal, and this can lead to reduced temporal resolution for sounds with slowly fluctuating envelopes. Hearing impairment of more central origin may also adversely affect temporal resolution, but the mechanisms responsible for this are not known. The acuity of across-channel temporal analysis depends on whether the task is one of discrimination or of identification of temporal order. The finest acuity (1-2 ms) occurs for discrimination tasks. Identification of temporal order is an order of magnitude worse. When the elements of a sequence of sounds are perceived as more than one source (more than one perceptual stream), the ability to judge the order of the elements can be very poor. Perceptual grouping processes can also have dramatic effects on the perceived temporal structure of sound. Conversely, temporal structure can have a powerful influence on perceptual grouping.

Dead regions in the cochlea: diagnosis, perceptual consequences, and implications for the fitting of hearing AIDS.

Hearing impairment is often associated with damage to the hair cells in the cochlea. Sometimes there may be complete loss of function of inner hair cells (IHCs) over a certain region of the cochlea; this is called a "dead region". The region can be defined in terms of the range of characteristic frequencies (CFs) of the IHCs and/or neurons immediately adjacent to the dead region. This paper reviews the following topics: the effect of dead regions on the audiogram; methods for the detection and delineation of dead regions based on psychophysical tuning curves (PTCs) and on the measurement of thresholds for pure tones in "threshold equalizing noise" (TEN); effects of dead regions on speech perception; effects of dead regions on the perception of tones; implications of dead regions for fitting hearing aids. The main conclusions are: (1) Dead regions may be relatively common in people with moderate-to-severe sensorineural hearing loss; (2) Dead regions cannot be reliably diagnosed from the audiogram; (3) PTCs provide a useful way of detecting dead regions and defining their boundaries. However, the determination of PTCs is probably too time-consuming to be used for routine diagnosis of dead regions in clinical practice; (4) The measurement of detection thresholds for pure tones in TEN provides a simple method for clinical diagnosis of dead regions; (5) Pure tones with frequencies falling in a dead region do not evoke clear pitch sensations (pitch matching is highly variable) and the perceived pitch is sometimes, but not always, different from "normal". However, ratings of pitch clarity cannot be used as a reliable indicator of a dead region; (6) Amplification of frequencies well inside a high-frequency dead region usually does not improve speech intelligibility, and may sometimes impair it. However, there may be some benefit in amplifying frequencies up to 50 to 100% above the estimated low-frequency edge of a high-frequency dead region; (7) The optimal form of amplification for people with low-frequency dead regions remains somewhat unclear. There may be some benefit from avoiding the amplification of frequencies well inside a dead region; (8) Patients with extensive dead regions are likely to get less benefit from hearing aids than patients without dead regions; (9) For patients with diagnosed dead regions at high frequencies, consideration should be given to use of a hearing aid incorporating frequency transposition and/or compression.

Formulae describing frequency selectivity as a function of frequency and level, and their use in calculating excitation patterns.

The auditory filter may be considered as a weighting function representing frequency selectivity at a particular centre frequency. Its shape can be derived using the power-spectrum model of masking which assumes: (1) in detecting a signal in a masker the observer uses the single auditory filter giving the highest signal-to-masker ratio; (2) threshold corresponds to a fixed signal-to-masker ratio at the output of that filter. Factors influencing the choice of a masker to measure the auditory filter shape are discussed. Narrow-band maskers are unsuitable for this purpose, since they violate the assumptions of the power-spectrum model. A method using a notched-noise masker is recommended, and typical results using that method are presented. The variation of the auditory filter shape with centre frequency and with level, and the relationship of the auditory filter shape and the excitation pattern are described. A method of calculating the excitation pattern of any sound as a function of level is presented, and examples and applications are given. The appendix gives a Fortran program for calculating excitation patterns.

Temporal effects in simultaneous pure-tone masking: effects of signal frequency, masker/signal frequency ratio, and masker level.

The effect of the temporal relationship between a pure-tone masker and a pure-tone signal in simultaneous masking was investigated in three experiments. The experiments extend previous work by: studying the temporal effect over a wide range of signal frequencies, studying the change in masking over time for several masker/signal frequency ratios, and studying the growth of masking for a brief signal at different temporal positions within a longer duration masker. In the first experiment, threshold was measured for a 20-ms signal temporally centered in a masker whose duration ranged from 20 ms to continuous. Signal frequency (fs) was 0.5, 1.0, 2.0, 4.0, or 8.0 kHz; masker frequency (fm) was 1.2 fs. For all signal frequencies, the amount of masking decreased as masker duration increased. In the second experiment, threshold was measured for a 20-ms, 1.0-kHz signal as a function of the signal's temporal position within a 400-ms masker whose frequency ranged from 1.0 to 1.25 kHz. For all but the 1.0-kHz masker, for which threshold was almost independent of the signal's temporal position, threshold decreased as signal onset was delayed relative to masker onset, but then increased slightly as the signal approached masker offset. In the final experiment, growth-of-masking functions were measured for a 20-ms, 1.0-kHz signal positioned at the beginning, at the temporal center, or at the end of a 400-ms masker whose frequency was 1.20 or 1.25 kHz. The masking functions generally were steepest for a signal at the onset of the masker and, for a given temporal position, steepest for the 1.20-kHz masker.

Effects of envelope fluctuations on gap detection.

The inherent fluctuations present in narrowbands of noise may limit the ability to detect gaps in the noise; 'dips' in the noise may be confused with the gap to be detected. For subjects with cochlear hearing loss, loudness recruitment may effectively magnify the fluctuations and this could partly account for the reduced ability to detect gaps in noise bands that is usually found in subjects with cochlear hearing loss. In the present experiments we tested these ideas by processing noise bands to alter the amount of envelope fluctuation. The envelopes of the noise bands were raised to a power, N. Powers greater than 1 result in expansion of the envelope (magnified fluctuations, simulating loudness recruitment), while powers less than 1 result in compression of the envelope (decreased fluctuations). Thresholds for detecting gaps in processed noise bands centered at 1 kHz were measured as a function of noise bandwidth and of N. To prevent the detection of spectral changes introduced by the gap or by the processing, stimuli were either presented in background noise, or at a low sensation level (20 dB). Three normally hearing subjects, two subjects with unilateral cochlear hearing loss and two subjects with bilateral cochlear hearing loss were tested. Gap thresholds generally increased with increasing N. This effect was large for small noise bandwidths (50 Hz or less) and smaller for larger noise bandwidths (200 Hz or more). For both the normal and impaired ears, gap thresholds at narrow bandwidths were improved relative to those for unprocessed noise bands (N = 1) by compressing the envelope fluctuations (N < 1). The results support the idea that fluctuations in narrowband noises affect gap detection, and that loudness recruitment may adversely affect the ability to detect gaps in noise bands. They also show that compression of the fluctuations in the noise can improve gap detection.

Modeling the additivity of nonsimultaneous masking.

Thresholds were measured for detecting a brief 6-kHz sinusoidal signal preceded by a broadband noise masker (forward masking), followed by the masker (backward masking), or both preceded by and followed by the masker (combined masking). The masker-signal interval was systematically varied. Consistent with the literature, thresholds in the combined-masking condition were higher than would be predicted by an energy-sum of the effects of the individual forward and backward maskers. This is often referred to as 'excess' masking. The data were modeled by subjecting the amplitude of the stimuli to a power-law nonlinearity followed by a sliding temporal integrator ('window'). It was assumed that threshold corresponds to a fixed signal-to-noise ratio at the output of the window. The best fits to the data were obtained using a power less than unity (0.5 to 0.7), i.e. by a compressive nonlinearity. Generally good fits to the data were achieved, indicating that the model is able to account for the decay of forward and backward masking as well as the effects of combining pairs of maskers (excess masking). The temporal windows derived from the data are also able to predict thresholds in decrement and increment detection tasks, and to account for the longer-term effects of masker duration in forward masking.

Derivation of auditory filter shapes from notched-noise data.

A well established method for estimating the shape of the auditory filter is based on the measurement of the threshold of a sinusoidal signal in a notched-noise masker, as a function of notch width. To measure the asymmetry of the filter, the notch has to be placed both symmetrically and asymmetrically about the signal frequency. In previous work several simplifying assumptions and approximations were made in deriving auditory filter shapes from the data. In this paper we describe modifications to the fitting procedure which allow more accurate derivations. These include: 1) taking into account changes in filter bandwidth with centre frequency when allowing for the effects of off-frequency listening; 2) correcting for the non-flat frequency response of the earphone; 3) correcting for the transmission characteristics of the outer and middle ear; 4) limiting the amount by which the centre frequency of the filter can shift in order to maximise the signal-to-masker ratio. In many cases, these modifications result in only small changes to the derived filter shape. However, at very high and very low centre frequencies and for hearing-impaired subjects the differences can be substantial. It is also shown that filter shapes derived from data where the notch is always placed symmetrically about the signal frequency can be seriously in error when the underlying filter is markedly asymmetric. New formulae are suggested describing the variation of the auditory filter with frequency and level. The implication of the results for the calculation of excitation patterns are discussed and a modified procedure is proposed. The appendix list FORTRAN computer programs for deriving auditory filter shapes from notched-noise data and for calculating excitation patterns. The first program can readily be modified so as to derive auditory filter shapes from data obtained with other types of maskers, such as rippled noise.

Detection and intensity discrimination of brief tones as a function of duration by hearing-impaired listeners.

For normal listeners, difference limens for intensity (DLs) for Gaussian-shaped tone pulses are largest at medium pulse durations (corresponding to about five cycles of the tonal carrier) when the pedestals are 10 dB above threshold, either in quiet or in a pink noise background. One explanation for this is that worst performance occurs when the internal representation of the tone pulses is most compact in time and frequency, affording minimal opportunity for 'multiple looks' (Van Schijndel et al., J. Acoust. Soc. Am. 105 (1999) 3425-3435). However, the mid-duration worsening is largest for medium overall levels, suggesting an involvement of compression on the basilar membrane (BM), which is also greatest at medium levels (Baer et al., J. Acoust. Soc. Am. 106 (1999) 1907-1916). If this is so, the mid-duration worsening should be reduced when BM compression is reduced by outer hair cell damage. To test this, subjects with sensorineural hearing losses were tested using 1-kHz or 4-kHz Gaussian-shaped tone pulses, in quiet or in pink noise that raised thresholds by 10-20 dB. For subjects with mild losses, poorest performance was sometimes found for medium durations. For more severe losses, intensity DLs tended to improve monotonically or remain roughly constant with increasing duration. Performance overall tended to be better for subjects with greater hearing losses. The results are more consistent with an explanation based on BM compression than with an explanation based on multiple looks.

Improving psychoacoustical tuning curves.

The probe signal in psychoacoustical tuning curves stimulates more than one neuron, even when presented at low levels. The subject can "listen" to neurons with characteristic frequencies away from the nominal probe frequency and optimize performance. This "off-frequency listening" can account for much of the discrepancy in the sharpness of tuning between psychoacoustical tuning curves obtained in forward masking and neurophysiological tuning curves. By adding a band-reject noise, centred on the probe frequency, to limit off-frequency listening, results in close agreement with the neurophysiological data can be produced.

The relative role of beats and combination tones in determining the shapes of masking patterns at 2 kHz: I. Normal-hearing listeners.

Masking patterns for a 2-kHz sinusoidal masker at 45, 65 or 85 dB SPL were measured for three normal-hearing subjects, using a 3-AFC method with feedback (condition 1). The patterns showed distinct irregularities, particularly at the highest masker level. In condition 2, a lowpass noise was added to mask combination tones. The noise increased thresholds mainly for the 85 dB masker, for signal frequencies of 2.3-3.0 kHz. In condition 3, a pair of high-frequency tones ('modulation detection interference (MDI) tones') was used to introduce beats at the same rate as produced by the interaction of the masker and signal. Thresholds were higher than for condition 1, particularly for signal frequencies adjacent to the masker frequency. In condition 4, the lowpass noise was presented simultaneously with the MDI tones. Thresholds were well predicted as a combination of the effects of the lowpass noise and the MDI tones. In condition 5, a pair of low-frequency MDI tones was added to the masker. The thresholds had the same overall pattern as in condition 4. We conclude that the shapes of masking patterns measured using a 2-kHz masker are influenced by the detection of beats for masker-signal frequency separations up to at least 300 Hz and by the detection of combination tones for separations between 300 and 1000 Hz.

The influence of external and internal noise on the detection of increments and decrements in the level of sinusoids.

This paper examines the influence of external and internal noise on the detection of increments and decrements in the level of sinusoidal pedestals. In experiment 1, the pedestals were presented either 18 dB above the masked threshold in broadband noise (condition 18-Masked) or 18 dB above the absolute threshold (condition 18-Abs). Pedestal frequencies were 250, 1000 or 4000 Hz, and increment/decrement durations ranged from 5 to 200 ms. For condition 18-Masked, thresholds decreased with increasing pedestal frequency, while for condition 18-Abs, thresholds did not change significantly with pedestal frequency. These results are consistent with the idea that, in condition 18-Masked, thresholds were influenced by the inherent fluctuations produced by the background noise at the output of the auditory filter centred at the pedestal frequency. These fluctuations would decrease in rate with decreasing centre frequency, and this might have a greater deleterious effect on performance. In contrast, the characteristics of the internal noise that presumably limited performance in condition 18-Abs do not appear to vary with pedestal frequency. In experiment 2, a 4000 Hz pedestal was used. It was presented either in quiet or in the presence of narrowband noise centred at 4000, or 7000 Hz, or both. The noise bandwidth ranged from 50 to 400 Hz. The increment/decrement duration ranged from 5 to 100 ms. The noise centred at 7000 Hz produced only a small deterioration in performance relative to that measured in quiet. The noise centred at 4000 Hz had a larger effect, and the effect increased with decreasing noise bandwidth. This is consistent with the idea that slow fluctuations at the output of the auditory filter impair increment and decrement detection more than rapid fluctuations. A model is proposed to account for the results, based on a simulated auditory filter, a compressive non-linearity, a sliding temporal integrator, a logarithmic transform and a template mechanism. Analysis using the model suggests that the effect of centre frequency observed in experiment 1, when background noise was present, cannot be explained entirely in terms of the fluctuations produced by the background noise at the output of the auditory filter centred at the pedestal frequency.

Induction of morphological deformities in Chironomus tentans exposed to zinc- and lead-spiked sediments.

Laboratory experiments were used to assess morphological responses of Chironomus tentans larvae exposed to three levels of zinc and lead. Chironomus tentans egg masses were placed into triplicate control and metal-spiked aquaria containing the measured concentrations 1,442, 3,383, and 5,562 microg/g Pb dry weight and 1,723, 3,743, and 5,252 microg/g Zn dry weight. Larvae were collected at 10-d intervals after egg masses were placed in aquaria until final emergence. Larvae were screened for mouthpart deformities and metal body burdens. Deformities increased with time of exposure in both Zn and Pb tanks. Deformity rates between the three Zn concentrations differed statistically, with low and medium Zn levels containing the highest overall deformity rates of 12%. Deformity rates for larvae held in the Pb aquaria were found to differ significantly. Larvae in the low-Pb tanks had a deformity rate of 9%. Larvae and water from both the Zn and Pb aquaria had increasing metal concentrations with increasing sediment metal concentration. Results demonstrate that Zn and Pb each induce chironomid mouthpart deformities at various concentrations. However, a clear dose-related response was not demonstrated. Our research provides more support for the potential use of chironomid deformities as a tool for the assessment of heavy metal pollution in aquatic systems.

Design and evaluation of a two-channel compression hearing aid.

The design of a two-channel compression hearing aid for persons with moderate sensorineural hearing losses with recruitment is described. The aid applies slow-acting automatic gain control (AGC) to the whole signal, and then splits the signal into two bands, with separate fast-acting (syllabic) AGC in each band. Trials evaluating the aid have shown that it allows speech in quiet to be understood over a wide range of sound levels without any need to adjust the controls on the aid. It also gives speech intelligibility in noise superior to that allowed by a comparable linear (non-compression) aid, a comparable single-channel compression aid, and by unaided listening. Pilot experiments comparing two different methods for fitting the aid suggest that fitting using speech as the test signal is superior to fitting using narrow band tonal signals.

Spectral feature enhancement for people with sensorineural hearing impairment: effects on speech intelligibility and quality.

People with sensorineural hearing loss often have difficulty understanding speech in background noise at speech-to-noise ratios (0 to +6 dB) for which normally hearing people have little difficulty. Spectral analysis of speech in noise at these ratios typically shows that the major spectral prominences in the speech (formants) are well represented, but the spectral valleys between the formants are filled with noise. Hearing impaired people have a reduced ability to pick out the spectral prominences, and are more affected by the noise filling in the valleys, partly because of their reduced frequency selectivity. This paper describes a 16-channel bandpass filter bank, implemented in analog electronics, that attempts to enhance spectral features of speech in noise to improve intelligibility for the hearing impaired. Each channel generates an 'activity function' that is proportional to the magnitude of the signal envelope in that channel, averaged over a short period of time. A positively weighted activity function from the nth channel is combined with negatively weighted functions from channels n-2, n-1, n+1, and n+2, giving a correction signal used to control the gain of the bandpass signal in the nth channel. Recombining the bandpass signals results in an enhancement of spectral features of the speech in noise. Two different experiments are described here, one using the activity function as described, and the other using a non-linear transform of the activity function. In both experiments, several different weighting patterns were used in calculating the correction signal. The intelligibility of speech in noise processed by the system was measured for subjects with moderate sensorineural hearing loss. In both experiments, no improvement in intelligibility was found. However, subjective ratings of the stimuli used in Experiment 2 indicated that some subjects judged the processed stimuli to have both higher quality and higher intelligibility than unprocessed stimuli.